Abstract：
:Aberrant activation of signal transducer and activator of transcription 3 (STAT3) is frequently observed in multiple myeloma (MM) cancer and can upregulate the expression of several genes involved in proliferation, survival, metastasis, and angiogenesis. The effect of farnesol (FOH) on STAT3 activation, associated protein kinases, its regulated gene products, cellular proliferation, and apoptosis was examined. The in vivo effect of FOH on the growth of human MM xenograft tumors alone and in combination with bortezomib (Bor) in athymic nu/nu female mice was also investigated. We found that FOH suppressed both constitutive and inducible STAT3 activation at Tyr705 in MM cells. The suppression of STAT3 was mediated through the inhibition of activation of upstream JAK1, JAK2, and c-Src kinases. Also, treatment with the protein tyrosine phosphatase (PTP) inhibitor, pervanadate treatment reversed the FOH-induced down-regulation of STAT3, possibly indicating the involvement of a PTP. Indeed, we found that FOH treatment induces the increased expression of SHP-2 protein and knockdown of the SHP-2 gene by small interfering RNA suppressed the ability of FOH to inhibit STAT3 activation. FOH inhibited proliferation and significantly potentiated the apoptotic effects of bortezomib (Bor) in U266 cells. When administered intraperitoneally, FOH enhanced Bor-induced growth suppression of human MM xenograft tumors in athymic nu/nu female mice. Our results suggest that FOH is a novel blocker of STAT3 signaling pathway and exerts both anti-proliferative and apoptotic activities in MM in vitro and in vivo.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Lee JH,Kim C,Kim SH,Sethi G,Ahn KSdoi
10.1016/j.canlet.2015.02.024subject
Has Abstractpub_date
2015-05-01 00:00:00pages
280-93issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(15)00128-7journal_volume
360pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract：:Despite the common expression of death receptors, many types of cancer including gliomas are resistant to the death receptor ligand (TRAIL). Melatonin antitumoral actions have been extensively described, including oncostatic properties on several tumor types and improvement of chemotherapeutic regimens. Here, we found...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2009.06.016
更新日期：2010-01-28 00:00:00
abstract：:Nitrosamine formation from the reaction of nitroprusside with morpholine was found to be a light-dependent reaction. Maximum nitrosation occurred when the reactants were exposed to UV light (lambda = 275-300 nm). However, considerable nitrosation also occurred with light in the visible spectrum up to 500 nm. No signif...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(88)90013-4
更新日期：1988-06-15 00:00:00
abstract：:Nuclear factor-kappa B (NF-kappaB) activation by tumor necrosis factor-alpha (TNF-alpha) attenuates the TNF-alpha-induced apoptosis pathway. Thus, blockage of NF-kappaB activity may improve the anti-cancer activity of TNF-alpha. HA14-1 induces apoptosis in various human cancer cells, and the molecular mechanisms of th...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2009.11.014
更新日期：2010-06-01 00:00:00
abstract：:Epigenetics is defined as heritable changes in gene expression that occur without changes in DNA sequence. Major mechanisms of epigenetics are post-translational histone modifications such as reversible acetylation. Histone deacetylases (HDACs) maintain the acetylation level of histones but also act on non-histone sub...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2009.01.040
更新日期：2009-08-08 00:00:00
abstract：:We have investigated the effects of hyperthermia on the apoptosis induced by tumor necrosis factor alpha (TNF-alpha). Confluent monolayers of human gastric cancer cell line MKN45 were either treated or untreated with hyperthermia for 1 h. The cells were subsequently stimulated with TNF-alpha. A 24-h incubation with TN...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(03)00463-4
更新日期：2003-11-10 00:00:00
abstract：:Alteration of the p16 tumor suppressor gene has been implicated as a critical lesion in the molecular pathogenesis of esophageal adenocarcinoma. The aim of this study was to characterize the spectrum of p16 alterations in surgically resected esophageal tissues, comprising histologically normal esophageal squamous and ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2004.06.025
更新日期：2005-01-20 00:00:00
abstract：:2-Amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine (PhIP) is known to induce colon tumors in male Fischer-344 rats. Using 32P-postlabeling assays, we have examined PhIP-DNA adduct formation in various organs and white blood cells (WBCs) of the male Fischer-344 rat 24 h after a single oral dose of 0, 0.5, 5 or 50 mg PhIP...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(92)90134-h
更新日期：1992-12-24 00:00:00
abstract：:Development of drug resistance to standard chemotherapy is a common phenomenon that leads to poor prognosis in patients. Thus, novel agents that can attenuate chemoresistance are urgently needed. Therefore, we analyzed whether isorhamnetin (IH), a 3'-O-methylated metabolite of quercetin, can enhance the potential effi...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2015.03.033
更新日期：2015-07-10 00:00:00
abstract：:CD271, known as a neurotrophin receptor, is expressed in various cancers such as hypopharyngeal cancer (HPC) and melanoma. We recently reported that CD271 is a cancer-stem-cell biomarker of HPC, and that its expression is essential for cancer-cell proliferation and is correlated with a poor prognosis in this disease. ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2019.07.011
更新日期：2019-10-01 00:00:00
abstract：:In order to adapt to the reduced availability of nutrients and oxygen in the tumor microenvironment and the increased requirements of energy and building blocks necessary for maintaining their high proliferation rate, malignant cells undergo metabolic changes that result in an increased production of lactate, nitric o...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2017.10.037
更新日期：2018-01-28 00:00:00
abstract：:Telomeres constitute the ends of the linear eukaryotic chromosomes and are essential for the maintenance of chromosome stability and genome integrity. One of the consequences of an altered telomere structure is the formation of telomeric fusions (TFs), that is aberrant chromosomes in which two elements are fused at th...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2003.08.028
更新日期：2004-01-08 00:00:00
abstract：:Two human cell lines, one established from a colon carcinoma (SW480) and the other from its lymph node metastasis (SW620), were compared with respect to their migration capacity employing a three-dimensional collagen matrix and time-lapse video recording. Non-motile cells were characterized by a round shape, whereas m...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(98)00201-8
更新日期：1998-09-11 00:00:00
abstract：:Tumors are highly heterogeneous at the patient, tissue, cellular, and molecular levels. This multi-scale heterogeneity poses significant challenges for effective therapies, which ideally must not only distinguish between tumorous and healthy tissue, but also fully address the wide variety of tumorous sub-clones. Commo...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2015.12.019
更新日期：2016-09-28 00:00:00
abstract：:The overexpression of the MDM2 oncoprotein frequently occurs in hepatocellular carcinoma (HCC). Small molecules that inhibit MDM2-p53 binding show efficacy against p53 wild-type HCC, but most patients have p53-mutant tumors and intrinsic resistance to such MDM2 inhibitors. We have recently discovered that the NFAT1 tr...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2019.114429
更新日期：2019-09-10 00:00:00
abstract：:The pulmonary tumorigenicity of dimethylarsinic acid (DMAA), a main metabolite of inorganic arsenics, was examined in A/J mice fed with drinking water containing DMAA for 25 and 50 weeks. Mice fed with 400 ppm DMAA for 50 weeks produced more pulmonary tumors than untreated mice (mean number per animal 1.36 versus 0.50...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(97)00484-9
更新日期：1998-03-13 00:00:00
abstract：:Carbaryl (1-naphthyl methyl carbamate: C12H11NO2) CAS Reg. No. 63-25-2) is a widely used broad spectrum carbamate insecticide known to exert various toxic effects on experimental animals. Along with various other toxicological effects carbaryl is reported to increase the incidence of neoplasm in various tissues in rat...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(92)90183-v
更新日期：1992-02-29 00:00:00
abstract：:The presence and the involvement of cancer stem-like cells (CSCs) in tumor initiation and progression, and chemo-resistance are documented. Herein, we functionally analyzed melanoma stem-like cells (MSC)/CD133(+) cells on their resistance and response to taxol-induced apoptosis. Besides being taxol resistant, the CD13...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2013.09.024
更新日期：2014-02-01 00:00:00
abstract：:A Mr 60,000 protein, detected by its ability to induce the release of RNA from isolated nuclei, is present in the plasma of tumor-bearing and carcinogen-treated rats, together with low amounts of 2 messenger RNA transport proteins identified earlier in normal cells. The Mr 60,000 protein has been identified in tumor c...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(83)90025-3
更新日期：1983-10-01 00:00:00
abstract：:Radiotherapy (RT) is one of the most important strategies in cancer treatment. Radioresistance is a major challenge to RT and results in locoregional recurrence and metastasis. Thus, there is a great interest in investigating biomarkers to distinguish radiosensitive from radioresistant (RR) cancer patients. The develo...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2015.09.013
更新日期：2015-12-28 00:00:00
abstract：:Bile acids are promoters of colon cancer; however, the mechanism(s) of action of this tumor promoter are largely unknown. Bile acids induce apoptosis in colon epithelial cells and it is probable that the modulation of apoptosis contributes, in part, to colon carcinogenesis. We tested the hypothesis that damage to mito...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(01)00786-8
更新日期：2002-03-28 00:00:00
abstract：:EGF-receptor family members (EGFRs) as well as c-Src are over expressed in approximately 70% of breast cancer, and in most of the tumors c-Src is co-over expressed with at least one of the EGFRs, suggesting that they may interact functionally and play a role in the development and progression of the malignancy. We hyp...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2009.03.035
更新日期：2009-10-08 00:00:00
abstract：:Patients with hormone-receptor-positive early breast cancer have a significant risk of recurrence despite the use of adjuvant tamoxifen. The third-generation aromatase inhibitors letrozole, anastrozole, and exemestane offer promise as alternative or additional therapy to tamoxifen. As extended adjuvant therapy followi...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2006.07.002
更新日期：2007-04-18 00:00:00
abstract：:The carcinogenic effects of the fungicide manganese ethylenebisdithiocarbamate (maneb) have been investigated in 2 populations of adult crested newt, which have different prevalences of spontaneous melanoma. Animals were exposed percutaneously to a 5 ppm solution of maneb 4 days a week for 37 weeks. No differences in ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(80)90033-6
更新日期：1980-08-01 00:00:00
abstract：:Conventional chemotherapies have some limitations, including the lack of selectivity, high toxicity to normal tissues, multidrug resistance, and tumor relapse. Recently, great progress was made in immunotherapies for anticancer research, with bacteria-mediated cancer therapy one of the most promising approaches among ...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2019.10.033
更新日期：2020-01-28 00:00:00
abstract：:Somatic mutations and chromosome instability are hallmarks of genomic aberrations in cancer cells. Aneuploidies represent common manifestations of chromosome instability, which is frequently observed in human embryos and malignant solid tumors. Activation of human endogenous retroviruses (HERV)-derived loci is documen...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2016.08.001
更新日期：2016-10-10 00:00:00
abstract：:Sobatum, the active fraction of the plant Solanum trilobatum was obtained from the petroleum ether/ethyl acetate (75:25) extractable portion. Sobatum was proven to be an anticancer agent by in vitro and in vivo methods. The aim of this study is to evaluate the effect of Sobatum on radiation-induced toxicity in mice. I...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(97)00408-4
更新日期：1998-01-30 00:00:00
abstract：:ArgBP2 is a multi-adapter protein involved in signal transduction associated to the cytoskeleton and was shown to regulate the migration and adhesion of pancreatic cancer cells thereby modulating their tumorigenicity. Here we describe the interaction of ArgBP2 with CIP4, a new associated protein identified by yeast tw...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2009.06.030
更新日期：2010-02-01 00:00:00
abstract：:Bombesin (BBS) has been shown to promote pancreatic growth as well as the development of pancreatic (pre)neoplasia in rats. The present study was carried out to determine the effects of bombesin on pancreatic growth and on the development of pancreatic (pre)neoplastic lesions in hamsters treated with N-nitrosobis(2-ox...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(91)90134-4
更新日期：1991-07-26 00:00:00
abstract：:Cancer cachexia patients experience significant muscle wasting, which impairs the quality of life and treatment efficacy for patients. Skeletal muscle protein turnover is imparted by increased expression of ubiquitin-proteasome pathway components. Mitogen-activated protein kinases p38 and ERK have been shown to augmen...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2020.07.025
更新日期：2020-10-28 00:00:00
abstract：:The limitations of current chemotherapies have motivated research in developing new treatments. Growing evidence shows that interaction between tumors and their microenvironment, but not tumor cells per se, is the key factor in tumor progression and therefore of obvious scientific interest and therapeutic value. Exoso...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2015.07.014
更新日期：2015-10-10 00:00:00
