Abstract:
:2-Amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine (PhIP) is known to induce colon tumors in male Fischer-344 rats. Using 32P-postlabeling assays, we have examined PhIP-DNA adduct formation in various organs and white blood cells (WBCs) of the male Fischer-344 rat 24 h after a single oral dose of 0, 0.5, 5 or 50 mg PhIP/kg. Three PhIP-DNA adducts were detected in WBCs and in all organs, except in the liver and stomach which had only two adducts. The extent of adduct formation was dose-related, but at 0.5 mg/kg no adducts could be detected in any of the organs. At 50 mg/kg, adduct levels, expressed as relative adduct labeling values (RAL x 10(7), or adducts per 10(7) nucleotides assuming complete labeling) were highest in the large intestine (5.66), followed by WBCs (5.04), stomach (1.44), small intestine (1.32), kidney (1.16), liver (0.67) and lungs (0.52). It is concluded that orally administered PhIP forms high levels of specific DNA adducts in the large intestine, the target organ in PhIP carcinogenesis in the male Fischer-344 rat, and that the high level of adducts in WBCs indicates that significant amounts of the ultimate carcinogenic form of PhIP are present in the circulation.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Schut HA,Herzog CRdoi
10.1016/0304-3835(92)90134-hkeywords:
subject
Has Abstractpub_date
1992-12-24 00:00:00pages
117-24issue
2-3eissn
0304-3835issn
1872-7980pii
0304-3835(92)90134-Hjournal_volume
67pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract::scFv fragments of a monoclonal antibody that penetrates living cells and localizes in nuclei were designed as fusion proteins with C-terminal p53 peptides and tested for restoring p53 function in p53 mutant cancer cells. scFv fragments transported a 30-mer C-terminal peptide of p53 into cancer cells and induced cellul...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(03)00151-4
更新日期:2003-06-10 00:00:00
abstract::Repeated application of the tumor promoter 12-O-tetradecanoyl phorbol-13-acetate (TPA) to the skin of mice previously treated with an initiating dose of the carcinogen 7,12-dimethylbenz[a] anthracene has been shown to lead to an increased incidence of papilloma. The studies presented here describe a modified murine tw...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(84)90011-9
更新日期:1984-01-01 00:00:00
abstract::Despite recent improvements in chemotherapy and surgery, the problem of non-response osteosarcoma to chemotherapy remains, and is a parameter that is critical for prognosis. The present work investigated the therapeutic value of NVP-BEZ235, a dual class I PI3K/mTOR inhibitor. NVP-BEZ235 inhibited osteosarcoma cell pro...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2013.11.017
更新日期:2014-03-28 00:00:00
abstract::Parthanatos is a new form of programmed cell death that is regulated by hyper-activated PARP-1, and is emerging as a new strategy to kill cancer cells. Deoxypodophyllotoxin (DPT) is a natural chemical that is found to induce cancer cell death, in which the role of parthanatos is unknown. Thus, we investigated this iss...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2015.11.044
更新日期:2016-02-28 00:00:00
abstract::Endostatin has been demonstrated to represent a promising novel medicine to treat malignant tumors, and it may be more effective when combined with conventional treatment. Meanwhile, a promising area of research in radiation oncology is the integration of molecular targeting agents to improve the effectiveness of radi...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2008.12.008
更新日期:2009-09-08 00:00:00
abstract::Large marker chromosomes were found in 2 hormone-independent (HI) GR mouse mammary tumors, i.e. a tumor (TSl 75) that was already HI at the first transplantation, and a tumor (TSl 66) that became HI at the 19th passage. These marker chromosomes appear to be translocations to distal and proximal ends of chromosome 1, r...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(85)90109-0
更新日期:1985-06-01 00:00:00
abstract::Chromosomal assignment of human transcribed sequences has been done mainly by high throughput genome analysis in specialized genome centres and, in a more classical fashion, by fluorescence in-situ hybridization (FISH) analysis. Not every laboratory has the ability to map cDNAs by FISH analysis. We here report a rapid...
journal_title:Cancer letters
pub_type: 更正并重新发布的文章,杂志文章
doi:10.1016/s0304-3835(00)00690-x
更新日期:2001-01-10 00:00:00
abstract::Fanconi Anemia has recently been associated with a high risk of head and neck squamous cell carcinoma (HNSCC). Inactivation of the Fanconi Anemia (FANC-BRCA) pathway via promoter methylation of the FANCF gene has been proposed to be responsible for variation in cisplatinum (CDDP) sensitivity seen in ovarian and HNSCCs...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2005.12.028
更新日期:2007-01-08 00:00:00
abstract::Aurora-A (Aur-A) is a centrosome-associated serine/threonine kinase that is overexpressed in various cancers and potentially correlated with chemoresistance. In the Ara-C-sensitive leukemia cell lines, silencing of Aur-A by small interfering RNA transfection led to a significant increase in the Ara-C-induced cell deat...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2010.05.009
更新日期:2010-11-28 00:00:00
abstract::The striking differences in the natural history of clinical subgroups of neuroblastoma (NB), and the evolving therapeutic approaches for each, makes it imperative for prognostic markers to be reevaluated within individual clinical categories. At least one third of NB cases present without distant metastasis and cytoto...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/s0304-3835(03)00094-6
更新日期:2003-07-18 00:00:00
abstract::In the present study, we tested the hypothesis that a mild cerebral tissue injury promotes subsequent glioma invasion via activation of the ADAM17-EGFR-PI3K-Akt pathway. Mild injury was induced by photodynamic therapy (PDT), which employs tissue-penetrating laser light exposure following systemic administration of a t...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2008.02.023
更新日期:2008-07-08 00:00:00
abstract::Medulloblastoma (MB) is the most frequent malignant brain tumour in children with a poor outcome. Divided into four molecular subgroups, MB of the Sonic hedgehog (SHH) subgroup accounts for approximately 25% of the cases and is driven by mutations within components of the SHH pathway, such as its receptors PTCH1 or SM...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2020.02.028
更新日期:2020-05-01 00:00:00
abstract::Human Vdelta2 gammadelta T lymphocytes killed multiple solid tumors, even displaying comparable therapeutic efficacy with anti-tumor chemical-cis-platinum in an adoptive experiment in both nude and SCID murine model shown in present study. We previously found that T cell receptor (TCR) gammadelta recognize tumors via ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2008.07.015
更新日期:2008-12-18 00:00:00
abstract::A hitherto unreported lactate dehydrogenase (LD) isoenzyme, which migrates electrophoretically to the relative position between LD2 and LD3 has been identified in the electropheratogram in 7 of 7 (100%) cultured hepatoma cell lines with various degrees of differentiation and is thus given the name LD2-3. LD2-3 seems t...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(94)90222-4
更新日期:1994-12-09 00:00:00
abstract::Gastrin-releasing peptide (GRP) activates phosphatidylinositol 3-kinase (PI3-K)/Akt, an important cell survival signaling pathway, to stimulate growth of various cell types. Transforming growth factor (TGF) superfamily ligands activate intracellular Smad signaling to regulate cell growth, differentiation and apoptosis...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2005.11.007
更新日期:2006-10-28 00:00:00
abstract::Gene-silencing with targeted siRNAs has great potential as a therapeutic approach for various diseases including cancer. However, intracellular delivery of siRNA is challenging. We used bovine milk exosomes as a novel system for siRNA delivery. First, we demonstrated that exosomes can deliver endogenous RNA payloads i...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2019.02.011
更新日期:2019-05-01 00:00:00
abstract::Castration-resistant prostate cancer (CRPC) following androgen deprivation therapy remains a major obstacle advanced prostate cancer management. Aromatase catalyzes estrogen from androgens, yet the role of aromatase-generated endogenous estrogen in CRPC is poorly understood. In this study, we assessed the expression a...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2019.09.001
更新日期:2019-12-28 00:00:00
abstract::The activity of 4 enzymes involved in the formation and interconversion of folate coenzymes has been examined in liver and kidney of healthy and Ehrlich ascites carcinoma-bearing mice. In the liver, a 50% increase of methylenetetrahydrofolate reductase activity was shown soon after tumour cell inoculation, while the a...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(84)80048-8
更新日期:1984-12-01 00:00:00
abstract::Overexpression of HER-2/neu proto-oncogene is found in many human cancers including 20-30% of breast cancer and is a predictor of poor prognosis. To target breast cancer cells that overexpress HER-2/neu mRNA, we previously described a novel strategy that combines the principle of antisense (AS) and translational inhib...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(01)00700-5
更新日期:2001-12-28 00:00:00
abstract::Tumor angiogenesis has been found to be prognostically significant in many types of malignant tumors. We assessed tumor vascularity in 43 cases of histologically proven primary fallopian tube cancer, FIGO stage I-IV, using the highly specific endothelial cell marker CD34. Microvessel count was determined by counting C...
journal_title:Cancer letters
pub_type: 杂志文章,多中心研究
doi:10.1016/s0304-3835(99)00104-4
更新日期:1999-07-01 00:00:00
abstract::Xanthine oxidase reduction of adriamycin (Am) and daunorubicin (Dm) to their respective 7-deoxy aglycones is inhibited by allopurinol. Administered to DBA/2 mice with L1210 leukemia, allopurinol (60 mg/kg per day X 3) enhances the antitumor activity of adriamycin. ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(83)90189-1
更新日期:1983-08-01 00:00:00
abstract::Apatinib, a novel tyrosine kinase inhibitor (TKI), has been confirmed for its efficacy and safety in the treatment of advanced gastric carcinoma and some other solid tumors. However, the direct functional mechanisms of tumor lethality mediated by apatinib have not yet been fully characterized, and the precise mechanis...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2018.05.046
更新日期:2018-09-01 00:00:00
abstract::Human promyelocytic leukemia cells (HL-60) were found to be induced by dimethylsulfoxide and several other compounds to phagocytize, reduce NBT dye, and change into forms that were morphologically similar to granulocytes and macrophages. Arginase also induced these differentiation-associated properties of the cells. T...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(80)90044-0
更新日期:1980-10-01 00:00:00
abstract::Gelatinases play important roles in tumor progression and are abundantly expressed in a variety of malignant tumors. Antibody targeting gelatinases is a possible avenue to fight against cancer. However, antibody alone can not achieve curative efficacy. Herein, we demonstrated the intensified targeting therapy of a tan...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2010.02.020
更新日期:2010-09-01 00:00:00
abstract::The phenomenon of cellular dormancy has been observed in normal adult stem cells in many different tissues such as the skin, the intestine and the hematopoietic system. These dormant cells have been proposed to be important for life-long self-renewal and for the generation of the different cellular lineages. As tumor ...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2013.04.019
更新日期:2013-11-28 00:00:00
abstract::Sobatum, the active fraction of the plant Solanum trilobatum was obtained from the petroleum ether/ethyl acetate (75:25) extractable portion. Sobatum was proven to be an anticancer agent by in vitro and in vivo methods. The aim of this study is to evaluate the effect of Sobatum on radiation-induced toxicity in mice. I...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(97)00408-4
更新日期:1998-01-30 00:00:00
abstract::There is an urgent need to elucidate the mechanistic links between obesity and colon cancer. Convincing evidence for the role of Lgr5(+) stem cells in colon tumorigenesis has been established; however, the influence of obesity on stem cell maintenance is unknown. We assessed the effects of high fat (HF) feeding on col...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2015.10.001
更新日期:2015-12-28 00:00:00
abstract::Non-small cell lung cancer (NSCLC) patients with activating EGFR mutations are often successfully treated with EGFR tyrosine kinase inhibitor (TKI) such as erlotinib; however, treatment resistance inevitably occurs. Given tumor metabolism of glucose and therapeutic response are intimately linked, we explored the metab...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2018.07.025
更新日期:2018-10-10 00:00:00
abstract::In order to determine the effects of intermittent hormonal manipulation on the promotion stage of rat prostate carcinogenesis, testosterone and/or estrogen were administered to F344 rats for 40 weeks after 20-weeks treatment with the prostate carcinogen, 3,2'-dimethyl-4-aminobiphenyl. For this purpose testosterone pro...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(97)00390-x
更新日期:1998-01-09 00:00:00
abstract::MDM2 is a phosphoprotein that interacts with P53 and inhibits its activity. Recently, a T/G substitution (SNP309) in the promoter of MDM2 was identified and has been demonstrated to be associated with an increased MDM2 expression and a significantly earlier age of onset of several tumors, including breast cancer. To t...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2005.09.019
更新日期:2006-08-28 00:00:00