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Induction of differentiation of human promyelocytic leukemia cells (HL-60) by arginase.

Abstract：

:Human promyelocytic leukemia cells (HL-60) were found to be induced by dimethylsulfoxide and several other compounds to phagocytize, reduce NBT dye, and change into forms that were morphologically similar to granulocytes and macrophages. Arginase also induced these differentiation-associated properties of the cells. The induction of differentiation by arginase was significantly inhibited by addition of excess arginine, but not by lysine or leucine; therefore, the effect of arginase may be due to arginase-mediated arginine depletion.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Honma Y,Fujita Y,Okabe-Kado J,Kasukabe T,Hozumi M

doi

10.1016/0304-3835(80)90044-0

subject

Has Abstract

pub_date

1980-10-01 00:00:00

pages

287-92

issue

4

eissn

0304-3835

issn

1872-7980

pii

0304-3835(80)90044-0

journal_volume

10

pub_type

杂志文章

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