Abstract:
:Despite recent improvements in chemotherapy and surgery, the problem of non-response osteosarcoma to chemotherapy remains, and is a parameter that is critical for prognosis. The present work investigated the therapeutic value of NVP-BEZ235, a dual class I PI3K/mTOR inhibitor. NVP-BEZ235 inhibited osteosarcoma cell proliferation by inducing G0/G1 cell cycle arrest with no caspase activation. In murine pre-clinical models, NVP-BEZ235 significantly slowed down tumor progression and ectopic tumor bone formation with decreased numbers of Ki67(+) cells and reduced tumor vasculature. Finally, NVP-BEZ235 considerably improved the survival rate of mice with osteosarcoma. Taken together, the results of the present work show that NVP-BEZ235 exhibits therapeutic interest in osteosarcoma and may be a promising adjuvant drug for bone sarcomas.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Gobin B,Battaglia S,Lanel R,Chesneau J,Amiaud J,Rédini F,Ory B,Heymann Ddoi
10.1016/j.canlet.2013.11.017subject
Has Abstractpub_date
2014-03-28 00:00:00pages
291-8issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(13)00827-6journal_volume
344pub_type
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