Effects of naturally occurring antioxidants on combined 1,2-dimethylhydrazine- and 1-methyl-1-nitrosourea-initiated carcinogenesis in F344 male rats.

abstract：:Immune checkpoint blockade (ICB) has revolutionised the treatment of solid tumours, yet most patients do not derive a clinical benefit. Resistance to ICB is often contingent on the tumour microenvironment (TME) and modulating aspects of this immunosuppressive milieu is a goal of combination treatment approaches. Radia...

journal_title：Cancer letters

authors： Donlon NE,Power R,Hayes C,Reynolds JV,Lysaght J

更新日期：2021-01-12 00:00:00

abstract：:In Mongolian gerbils, the gastric mucosa shows dramatic changes after Helicobacter pylori inoculation. The influence of the timing of N-methyl-N-nitrosourea (MNU) administration after H. pylori inoculation on gastric carcinogenesis was investigated. Ninety-two gerbils were divided into four groups. One group was given...

journal_title：Cancer letters

authors： Maruta F,Sugiyama A,Ishida K,Ikeno T,Murakami M,Kawasaki S,Ota H,Tatematsu M,Katsuyama T

更新日期：2000-11-10 00:00:00

abstract：:Because lipoperoxides seem able to modulate tumor growth, we have examined the concomitant effects of dietary antioxidant (vitamin E) and of a high amount of polyunsaturated fatty acids (PUFA) in a model of chemically-induced mammary carcinogenesis. Two groups of rats received a high fat diet with or without added vit...

journal_title：Cancer letters

authors： Lhuillery C,Cognault S,Germain E,Jourdan ML,Bougnoux P

更新日期：1997-03-19 00:00:00

abstract：:Cancer stem cells (CSCs) represent a minor population that have clonal tumor initiation and self-renewal capacity and are responsible for tumor initiation, metastasis, and therapeutic resistance. CSCs reside in niches, which are composed of diverse types of stromal cells and extracellular matrix components. These stro...

journal_title：Cancer letters

authors： Saijo A,Goto H,Nakano M,Mitsuhashi A,Aono Y,Hanibuchi M,Ogawa H,Uehara H,Kondo K,Nishioka Y

更新日期：2018-05-01 00:00:00

abstract：:The underlying molecular mechanism of lung cancer drug resistance is poorly understood. The mediator of endoplasmic reticulum stress CHOP (DNA damage inducible transcript 3) promotes stress-induced apoptosis and appears to function as a transcription factor in multiple diseases. However, its potential contributions to...

journal_title：Cancer letters

authors： Tan W,Liao Y,Qiu Y,Liu H,Tan D,Wu T,Tang M,Zhang S,Wang H

更新日期：2018-08-01 00:00:00

abstract：:Susceptibility of hairless inbred S/RV Cri-ba or Bare mice to skin tumor development with suboptimal doses of 7,12-dimethylbenz[a]anthracene (DMBA), DMBA-TPA two stage protocol and two stage promotion using 12-O-tetradecanoylphorbol-13-acetate (TPA) as sub-stage 1 promoter and mezerein (MEZ) or phorbol retinoate aceta...

journal_title：Cancer letters

authors： Bhisey RA,Veturkar PL

更新日期：1990-06-30 00:00:00

abstract：:Tumor hypoxia has been commonly observed in a broad spectrum of primary solid malignancies. Hypoxia is associated with tumor progression, increased aggressiveness, enhanced metastatic potential and poor prognosis. Hypoxic tumor cells are resistant to radiotherapy and some forms of chemotherapy. Using an animal model, ...

journal_title：Cancer letters

authors： Li XF,O'Donoghue JA

更新日期：2008-06-18 00:00:00

abstract：:Ascorbate anion and glutathione were found to inhibit the aqueous reaction between nitrogen dioxide (NO2) and morpholine (MOR) and thereby prevented the formation of N-nitrosomorpholine (NMOR) and N-nitromorpholine (NTMOR) at both pH 7.4 and 12.5. These antioxidants are approximately 3 orders of magnitude more reactiv...

journal_title：Cancer letters

authors： Cooney RV,Ross PD,Bartolini GL

更新日期：1986-07-01 00:00:00

abstract：:Modern protocols of concomitant chemo/radiotherapy provide a very effective strategy to treat certain types of tumors. High-linear energy transfer (LET) radiations, on the other hand, have an increased efficacy against cancer with low radiosensibility and critical localization. We previously reported that oxaliplatin,...

journal_title：Cancer letters

authors： Benzina S,Altmeyer A,Malek F,Dufour P,Denis JM,Gueulette J,Bischoff P

更新日期：2008-06-08 00:00:00

abstract：BACKGROUND:This study characterizes the second hit spectrum in BRCA1 and BRCA2-associated breast and ovarian cancers at both gene loci to investigate if second hit mechanisms are mutually exclusive or able to coincide within the same tumor. METHODS:Loss of heterozygosity, somatic point mutations and copy number altera...

journal_title：Cancer letters

authors： Van Heetvelde M,Van Bockstal M,Poppe B,Lambein K,Rosseel T,Atanesyan L,Deforce D,Van Den Berghe I,De Leeneer K,Van Dorpe J,Vral A,Claes KBM

更新日期：2018-07-01 00:00:00

abstract：:The therapeutic efficacy of antineoplastic purine analogs can be jeopardized by the emergence of drug-resistant mutant subpopulations of tumor cells. To determine whether such mutant populations might be eradicable in vivo with the type of HAT combination (hypoxanthine + an antifolate + thymidine) known to be selectiv...

journal_title：Cancer letters

authors： Moolten FL

更新日期：1986-06-01 00:00:00

abstract：:Increasing evidence points to a fundamental role for cancer stem cells (CSC) in the initiation and propagation of many tumors. As such, in the context of glioblastoma multiforme (GBM), the development of treatment strategies specifically targeted towards CSC-like populations may hold significant therapeutic promise. T...

journal_title：Cancer letters

authors： Ehtesham M,Mapara KY,Stevenson CB,Thompson RC

更新日期：2009-02-18 00:00:00

abstract：:Retinoids are derivatives of vitamin A that include all trans-retinoic acid (ATRA), 13-cis-retinoic acid, (13-cis-RA), and fenretinide (4-HPR). High levels of either ATRA or 13-cis-RA can cause arrest of cell growth and morphological differentiation of human neuroblastoma cell lines, and phase I trials showed that hig...

journal_title：Cancer letters

authors： Reynolds CP,Matthay KK,Villablanca JG,Maurer BJ

更新日期：2003-07-18 00:00:00

abstract：:Free hematoporphyrin administered intravenously to healthy rabbits (1-28 mg/kg body weight) is bound by the 3 major lipoprotein components of plasma (VLDL, LDL and HDL) with different efficiency. In vitro-prepared complexes of hematoporphyrin (Hp) with lipoprotein fractions isolated from mouse serum have been injected...

journal_title：Cancer letters

authors： Barel A,Jori G,Perin A,Romandini P,Pagnan A,Biffanti S

更新日期：1986-08-01 00:00:00

abstract：:We aimed to clarify the clinical significance of des-gamma-carboxy prothrombin (DCP) levels in both hepatocellular carcinoma (HCC) and liver tissues with a special reference to the relationship between DCP level in non-cancerous parts of the liver and the multicentric occurrence of HCC. Twenty-eight patients with HCC,...

journal_title：Cancer letters

authors： Shimada M,Yamashita Y,Hamatsu T,Hasegawa H,Utsunomiya T,Aishima S,Sugimachi K

更新日期：2000-10-16 00:00:00

abstract：:We describe an optimized systematic screen of known kinases using osteosarcoma cell lines (KHOS and U-2OS) and a lentiviral-based short hairpin RNA (shRNA) human kinase library. CellTiter 96(R)AQueous One Solution Cell Proliferation Assay was used to measure cell growth and survival. We identified several kinases, inc...

journal_title：Cancer letters

authors： Duan Z,Ji D,Weinstein EJ,Liu X,Susa M,Choy E,Yang C,Mankin H,Hornicek FJ

更新日期：2010-07-28 00:00:00

abstract：:The rationale for melanoma specific antitumor agents containing phenolic amines is based in part upon the ability of the enzyme tyrosinase to oxidize these prodrugs to toxic intermediates. Two phenolic amine compounds, N-acetyl-4-S-cysteaminylphenol (N-Ac-4-S-CAP) and 4-S-cysteaminylphenol (4-S-CAP), demonstrated grow...

journal_title：Cancer letters

authors： Prezioso JA,Epperly MW,Wang N,Bloomer WD

更新日期：1992-03-31 00:00:00

abstract：:Although it is well known that ovarian endometriosis occasionally gives rise to ovarian cancers with specific histology such as endometrioid and clear cell carcinomas, its etiology is not fully understood. We have shown that a stressful microenvironment within the endometriotic cyst may lead to cancer development by i...

journal_title：Cancer letters

authors： Mandai M,Matsumura N,Baba T,Yamaguchi K,Hamanishi J,Konishi I

更新日期：2011-11-28 00:00:00

abstract：:Glutathione S-transferases (GST) alpha and pi, glutathione (GSH) and aldehyde dehydrogenase (ADH) were determined in colorectal cancer tissue specimens and in the adjacent normal colon tissue. The median contents in normal and cancer tissue were 8.1 (2.3-30.3) (5-95% quantiles) and 15.1 (5.3-50.3) microg/mg protein fo...

journal_title：Cancer letters

authors： Hengstler JG,Böttger T,Tanner B,Dietrich B,Henrich M,Knapstein PG,Junginger T,Oesch F

更新日期：1998-06-05 00:00:00

abstract：:Glioblastoma (GBM) has limited therapeutic options. DNA repair mechanisms contribute GBM cells to escape therapies and re-establish tumor growth. Multiple studies have shown that POLD2 plays a critical role in DNA replication, DNA repair and genomic stability. We demonstrate for the first time that POLD2 is highly exp...

journal_title：Cancer letters

authors： Xu Q,Hu C,Zhu Y,Wang K,Lal B,Li L,Tang J,Wei S,Huang G,Xia S,Lv S,Laterra J,Jiang Y,Li Y

更新日期：2020-07-10 00:00:00

abstract：:Metastatic colonization involves paracrine/juxtacrine interactions with the microenvironment inducing an adaptive response through transcriptional regulation. However, the identities of transcription factors (TFs) induced by the metastatic microenvironment in ovarian cancer (OC) and their mechanism of action is poorly...

journal_title：Cancer letters

authors： Tomar S,Plotnik JP,Haley J,Scantland J,Dasari S,Sheikh Z,Emerson R,Lenz D,Hollenhorst PC,Mitra AK

更新日期：2018-02-01 00:00:00

abstract：:In the present work we investigated the in vivo regulation of the mucin gene MUC2, which is overexpressed in all mucinous colorectal carcinomas. The inhibition of methylation by 5-azadeoxycytidine induces de novo expression of MUC2 in the colon carcinoma cell line COLO 205. The expression is retained in xenograft tiss...

journal_title：Cancer letters

authors： Gratchev A,Siedow A,Bumke-Vogt C,Hummel M,Foss HD,Hanski ML,Kobalz U,Mann B,Lammert H,Mansmann U,Stein H,Riecken EO,Hanski C

更新日期：2001-07-10 00:00:00

abstract：:Chemically-induced mutagenesis and carcinogenesis is modulated by various plant products, some of which are present in the human diet. 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a potent carcinogen in tobacco and tobacco smoke, is activated by microsomal enzymes. In this study, we investigated the effects o...

journal_title：Cancer letters

authors： Miller CH,Zhang Z,Hamilton SM,Teel RW

更新日期：1993-11-30 00:00:00

abstract：:When injected into female NMRI mice tumour necrosis factor-alpha (TNF) produced a dose-related weight loss over the first 24 h, which was accompanied by and directly proportional to a decrease in both food and water intake. Body composition analysis after the first 8 h revealed that the weight loss was associated with...

journal_title：Cancer letters

authors： Mahony SM,Tisdale MJ

更新日期：1989-06-01 00:00:00

abstract：:Male and female transgenic mice carrying the human prototype c-Ha-ras gene (rasH2 mice) and their wild littermates (non-Tg mice) received three subcutaneous injections of 0.3 mg N-methyl-N-nitrosourethane (MNUR) once every 2 weeks for the first 4 weeks followed by a single intraperitoneal injection of 1000 or 0 mg/kg ...

journal_title：Cancer letters

authors： Mitsumori K,Yasuhara K,Mori I,Hayashi S,Shimo T,Onodera H,Nomura T,Hayashi Y

更新日期：1998-07-17 00:00:00

abstract：:Epigenetic events have emerged as key mechanisms in the regulation of critical biological processes and in the development of a wide variety of human malignancies, including gastric cancer (GC), however precise gene targets of aberrant DNA methylation in GC remain largely unknown. Here, we have combined pyrosequencing...

journal_title：Cancer letters

authors： Balassiano K,Lima S,Jenab M,Overvad K,Tjonneland A,Boutron-Ruault MC,Clavel-Chapelon F,Canzian F,Kaaks R,Boeing H,Meidtner K,Trichopoulou A,Laglou P,Vineis P,Panico S,Palli D,Grioni S,Tumino R,Lund E,Bueno-de-Mesqui

更新日期：2011-12-01 00:00:00

abstract：:Targeting specific tumor metabolic needs represents an actively investigated therapeutic strategy to bypass tumor resistance mechanisms. In this study, we describe an original approach to impact the cancer metabolism by exploiting the redox properties of a ruthenium organometallic compound. This organometallic complex...

journal_title：Cancer letters

authors： Vidimar V,Licona C,Cerón-Camacho R,Guerin E,Coliat P,Venkatasamy A,Ali M,Guenot D,Le Lagadec R,Jung AC,Freund JN,Pfeffer M,Mellitzer G,Sava G,Gaiddon C

更新日期：2019-01-01 00:00:00

abstract：:In the present study, we tested the hypothesis that a mild cerebral tissue injury promotes subsequent glioma invasion via activation of the ADAM17-EGFR-PI3K-Akt pathway. Mild injury was induced by photodynamic therapy (PDT), which employs tissue-penetrating laser light exposure following systemic administration of a t...

journal_title：Cancer letters

authors： Zheng X,Jiang F,Katakowski M,Zhang X,Jiang H,Zhang ZG,Chopp M

更新日期：2008-07-08 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) is highly expressed in many human tumors including hepatocellular carcinoma (HCC). Therefore, inhibition of EGF receptors could be a potential target for anticancer therapy. In this study, we investigated the effects of two EGFR tyrosine kinase inhibitors, PD153035 and its analo...

journal_title：Cancer letters

authors： Liu Y,Poon RT,Shao W,Sun X,Chen H,Kok TW,Fan ST

更新日期：2007-04-08 00:00:00

abstract：:Serum alpha-N-acetylgalactosaminidase (NaGalase) is responsible for the deglycosylation of vitamin D(3)-binding protein (Gc protein). The deglycosylated Gc protein cannot be converted into major macrophage-activating factor (MAF), leading to immunosuppression. NaGalase is universally detected in a variety of cancer pa...

journal_title：Cancer letters

authors： Reddi AL,Sankaranarayanan K,Arulraj HS,Devaraj N,Devaraj H

更新日期：2000-09-29 00:00:00