Abstract：
:Modern protocols of concomitant chemo/radiotherapy provide a very effective strategy to treat certain types of tumors. High-linear energy transfer (LET) radiations, on the other hand, have an increased efficacy against cancer with low radiosensibility and critical localization. We previously reported that oxaliplatin, a third generation platinum drug, was able to reinforce the cytotoxicity of an irradiation by fast neutrons towards human glioblastoma U-87 cells in culture. We show here that such a combination has the capacity to enhance the number of double strand breaks in DNA and to induce autophagy in these cells. Xenografts experiments were further performed in nude mice subcutaneously transplanted with U-87 cells. When injected shortly before a single irradiation by fast neutrons, oxaliplatin causes a marked reduction of tumor growth compared with the irradiation alone. Overall, our data indicate the unique cytotoxic mechanism of a combined high-LET irradiation and oxaliplatin treatment modality and suggest its potential application in anticancer therapy.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Benzina S,Altmeyer A,Malek F,Dufour P,Denis JM,Gueulette J,Bischoff Pdoi
10.1016/j.canlet.2008.01.023subject
Has Abstractpub_date
2008-06-08 00:00:00pages
63-70issue
1eissn
0304-3835issn
1872-7980pii
S0304-3835(08)00034-7journal_volume
264pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract：:We investigated the molecular mechanisms involved in the anti-proliferative activity exerted by conjugated linoleic acid (CLA) on the estrogen unresponsive MDA-MB-231 human breast cancer cell line. The effects on cell proliferation, cell cycle progression and induction of apoptosis were examined. CLA caused the reduct...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2005.03.029
更新日期：2006-03-28 00:00:00
abstract：:The mutagenic effects of chamuvaritin, dihydrobenzylchalcone isolated from Uvaria chamae, were investigated using Salmonella typhimurium tester strains TA92, TA94--98, TA100--1535, TA1537 and TA1538. The phytochemical was mutagenic in tester strains TA98 and TA100 and required activation by the hepatic S-9 microsomal ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(79)90027-2
更新日期：1979-11-01 00:00:00
abstract：:Effects of cis-dichlorodiammineplatinum-(II) (cis-DDP), an anticancer agent, on capping of membrane receptors were investigated in mouse spleen cells in vitro, using fluorescein labeled ligands. Cap formations of surface immunoglobulin and of concanavalin A receptors were significantly reduced by cis-DDP in relation t...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(80)90079-8
更新日期：1980-09-01 00:00:00
abstract：:Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver cancer. Appropriate treatment of this aggressive and heterogeneous cancer requires accurate staging and prognostic stratification, as does patient selection for clinical trials. Over the past two decades, several staging systems and prognost...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2019.114426
更新日期：2019-09-28 00:00:00
abstract：:ArgBP2 is a multi-adapter protein involved in signal transduction associated to the cytoskeleton and was shown to regulate the migration and adhesion of pancreatic cancer cells thereby modulating their tumorigenicity. Here we describe the interaction of ArgBP2 with CIP4, a new associated protein identified by yeast tw...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2009.06.030
更新日期：2010-02-01 00:00:00
abstract：:Matrix metalloproteinases (MMPs) are an homologous family of proteolytic enzymes capable of degrading components of the extracellular matrix (ECM) and thereby facilitating the invasion of tumour cells into normal tissues. The neural cell adhesion molecules (NCAMs) of neuronal and glial cells provide a Ca2+-independent...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(97)00171-7
更新日期：1997-06-03 00:00:00
abstract：:RXRalpha is an obligatory heterodimerization partner in many signal transducing pathways. To evaluate RXRalpha expression during laryngeal carcinogenesis, immunohistochemistry was performed on laryngeal epithelial specimens of 154 patients with normal-appearing, hyperplastic, dysplastic laryngeal epithelium and squamo...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(03)00346-x
更新日期：2003-09-25 00:00:00
abstract：:Id1 promotes carcinogenesis and metastasis, and predicts prognosis of non-small cell lung cancer (NSCLC)-adenocarcionoma patients. We hypothesized that Id1 may play a critical role in lung cancer colonization of the liver by affecting both tumor cells and the microenvironment. Depleted levels of Id1 in LLC (Lewis lung...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2017.05.012
更新日期：2017-08-28 00:00:00
abstract：:We studied the effect of staurosporine (SSP), a broad-spectrum protein kinase inhibitor, on the levels of protein kinase C (PKC) activity and proliferation in two murine neuroblastoma cell lines, Neuro2a and its clone NB41A3. The PKC activity was examined in whole cell lysate, cytosolic and particulate fractions. A di...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(99)00021-x
更新日期：1999-05-24 00:00:00
abstract：:The insulin-like growth factor (IGF) family of ligands, binding proteins and receptors is an important growth factor system involved in both the development of the organism and the maintenance of normal function of many cells of the body. The system also has powerful anti-apoptotic effects. More recently, evidence has...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/s0304-3835(03)00159-9
更新日期：2003-06-10 00:00:00
abstract：:We have examined the effect of theanine, a specific amino acid in green tea, on idarubicin (IDA)-induced antitumor activity and toxicity. In combination with theanine, IDA (0.25 mg/kg per day x4 days, a dose that does not show antitumor activity) had significant antitumor activity in P388-bearing mice. The IDA concent...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(00)00491-2
更新日期：2000-10-01 00:00:00
abstract：:Pyrazolon derivatives were reported to have cytotoxicity to some tumour cells. In the present study, we investigated the effect of Lgf-YL-9 on cytotoxicity and cell apoptosis in human epidermoid carcinoma drug-sensitive parental KB cells and multidrug resistant (MDR) KBv200 cells. Lgf-YL-9 exhibited potent cytotoxicit...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2006.09.008
更新日期：2007-05-08 00:00:00
abstract：:Human microsomal epoxide hydrolase (mEH) catalyzes a key step in the biotransformation of benzo[a]pyrene that yields the highly mutagenic (+)-anti-7,8-diol-9,10 epoxide (BPDE). Two polymorphisms have been described in the coding region of the mEH gene (EPHX1) that produce two protein variants: 113Tyr-->113His (exon 3)...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(01)00626-7
更新日期：2001-11-28 00:00:00
abstract：:Human RecQ helicases that share homology with E. coli RecQ helicase play critical roles in diverse biological activities such as DNA replication, transcription, recombination and repair. Mutations in three of the five human RecQ helicases (RecQ1, WRN, BLM, RecQL4 and RecQ5) result in autosomal recessive syndromes char...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2017.10.021
更新日期：2018-01-28 00:00:00
abstract：:The in vitro chemosensitizing effect of triptolide (PG490) on the cytotoxicity of 5-fluorouracil (5-FU) was determined in three colorectal cancer (CRC) cell lines. PG490 alone was toxic to CRC cell lines (IC(50)s: 1.39-5.51nM). The cytotoxicity of 5-FU to CRC cell lines was 4-15-fold sensitized by combining use of low...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2009.10.013
更新日期：2010-05-28 00:00:00
abstract：:cDNA libraries were generated from the prostate gland tissue obtained from a normal donor and from a patient with prostate cancer. Subtractive cDNA cloning was used to identify phenotype-specific cDNA sequences from both normal and cancerous prostate tissue. One clone, pN44, isolated from normal prostate tissue, codes...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(93)90049-f
更新日期：1993-10-15 00:00:00
abstract：:We describe the events triggered by a sub-lethal concentration of airborne particulate matter (PM(10)) in A549 cells, which include the formation DNA double-strand breaks, gammaH2A.X generation, and 53BP1 recruitment. To protect the genome, cells activated ATM/ATR/Chk1/Chk2/p53 pathway but, after 48 h, cells turned in...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2009.01.010
更新日期：2009-06-18 00:00:00
abstract：:The effect of ligation of the left ureter on the development of lesions in the urinary bladder were investigated in male F344 rats treated with 0.05% N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) for 2 weeks followed by 0.002% N-ethyl-N-(4-hydroxybutyl)nitrosamine (EHBN) for 10 or 22 weeks. The lesions of the urinary b...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(84)90093-4
更新日期：1984-07-01 00:00:00
abstract：:The stem cell-like characteristics of tumor cells are not only essential for tumor development and malignant progression, but also significantly contribute to therapy resistance. However, it remains poorly understood how cancer cell differentiation or stemness is regulated in vivo. We investigated the role of the stem...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2011.11.032
更新日期：2012-05-01 00:00:00
abstract：:When injected into female NMRI mice tumour necrosis factor-alpha (TNF) produced a dose-related weight loss over the first 24 h, which was accompanied by and directly proportional to a decrease in both food and water intake. Body composition analysis after the first 8 h revealed that the weight loss was associated with...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(89)90072-4
更新日期：1989-06-01 00:00:00
abstract：:To search for possible cancer chemopreventive agents from natural sources, we performed primary screening of ten flavanones isolated from plants belonging to Rutaceae and Leguminosae by examining their possible inhibitory effects on Epstein-Barr virus (EBV) early antigen activation induced by 12-O-tetradecanoylphorbol...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(01)00740-6
更新日期：2002-02-08 00:00:00
abstract：:The ability of the cytosolic arylamine oxidase to convert structurally diverse aromatic and heterocyclic amines to mutagens in the Ames test was investigated using hepatic cytosol from Aroclor 1254-treated rats as the activation system. Using this system, only amino compounds containing at least three fused aromatic r...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(98)00037-8
更新日期：1998-05-15 00:00:00
abstract：:Tumor-associated mesenchymal stem cells (MSCs) play a critical role in the growth and metastasis of hepatocellular carcinoma (HCC). However, the mechanism underlying the crosstalk between MSCs and HCC cells is not completely understood. Here, HCC cells were treated with or without conditioned medium of MSCs (CM-MSC), ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2021.01.011
更新日期：2021-01-17 00:00:00
abstract：:Activation of the cytoplasmic (Ras-Raf-MEK-ERK) signaling cascade was shown to be both, necessary and sufficient for transformation in vitro as well as in vivo. However, over the last years the involvement of stress-activated protein kinases (SAPKs)/Jun N-terminal kinases (JNKs), and their substrate c-Jun in the proce...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2004.05.015
更新日期：2004-11-08 00:00:00
abstract：:Grp75 is a stress-inducible mitochondrial chaperone which has a high homology to senescence-related protein, p66mot mortalin. In human cells the mortalin gene assigns to the locus of a putative tumor suppressor gene for myeloid malignancies. In order to study expression and localization of Grp75 and p66mot in human an...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(97)00270-x
更新日期：1997-11-11 00:00:00
abstract：:The influence of the carcinogen 2-acetylaminofluorene (2AAF) administration on splenic natural killer (NK) cell function in two strains of rats has been examined and compared with that of the non-carcinogenic analogue 4-acetylaminofluorene (4AAF). In both strains it was observed that daily exposure to 25 mg kg-1 2AAF ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(86)90130-8
更新日期：1986-01-01 00:00:00
abstract：:Akt signaling pathway has attracted much attention as a promising target for cancer therapeutics. Herein, we report that Isobavachalcone (IBC), a natural chalcone, potently abrogates Akt signaling and exerts anti-proliferative effects on several human cancer cell lines. Modeling results from the Sybyl/FlexiDock progra...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2010.01.035
更新日期：2010-08-28 00:00:00
abstract：:Multidrug resistance (MDR) is a serious obstacle for cancer chemotherapy. The aim of this study was to reverse MDR of breast carcinoma cells specifically by degrading mdr1 mRNA with anti-mdr1 ribozyme. Our strategy was to limit the expression of ribozyme to only breast-derived cells, but not other type of cells. The r...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2007.06.005
更新日期：2007-10-18 00:00:00
abstract：:The modulating effect of ethanol/acetone (E/A) soluble fractions, prepared from methanolic extracts of processed and unprocessed rooibos (Aspalathus linearis) and honeybush (Cyclopia intermedia) as well as green (Camellia sinensis) teas was established in a two-stage mouse skin carcinogenesis assay. Topical applicatio...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2004.11.014
更新日期：2005-06-28 00:00:00
abstract：:We describe an optimized systematic screen of known kinases using osteosarcoma cell lines (KHOS and U-2OS) and a lentiviral-based short hairpin RNA (shRNA) human kinase library. CellTiter 96(R)AQueous One Solution Cell Proliferation Assay was used to measure cell growth and survival. We identified several kinases, inc...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2010.01.014
更新日期：2010-07-28 00:00:00
