Abstract:
:We studied the effect of staurosporine (SSP), a broad-spectrum protein kinase inhibitor, on the levels of protein kinase C (PKC) activity and proliferation in two murine neuroblastoma cell lines, Neuro2a and its clone NB41A3. The PKC activity was examined in whole cell lysate, cytosolic and particulate fractions. A differential response to SSP treatment in the enzyme activity in whole cell lysate and particulate fractions was demonstrated in the two cell lines. The data on proliferation indicated that Neuro2a cells were more sensitive to the SSP treatment with significant inhibition in DNA synthesis in a time course study. Our findings suggest that the data on basal levels of PKC activity in tumors will be of significance in studies using PKC inhibitors as an approach for therapeutic intervention.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Mohan DR,Nagarathna R,Krishna M,Jagtap JC,Shastry Pdoi
10.1016/s0304-3835(99)00021-xkeywords:
subject
Has Abstractpub_date
1999-05-24 00:00:00pages
137-43issue
2eissn
0304-3835issn
1872-7980pii
S030438359900021Xjournal_volume
139pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract::Glypican-5 (GPC5) may be a potential tumor suppressor gene in non-small cell lung cancer (NSCLC). The present study aimed to clarify the GPC5 expression pattern and to explore its potential functions in NSCLC. The expression of GPC5 gene was lower in lung cancer tissues compared with adjacent noncancerous tissues. The...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2013.08.020
更新日期:2013-12-01 00:00:00
abstract::EglN prolyl hydroxylases, a family of oxygen-sensing enzymes, hydroxylate distinct proteins to modulate diverse physiopathological signals. Aberrant regulations of EglNs result in multiple human diseases, including cancer. Different from EglN1 which function largely depends on the role of hypoxia-induce factor alpha (...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2017.01.003
更新日期:2017-04-01 00:00:00
abstract::The peptide aptamer DUP-1 targets prostate-specific membrane antigen (PSMA)-negative cells, while the RNA aptamer A10-3.2 targets PSMA-positive prostate cancer cells. Moreover, the tumor-suppressor gene phosphatase and tensin homolog (PTEN) and the chemotherapeutic agent doxorubicin (DOX) effectively inhibit prostate ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.10.003
更新日期:2016-12-28 00:00:00
abstract::Expression of the MUC2 gene is controlled by the methylation of CpG sites in the promoter region, but the detailed methylation status of this region has yet to be reported. We have mapped the complete methylation status of the MUC2 promoter from position -1989 to position +288 upstream, a region that contains 59 CpG s...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2004.11.058
更新日期:2005-09-28 00:00:00
abstract::Spectroscopic techniques have demonstrated that in the microscopically normal mucosa, there is an increase in mucosal micro-circulation in patients harboring neoplasia elsewhere in the colon (i.e. marker of field carcinogenesis). However, the physiological and molecular basis of this early increase in blood supply (EI...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2011.03.008
更新日期:2011-07-28 00:00:00
abstract::Metabolic reprogramming such as the aerobic glycolysis or Warburg effect is well recognized as a common feature of tumorigenesis. However, molecular mechanisms underlying metabolic alterations for tumor therapeutic resistance are poorly understood. Through gene expression profiling analysis we found that histone H3K36...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.05.004
更新日期:2016-08-10 00:00:00
abstract::Two-month-old outbred female LIO rats were exposed weekly to 15 (experiment I, groups 1, 2 and 3) or to 5 (experiment II, groups 4, 5 and 6) subcutaneous injections of 1,2-dimethylhydrazine (DMH) at a single dose of 21 mg/kg of body weight. From the day of the first injection of the carcinogen, the rats from groups 2,...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(98)00362-0
更新日期:1999-04-26 00:00:00
abstract::Dendritic cell (DC) vaccine-based immunotherapy for glioblastoma multiforme (GBM) has shown apparent benefit in animal experiments and early-phase clinical trials, but the survival benefit is variable. In this work, we analyzed the mechanism of the potent antitumor immune response induced in vivo by tumor-associated a...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2017.09.022
更新日期:2017-12-28 00:00:00
abstract::Hepatocellular carcinoma (HCC) is a highly lethal malignancy mostly because of de novo and acquired resistance to conventional chemotherapy. Constitutive activation of Akt and nuclear factor-κB (NF-κB) represent major cellular abnormalities associated with both the pathogenesis and therapeutic resistance of HCC. The a...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2010.10.022
更新日期:2011-02-01 00:00:00
abstract::The effects of di(2-ethylhexyl)phthalate (DEHP), a widely used plasticizer and environmental contaminant, on the emergence of gamma-glutamyltrans-peptidase positive (GGT+) preneoplastic foci in the liver was investigated. Sprague--Dawley male rats initiated with diethylnitrosamine (DEN) following partial hepatectomy w...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(83)90049-6
更新日期:1983-09-01 00:00:00
abstract::We planned to determine the relationship between angiogenesis and p53 mutational status in advanced-stage epithelial ovarian cancer. Using 190 tumor samples from patients with stage III and IV ovarian cancer we performed p53 sequencing, immunohistochemistry, and CD31 microvessel density (MVD) determination. MVD was el...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2012.12.016
更新日期:2013-04-30 00:00:00
abstract::YM529, a new third generation bisphosphonate, induced apoptosis of a human breast cancer cell line, MX-1. Cytotoxic activity of YM529 was more potent than that of incadronate. YM529 activated caspase-9, but not caspase-8, and induced the release of cytochrome c into cytosol. YM529 increased Bax expression and decrease...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2007.01.008
更新日期:2007-08-08 00:00:00
abstract::Cancer cells often exhibit altered epigenetic signatures that can misregulate genes involved in processes such as transcription, proliferation, apoptosis and DNA repair. As regulation of chromatin structure is crucial for DNA repair processes, and both DNA repair and epigenetic controls are deregulated in many cancers...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.07.009
更新日期:2016-10-01 00:00:00
abstract::Here we found that dual mTORC1/2 inhibitor AZD-2014 significantly inhibited RCC cell survival and growth, with higher efficiency than conventional mTORC1 inhibitors rapamycin and RAD001. RCC cell apoptosis was also induced by AZD-2014. AZD-2014 disrupted mTORC1/2 assembly and activation, while downregulating HIF-1α/2α...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2014.11.012
更新日期:2015-02-28 00:00:00
abstract::The identification of frameshift mutations in the coding region of the bax gene in Western cases of hereditary non-polyposis colorectal cancer provided evidence that the disease could be caused by the disruption of a tumor suppressor gene associated with microsatellite instability. In order to determine whether this o...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(97)00477-1
更新日期:1998-02-27 00:00:00
abstract::When injected into female NMRI mice tumour necrosis factor-alpha (TNF) produced a dose-related weight loss over the first 24 h, which was accompanied by and directly proportional to a decrease in both food and water intake. Body composition analysis after the first 8 h revealed that the weight loss was associated with...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(89)90072-4
更新日期:1989-06-01 00:00:00
abstract::Myosin light-chain kinase (MLCK) plays a crucial role in the cell migration and tumor metastasis. Herein, we investigated the signaling pathways involved in MLCK using ML-7, a specific inhibitor of MLCK, in breast cancer cell proliferation and migration. Our data showed that reduction of MLCK in breast cancer cells me...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2008.05.028
更新日期:2008-11-08 00:00:00
abstract::To improve the knowledge of the underlying mechanisms of action involved in air pollution Particulate Matter (PM)-induced toxicity in human lungs, with a particular interest of the crucial role played by coated-organic chemicals, we were interested in the metabolic activation of Polycyclic Aromatic Hydrocarbons (PAH)-...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2008.04.044
更新日期:2008-10-18 00:00:00
abstract::Bacteria are always a considerable tool for the cancer therapy. The bacteria-derived minicells are re-emerged as a promising drug delivery system for cancer therapy. The minicells are nano-sized, anucleated, non-dividing, and metabolically active cells produced by abnormal bacterial cell division that are able to tran...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2020.07.024
更新日期:2020-10-28 00:00:00
abstract::Dating back to the seminal work of Paul Ehrlich, the idea of harnessing our immune system to eliminate cancerous cells is now over a century old. In the presence of a functional immune system that so efficiently guards the host against developing neoplasms, tumour cells must evolve sophisticated strategies to escape i...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2020.05.011
更新日期:2020-09-01 00:00:00
abstract::In previous National Toxicology Program (NTP) studies, rotenone reduced the background incidence of hepatocellular carcinoma in male B6C3F1 mice. In the present studies, rotenone reduced the basal hepatic labeling index of male B6C3F1 mice in a dose-dependent fashion and inhibited hepatocellular proliferation, but not...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(95)03869-x
更新日期:1995-08-16 00:00:00
abstract::Recent studies in several tumor models indicated that treatment with angiogenic inhibitors may trigger induction of metastasis to other organs. Here we investigated modes of resistance and invasion in several tumor cell lines including 4T1 (breast), H460 (lung) and Colo205 (colorectal) using sunitinib at doses compara...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2012.01.026
更新日期:2012-07-01 00:00:00
abstract::Dihydroagarofuran sesquiterpenes, which were isolated from Tripterygium wilfordii Hook fil. var. regelii Makino and Euonymus sieboldianus Blume, showed inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). Triptogelin A-1, one of the active di...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(93)90138-y
更新日期:1993-02-01 00:00:00
abstract::Butylated hydroxyanisole (BHA) was given to pregnant SPF pigs (Danish Landrace) in doses of 0, 50, 200 and 400 mg/kg body wt per day for 110 days. BHA was mixed in the diet (pelleted). Hyperkeratotic and parakeratotic proliferative changes of the stratified epithelium of the stomach were found at various degree in bot...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(83)90090-3
更新日期:1983-11-01 00:00:00
abstract::The p53 tumor suppressor gene is often mutated in various human cancers. Recently, the p53 codon 72 polymorphism has been extensively studied to determine the risk factors responsible for cancer formation. We investigated the genotype distribution of the p53 codon 72 polymorphism in 112 male urothelial cancer cases an...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(02)00518-9
更新日期:2003-01-10 00:00:00
abstract::One of the most promising strategies to increase the efficacy of standard chemotherapy drugs is by combining them with low doses of histone deacetylases inhibitors (HDACis). Regarded as chemosensitizers, the addition of well-tolerated doses of HDACis to platinum-based chemotherapeutics has been proven in vitro and in ...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2012.09.018
更新日期:2013-02-01 00:00:00
abstract::We analysed the expression of BIRC5 and BIRC5-2B in primary neuroblastoma (NB) tumors and NB model systems. In tumors, overexpression of BIRC5 correlated closely with its isoform BIRC5-2B. Expression of both transcripts was stage-dependent, associated with poor prognosis and with the expression of the transcription fa...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2009.05.007
更新日期:2009-11-18 00:00:00
abstract::The age-standardized mortality rates by sex for cancer of all sites and some specific sites were calculated in the 22 areas of Rosario (Argentina). The rates by area were correlated with education, occupation, housing quality and population density, applying Kendall's tau. Cervical cancer rates showed the strongest co...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(90)90159-u
更新日期:1990-03-01 00:00:00
abstract::Malignant tumor cells of different origin seem to have preferential sites for metastasis. Breast cancer, prostate cancer and certain melanomas have bone as one of their preferential targets for metastasis. Bone is continuously being remodelled, a process largely controlled by local growth factors. A possible explanati...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(95)03955-v
更新日期:1995-10-20 00:00:00
abstract::Epidermal growth factor receptors (EGFR) expression is frequently amplified in human glioblastoma cells. Nimotuzumab, a monoclonal antibody (mAb) against EGFR, has been used globally in clinics as an anti-cancer agent. It is largely unknown whether the blockade of miR-21, a microRNA that is upregulated in glioma cells...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2013.08.043
更新日期:2014-01-01 00:00:00