Genistein potentiates the effect of arsenic trioxide against human hepatocellular carcinoma: role of Akt and nuclear factor-κB.

abstract：:Populations consuming soybeans have reduced rates of breast, colon and prostate cancer possibly due, in part, to the presence in soybeans of two estrogenic isoflavones, genistein and daidzein. This study investigated the genotoxicity of these soya isoflavones and their interactions with 7,12-dimethylbenz[a]anthracene ...

journal_title：Cancer letters

authors： Giri AK,Lu LJ

更新日期：1995-08-16 00:00:00

abstract：:A field for cancerization, or a field defect, is formed by the accumulation of genetic and epigenetic alterations in normal-appearing tissues, and is involved in various cancers, especially multiple cancers. Epigenetic alterations are frequently present in chronic inflammation-exposed tissues, but information on indiv...

journal_title：Cancer letters

authors： Takeshima H,Niwa T,Takahashi T,Wakabayashi M,Yamashita S,Ando T,Inagawa Y,Taniguchi H,Katai H,Sugiyama T,Kiyono T,Ushijima T

更新日期：2015-02-01 00:00:00

abstract：:Women who have breast cysts with intracystic Na+/K+ < 3 may have a higher risk of developing breast cancer than women who have breast cysts with intracystic Na+/K+ > 3. In this study wide-ranging intracystic concentrations of cathepsin D and pS2 (oestrogen inducible proteins/polypeptides) as well as oestradiol were fo...

journal_title：Cancer letters

authors： Lai LC,Cornell C,Lennard TW

更新日期：1993-04-15 00:00:00

abstract：:EGFR polymorphisms have not been thoroughly evaluated for association with head and neck squamous cell carcinoma (HNSCC) risk. We genotyped 578 HNSCC patients and 588 cancer-free controls for 60 EGFR single nucleotide polymorphisms (SNPs) and tested associations with HNSCC risk. EGFR intronic SNPs rs12535536, rs207511...

journal_title：Cancer letters

authors： Fung C,Zhou P,Joyce S,Trent K,Yuan JM,Grandis JR,Weissfeld JL,Romkes M,Weeks DE,Egloff AM

更新日期：2015-02-28 00:00:00

abstract：:Recently developed quantitative and high-throughput technologies that allow automated and rapid screening of the whole genome, transcriptome and proteome have revolutionized the field of cancer genetics. At the same time, new challenges are met, e.g. the need for improved data analysis and standardization of tumor sam...

journal_title：Cancer letters

authors： De Preter K,Vandesompele J,Heimann P,Kockx MM,Van Gele M,Hoebeeck J,De Smet E,Demarche M,Laureys G,Van Roy N,De Paepe A,Speleman F

更新日期：2003-07-18 00:00:00

abstract：:To better understand causative relations of smoking to lung adenocarcinomas, the frequency of loss of heterozygosity (LOH) of all autosomal chromosomes was compared among the three grades of histological differentiation with 119 pulmonary adenocarcinomas (AC) and 41 squamous cell carcinomas (SCC), using Southern blott...

journal_title：Cancer letters

authors： Ishikawa Y,Furuta R,Miyoshi T,Satoh Y,Okumura S,Nakagawa K,Tsuchiya E

更新日期：2002-12-10 00:00:00

abstract：:Pancreatic adenocarcinoma (PDAC) is associated with poor clinical outcomes and incomplete responses to conventional therapy. Therefore, there is an unmet clinical need to better understand the predisposing factors for pancreatic cancer in hopes of providing early screening to high-risk patients. While select risk fact...

journal_title：Cancer letters

authors： Principe DR,Rana A

更新日期：2020-08-10 00:00:00

abstract：:In many parts of the world, green tea and black tea are produced from the plant Camellia sinensis. Tea is one of the most widely consumed beverages, second only to water. It is one of the safest beverages since it is made with boiling, sterile water and has been popular for over 4000 years. Dogma has it that people kn...

journal_title：Cancer letters

authors： Weisburger JH

更新日期：1997-03-19 00:00:00

abstract：:Pretreatment of EMT-6 murine tumor cells for 24 h with 10(-4) M 8-methoxypsoralen (8-MOP) increased the photocytotoxicity of Photofrin II (P2) after cell exposure to low doses (1-1.5 J/cm2) of UVA by two- to three-fold. 8-MOP alone had no cytotoxic action under these experimental conditions and did not significantly c...

journal_title：Cancer letters

authors： Sousa C,Mazière C,Melo TS,Vincent-Fiquet O,Rogez JC,Santus R,Mazière JC

更新日期：1998-06-19 00:00:00

abstract：:Microtubule targeting based therapies have revolutionized cancer treatment; however, resistance and side effects remain a major limitation. Therefore, novel strategies that can overcome these limitations are urgently needed. We made a novel discovery that fisetin, a hydroxyflavone, is a microtubule stabilizing agent. ...

journal_title：Cancer letters

authors： Mukhtar E,Adhami VM,Sechi M,Mukhtar H

更新日期：2015-10-28 00:00:00

abstract：:The overexpression of the MDM2 oncoprotein frequently occurs in hepatocellular carcinoma (HCC). Small molecules that inhibit MDM2-p53 binding show efficacy against p53 wild-type HCC, but most patients have p53-mutant tumors and intrinsic resistance to such MDM2 inhibitors. We have recently discovered that the NFAT1 tr...

journal_title：Cancer letters

authors： Wang W,Cheng JW,Qin JJ,Hu B,Li X,Nijampatnam B,Velu SE,Fan J,Yang XR,Zhang R

更新日期：2019-09-10 00:00:00

abstract：:Growing epidemiological evidence points out the carcinogenic hazard of inhaled aflatoxin B1 (AFB1) to the pulmonary system. Metabolism of AFB1 by lung microsomes and its binding to calf thymus DNA are reported for the first time in this paper. In addition, the ability of dietary butylated hydroxyanisole (BHA) to modul...

journal_title：Cancer letters

authors： Allameh A,Saxena M,Raj HG

更新日期：1988-05-01 00:00:00

abstract：:To date, several kinds of immunomodulating monoclonal antibodies (mAbs) have been applied in clinical trials, such as anti-cytotoxic T-lymphocyte antigen-4 (anti-CTLA-4) mAb and anti-programmed death-1 (anti-PD-1) mAb. With the recent success of cancer immunotherapy, especially the checkpoint inhibitors, the renewed i...

journal_title：Cancer letters

authors： Teng F,Kong L,Meng X,Yang J,Yu J

更新日期：2015-08-28 00:00:00

abstract：:We investigated whether the level of bone marrow-derived progenitor cells and mature endothelial cells could be used as predictors of clinical outcome in patients receiving taxotere-based chemotherapy for advanced gastric cancer. Peripheral blood mononuclear cells were obtained from 49 gastric cancer patients who rece...

journal_title：Cancer letters

authors： Shin SJ,Jeung HC,Ahn JB,Rha SY,Yoo NC,Roh JK,Noh SH,Chung HC

更新日期：2008-11-08 00:00:00

abstract：:2'-Deoxy-N4-[2-(4-nitrophenyl)ethoxycarbonyl]-5-azacytidine (NPEOC-DAC), decitabine with a modification of the N4 position of the azacitidine ring can be used to inhibit DNA methyltransferase. This modification protects the azacitidine ring and can be cleaved by carboxylesterase to release decitabine. NPEOC-DAC was 23...

journal_title：Cancer letters

authors： Byun HM,Choi SH,Laird PW,Trinh B,Siddiqui MA,Marquez VE,Yang AS

更新日期：2008-08-08 00:00:00

abstract：:The pharmacological specificity of adrenergic receptors in the plasma membrane of rat ascites hepatoma AH130 cells was compared with that in normal rat hepatocytes. The number of [125I]iodocyanopindolol-binding sites was much greater in AH130 cells than in the hepatocytes. We characterized the alpha-adrenergic recepto...

journal_title：Cancer letters

authors： Sanae F,Miyamoto K,Koshiura R

更新日期：1988-04-01 00:00:00

abstract：:Bacteria are always a considerable tool for the cancer therapy. The bacteria-derived minicells are re-emerged as a promising drug delivery system for cancer therapy. The minicells are nano-sized, anucleated, non-dividing, and metabolically active cells produced by abnormal bacterial cell division that are able to tran...

journal_title：Cancer letters

authors： Ali MK,Liu Q,Liang K,Li P,Kong Q

更新日期：2020-10-28 00:00:00

abstract：:Malignant tumors remain a major health burden throughout the world, and effective therapeutic strategies are urgently needed. Combining gene therapy with chemotherapeutics in a single delivery system is more effective than co-treatment of cancer with individual delivery systems carrying either gene or drug. In this st...

journal_title：Cancer letters

authors： Dong D,Gao W,Liu Y,Qi XR

更新日期：2015-04-10 00:00:00

abstract：:As myeloma cells actively produce and secrete immunoglobulins, they are prone to ER stress, which if unresolved leads to apoptosis. We found that myeloma cell death induced by the ER stressor Thapsigargin was highly variable, ranging from 2 to 89%. Induction of ATF4 and CHOP was observed in myeloma cells under Thapsig...

journal_title：Cancer letters

authors： Gomez-Bougie P,Halliez M,Moreau P,Pellat-Deceunynck C,Amiot M

更新日期：2016-12-28 00:00:00

abstract：:In order to examine the in vivo genotoxic activity of dichlorvos, lambdalacZ transgenic mice (Muta Mouse) were treated i.p. with single (4.4 or 11 mg/kg) or multiple (5 x 11 mg/kg) doses of this agent and sacrificed 4 h or 14 days post-treatment for DNA adduct measurement or mutant frequency analysis, respectively. Ne...

journal_title：Cancer letters

authors： Pletsa V,Steenwinkel MJ,van Delft JH,Baan RA,Kyrtopoulos SA

更新日期：1999-11-15 00:00:00

abstract：:The binding of hematoporphyrin (HP) to human cells of the line NHIK 3025 has been studied with the aid of microfluorometry. HP is concentrated within cells when present in Hank's balanced salt solution in the concentration range 10(-5)--3 x 10(-3) M. The time course of binding is biphasic with a rapid initial binding ...

journal_title：Cancer letters

authors： Christensen T,Moan J

更新日期：1980-04-01 00:00:00

abstract：:The antitumor effects of 2'-C-cyano-2'-deoxy-1-beta-D- arabinofuranosylcytosine (CN-DAC), a synthetic 1-beta-D-arabinofuranosyl-cytosine (ara-C) derivative, were examined and compared with that of ara-C in murine tumors and in various human tumors using three different chemosensitivity tests. CNDAC extended the life s...

journal_title：Cancer letters

authors： Tanaka M,Matsuda A,Terao T,Sasaki T

更新日期：1992-05-30 00:00:00

abstract：:Recent clinical studies have indicated that intra-tumoral gene expression levels of 5-fluorouracil (5-FU) metabolism-related enzymes may predict the clinical response of several cancers to 5-FU-based chemotherapy. However, few studies examining oral squamous cell carcinomas (OSCCs) have been reported. In this study, w...

journal_title：Cancer letters

authors： Tateishi Y,Tatemoto Y,Ohno S,Morishita K,Ueta E,Yamamoto T

更新日期：2009-02-18 00:00:00

abstract：:The effects of glucocorticoids and cholesterol on morphological transformation have been studied using hamster embryo cells. The cells were exposed sequentially to benzo[a]pyrene (BP) (3 days) and the tumor promotor 12-O-tetradecanoylphorbol-13-acetate (TPA) (4 days) before scoring for morphologically transformed colo...

journal_title：Cancer letters

authors： Rivedal E

更新日期：1982-02-01 00:00:00

abstract：:We investigated the relative effectiveness of four differentiation-inducing chemicals to induce a more normal or benign phenotype in the human colon cancer cell lines Moser and HT29. The differentiation-inducing capability of all-trans retinoic acid (ATRA), difluoromethylornithine (DFMO), sodium butyrate (NaB) and sod...

journal_title：Cancer letters

authors： Reynolds S,Rajagopal S,Chakrabarty S

更新日期：1998-12-11 00:00:00

abstract：:The in vitro sensitivities to differentiating agents of a murine neuroblastoma cell line (N18) and a selected variant cell line (N18-LM5) were examined. In addition, the sensitivities to differentiating agents of cells from spontaneous metastases produced by N18 cells were examined. When N18 cells (1 X 10(5) cells/mou...

journal_title：Cancer letters

authors： Takenaga K

更新日期：1983-05-01 00:00:00

abstract：:The promoting potential of oxymetholone (OXM) administration on development of liver cell foci was investigated in male F344 rats previously treated with N-diethylnitrosamine (DEN). One week after a single injection of DEN (100 mg/kg, i.p.), rats were given OXM at a dietary level of 0.2% for the first 4 weeks and then...

journal_title：Cancer letters

authors： Shimoji N,Imaida K,Hasegawa R,Matsuoka C,Uneyama CT,Takahashi M,Hayashi Y

更新日期：1990-02-01 00:00:00

abstract：:Angiogenesis is regulated by numerous "classic" factors such as vascular endothelial growth factor (VEGF) and many other endogenous "non-classic"peptides, including erythropoietin (Epo), and granulocyte-/granulocyte macrophage colony stimulating factor (G-/GM-CSF). The latter play an important regulatory role in angio...

journal_title：Cancer letters

authors： Ribatti D,Tamma R

更新日期：2019-01-01 00:00:00

abstract：:The mitochondrial genetic system is indispensable for the biosynthesis of the enzyme complexes involved in aerobic energy generation. Tetracyclines inhibit the expression of only the mitochondrial genes because they specifically block mitochondrial protein synthesis. A salient feature is that this inhibition occurs at...

journal_title：Cancer letters

authors： Kroon AM,Dontje BH,Holtrop M,Van den Bogert C

更新日期：1984-11-01 00:00:00

abstract：:The binding of [14C] azaserine or its metabolites to DNA and protein in the organs of rats and hamsters was determined at various time after treatment with [14C] azaserine. The specific activity of 14C labelling of DNA and protein was determined. Rat liver DNA and protein were most extensively labelled at 90 min post-...

journal_title：Cancer letters

authors： Zurlo J,Coon CI,Longnecker DS,Curphey TJ

更新日期：1982-05-01 00:00:00