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Induction of mitochondria-dependent apoptosis through the inhibition of mevalonate pathway in human breast cancer cells by YM529, a new third generation bisphosphonate.

Abstract：

:YM529, a new third generation bisphosphonate, induced apoptosis of a human breast cancer cell line, MX-1. Cytotoxic activity of YM529 was more potent than that of incadronate. YM529 activated caspase-9, but not caspase-8, and induced the release of cytochrome c into cytosol. YM529 increased Bax expression and decreased Bcl-2 expression, while it did not induce caspase-8-dependent Bid truncation. Farnesyl pyrophosphate prevented YM529-mediated cytotoxicity. These results suggest that YM529 is a potent therapeutic agent for human breast cancers, activating the mitochondria-dependent apoptotic pathway through the inhibition of protein farnesylation.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Nakajima H,Magae J,Tsuruga M,Sakaguchi K,Fujiwara I,Mizuta M,Sawai K,Yamagishi H,Mizuta N

doi

10.1016/j.canlet.2007.01.008

subject

Has Abstract

pub_date

2007-08-08 00:00:00

pages

89-96

issue

1

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(07)00019-5

journal_volume

253

pub_type

杂志文章

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