Abstract：
:Angiotensin II (Ang II) has been implicated in muscle protein loss in cachexia. To determine whether the Ang I/II system directly inhibits protein synthesis in muscle their effect has been monitored in vitro using murine myotubes as a surrogate model system. Ang I inhibited protein synthesis by 40-50% over the concentration range of 0.05-2.5 microM within 30 min of addition, and the inhibition remained relatively constant over 24 h. The effect was attenuated by co-incubation with the angiotensin converting enzyme inhibitor imidaprilat (50 microM) suggesting that inhibition of protein synthesis was due to the formation of Ang II. Ang II also inhibited protein synthesis by 40-50% over the concentration range of 0.1-5 microM, and the inhibition also remained relatively constant between 30 min and 24 h after addition. The effect was attenuated by insulin-like growth factor-1 (IGF-1) (25-100 ng/ml). Thus, Ang I/II have the ability to induce muscle atrophy through inhibition of protein synthesis.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Russell ST,Sanders PM,Tisdale MJdoi
10.1016/j.canlet.2005.02.007keywords:
subject
Has Abstractpub_date
2006-01-18 00:00:00pages
290-4issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(05)00149-7journal_volume
231pub_type
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