Abstract：
:The alkylation of hamster liver, lung and pancreas DNA by [1-14C]- and [2,3-14C]N-nitrosobis (2-oxopropyl) amine (BOP) has been examined. The specific activity of pancreas DNA after [2,3-14C]BOP administration was only 2% of that when [1-14C]BOP was given. 7-Methylguanine, but not O-6-methylguanine, was found in hydrolysates of liver and pancreas DNA. Nearly equal amount of alkylation were produced in the liver when [1-14C]- and [2,3-14C]BOP were given. At least one-half of the radioactivity in the liver was associated with N-alkylated purines, whereas only 20% was in this form in the pancreas.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Lawson TA,Gingell R,Nagel D,Hines LA,Ross Adoi
10.1016/0304-3835(81)90116-6subject
Has Abstractpub_date
1981-01-01 00:00:00pages
251-5issue
3eissn
0304-3835issn
1872-7980pii
0304-3835(81)90116-6journal_volume
11pub_type
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