Abstract:
:It has been nearly 9years since the FDA (Food and Drug Administration) approved the first anti-angiogenic drug (bevacizumab) for treatment of metastatic colorectal cancer. Other angiogenic inhibitors have since been approved or are in different stages of clinical trials. However, continued clinical and preclinical investigations have identified major drawbacks associated with the application of this class of agents, including inherent/acquired resistance and induction of tumor invasiveness. In addition, lack of thoroughly validated predictive biomarkers has been one of the major hurdles to stratify cancer patients and to monitor tumor progression and response to the therapy. Investigations in clinic and preclinical models have provided some molecular and cellular mechanisms for the above challenges. This review aims to provide a concise update from recent findings.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Shojaei Fdoi
10.1016/j.canlet.2012.03.008subject
Has Abstractpub_date
2012-07-28 00:00:00pages
130-7issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(12)00167-Xjournal_volume
320pub_type
杂志文章,评审相关文献
CANCER LETTERS文献大全abstract::The capacity of the human adrenal gland to metabolize various xenobiotics was investigated. Adrenal microsomal and mitochondrial preparations showed a maximal absorption at 450 nm for dithionite-reduced cytochromes in the presence of carbon monoxide. Occasionally, absorption maxima at 448 nm were observed with both mi...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(84)90039-9
更新日期:1984-02-01 00:00:00
abstract::Effects of cis-dichlorodiammineplatinum-(II) (cis-DDP), an anticancer agent, on capping of membrane receptors were investigated in mouse spleen cells in vitro, using fluorescein labeled ligands. Cap formations of surface immunoglobulin and of concanavalin A receptors were significantly reduced by cis-DDP in relation t...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(80)90079-8
更新日期:1980-09-01 00:00:00
abstract::The lack of effective anti-tumor therapy for renal cell carcinoma (RCC) has stimulated the search for novel target whose inhibition could block tumorigenesis. Recently, reduced DLC-1 has been shown to be associated with aggressive and highly metastatic renal cell carcinoma. In this study, the biological role of DLC-1 ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2009.03.025
更新日期:2009-09-28 00:00:00
abstract::Immunometabolism, which has important implications in cancer biology, has emerged as a major regulator of different immune cell types. Various factors that integrate metabolic switches within immune cells with signal directed program that promote or inhibit their functions remain largely unidentified. Furthermore, sex...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2017.12.001
更新日期:2018-02-28 00:00:00
abstract::Inclusion of 10% ethanol with 6.8 ppm N-nitrosodiethylamine in the drinking water of strain A male mice resulted in a 4-fold enhancement of multiplicity of lung tumors and a 16-fold increase in incidence of fore-stomach tumors, compared with carcinogen alone. Given with 40 ppm N-nitrosopyrrolidine, ethanol caused a 5....
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(93)90220-4
更新日期:1993-01-15 00:00:00
abstract::Protease inhibitors have been shown to be highly effective suppressors of carcinogenesis in both in vivo and in vitro model systems. For example, the soybean derived Bowman Birk inhibitor (BBI) has been shown to inhibit colon carcinogenesis. Although the precise mechanisms by which protease inhibitors suppress carcino...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(92)90063-2
更新日期:1992-04-15 00:00:00
abstract::We studied the effect of staurosporine (SSP), a broad-spectrum protein kinase inhibitor, on the levels of protein kinase C (PKC) activity and proliferation in two murine neuroblastoma cell lines, Neuro2a and its clone NB41A3. The PKC activity was examined in whole cell lysate, cytosolic and particulate fractions. A di...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(99)00021-x
更新日期:1999-05-24 00:00:00
abstract::The fruiting body of Antrodia camphorata is well known in Taiwan as a traditional medicine for treating cancer and inflammation. The purpose of this study was to evaluate the apoptotic effects of ethylacetate extract from A. camphorata (EAC) fruiting bodies in two human liver cancer cell lines, Hep G2 and PLC/PRF/5. T...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2004.08.012
更新日期:2005-04-18 00:00:00
abstract::Stem cell factor (SCF) is a multifunctional cytokine responsible for tumorigenesis and progression. In this study, we report that increased expression of SCF in hepatocellular carcinoma (HCC) patients is highly associated with metastasis and poor prognosis. SCF inhibition with RNAi inhibited HCC cell migration, invasi...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2017.01.032
更新日期:2017-05-01 00:00:00
abstract::scFv fragments of a monoclonal antibody that penetrates living cells and localizes in nuclei were designed as fusion proteins with C-terminal p53 peptides and tested for restoring p53 function in p53 mutant cancer cells. scFv fragments transported a 30-mer C-terminal peptide of p53 into cancer cells and induced cellul...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(03)00151-4
更新日期:2003-06-10 00:00:00
abstract::cIAP-1, an apoptosis inhibiting protein, has been suggested to play important roles in the development of cervical and esophageal squamous cell carcinomas (SCCs). In order to clarify the subcellular localization of cIAP-1 and to investigate its clinicopathological significance in head and neck SCCs (HNSCCs), we examin...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2004.11.049
更新日期:2005-06-16 00:00:00
abstract::HGT cells are a human gastric cell line derived from a tumour of the stomach. We have investigated the effects of lipoxygenase and cyclooxygenase metabolism inhibitors on HGT cell proliferation, on fatty acid composition of HGT cells and on the incorporation and distribution of arachidonic acid (AA) in HGT lipids. The...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(93)90189-g
更新日期:1993-09-15 00:00:00
abstract::Epigenetic aberrations have been associated with cutaneous melanoma tumorigenesis and progression including dysregulated DNA gene promoter region methylation, histone modification, and microRNA. Several of these major epigenetic aberrations have been developed into biomarkers. Epigenetic biomarkers can be detected in ...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2012.01.020
更新日期:2014-01-28 00:00:00
abstract::Circulating free DNA (CFDNA) has been shown to be a good source of liver tissue-derived DNA in African and Asian patients with chronic liver disease or HCC. In Egypt, HCC is a frequent carcinoma and mostly occur in the context of chronic infection by HCV, a widespread infection in the Egyptian population. Here we have...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2008.01.031
更新日期:2008-06-18 00:00:00
abstract::As a continuation of studies using natural and synthetic products as cancer chemopreventive agents, we examined the reduction-oxidation potentials of hydroxylated emodin derivatives prepared from emodin in phosphate buffer at pH 7.2 using cyclic voltammetry. A significant correlation was found between the reduction po...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2005.10.043
更新日期:2006-09-28 00:00:00
abstract::Neuroblastoma is the most common extra-cranial solid tumor in children. Despite advances in the treatment of childhood cancer, outcomes for children with advanced-stage neuroblastoma remain poor. Here we reported that 2-methoxyestradiol (2-ME) inhibited the proliferation and induced apoptosis in human neuroblastoma SK...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2011.09.005
更新日期:2011-12-27 00:00:00
abstract::Survivin is a recently characterised inhibitor of apoptosis protein that has been implicated in the pathogenesis of several types of solid organ cancer. This study sought to describe the expression of survivin in a cohort of 90 benign meningiomas, together with the pattern of expression of other genes involved in the ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(02)00741-3
更新日期:2003-04-25 00:00:00
abstract::Glucocorticoids (GCs) are pro-apoptotic as a co-medication to treat leukemia and lymphoma. However, the effects in breast cancer (BC) are diverse with mechanisms less understood. In this study using BC model cell MCF7, we found that dexamethasone (Dex) promotes cell proliferation. Gene expression analysis identified t...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2013.05.020
更新日期:2013-08-28 00:00:00
abstract::These studies examined the impact of dietary corn oil and its major constituent fatty acids on the occurrence of 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary DNA adducts. In study 1, rats were fed diets containing 5, 10 or 20% corn oil for 2 weeks prior to DMBA treatment (25 mg/kg). Mammary DNA adducts increa...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(96)04323-6
更新日期:1996-09-10 00:00:00
abstract::Sperm protein 17 (Sp17) is a highly antigenic, testes-specific protein whose known function is to bind sperm to the zona pellucida. However, the Sp17 gene has been recently detected in normal non-testes tissues and malignant neoplasias. As the role of Sp17 in non-testes tissues is unknown, the characterization of the ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(02)00350-6
更新日期:2002-12-05 00:00:00
abstract::The intrinsic limits of conventional ultrasound microbubble contrast agent greatly promoted the development and application of various nanomaterials for more efficient cancer ultrasound theranostics. Considerable successes have been achieved in the field of ultrasound molecular imaging and targeted therapy for tumor b...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2019.11.034
更新日期:2020-02-01 00:00:00
abstract::The present study was performed to investigate the possible role of mTOR inhibitors in restoring chemosensitivity to adriamycin/cisplatin and elucidate the underlying mechanism. Combining adriamycin/cisplatin with torisel synergistically inhibited the cell proliferation in human oropharyngeal carcinoma cell line KB an...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2011.06.005
更新日期:2011-12-01 00:00:00
abstract::Microsomes isolated from hyperplastic liver nodules and hepatomas, induced by DL-ethionine, exhibited a reduced cytochrome P-450 content and aminopyrine N-demethylase activity when compared to the organelles of control and surrounding non-nodular liver. Phenobarbital administration to rats caused an increase of micros...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(78)80006-8
更新日期:1978-07-01 00:00:00
abstract::Non-small cell lung cancer (NSCLC) remains one of the most metastasizing tumors, and directional cell migration is critical for targeting tumor metastasis. GIT2 has been known to bind to Paxillin to control cell polarization and directional migration. However, the molecular mechanisms underlying roles of GIT2 in contr...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.05.027
更新日期:2016-08-28 00:00:00
abstract::The human multidrug resistance ABC transporters provide a protective function in our body against a large number of toxic compounds. These proteins, residing in the plasma membrane, perform an active, ATP-dependent extrusion of such xenobiotics. However, the same proteins are also used by the tumor cells to fight vari...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2005.01.061
更新日期:2006-03-08 00:00:00
abstract::These experiments were designed to test the role of the polyamine pathway in breast cancer progression utilizing an experimental system based on the development of ovary-independent rat mammary tumors and their sequential transplantation into syngeneic hosts. Three key enzymes involved in the PA biosynthetic/catabolic...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(95)03763-m
更新日期:1995-05-25 00:00:00
abstract::Although brain tumors are classified as if their lineage were well understood, the relationship between the molecular events that specify neural cell lineage and brain tumors remains enigmatic. Traditionally, cell surface membrane antigens have served as biomarkers that distinguish brain tumor origin and malignancy. I...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2008.01.007
更新日期:2008-05-18 00:00:00
abstract::Epidermal growth factor receptors (EGFR) expression is frequently amplified in human glioblastoma cells. Nimotuzumab, a monoclonal antibody (mAb) against EGFR, has been used globally in clinics as an anti-cancer agent. It is largely unknown whether the blockade of miR-21, a microRNA that is upregulated in glioma cells...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2013.08.043
更新日期:2014-01-01 00:00:00
abstract::Liver hyperplasia was induced in rats by daily administration of methylclofenapate (25 mg/kg by gavage). An increase in the incidence of colchicine-arrested metaphases was observed with peaks occurring at 40 h (1.3%), 64 h (6.4%) and 84 h (6.8%) after the start of treatment. This response contrasted with the much larg...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(90)90250-2
更新日期:1990-07-16 00:00:00
abstract::Endometrial cancer is the leading gynecologic cancer in women in the United States with 52,630 women predicted to be diagnosed with the disease in 2014. The objective of this study was to determine if progesterone (P4) receptor membrane component 1 (PGRMC1) influenced endometrial cancer cell viability in response to c...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2014.09.036
更新日期:2015-01-28 00:00:00