Abstract:
:Diabetes mellitus type II (DM) and immune cell infiltration determine patient outcome in many tumor entities. Here we studied a possible link between the metabolic and immune cell status of OSCC patients. Glucose transporter (GLUT) 1 mRNA expression was elevated in all tumor samples, whereas other glycolytic markers such as lactate dehydrogenase (LDH) A or monocarboxylate transporter (MCT) 1 were increased in tumor samples from patients with diabetes and these patients had a significantly worse prognosis compared to non-diabetic patients. Analyses of immune cell infiltration in tumors from diabetic and non-diabetic patients revealed an increased leukocyte (CD45+) infiltration compared to normal mucosa only in non-diabetic patients. In line, the amount of CD3+ T cells per mm2 tumor tissue, was elevated in patients without diabetes and crucial for patient outcome in OSCC patients without diabetes, as compared to healthy mucosa using fluorescence immunohistochemistry in tissue microarrays of 229 patients. Our results demonstrate that diabetes is a prognostic factor for OSCC patients and associates with decreased leukocyte and CD3+ infiltration indicating that metabolic differences between diabetic and non-diabetic patients may alter tumor-infiltrating T cells and thereby determine patient outcome.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Spanier G,Ugele I,Nieberle F,Symeou L,Schmidhofer S,Brand A,Meier J,Spoerl S,Krupar R,Rümmele P,Siska P,Renner K,Peter K,Gerken M,Beckhove P,Reichert TE,Kreutz M,Singer Kdoi
10.1016/j.canlet.2020.11.029subject
Has Abstractpub_date
2021-02-28 00:00:00pages
209-219eissn
0304-3835issn
1872-7980pii
S0304-3835(20)30628-5journal_volume
499pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract::The presence and the involvement of cancer stem-like cells (CSCs) in tumor initiation and progression, and chemo-resistance are documented. Herein, we functionally analyzed melanoma stem-like cells (MSC)/CD133(+) cells on their resistance and response to taxol-induced apoptosis. Besides being taxol resistant, the CD13...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2013.09.024
更新日期:2014-02-01 00:00:00
abstract::Pancreatic cancer remains a highly lethal malignancy. We have recently shown that simultaneous expression of Kras and mutant Tp53R175H promotes invasive ductal adenocarcinoma from pancreatic ductal cells. We hypothesized specific mutations in TP53 have divergent mechanisms of transforming ductal cells. In order to und...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2019.03.047
更新日期:2019-07-01 00:00:00
abstract::The progression of hepatocellular carcinoma (HCC) is known to be strongly related to overexpression of hepatitis Bx (HBx) protein and dysfunction of p53. While the inhibition of p53 by HBx is well known, the effect of p53 on HBx function has not been well studied. In this report, we found that p53 affects the stabilit...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2009.03.019
更新日期:2009-09-18 00:00:00
abstract::Overall survival and quality of life of patients with metastatic colorectal cancer (mCRC) have improved due to the development of standard systemic treatment. However, many patients are still suffering from the eventual progression of cancer, treatment-related toxicities, and the economic burden of new drugs. Salvage ...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2017.02.034
更新日期:2017-08-01 00:00:00
abstract::A 65K protein, known for promoting nucleocytoplasmic mRNA transport in a cell-free system, was previously found in fetal and tumor cells of the rat. The primary objective of this study was to show specificity of immunohistochemical staining for the 65K protein in the livers of rats subjected to a hepatocarcinogenesis ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(89)90120-1
更新日期:1989-12-01 00:00:00
abstract::Tumor hypoxia has been commonly observed in a broad spectrum of primary solid malignancies. Hypoxia is associated with tumor progression, increased aggressiveness, enhanced metastatic potential and poor prognosis. Hypoxic tumor cells are resistant to radiotherapy and some forms of chemotherapy. Using an animal model, ...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2008.02.037
更新日期:2008-06-18 00:00:00
abstract::The formation of nitroso compounds and mutagens from 5 nitrogen-containing drugs (cinnarizine, ethambutol, piromidic acid, pyridinol carbamate and tiaramide) by drug/nitrite interaction was examined. On the reaction of 50 micrometers drug and 500 micrometers nitrite at pH 3.0--3.4 and 37 degrees C for 4 h, the conside...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(82)90075-1
更新日期:1982-01-01 00:00:00
abstract::We previously reported that prostaglandin E(2) contributes to colon carcinogenesis through its binding to the prostaglandin E receptor subtype EP(1) using a genetic approach in EP(1)-knockout mice and a pharmacological approach with the EP(1) selective antagonist, ONO-8711. In the present study, we examined the effect...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(00)00440-7
更新日期:2000-08-01 00:00:00
abstract::The chemopreventive influence of phenethyl isothiocyanate (PEITC) during the post-initiation stage was investigated in the N-nitrosobis(2-oxopropyl)amine (BOP)-initiated hamster tumorigenesis model. A total of 120 female 5-week-old hamsters were divided into six groups. Animals in groups 1-3, each consisting of 30 ham...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(99)00089-0
更新日期:1999-07-01 00:00:00
abstract::Glioblastoma multiforme (GBM) is the most common malignant brain tumor, which remains incurable. Plant extracts are a potential source of potent anticancer medicines. In this study, we investigated the effect of isolinderalactone from Lindera aggregata on tumor growth using U-87 human glioblastoma cells. Treatment wit...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2018.11.027
更新日期:2019-02-28 00:00:00
abstract::Evidence is growing that low folate status may be a factor in the aetiology of several cancers, including breast cancer. The methylenetetrahydrofolate reductase gene (MTHFR), which has a key role in folate metabolism, is polymorphic. We report a case-control study of two functional polymorphisms in MTHFR, dietary fola...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(02)00030-7
更新日期:2002-07-08 00:00:00
abstract::Angiogenesis remains a sensible target for pancreatic ductal adenocarcinoma (PDAC) therapy. VEGF, PDGF, FGF and their receptors are expressed at high levels and correlate with poor prognosis in human PDAC. Nintedanib is a triple angiokinase inhibitor that targets VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β signaling. We invest...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2014.12.027
更新日期:2015-03-01 00:00:00
abstract::In this study, we demonstrated that thrombin activates protein kinase C (PKC), mitogen activated protein kinases (MAP kinases), transcription factor nuclear factor-kappa B (NF-kappa B), and cAMP-dependent protein kinase (PKA) in the human renal carcinoma cell line A-498. In addition, it enhanced the migratory capacity...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(01)00870-9
更新日期:2002-06-28 00:00:00
abstract::We evaluated the changes in CTC count and CTC-associated miRNAs during the course of chemotherapy in patients with metastatic colorectal cancer. Blood samples were collected from 9 metastatic colorectal cancer patients prior to chemotherapy and at every other chemotherapy session during the course of treatment. CTCs w...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2018.02.039
更新日期:2018-06-01 00:00:00
abstract::Hypoxia causes upregulation of vascular endothelial growth factor (VEGF) which is a key regulator in tumor angiogenesis and essential for the proliferation of endothelial cells. Endothelial cells have been described to accumulate radiotracers like (18)F-FDG. However, the contribution of radiotracer uptake by endotheli...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2007.02.016
更新日期:2007-08-28 00:00:00
abstract::Forty female CBA mice aged 3-4 months were exposed twice a week during 2 months to intravaginal applications of polyurethane sponges impregnated with 0.1% solution of 7,12-dimethylbenz[a]anthracene (DMBA) in triethyleneglycol. Three hours after each application the sponges were taken out. Starting from the day of the ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(00)00463-8
更新日期:2000-08-11 00:00:00
abstract::The GH/IGF1 response of somatotropinomas to somatostatin analogues (SSA) is associated with their pattern of somatostatin receptor (sst1-sst5) expression. Recently, we demonstrated that expression of a truncated sst5-variant (sst5TMD4) can influence the secretory response of somatotropinomas to SSA-therapy; however, i...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2015.01.037
更新日期:2015-04-10 00:00:00
abstract::The human multidrug resistance ABC transporters provide a protective function in our body against a large number of toxic compounds. These proteins, residing in the plasma membrane, perform an active, ATP-dependent extrusion of such xenobiotics. However, the same proteins are also used by the tumor cells to fight vari...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2005.01.061
更新日期:2006-03-08 00:00:00
abstract::The clinical use of chemotherapy in cancer treatment is limited by the occurrence of multidrug resistance (MDR) associated with the overexpression of membrane transporters, one of the best known is P-glycoprotein (Pgp), that actively expels drugs out of tumor cells. To overcome Pgp-mediated MDR, synthetic peptides cor...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2007.04.001
更新日期:2007-11-18 00:00:00
abstract::Numbers of circulating endothelial cells (CECs) are increased in cancer patients with progressive disease. Also, cancer patients have an increased risk for thrombotic events, being negatively associated with prognosis. Tissue factor (TF), the physiological initiator of coagulation, is present on the surface of many ex...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2004.04.019
更新日期:2004-09-30 00:00:00
abstract::The mouse monoclonal anti-BAL antibody induced apoptosis in a pre-B acute lymphocytic leukemia cell line within 2 days of incubation, after being crosslinked by a secondary antibody. The antibody specifically recognized a 37 kDa membrane protein that was expressed on a wide spectrum of normal and malignant cells, but ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(93)90194-e
更新日期:1993-12-10 00:00:00
abstract::We have demonstrated previously that a phosphorothioate antisense oligonucleotide to the p65 subunit of the inducible transcription factor NF-kappaB produced rapid changes in the expression of leukocyte integrin CD11b (Mo 1) and in the adhesion of dimethylsulfoxide (DMSO)-differentiated HL-60 cells stimulated by 12-O-...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(97)00505-3
更新日期:1998-03-13 00:00:00
abstract::Naturally occurring fecal mutagens, called fecapentaenes, are hypothesized to contribute to large bowel carcinogenesis. To understand health risks it is necessary to relate fecal mutagen concentrations to intestinal pathologies, i.e. colon cancer. However, fast and reliable methods for analysis of stool for fecapentae...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(89)90104-3
更新日期:1989-01-01 00:00:00
abstract::These studies examined the impact of dietary corn oil and its major constituent fatty acids on the occurrence of 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary DNA adducts. In study 1, rats were fed diets containing 5, 10 or 20% corn oil for 2 weeks prior to DMBA treatment (25 mg/kg). Mammary DNA adducts increa...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(96)04323-6
更新日期:1996-09-10 00:00:00
abstract::The quality and frequency of mutations in PTEN gene were assessed in 59 carcinomas and 6 hyperplasias of the endometrium in women. Screening for mutations was done in all exons of PTEN gene by the PCR-SSCP analysis and DNA sequencing. Results were correlated with histological status and clinical features of endometria...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(01)00815-1
更新日期:2002-04-08 00:00:00
abstract::The polymorphism in the ALDH2 gene plays a central role in Asian alcohol hypersensitivity and has been associated with the risk for esophageal cancer. In the present study, we attempted to examine associations between the ADH2 and ALDH2 polymorphisms, alcohol drinking and hepatocellular carcinoma (HCC) development in ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(99)00343-2
更新日期:2000-02-28 00:00:00
abstract::In vitro cytotoxicity tests currently in use applied in the developmental stages of anticancer drug discovery are able to select the most potent compounds, but are not predictive of their potential toxicity. In this study, we have demonstrated the applicability of neutral red uptake assay using mouse fibroblasts Balb/...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2005.01.014
更新日期:2005-11-08 00:00:00
abstract::A series of experiments was carried out to assess cytotoxic and cytogenetic effects in bone marrow polychromatic erythrocytes (PCE) and pulmonary alveolar macrophages (PAM) resulting from individual or combined exposure of male BD6 rats to ethanol, cigarette smoke and Aroclor 1254. Addition of 5% ethanol to drinking w...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(93)90127-u
更新日期:1993-08-31 00:00:00
abstract::The suitability of a colorimetric [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT)] assay to the determination of cell viability following photoradiation therapy (PRT) of human breast and melanoma cell lines has been examined. Results have been shown to correlate with those obtained using a clonogen...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(88)90293-5
更新日期:1988-08-30 00:00:00
abstract::The aim of this study was to evaluate diagnostic performance of radiomics models of MRI in the detection of differentiation degree (DD) and lymph node metastases (LNM) of extrahepatic cholangiocarcinoma (ECC). We retrospectively enrolled 100 patients with ECC confirmed by pathology from January 2011 to December 2018. ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2019.11.036
更新日期:2020-02-01 00:00:00