Abstract:
:Naturally occurring fecal mutagens, called fecapentaenes, are hypothesized to contribute to large bowel carcinogenesis. To understand health risks it is necessary to relate fecal mutagen concentrations to intestinal pathologies, i.e. colon cancer. However, fast and reliable methods for analysis of stool for fecapentaene levels are not available. This study presents an evaluation of stabilizing effects on synthetic fecapentaene-12 of various antioxidants, indicating tri-ethylamine to give the best results. Furthermore, it describes a fast extraction procedure for human stool and a subsequent HPLC-analysis which produces quantitative data on fecapentaene-12 concentrations within 30 min.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Kleinjans JC,Pluijmen MH,Hageman GJ,Verhagen Hdoi
10.1016/0304-3835(89)90104-3subject
Has Abstractpub_date
1989-01-01 00:00:00pages
33-7issue
1eissn
0304-3835issn
1872-7980pii
0304-3835(89)90104-3journal_volume
44pub_type
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