Abstract:
:FOY-305 is a synthetic serine protease inhibitor and ONO-3403 and FO-349 are its derivatives. The effects of these compounds on the proliferation of 13 human neuroblastoma cell lines were investigated in vitro by MTT colorimetric assay. The half maximum inhibition concentrations of ONO-3403 varied between 22 and 90 microg/ml while those of FOY-305 and FO-349 were higher than 100 microg/ml. ONO-3403 showed higher growth-inhibitory activity for N-myc-amplified neuroblastomas as compared with that for non-amplified cells. Since N-myc amplification in neuroblastomas is well correlated with a poor prognosis, ONO-3403 could be an effective anticancer drug for malignant neuroblastomas.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Hiwasa T,Kondo K,Nakagawara A,Ohkoshi Mdoi
10.1016/s0304-3835(98)00015-9subject
Has Abstractpub_date
1998-04-24 00:00:00pages
221-5issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(98)00015-9journal_volume
126pub_type
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