Abstract：
:We examined the effect of alcohol consumption, cigarette smoking and flushing response on esophageal squamous cell carcinoma (ESCC) in a large-scale population-based cohort study. 44,970 middle-aged and older Japanese men were followed. A total of 215 cases of ESCC were newly diagnosed. Alcohol consumption and cigarette smoking are strongly associated with the incidence of ESCC. Heavy alcohol consumption increased the risk of ESCC especially among heavy smokers with the flushing response (HR = 3.41, 95% CI = 2.10-5.51). Strong effect modification was detected in heavy smokers. Our results suggest that heavy alcohol consumption together with heavy smoking may increase the risk of ESCC particularly in individuals with the flushing response.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Ishiguro S,Sasazuki S,Inoue M,Kurahashi N,Iwasaki M,Tsugane S,JPHC Study Group.doi
10.1016/j.canlet.2008.10.020subject
Has Abstractpub_date
2009-03-18 00:00:00pages
240-6issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(08)00834-3journal_volume
275pub_type
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