Melanoma circulating tumor cells: Benefits and challenges required for clinical application.

abstract：:As a tumor antigen, mesothelin (MSLN) can be identified in various malignancies. MSLN is potential for antigen-specific cancer vaccines. We generated a novel chimeric DNA vaccine using antigen-specific connective tissue growth factor lined with MSLN (CTGF/MSLN). The anti-tumor effects of the CTGF/MSLN DNA vaccine comb...

journal_title：Cancer letters

authors： Chen YL,Chang MC,Chiang YC,Lin HW,Sun NY,Chen CA,Sun WZ,Cheng WF

更新日期：2018-07-01 00:00:00

abstract：:The pharmacological specificity of adrenergic receptors in the plasma membrane of rat ascites hepatoma AH130 cells was compared with that in normal rat hepatocytes. The number of [125I]iodocyanopindolol-binding sites was much greater in AH130 cells than in the hepatocytes. We characterized the alpha-adrenergic recepto...

journal_title：Cancer letters

authors： Sanae F,Miyamoto K,Koshiura R

更新日期：1988-04-01 00:00:00

abstract：:Cancerous breast hyperthermia is seemingly associated with non-neurological vasodilation modulated by nitric oxide (NO). NO, associated with enhanced immune response, is produced autocatalytically involving ferritin as the supplier of Fe2+, which catalyses the formation of NO. NO, in turn, releases Fe2+ from ferritin....

journal_title：Cancer letters

authors： Anbar M

更新日期：1994-08-29 00:00:00

abstract：:Immunohistochemically detected expression of sialyl Lewis(x) (Le(x)) antigen was analyzed in 101 stage 0-II gastric cancers to clarify its prognostic value after curative gastrectomy. Patients with a high-expression of sialyl Le(x) antigen within their tumors had shorter disease-specific intervals than those with nega...

journal_title：Cancer letters

authors： Nakagoe T,Fukushima K,Sawai T,Tsuji T,Jibiki Ma,Nanashima A,Tanaka K,Yamaguchi H,Yasutake T,Ayabe H,Arisawa K,Ishikawa H

更新日期：2002-01-25 00:00:00

abstract：:We have examined the expression of nitrotyrosine, a marker of peroxynitrite formation, in 55 esophageal cancers by immunohistochemistry. Nitrotyrosine was detected in 21 of 55 (38.2%) esophageal cancers. Comparison of nitrotyrosine expression and the pathological findings showed that there was a significant associatio...

journal_title：Cancer letters

authors： Kato H,Miyazaki T,Yoshikawa M,Nakajima M,Fukai Y,Tajima K,Masuda N,Tsutsumi S,Tsukada K,Nakajima T,Kuwano H

更新日期：2000-05-29 00:00:00

abstract：:As a promising method for local tumor treatment, nanosecond pulsed electric field (nsPEF) ablation elicits a potent anti-tumor immune response. However, the mechanism of the nsPEF-mediated anti-tumor immune response and its effects on the tumor microenvironment remains unclear. Here, we demonstrated that nsPEF treatme...

journal_title：Cancer letters

authors： Qian J,Chen T,Wu Q,Zhou L,Zhou W,Wu L,Wang S,Lu J,Wang W,Li D,Xie H,Su R,Guo D,Liu Z,He N,Yin S,Zheng S

更新日期：2020-12-28 00:00:00

abstract：:The AT-rich interaction domain 1A (ARID1A, also known as BAF250a) is a chromatin remodeling gene, which frequently mutates across a broad spectrum of cancers with loss expression of the ARID1A protein. Recently, the association between ARID1A deficiency and immune checkpoint blockade (ICB) therapy has been reported. A...

journal_title：Cancer letters

authors： Hu G,Tu W,Yang L,Peng G,Yang L

更新日期：2020-03-31 00:00:00

abstract：:R-spondins play critical roles in development, stem cell survival, and tumorigenicity by modulating Wnt/β-catenin signaling; however, the role of R-spondins in noncanonical Wnt signaling regulation remains largely unknown. We demonstrate here that R-spondin 2 (RSPO2) has an inhibitory effect on colorectal cancer (CRC)...

journal_title：Cancer letters

authors： Dong X,Liao W,Zhang L,Tu X,Hu J,Chen T,Dai X,Xiong Y,Liang W,Ding C,Liu R,Dai J,Wang O,Lu L,Lu X

更新日期：2017-08-28 00:00:00

abstract：:Epstein-Barr virus (EBV) has been well documented in the aetiology of nasopharyngeal carcinoma (NPC), although its role as well as the genetic basis in the genesis of NPC have not been elucidated. The p53 gene mutations are infrequently found in NPC, but the expression of p53 protein, as well as bcl-2 oncoprotein, has...

journal_title：Cancer letters

authors： Niemhom S,Kitazawa S,Murao S,Kunachak S,Maeda S

更新日期：2000-11-28 00:00:00

abstract：:Exposure of HeLa cells to 0, 5, 10, 25, 50 and 100 microg/ml of guduchi extracts (methanol, aqueous and methylene chloride) resulted in a dose-dependent but significant increase in cell killing, when compared to non-drug-treated controls. The effects of methanol and aqueous extracts were almost identical. However, met...

journal_title：Cancer letters

authors： Jagetia GC,Nayak V,Vidyasagar MS

更新日期：1998-05-15 00:00:00

abstract：:Staurosporine and its derivative 7-hydroxystaurosporine are protein kinase inhibitors that are being considered for treatments of cancers. Several recent studies have shown that cells with defective pRB protein are resistant to the G(1) cell cycle-inhibiting effects of staurosporine compounds. In this study, we examin...

journal_title：Cancer letters

authors： Zhou W,Lin Y,Wersto R,Chrest J,Gabrielson E

更新日期：2002-09-08 00:00:00

abstract：:The goal was to evaluate whether melatonin (Mel) down-regulates hTERT expression induced by 17beta-estradiol (E(2)) or cadmium (Cd) in breast cancer cells. We found that: (a) Mel inhibits E(2) or Cd-induced hTERT transcription in hTERT-Luc transfected MCF-7 cells, (b) Mel significantly reduces E(2)- and Cd-mediated hT...

journal_title：Cancer letters

authors： Martínez-Campa CM,Alonso-González C,Mediavilla MD,Cos S,González A,Sanchez-Barcelo EJ

更新日期：2008-09-18 00:00:00

abstract：:Previously, we had reviewed 43 cases of invasive cancers, adenosquamous cell carcinoma and adenocarcinoma for HPV type infections. With the same cases we extended the investigation to cytomegalovirus (CMV) and herpes simplex virus (HSV) infections. Results show that the prevalence of CMV and HSV infections from these ...

journal_title：Cancer letters

authors： Han CP,Tsao YP,Sun CA,Ng HT,Chen SL

更新日期：1997-12-09 00:00:00

abstract：:Epigenetic modification of miR-429 can manipulate liver T-ICs via targeting the RBBP4/E2F1/Oct4 axis, which might be crucial for hepatocarcinogenesis. However, whether miR-429 plays a role in regulating metastasis of hepatocellular carcinoma is still unclear. Using quantitative methylation analysis and real-time PCR, ...

journal_title：Cancer letters

authors： Tang J,Li L,Huang W,Sui C,Yang Y,Lin X,Hou G,Chen X,Fu J,Yuan S,Li S,Wen W,Tang S,Cao D,Wu M,Chen L,Wang H

更新日期：2015-08-01 00:00:00

abstract：:We have characterized the changes in composition of the nuclear matrix-intermediate filament complex (NM-IF) isolated from prostate cancer (PCa), compared with benign prostatic hyperplasia (BPH). We prepared the NM-IF from ten patients undergoing radical retropubic prostectomy; the benign hyperplastic tissue was obtai...

journal_title：Cancer letters

authors： Alberti I,Parodi S,Barboro P,Sanna P,Nicolò G,Allera C,Patrone E,Galli S,Balbi C

更新日期：1996-12-03 00:00:00

abstract：:Cell kinetics (cell proliferation and cell death) and the expression of progesterone receptor (PgR) during growth and regression of pregnancy-dependent mammary tumors (PDMT) of female GRS/A mice were investigated on the histologic level. Cell proliferation was determined using monoclonal anti-proliferating cell nuclea...

journal_title：Cancer letters

authors： Yang J,Senzaki H,Nambu H,Tsubura A

更新日期：1996-08-23 00:00:00

abstract：:Photodynamic action has been advocated as an alternative treatment of tumors but the most common used dyes, hematoporphyrin derivatives, are substrate for P-glycoprotein. This study investigated the MDR-reverting properties of methylene blue (MB) and compared the sensitivity to its photodynamic action (PDA) in five ce...

journal_title：Cancer letters

authors： Trindade GS,Farias SL,Rumjanek VM,Capella MA

更新日期：2000-04-14 00:00:00

abstract：:Breast carcinomas are frequently characterized by hyperactivated c-erbB receptor tyrosine kinase signaling. Combination of anti-proliferative retinoids with growth-inhibitory c-erbB-specific agents might induce therapeutic benefit. We demonstrate close interactions between the c-erbB and the retinoic acid receptor sys...

journal_title：Cancer letters

authors： Flicker SH,Schneider SM,Offterdinger M,Dittrich E,Fazeny B,Valenta R,Huber H,Dittrich C,Grunt TW

更新日期：1997-05-01 00:00:00

abstract：:Triple negative breast cancer (TNBC) typically exhibits rapid progression, high mortality and faster relapse rates relative to other breast cancer subtypes. In this report we examine the combination of taxanes (paclitaxel or docetaxel) with a breast cancer stem cell (CSC)-targeting agent sulforaphane for use against T...

journal_title：Cancer letters

authors： Burnett JP,Lim G,Li Y,Shah RB,Lim R,Paholak HJ,McDermott SP,Sun L,Tsume Y,Bai S,Wicha MS,Sun D,Zhang T

更新日期：2017-05-28 00:00:00

abstract：:Activation of telomerase by the induction of a full-length telomerase reverse transcriptase (hTERT) transcript is a critical step during cellular immortalization and malignant transformation. Telomerase activity or hTERT expression has thus served as diagnostic and/or prognostic markers in different types of human mal...

journal_title：Cancer letters

authors： Li W,Li L,Liu Z,Liu C,Liu Z,Strååt K,Björkholm M,Jia J,Xu D

更新日期：2008-02-18 00:00:00

abstract：:Numbers of circulating endothelial cells (CECs) are increased in cancer patients with progressive disease. Also, cancer patients have an increased risk for thrombotic events, being negatively associated with prognosis. Tissue factor (TF), the physiological initiator of coagulation, is present on the surface of many ex...

journal_title：Cancer letters

authors： Beerepoot LV,Mehra N,Linschoten F,Jorna AS,Lisman T,Verheul HM,Voest EE

更新日期：2004-09-30 00:00:00

abstract：:Vascular recovery or re-angiogenesis after radiotherapy plays a significant role in tumor recurrence, whereas molecular mechanisms of this process remain elusive. In this work, we found that dying glioma cells promoted post-irradiation angiogenesis through a caspase 3 dependent mechanism. Evidence in vitro and in vivo...

journal_title：Cancer letters

authors： Feng X,Yu Y,He S,Cheng J,Gong Y,Zhang Z,Yang X,Xu B,Liu X,Li CY,Tian L,Huang Q

更新日期：2017-01-28 00:00:00

abstract：:Ibrutinib, an inhibitor of Bruton tyrosine kinase (BTK), has shown promising pharmacologic effects in acute myeloid leukemia (AML). In this study, we report that abivertinib or AC0010, a novel BTK inhibitor, inhibits cell proliferation, reduces colony-forming capacity, and induces apoptosis and cell cycle arrest in AM...

journal_title：Cancer letters

authors： Huang S,Pan J,Jin J,Li C,Li X,Huang J,Huang X,Yan X,Li F,Yu M,Hu C,Jin J,Xu Y,Ling Q,Ye W,Wang Y,Jin J

更新日期：2019-10-01 00:00:00

abstract：:The relationship between tumor cell differentiation and photosensitizer accumulation used in PDT is poorly defined. In the present work, specific cell differentiation of colon carcinoma CT26 cells induced by sodium butyrate was manifested by morphological changes, proliferation and protein expression and was correlate...

journal_title：Cancer letters

authors： Siboni G,Amit-Patito I,Weizman E,Waintraub-Porat M,Weitman H,Ehrenberg B,Malik Z

更新日期：2003-06-30 00:00:00

abstract：:Recent work has demonstrated that oncogenes and tumor suppressor proteins regulate apoptotic cell death. Current efforts are therefore directed at determining how they exert their effects. It appears that oncogenes can control activation of the apoptosis endonuclease(s) either by regulating the signal(s) that trigger ...

journal_title：Cancer letters

authors： McConkey DJ,Fernandez A,Trent J 2nd,Ananthaswamy HN

更新日期：1995-07-20 00:00:00

abstract：:The mesenchymal (MES) subtype of glioblastoma (GBM) indicated a more malignant phenotype and worse prognosis compared with their proneural (PN) counterpart. The plasticity between PN and MES transcriptome signatures provided an approach for clinical intervention. However, few miRNAs have been identified to participate...

journal_title：Cancer letters

authors： Yang F,Liu X,Liu Y,Liu Y,Zhang C,Wang Z,Jiang T,Wang Y

更新日期：2017-06-28 00:00:00

abstract：:2-Amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine (PhIP) is known to induce colon tumors in male Fischer-344 rats. Using 32P-postlabeling assays, we have examined PhIP-DNA adduct formation in various organs and white blood cells (WBCs) of the male Fischer-344 rat 24 h after a single oral dose of 0, 0.5, 5 or 50 mg PhIP...

journal_title：Cancer letters

authors： Schut HA,Herzog CR

更新日期：1992-12-24 00:00:00

abstract：:We describe here the establishment of a new synovial sarcoma cell line, SYO-1, derived from a biphasic synovial sarcoma that developed in the groin of a 19-year-old female. The cell line was maintained for more than 70 passages (more than 24 months) in vitro. The SYO-1 cells in monolayer culture exhibited a spindle sh...

journal_title：Cancer letters

authors： Kawai A,Naito N,Yoshida A,Morimoto Y,Ouchida M,Shimizu K,Beppu Y

更新日期：2004-02-10 00:00:00

abstract：:Ellagic acid (EA) and 13-cis-retinoic acid (CRA), both alone and in combination, were tested for their ability to inhibit N-nitrosobenzylmethylamine-induced tumors in the rat esophagus. Groups of male rats were fed AIN-76A diet containing EA (4 g/kg), CRA (240 mg/kg), or a combination of EA and CRA (4 g/kg and 240 mg/...

journal_title：Cancer letters

authors： Daniel EM,Stoner GD

更新日期：1991-02-01 00:00:00

abstract：:The majority of ovarian cancer (OC) patients recur with a platinum-resistant disease. OC cells activate adaptive resistance mechanisms that are only partially described. Here we show that OC cells can adapt to chemotherapy through a positive-feedback loop that favors chemoresistance. In platinum-resistant OC cells we ...

journal_title：Cancer letters

authors： Tocci P,Cianfrocca R,Sestito R,Rosanò L,Di Castro V,Blandino G,Bagnato A

更新日期：2020-11-01 00:00:00