Abstract:
:The goal was to evaluate whether melatonin (Mel) down-regulates hTERT expression induced by 17beta-estradiol (E(2)) or cadmium (Cd) in breast cancer cells. We found that: (a) Mel inhibits E(2) or Cd-induced hTERT transcription in hTERT-Luc transfected MCF-7 cells, (b) Mel significantly reduces E(2)- and Cd-mediated hTERT transactivation triggered by ERalpha in transfected HeLa cells, (c) Mel inhibits hTERT expression induced by E(2) or Cd in MCF-7 cells. Melatonin inhibition of telomerase activity supports a possible role in treatment of estrogen-dependent tumors or carcinogenesis by environmental or occupational exposure to xenoestrogens.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Martínez-Campa CM,Alonso-González C,Mediavilla MD,Cos S,González A,Sanchez-Barcelo EJdoi
10.1016/j.canlet.2008.04.001subject
Has Abstractpub_date
2008-09-18 00:00:00pages
272-7issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(08)00278-4journal_volume
268pub_type
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