Abstract:
:Epigenetic modification of miR-429 can manipulate liver T-ICs via targeting the RBBP4/E2F1/Oct4 axis, which might be crucial for hepatocarcinogenesis. However, whether miR-429 plays a role in regulating metastasis of hepatocellular carcinoma is still unclear. Using quantitative methylation analysis and real-time PCR, we have identified the hypomethylated status and upregulation of miR-429 in portal vein metastasis samples in comparison with their matched primary tumor. The ectopic expression of miR-429 dramatically induced the expression of MMP2/7/9 and enhanced HCC migration and invasion in vitro and in vivo in an EMT-independent manner. Both bioinformatics and functional studies elucidated the direct regulation of miR-429 on the 3'UTR of the PTEN gene, which leads to the activation of PI3K/AKT signaling and the nuclear translocation of β-catenin, eventually. Conversely, the knockdown of miR-429 efficiently recovered the expression of PTEN and attenuated PI3K/AKT/β-catenin-mediated cell metastasis. Clinically, the higher expression of miR-429 and nucleus relocation of β-catenin were identified as the adverse prognosis factors for recurrence-free survival (RFS) and overall survival (OS). In summary, our results here defined miR-429 as a key inducer for HCC pathogenesis and metastasis with potential utility for tumor intervention.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Tang J,Li L,Huang W,Sui C,Yang Y,Lin X,Hou G,Chen X,Fu J,Yuan S,Li S,Wen W,Tang S,Cao D,Wu M,Chen L,Wang Hdoi
10.1016/j.canlet.2015.04.023subject
Has Abstractpub_date
2015-08-01 00:00:00pages
33-43issue
1eissn
0304-3835issn
1872-7980pii
S0304-3835(15)00291-8journal_volume
364pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract::We detected aberrant Midkine (MK) expressions in human insulinoma and pancreatic cancer tissues by immunohistochemistry, revealing its potential role in tumorigenesis/carcinogenesis. With a nested-touchdown PCR program we were able to detect the tMK in all human tumor/cancer tissues and cancer/tumor cell lines. Detect...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2007.01.019
更新日期:2007-08-08 00:00:00
abstract::Growing evidence from epidemiologic and preclinical studies suggests that nonsteroidal anti-inflammatory drugs (NSAIDs) reduce the risk of gastrointestinal (GI) cancers, including esophageal, gastric, pancreatic, colorectal cancer, and hepatocellular carcinoma. However, there is also evidence indicating the absence of...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2013.09.001
更新日期:2014-04-10 00:00:00
abstract:INTRODUCTION:Glioma initiating cells (GICs) play important roles in tumor initiation and progression. However, interactions between tumor cells and host cells of local tumor microenvironment are kept largely unknown. Besides GICs and their progeny cells, whether adjacent normal glial cells contribute to tumorigenesis d...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2015.05.026
更新日期:2015-09-01 00:00:00
abstract::The immunomodulatory and antimetastatic/antitumor activity of thymosin alpha(1) (Talpha(1)) was evaluated in BALB/c-mice. Daily subcutaneous application (7 consecutive days, 0.01-10 microg of Talpha(1)/injection per mouse) upregulated the number of thymocytes and peripheral blood cells in tumor bearing mice. To check ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(00)00510-3
更新日期:2000-10-16 00:00:00
abstract::The mutagenicity of a non-carcinogenic nitrosamine, N,N-dibenzylnitrosamine (I), and a chemically synthesized alpha-acetoxy derivative, N-(alpha-acetoxy-benzyl)-N-benzylnitrosamine (II), has been examined in Salmonella typhimurium TA100 and TA1535. Compound (I) was non-mutagenic when tested directly or in the presence...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(79)80005-1
更新日期:1979-02-01 00:00:00
abstract::Thrombospondin-1 is one of most important natural angiogenic inhibitors. The three thrombospondin-1 type 1 repeats (3TSR), an anti-angiogenic domain of thrombospondin-1, is a promising novel agent for anti-angiogenic treatment. In the present study, we showed 3TSR was biologically stable at least for 7 days in mini-os...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2006.04.003
更新日期:2007-03-08 00:00:00
abstract::Oncogenic transformation of mouse C3H10T1/2 cells induced by X-rays was suppressed in the presence of extract of Rooibos tea, Aspalathus linealis. Transformation was reduced with increased concentration of the extract, so that at an extract concentration of 10%, transformation incidence was similar to the spontaneous ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(94)90344-1
更新日期:1994-02-28 00:00:00
abstract::We examined the antitumor effect and safety of the adenovirus-mediated expression of antisense K-ras RNA in two peritoneal dissemination models of pancreatic cancer. First, we found that the infection of an adenovirus vector expressing antisense human K-ras RNA (AxCA-AS) induced significant apoptosis in vitro in human...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2004.08.015
更新日期:2005-01-31 00:00:00
abstract::Despite its documented role in cell cycle regulation, over-expression of the cyclin-dependent kinase activator CDC25A does not consistently correlate with worse cancer patient outcomes or predict successful clinical response to CDC25A inhibition. The current study was undertaken to investigate CDC25A in skin cancer an...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2017.09.023
更新日期:2017-12-01 00:00:00
abstract::Tumor cells need to attain anoikis resistance to survive prior to metastasis making it a vital trait of malignancy. The molecular mechanism by which hepatocellular carcinoma (HCC) cells resist anoikis remains not fully understood. Here, we report that ZNF32 expression is markedly upregulated in HCC cells upon detachme...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2018.09.033
更新日期:2019-02-01 00:00:00
abstract::The Wnt signaling pathway has long been known to direct growth and patterning during embryonic development. Recent evidence also implicates this pathway in the development of childhood tumors of the liver, the kidney, the brain, and the pancreas. Here, we review the current evidence on how constitutive activation of t...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/s0304-3835(03)00367-7
更新日期:2003-08-20 00:00:00
abstract::The important goal of cancer drug discovery is to develop therapeutic agents that are effective, safe, and affordable. In the present study, we demonstrated that alantolactone, which is a sesquiterpene lactone, has potential activity against triple-negative breast cancer MDA-MB-231 cells by suppressing the signal tran...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2014.11.049
更新日期:2015-02-01 00:00:00
abstract::MLL-rearranged leukemia is an aggressive malignancy associated with poor outcome, which is refractory to conventional treatment. Melatonin has been proven to exert anti-tumor activity, but the effect of melatonin on MLL-r leukemia and the underlying mechanism remain poorly understood. In this study, melatonin inhibite...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2018.11.037
更新日期:2019-02-28 00:00:00
abstract::The capacity of the human adrenal gland to metabolize various xenobiotics was investigated. Adrenal microsomal and mitochondrial preparations showed a maximal absorption at 450 nm for dithionite-reduced cytochromes in the presence of carbon monoxide. Occasionally, absorption maxima at 448 nm were observed with both mi...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(84)90039-9
更新日期:1984-02-01 00:00:00
abstract::The effect of vitamin A (retinyl acetate) on lung tumor development in strain A mice exposed to radiation was assessed. Four groups of 75 mice were utilized. Two groups were fed a low vitamin A diet (less than 100 IU/100 g diet) and the other 2 were fed a high vitamin A diet (800 IU/100 g diet). After 2 weeks one grou...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(84)90051-x
更新日期:1984-02-01 00:00:00
abstract::Both insulin-like growth factor II (IGF2) and H19 gene are located on chromosome 11p15.5 in close vicinity to each other, and are imprinted on different parental alleles. Although the exact mechanism remains unclear, loss of imprinting (LOI) leading to the biallelic expression of IGF2 and H19 genes has recently been r...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(97)00279-6
更新日期:1997-11-25 00:00:00
abstract::Malignant mesothelioma (MM) frequently exhibits Hippo signaling pathway inactivation (HPI) mainly due to NF2 and/or LATS2 mutations, which leads to the activation of YAP transcriptional co-activator. Here, we show antitumor effects of statin on MM cells with HPI, through the interplay of the mevalonate and Hippo signa...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.10.020
更新日期:2017-01-28 00:00:00
abstract::We investigated the relationship between ErbB-2 and HLA in order to clarify the clinical and genetic factors related to Japanese patients with lung cancer. Thirty-nine of the 73 lung cancer patients (53.4%) had elevated levels of ErbB-2. Only seven of 23 (30. 4%) patients with small cell carcinoma had elevated ErbB-2 ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(99)00437-1
更新日期:2000-04-28 00:00:00
abstract::Bone metastasis is a major cause of prostate cancer (PCa) mortality. Although docetaxel chemotherapy initially extends patients' survival, in most cases PCa becomes chemoresistant and eventually progresses without a cure. In this study, we developed a novel small-molecule compound BKM1972, which exhibited potent in vi...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2019.01.010
更新日期:2019-04-01 00:00:00
abstract::Costunolide (CT), a sesquiterpene lactone constituent isolated from Saussurea lappa (Compositae), exerted an antiangiogenic effect. CT selectively inhibited the endothelial cell proliferation induced by vascular endothelial growth factor (VEGF). Further, CT was also found to inhibit the VEGF-induced chemotaxis of huma...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(02)00361-0
更新日期:2002-12-10 00:00:00
abstract::This study demonstrates that mammalian cell targets (erythrocytes and tumour cells) may be sensitised to ultrasound using electric pulses and this combination treatment results in destruction of those cells in vitro. It further demonstrates that when a tumour mass is treated in vivo using combined electric field and u...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2004.09.033
更新日期:2005-05-10 00:00:00
abstract::Acute myeloid leukemia (AML) cells in vivo are constantly exposed to lymphangiogenic cytokines such as VEGF-C. However, it is poorly understood how the VEGF-C signaling modulates the immune functions in the tumor microenvironment. We have previously reported that natural killer (NK) cells in AML patients strongly upre...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2014.08.027
更新日期:2014-11-28 00:00:00
abstract::Prolonged exposure to elevated levels of estrogen is a risk factor for breast cancer. Though increased cell growth and loss of DNA repair capacity is one of the proposed mechanisms for estrogen-induced cancers, the mechanism through which estrogen induces cell growth and decreases DNA repair capacity is not clear. DNA...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2011.10.022
更新日期:2012-03-01 00:00:00
abstract::To investigate mucin expression in breast cancer, immunohistochemical staining was performed on 30 mucinous carcinomas and 95 non-mucinous invasive carcinomas. MUC2 expression was detected in all mucinous carcinomas, but only in 11.1% of invasive ductal carcinomas, and in none of the invasive lobular carcinomas and me...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(99)00161-5
更新日期:1999-07-19 00:00:00
abstract::Ring1 and YY1 binding protein (RYBP) is a member of the Polycomb group (PcG) proteins and regulates cell growth through both PcG-dependent and -independent mechanisms. Our initial study indicated that RYBP is down-regulated in human non-small cell lung cancer (NSCLC) tissues. The present study determined the molecular...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2015.09.003
更新日期:2015-12-28 00:00:00
abstract::The role of p53 in the evolution of non-Hodgkin's lymphomas (NHL) is unclear. Mutations of the p53 gene appear to be relatively uncommon but stabilized p53 protein, as detected by immunohistochemistry, has indicated a more frequent involvement of p53. As dysfunction of p53 protein has also been suggested to occur afte...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(94)90081-7
更新日期:1994-11-11 00:00:00
abstract::Long non-coding RNAs (lncRNAs) play critical roles in multiple cellular processes in non-small cell lung cancer (NSCLC); however, the involvement of lncRNAs in the transforming growth factor-beta (TGFβ) signaling pathway, the critical tumor cell epithelial-mesenchymal transition (EMT) and metastasis pathway, remains p...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2018.06.013
更新日期:2018-09-28 00:00:00
abstract::The regulator of G protein signaling 10 (RGS10) protein is a GTPase activating protein that accelerates the hydrolysis of GTP and therefore canonically inactivates G proteins, ultimately terminating signaling. Rheb is a small GTPase protein that shuttles between its GDP- and GTP-bound forms to activate mTOR. Since RGS...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2015.08.012
更新日期:2015-12-01 00:00:00
abstract::We examined the effect of alcohol consumption, cigarette smoking and flushing response on esophageal squamous cell carcinoma (ESCC) in a large-scale population-based cohort study. 44,970 middle-aged and older Japanese men were followed. A total of 215 cases of ESCC were newly diagnosed. Alcohol consumption and cigaret...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2008.10.020
更新日期:2009-03-18 00:00:00
abstract::Interferon regulatory factor (IRF1) is a potent antiviral, antitumor and immune regulatory protein. Recently, we found that activated Ras/MEK inhibits antiviral response by downregulating IRF1 expression and renders cancer cells susceptible to oncolytic viruses. In this study, we sought to determine whether IRF1 downr...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2014.12.017
更新日期:2015-02-28 00:00:00