Thymosin alpha(1) application augments immune response and down-regulates tumor weight and organ colonization in BALB/c-mice.

abstract：:The effects of vitamin E, vitamin B2 and selenite on DNA single strand breaks induced by Na2CrO4 were examined by alkaline elution. Incubation of Chinese hamster V-79 cells with alpha-tocopherol succinate (vitamin E) for 24 h prior to exposure to Na2CrO4 resulted in a decrease of DNA breaks produced by this compound. ...

journal_title：Cancer letters

authors： Sugiyama M,Ando A,Furuno A,Furlong NB,Hidaka T,Ogura R

更新日期：1987-12-01 00:00:00

abstract：:HGT cells are a human gastric cell line derived from a tumour of the stomach. We have investigated the effects of lipoxygenase and cyclooxygenase metabolism inhibitors on HGT cell proliferation, on fatty acid composition of HGT cells and on the incorporation and distribution of arachidonic acid (AA) in HGT lipids. The...

journal_title：Cancer letters

authors： Denizot Y,Najid A,Rigaud M

更新日期：1993-09-15 00:00:00

abstract：:The promoting potential of oxymetholone (OXM) administration on development of liver cell foci was investigated in male F344 rats previously treated with N-diethylnitrosamine (DEN). One week after a single injection of DEN (100 mg/kg, i.p.), rats were given OXM at a dietary level of 0.2% for the first 4 weeks and then...

journal_title：Cancer letters

authors： Shimoji N,Imaida K,Hasegawa R,Matsuoka C,Uneyama CT,Takahashi M,Hayashi Y

更新日期：1990-02-01 00:00:00

abstract：:14-3-3 sigma is a negative regulator of the cell cycle and contributes to G2 arrest. Thus far, the lack of its expression due to hypermethylation of the CpG islands has been reported in some carcinomas. In this study, we investigated the expression of 14-3-3 sigma in thyroid neoplasms by means of immunohistochemistry ...

journal_title：Cancer letters

authors： Ito Y,Miyoshi E,Uda E,Yoshida H,Uruno T,Takamura Y,Miya A,Kobayashi K,Matsuzuka F,Matsuura N,Kakudo K,Kuma K,Miyauchi A

更新日期：2003-10-28 00:00:00

abstract：AIM:To estimate the incidence and latency of Vaginal Intraepithelial Neoplasia (VAIN) in women previously hysterectomized for benign/malign pathology and to evaluate the role of high risk HPVs in the prediction of persistent or recurrent disease. SUBJECTS AND METHODS:830 women with prior hysterectomy for benign/malign...

journal_title：Cancer letters

authors： Frega A,French D,Piazze J,Cerekja A,Vetrano G,Moscarini M

更新日期：2007-05-08 00:00:00

abstract：:Epidermal growth factor receptors (EGFR) expression is frequently amplified in human glioblastoma cells. Nimotuzumab, a monoclonal antibody (mAb) against EGFR, has been used globally in clinics as an anti-cancer agent. It is largely unknown whether the blockade of miR-21, a microRNA that is upregulated in glioma cells...

journal_title：Cancer letters

authors： Zhang KL,Han L,Chen LY,Shi ZD,Yang M,Ren Y,Chen LC,Zhang JX,Pu PY,Kang CS

更新日期：2014-01-01 00:00:00

abstract：:Our earlier studies have shown that simultaneous inhibition of glycolysis and pentose phosphate pathway using 2-deoxy-d-glucose (2-DG, an inhibitor of glycolysis) and 6-aminonicotinamide (6-AN, an inhibitor of pentose phosphate pathway) lead to metabolic oxidative stress (MOS), resulting in radiosensitization in malig...

journal_title：Cancer letters

authors： Sharma PK,Bhardwaj R,Dwarakanath BS,Varshney R

更新日期：2010-09-28 00:00:00

abstract：:Pancreatic cancer remains a highly lethal malignancy. We have recently shown that simultaneous expression of Kras and mutant Tp53R175H promotes invasive ductal adenocarcinoma from pancreatic ductal cells. We hypothesized specific mutations in TP53 have divergent mechanisms of transforming ductal cells. In order to und...

journal_title：Cancer letters

authors： Polireddy K,Singh K,Pruski M,Jones NC,Manisundaram NV,Ponnela P,Ouellette M,Van Buren G,Younes M,Bynon JS,Dar WA,Bailey JM

更新日期：2019-07-01 00:00:00

abstract：:The mutagenic activities of N-nitrosobis(2-hydroxypropyl)amine (BHP) and its related compounds were studied in Salmonella typhimurium TA100 and TA98 strains by Ames's liquid incubation assay in the presence or absence of lung and liver S9 of rats treated with polychlorinated biphenyl (PCB). BHP and its related compoun...

journal_title：Cancer letters

authors： Mori Y,Niwa T,Takahashi H,Toyoshi K,Denda A,Takahashi S,Konishi Y

更新日期：1983-04-01 00:00:00

abstract：:Apatinib, a novel tyrosine kinase inhibitor (TKI), has been confirmed for its efficacy and safety in the treatment of advanced gastric carcinoma and some other solid tumors. However, the direct functional mechanisms of tumor lethality mediated by apatinib have not yet been fully characterized, and the precise mechanis...

journal_title：Cancer letters

authors： Cheng X,Feng H,Wu H,Jin Z,Shen X,Kuang J,Huo Z,Chen X,Gao H,Ye F,Ji X,Jing X,Zhang Y,Zhang T,Qiu W,Zhao R

更新日期：2018-09-01 00:00:00

abstract：:Expression of the MUC2 gene is controlled by the methylation of CpG sites in the promoter region, but the detailed methylation status of this region has yet to be reported. We have mapped the complete methylation status of the MUC2 promoter from position -1989 to position +288 upstream, a region that contains 59 CpG s...

journal_title：Cancer letters

authors： Hamada T,Goto M,Tsutsumida H,Nomoto M,Higashi M,Sugai T,Nakamura S,Yonezawa S

更新日期：2005-09-28 00:00:00

abstract：:Comparison of LCC2, the E(2)-independent, tamoxifen-resistant subline of the MCF-7 human breast cancer cell line with its parent line, disclosed that it is more resistant to growth inhibition and apoptosis induction by a variety of agents acting by diverse mechanisms. Thus, LCC2 cells can serve as a useful in-vitro mo...

journal_title：Cancer letters

authors： Lilling G,Hacohen H,Nordenberg J,Livnat T,Rotter V,Sidi Y

更新日期：2000-12-08 00:00:00

abstract：:Bombesin (BBS) has been shown to promote pancreatic growth as well as the development of pancreatic (pre)neoplasia in rats. The present study was carried out to determine the effects of bombesin on pancreatic growth and on the development of pancreatic (pre)neoplastic lesions in hamsters treated with N-nitrosobis(2-ox...

journal_title：Cancer letters

authors： Meijers M,van Garderen-Hoetmer A,Lamers CB,Rovati LC,Jansen JB,Woutersen RA

更新日期：1991-07-26 00:00:00

abstract：:The effects of the ornithine decarboxylase suicide substrate, difluoromethylornithine (DFMO), and of cyclophosphamide, individually and in combination, on the growth of the R3327MAT-Lu prostate derived tumor were determined. DFMO decreased the growth rate and resulted in a 75% reduction in DNA content compared to the ...

journal_title：Cancer letters

authors： Heston WD,Kadmon D,Fair WR

更新日期：1982-05-01 00:00:00

abstract：:We have previously shown that transforming growth factor (TGF)-beta up-regulates matrix metalloproteinase (MMP)-2 leading to the induction of oncogenic signaling in preneoplastic MCF10A human breast epithelial cells. The present study investigated the mechanism of transcriptional regulation of MMP-2 by TGF-beta in MCF...

journal_title：Cancer letters

authors： Kim ES,Sohn YW,Moon A

更新日期：2007-07-08 00:00:00

abstract：:Patients (459) with chronic gastritis, ulcers, polyposis and different types of gastric cancers were examined by endoscopic fluorescent technique using a special drug based on the sodium salt of fluorescein (F1). Eighty-five percent of gastric cancers showed positive fluorescence. The F1 distribution in the stomach of...

journal_title：Cancer letters

authors： Braginskaja OV,Lazarev VV,Polsachev VI,Rubin LB,Stoskii VE

更新日期：1993-04-30 00:00:00

abstract：:Eight chlorinated ethanes and 3 chlorinated ethylenes were tested in the BALB/c-3T3 cell transformation assay. Under the conditions of the assay, vinyl chloride and 1,1,1-trichloroethane induced a clear positive transformation response while 1,1,2-trichloroethane and trichloroethylene were weakly positive. Chloroethan...

journal_title：Cancer letters

authors： Tu AS,Murray TA,Hatch KM,Sivak A,Milman HA

更新日期：1985-08-01 00:00:00

abstract：:Cervical cytology specimens prepared as monolayers were analyzed with a combination of high-resolution single-cell image analysis and lower-resolution contextual image analysis. For the latter, quantitative features of cluster architecture, object distribution and background were used to mimic the pathologists global ...

journal_title：Cancer letters

authors： Zahniser DJ,Isenstein LM,Hutchinson ML

更新日期：1994-03-15 00:00:00

abstract：:To investigate if genomic instability exists in tumors with cytogenetically normal karyotypes, we analyzed four diploid cancer cell lines A204, CAL51, CH1 and SK-UT-1B. We detected subtle genomic changes in all four cell lines. More of these alterations were found in A204 and CH1 than in the microsatellite unstable li...

journal_title：Cancer letters

authors： Mao X,Young BD,Chaplin T,Shipley J,Lu YJ

更新日期：2008-08-18 00:00:00

abstract：:The effect of glucocorticoids on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inhibition of gap-junctional intercellular communication (GJIC) and morphological transformation in Syrian hamster embryo (SHE) cells was examined. Fluocinolone acetonide (FA) and dexamethasone (DEX) almost completely suppressed the ef...

journal_title：Cancer letters

authors： Roseng LE,Rivedal E

更新日期：1993-08-16 00:00:00

abstract：:Overexpression of ACTR/AIB1 is frequently found in different cancers with distant metastasis. To address its possible involvement in tumor metastasis, we performed invasion assays to examine the effect of ACTR alteration on the invasiveness of breast cancer cells (MDA-MB-231 or T-47D) and found that high levels of ACT...

journal_title：Cancer letters

authors： Li LB,Louie MC,Chen HW,Zou JX

更新日期：2008-03-08 00:00:00

abstract：:Large marker chromosomes were found in 2 hormone-independent (HI) GR mouse mammary tumors, i.e. a tumor (TSl 75) that was already HI at the first transplantation, and a tumor (TSl 66) that became HI at the 19th passage. These marker chromosomes appear to be translocations to distal and proximal ends of chromosome 1, r...

journal_title：Cancer letters

authors： Sluyser M,Evers P,Hilgers J

更新日期：1985-06-01 00:00:00

abstract：:Epigenetic modification of miR-429 can manipulate liver T-ICs via targeting the RBBP4/E2F1/Oct4 axis, which might be crucial for hepatocarcinogenesis. However, whether miR-429 plays a role in regulating metastasis of hepatocellular carcinoma is still unclear. Using quantitative methylation analysis and real-time PCR, ...

journal_title：Cancer letters

authors： Tang J,Li L,Huang W,Sui C,Yang Y,Lin X,Hou G,Chen X,Fu J,Yuan S,Li S,Wen W,Tang S,Cao D,Wu M,Chen L,Wang H

更新日期：2015-08-01 00:00:00

abstract：:Malachite green (MG), an industrial compound and potential environmental health hazard, is highly cytotoxic to mammalian cells in culture. In an attempt to define the biochemical basis, we have compared the cytotoxic effects and morphological alterations shown by MG in Syrian hamster embryo (SHE) cells with the levels...

journal_title：Cancer letters

authors： Panandiker A,Fernandes C,Rao KV

更新日期：1992-12-24 00:00:00

abstract：:Growing epidemiological evidence points out the carcinogenic hazard of inhaled aflatoxin B1 (AFB1) to the pulmonary system. Metabolism of AFB1 by lung microsomes and its binding to calf thymus DNA are reported for the first time in this paper. In addition, the ability of dietary butylated hydroxyanisole (BHA) to modul...

journal_title：Cancer letters

authors： Allameh A,Saxena M,Raj HG

更新日期：1988-05-01 00:00:00

abstract：:Human hepatoma Hep 3B cells underwent apoptosis in response to 100 microM all-trans retinoic acid (RA) in full serum (10% fetal calf serum) condition in vitro. Cell death began approximately 24 h following treatment, with more than 80% of the cells dead after 60 h. The dead cells, mainly detached cells, exhibited cond...

journal_title：Cancer letters

authors： Kim DG,Jo BH,You KR,Ahn DS

更新日期：1996-10-01 00:00:00

abstract：:We repeated and extended a 1973 study by Sander and Schweinsberg on forestomach tumorigenesis in mice by methylbenzylnitrosamine (MBZN). Groups of 80 adult CD-1 mice of both sexes received 96 mg/kg of MBZN subdivided into 24 doses of 4 mg/kg, 12 doses of 8 mg/kg or 6 doses of 16 mg/kg (groups 1-3, respectively). The m...

journal_title：Cancer letters

authors： Schneider P,Hinrichs S,Zulim R,Towery R,Morris C,Mirvish SS

更新日期：1996-04-19 00:00:00

abstract：:Monitoring angiogenesis is potentially an effective strategy for the early detection of cancer. In this study, early detection was achieved by evaluating blood vessel density in the liver using a three-dimensional contrast-enhanced high-frequency ultrasound (CE-HFUS) system and Sonazoid microbubbles. Three-dimensional...

journal_title：Cancer letters

authors： Horie S,Chen R,Li L,Mori S,Kodama T

更新日期：2013-10-10 00:00:00

abstract：:Microtubule targeting based therapies have revolutionized cancer treatment; however, resistance and side effects remain a major limitation. Therefore, novel strategies that can overcome these limitations are urgently needed. We made a novel discovery that fisetin, a hydroxyflavone, is a microtubule stabilizing agent. ...

journal_title：Cancer letters

authors： Mukhtar E,Adhami VM,Sechi M,Mukhtar H

更新日期：2015-10-28 00:00:00

abstract：:It has been nearly 9years since the FDA (Food and Drug Administration) approved the first anti-angiogenic drug (bevacizumab) for treatment of metastatic colorectal cancer. Other angiogenic inhibitors have since been approved or are in different stages of clinical trials. However, continued clinical and preclinical inv...

journal_title：Cancer letters

authors： Shojaei F

更新日期：2012-07-28 00:00:00