Abstract：
:The effects of vitamin E, vitamin B2 and selenite on DNA single strand breaks induced by Na2CrO4 were examined by alkaline elution. Incubation of Chinese hamster V-79 cells with alpha-tocopherol succinate (vitamin E) for 24 h prior to exposure to Na2CrO4 resulted in a decrease of DNA breaks produced by this compound. However, similar pretreatment with riboflavin (vitamin B2) or Na2SeO3 resulted in an enhanced formation of breaks induced by Na2CrO4. Pretreatment with Na2SeO3 resulted in increased levels of glutathione in these cells while levels of glutathione remained the same with vitamin E or vitamin B2. These results suggest that Na2CrO4 induced DNA breaks appear to be mediated by the formation of free radicals and/or cellular reductive metabolism.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Sugiyama M,Ando A,Furuno A,Furlong NB,Hidaka T,Ogura Rdoi
10.1016/0304-3835(87)90193-5subject
Has Abstractpub_date
1987-12-01 00:00:00pages
1-7issue
1-2eissn
0304-3835issn
1872-7980pii
0304-3835(87)90193-5journal_volume
38pub_type
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