Combined effects of gender, skin type and polymorphic genes on clinical phenotype: use of rate of increase in numbers of basal cell carcinomas as a model system.

abstract：:The mechanism of DDB (dimethyl 4,4'-dimethoxy-5,6,5',6'-dimethylenedioxy biphenyl-2,2'-dicarboxylate) prevention of aflatoxin B1 (AFB1)-induced hepatotoxicity in rats has been investigated. Pretreatment of DDB (200 mg/kg) daily for 4 days significantly suppressed (P < 0.05) the AFB1-induced hepatic damage as evidenced...

journal_title：Cancer letters

authors： Liu TY,Hwua YS,Chao TW,Chi CW

更新日期：1995-03-02 00:00:00

abstract：:The stem cell-like characteristics of tumor cells are not only essential for tumor development and malignant progression, but also significantly contribute to therapy resistance. However, it remains poorly understood how cancer cell differentiation or stemness is regulated in vivo. We investigated the role of the stem...

journal_title：Cancer letters

authors： Begum A,Kim Y,Lin Q,Yun Z

更新日期：2012-05-01 00:00:00

abstract：:Semi-permeable magnetic microcapsules containing polyethyleneimine (PEI) have been developed as retrievable carcinogen traps. In vitro, the soluble core PEI and membrane both bound reactive substances of limited aqueous stability, such as from [14C]N-methyl-N-nitrosourea ([14C]NMU), and aqueous stable dyes of molecula...

journal_title：Cancer letters

authors： Povey AC,Bartsch H,O'Neill IK

更新日期：1987-07-01 00:00:00

abstract：:Resistance to anoikis is a hallmark of human malignancies. Our results showed that hepatoma cells resisted anoikis by non-proliferation, non-apoptosis and cell cycle arrest which were termed synoikis-like. These synoikis-like cells are more resistant to extracellular stimuli and could spontaneously attach and prolifer...

journal_title：Cancer letters

authors： Zhang Z,Cao L,Li J,Liang X,Liu Y,Liu H,Du J,Qu Z,Cui M,Liu S,Gao L,Ma C,Zhang L,Han L,Sun W

更新日期：2008-08-18 00:00:00

abstract：:As myeloma cells actively produce and secrete immunoglobulins, they are prone to ER stress, which if unresolved leads to apoptosis. We found that myeloma cell death induced by the ER stressor Thapsigargin was highly variable, ranging from 2 to 89%. Induction of ATF4 and CHOP was observed in myeloma cells under Thapsig...

journal_title：Cancer letters

authors： Gomez-Bougie P,Halliez M,Moreau P,Pellat-Deceunynck C,Amiot M

更新日期：2016-12-28 00:00:00

abstract：:The present study was undertaken to determine the kinetics of DNA synthesis and expression of cell cycle dependent proto-oncogenes in response to two types of cell proliferative stimuli in male Wistar rat liver. The peak of DNA synthesis was approximately 24 h after a compensatory cell proliferative stimulus induced b...

journal_title：Cancer letters

authors： Coni P,Bignone FA,Pichiri G,Ledda-Columbano GM,Columbano A,Rao PM,Rajalakshmi S,Sarma DS

更新日期：1989-09-15 00:00:00

abstract：:Intussusception is an alternative to the sprouting mode of angiogenesis. The advantage of this mechanism of vascular growth is that blood vessels are generated more rapidly and the capillaries thereby formed are less leaky. This review article summarizes our current knowledge concerning the role played by intussuscept...

journal_title：Cancer letters

authors： Ribatti D,Djonov V

更新日期：2012-03-28 00:00:00

abstract：:Head and neck cancers are commonly treated with the DNA-damaging agent cisplatin. While many tumors respond well to cisplatin treatment, some do not. The mechanism for this differential sensitivity of head and neck tumors to cisplatin is not understood in detail. In this study, we explored whether the functional statu...

journal_title：Cancer letters

authors： Burkitt K,Ljungman M

更新日期：2007-08-08 00:00:00

abstract：:Conditioned medium from a series of human breast cancer cell lines representing the phenotypes of estrogen dependence ZR-75-1, MCF-7), tamoxifen resistance (Z(+)-75-9a1, LY2) and estrogen independence (ZR-PR-Lt) contained four detectable insulin-like growth factor binding proteins (IGFBPs) of MW 24, 34, 44 and 70 kDa....

journal_title：Cancer letters

authors： McCotter D,van den Berg HW,Boylan M,McKibben B

更新日期：1996-02-06 00:00:00

abstract：:We have successfully generated cytotoxic monoclonal antibodies against a rat histiocytoma, AK-5. Monoclonal antibodies obtained after fusing immunized rat splenocytes with SP2/0 myeloma, were cytotoxic to AK-5 cells in the presence of complement. These monoclonals were highly specific and did not show any cross reacti...

journal_title：Cancer letters

authors： Khar A,Varalakshmi C,Pardhasaradhi BV,Ali AM

更新日期：1992-06-15 00:00:00

abstract：:Benign mammary gross cystic disease is the most common breast lesion; women with apocrine changes of epithelium lining the cysts are at higher risk for developing breast cancer than the normal population. Total cholesterol, high- and low-density lipoproteins fractions, triglycerides and phospholipids, lipase activity ...

journal_title：Cancer letters

authors： Mannello F,Bocchiotti GD,Morano FP,Fratepietro LM,Gazzanelli G

更新日期：1996-01-02 00:00:00

abstract：:Smoking women are probably at a higher risk to develop lung cancer than men. Different explanations exist for these findings, a gender-specific impairment of tobacco carcinogen metabolism being one of them. In this study, we examined the inhibition of NNK reduction to NNAL, the first and most important detoxication st...

journal_title：Cancer letters

authors： Stapelfeld C,Neumann KT,Maser E

更新日期：2017-10-01 00:00:00

abstract：:BRCA1 regulates gene transcription as part of its tumor suppressor function. Prior studies on BRCA1 transactivation did not account for the impact of its binding partner, BARD1. Here we tested the effect of BARD1 on BRCA1 transactivation of the p21 and Gadd45 promoters. We show that BARD1 promoted nuclear accumulation...

journal_title：Cancer letters

authors： Fabbro M,Henderson BR

更新日期：2008-05-18 00:00:00

abstract：:The present study was conducted to clarify the mechanism responsible for enhancement of the anti-melanoma activity of levodopa methylester by supplemental ascorbate in vivo. 5-Hydroxydopa, a known cytotoxic agent and the major metabolite formed from levodopa in the presence of ascorbate and mushroom tyrosinase in vitr...

journal_title：Cancer letters

authors： Pierson HF,Meadows GG

更新日期：1985-11-01 00:00:00

abstract：:Endometrial cancer is the leading gynecologic cancer in women in the United States with 52,630 women predicted to be diagnosed with the disease in 2014. The objective of this study was to determine if progesterone (P4) receptor membrane component 1 (PGRMC1) influenced endometrial cancer cell viability in response to c...

journal_title：Cancer letters

authors： Friel AM,Zhang L,Pru CA,Clark NC,McCallum ML,Blok LJ,Shioda T,Peluso JJ,Rueda BR,Pru JK

更新日期：2015-01-28 00:00:00

abstract：:There is an urgent need to elucidate the mechanistic links between obesity and colon cancer. Convincing evidence for the role of Lgr5(+) stem cells in colon tumorigenesis has been established; however, the influence of obesity on stem cell maintenance is unknown. We assessed the effects of high fat (HF) feeding on col...

journal_title：Cancer letters

authors： DeClercq V,McMurray DN,Chapkin RS

更新日期：2015-12-28 00:00:00

abstract：:cDNA libraries were generated from the prostate gland tissue obtained from a normal donor and from a patient with prostate cancer. Subtractive cDNA cloning was used to identify phenotype-specific cDNA sequences from both normal and cancerous prostate tissue. One clone, pN44, isolated from normal prostate tissue, codes...

journal_title：Cancer letters

authors： Liu AY,Bradner RC,Vessella RL

更新日期：1993-10-15 00:00:00

abstract：:The mutagenic activities of N-nitrosobis(2-hydroxypropyl)amine (BHP) and its related compounds were studied in Salmonella typhimurium TA100 and TA98 strains by Ames's liquid incubation assay in the presence or absence of lung and liver S9 of rats treated with polychlorinated biphenyl (PCB). BHP and its related compoun...

journal_title：Cancer letters

authors： Mori Y,Niwa T,Takahashi H,Toyoshi K,Denda A,Takahashi S,Konishi Y

更新日期：1983-04-01 00:00:00

abstract：:The mitochondrial genetic system is indispensable for the biosynthesis of the enzyme complexes involved in aerobic energy generation. Tetracyclines inhibit the expression of only the mitochondrial genes because they specifically block mitochondrial protein synthesis. A salient feature is that this inhibition occurs at...

journal_title：Cancer letters

authors： Kroon AM,Dontje BH,Holtrop M,Van den Bogert C

更新日期：1984-11-01 00:00:00

abstract：:Epstein-Barr virus (EBV) is known to be linear in viral particles but EBV circularizes into an episomal form after infection. Recently, the presence of integrated EBV DNA has been reported. We investigated EBV integration into the human genome in EBV-associated disease using Southern blotting. One hundred four cases i...

journal_title：Cancer letters

authors： Ohshima K,Suzumiya J,Kanda M,Kato A,Kikuchi M

更新日期：1998-01-09 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha) is a macrophage-derived multifunctional cytokine that acts as a cytostatic or cytotoxic agent in many tumor cells. However, the molecular mechanisms by which tumor cells become sensitive to the cytotoxic action of TNF-alpha are not clear. In this study we demonstrated that the c...

journal_title：Cancer letters

authors： Park IC,Park MJ,Lee SH,Choe TB,Jang JJ,Hong SI

更新日期：1998-03-13 00:00:00

abstract：:Hypusine formation on the eukaryotic initiation factor 5A (eIF-5A) precursor is ubiquitously present in eukaryotic cells and archebacteria. In this reaction, deoxyhypusine synthase catalyzes the conversion of one unique lysine residue on eIF-5A to deoxyhypusine using spermidine as the substrate. Hydroxylation of the d...

journal_title：Cancer letters

authors： Chen ZP,Chen KY

更新日期：1997-05-19 00:00:00

abstract：:Herein we report a method for studying slow acting pharmaceutical COX-2 inhibitors in the MCF-7 breast cancer cell line where cells are grown in a three-dimensional format within an agarose matrix. The cancer cells are suspended in agarose and plated in a cell culture dish, where they will form small multicellular 'tu...

journal_title：Cancer letters

authors： Kinder DH,Aulthouse AL

更新日期：2004-03-08 00:00:00

abstract：:We induced tolerance to hexadecylphosphocholine (HePC) in the human epidermoid tumor cell line, KB. After 70 weeks of adaptation, the IC50 of HePC in the resistant cells KBr was 32-fold higher than in parental KB cells, and they were 30-fold more resistant to another ether lipid analogue, ET-18-OCH3. The KBr cells als...

journal_title：Cancer letters

authors： Fu D,Shi Z,Wang Y

更新日期：1999-08-03 00:00:00

abstract：:Medulloblastoma (MB) is the most frequent malignant brain tumour in children with a poor outcome. Divided into four molecular subgroups, MB of the Sonic hedgehog (SHH) subgroup accounts for approximately 25% of the cases and is driven by mutations within components of the SHH pathway, such as its receptors PTCH1 or SM...

journal_title：Cancer letters

authors： Niesen J,Ohli J,Sedlacik J,Dührsen L,Hellwig M,Spohn M,Holsten T,Schüller U

更新日期：2020-05-01 00:00:00

abstract：:N-Acetyltransferase activities with p-aminobenzoic acid and 2-aminofluorene were determined in Anisakis simplex, a nematode found in the intestine of the salt water fish Trichiurus lepturus. The N-acetyltransferase activity was determined using an acetyl CoA recycling assay and high pressure liquid chromatography. The...

journal_title：Cancer letters

authors： Chung JG,Kuo HM,Lin TH,Ho CC,Lee JH,Lai JM,Levy GN,Weber WW

更新日期：1996-08-23 00:00:00

abstract：:Adult T-cell leukemia (ATL) is a fatal malignancy caused by infection with human T lymphotropic virus type-1 (HTLV-1). To search for a new biomarker of ATL, we analyzed sera from ATL patients using ProteinChip arrays. The spectral comparison of ATL patients with HTLV-1 carriers and healthy volunteers showed that the i...

journal_title：Cancer letters

authors： Ishida Y,Yamashita K,Sasaki H,Takajou I,Kubuki Y,Morishita K,Tsubouchi H,Okayama A

更新日期：2008-11-18 00:00:00

abstract：:We examined the antitumor effect and safety of the adenovirus-mediated expression of antisense K-ras RNA in two peritoneal dissemination models of pancreatic cancer. First, we found that the infection of an adenovirus vector expressing antisense human K-ras RNA (AxCA-AS) induced significant apoptosis in vitro in human...

journal_title：Cancer letters

authors： Miura Y,Ohnami S,Yoshida K,Ohashi M,Nakano M,Ohnami S,Fukuhara M,Yanagi K,Matsushita A,Uchida E,Asaka M,Yoshida T,Aoki K

更新日期：2005-01-31 00:00:00

abstract：:Vascular mimicry (VM) describes the phenomenon that tumor cells but not endothelial cells form vascular-like channels, which provide blood perfusion for tumor tissues. VM is associated with tumor growth, metastasis and worse survival of different cancers. The mechanisms of VM formation remain largely unknown. We showe...

journal_title：Cancer letters

authors： Yang J,Lu Y,Lin YY,Zheng ZY,Fang JH,He S,Zhuang SM

更新日期：2016-12-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most malignant form of central nervous system tumor, and current therapies are largely ineffective at treating the cancer. Developing a more complete understanding of the mechanisms controlling the tumor is important in order to explore new possible treatment options. It is specula...

journal_title：Cancer letters

authors： Haley EM,Kim Y

更新日期：2014-04-28 00:00:00