Abstract:
:The mitochondrial genetic system is indispensable for the biosynthesis of the enzyme complexes involved in aerobic energy generation. Tetracyclines inhibit the expression of only the mitochondrial genes because they specifically block mitochondrial protein synthesis. A salient feature is that this inhibition occurs at the low concentration required for anti-bacterial treatment, provided that this concentration is maintained continuously. Evidence is presented that the growth of carcinogen-induced tumors can be inhibited by tetracyclines. It is further shown that the development in the cheek pouch of the Syrian hamster of a transplantable hypernephroma from human origin can be strongly retarded by tetracyclines as well. Therefore, the mitochondrial genetic system has to be reckoned as a target for chemotherapy and tetracyclines as cytostatic agents.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Kroon AM,Dontje BH,Holtrop M,Van den Bogert Cdoi
10.1016/s0304-3835(84)80023-3subject
Has Abstractpub_date
1984-11-01 00:00:00pages
33-40issue
1eissn
0304-3835issn
1872-7980pii
S0304-3835(84)80023-3journal_volume
25pub_type
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