Azelaic acid as a competitive inhibitor of thioredoxin reductase in human melanoma cells.

abstract：:The chimeric transcripts described in endometrial stromal sarcomas (ESS) are JAZF1/SUZ12, YWHAE/FAM22, ZC3H7/BCOR, MBTD1/CXorf67, and recombinations of PHF1 with JAZF1, EPC1, and MEAF6. The MEAF6/PHF1 fusion had hitherto been identified in only one tumor. We present two more ESS with MEAF6/PHF1 detected by transcripto...

journal_title：Cancer letters

authors： Micci F,Gorunova L,Gatius S,Matias-Guiu X,Davidson B,Heim S,Panagopoulos I

更新日期：2014-05-28 00:00:00

abstract：:Survivin is a recently characterised inhibitor of apoptosis protein that has been implicated in the pathogenesis of several types of solid organ cancer. This study sought to describe the expression of survivin in a cohort of 90 benign meningiomas, together with the pattern of expression of other genes involved in the ...

journal_title：Cancer letters

authors： Das A,Tan WL,Smith DR

更新日期：2003-04-25 00:00:00

abstract：:Dioxane, perchloroethylene, and trichloroethylene were investigated as rat liver altered foci promoters in an initiation/promotion protocol. Animals were initiated with diethylnitrosamine, 30 mg/kg, injected i.p. 24 h after 2/3 partial hepatectomy. The chemical under study was administered by gavage once a day, 5 time...

journal_title：Cancer letters

authors： Lundberg I,Högberg J,Kronevi T,Holmberg B

更新日期：1987-07-01 00:00:00

abstract：:Experimental data were provided to demonstrate the inhibitory effects of retinoids (retinal, retinoic acid, retinyl acetate and retinyl palmitate) and carotenoids (beta-carotene, lycopene and crocetin) on the growth and development of the C-6 glioma cells inoculated in rats. In the pretreatment experiments, most of th...

journal_title：Cancer letters

authors： Wang CJ,Chou MY,Lin JK

更新日期：1989-11-30 00:00:00

abstract：:Neuroblastoma (NB) is a common neuroectodermal tumor of childhood with low response to conventional therapy in patients with advanced stage disease. Among novel strategies, immumotherapy has attracted much interest. However, scanty information is available about the immunogenicity of human NB. Here, we review our data...

journal_title：Cancer letters

authors： Raffaghello L,Prigione I,Airoldi I,Camoriano M,Morandi F,Bocca P,Gambini C,Ferrone S,Pistoia V

更新日期：2005-10-18 00:00:00

abstract：:Primary effusion lymphoma (PEL) is a subtype of aggressive and resistant non-Hodgkin lymphoma that occurs predominantly in patients with advanced AIDS. In this study, we examined the antitumor activity of zoledronic acid (Zol)-induced Vγ9Vδ2 T cells against PEL cells in vitro and in vivo. Vγ9Vδ2 T cells recognized end...

journal_title：Cancer letters

authors： Goto H,Matsuda K,Srikoon P,Kariya R,Hattori S,Taura M,Katano H,Okada S

更新日期：2013-05-01 00:00:00

abstract：:Standard chemotherapeutic protocols, based on maximum tolerated doses, do not prevent nor overcome chemoresistance caused by the efflux transporter P-glycoprotein (Pgp). We compared the effects of two consecutive low doses versus a single high dose of doxorubicin in drug-sensitive Pgp-negative and drug-resistant Pgp-p...

journal_title：Cancer letters

authors： Riganti C,Gazzano E,Gulino GR,Volante M,Ghigo D,Kopecka J

更新日期：2015-05-01 00:00:00

abstract：:Ashwagandha, also called as "Queen of Ayurveda" and "Indian ginseng", is a commonly used plant in Indian traditional medicine, Ayurveda. Its roots have been used as herb remedy to treat a variety of ailments and to promote general wellness. However, scientific evidence to its effects is limited to only a small number ...

journal_title：Cancer letters

authors： Widodo N,Takagi Y,Shrestha BG,Ishii T,Kaul SC,Wadhwa R

更新日期：2008-04-08 00:00:00

abstract：:Somatic mutations and chromosome instability are hallmarks of genomic aberrations in cancer cells. Aneuploidies represent common manifestations of chromosome instability, which is frequently observed in human embryos and malignant solid tumors. Activation of human endogenous retroviruses (HERV)-derived loci is documen...

journal_title：Cancer letters

authors： Glinsky GV

更新日期：2016-10-10 00:00:00

abstract：:We previously showed that polyphyllin D (PD) produced a stronger apoptotic effect in R-HepG2 with multi-drug resistance (MDR) than that in its parent HepG2 cells without MDR. In this study, PD was found to elicit mitochondrial fragmentation in live cells by using total internal reflection fluorescence microscopy (TIRF...

journal_title：Cancer letters

authors： Ong RC,Lei J,Lee RK,Cheung JY,Fung KP,Lin C,Ho HP,Yu B,Li M,Kong SK

更新日期：2008-03-18 00:00:00

abstract：:The addition of recombinant human interleukin-6 (rIL-6) to either soleus or extensor digitorum longus (EDL) muscle preparations did not affect the rate of protein breakdown as measured by the rate of tyrosine released to the medium. In addition, the presence of the cytokine did not influence either the rate of protein...

journal_title：Cancer letters

authors： García-Martínez C,López-Soriano FJ,Argilés JM

更新日期：1994-01-15 00:00:00

abstract：:Smoking women are probably at a higher risk to develop lung cancer than men. Different explanations exist for these findings, a gender-specific impairment of tobacco carcinogen metabolism being one of them. In this study, we examined the inhibition of NNK reduction to NNAL, the first and most important detoxication st...

journal_title：Cancer letters

authors： Stapelfeld C,Neumann KT,Maser E

更新日期：2017-10-01 00:00:00

abstract：:In order to adapt to the reduced availability of nutrients and oxygen in the tumor microenvironment and the increased requirements of energy and building blocks necessary for maintaining their high proliferation rate, malignant cells undergo metabolic changes that result in an increased production of lactate, nitric o...

journal_title：Cancer letters

authors： Netea-Maier RT,Smit JWA,Netea MG

更新日期：2018-01-28 00:00:00

abstract：:ING family genes (Inhibitor of Growth) are tumor suppressor genes that play a vital role in cell homeostasis. It has been shown that their expression is lost or diminished in many cancers and other diseases. The main mechanisms by which they are regulated in oncogenesis have not yet been fully elucidated. The involvem...

journal_title：Cancer letters

authors： Gournay M,Paineau M,Archambeau J,Pedeux R

更新日期：2019-04-10 00:00:00

abstract：:It is well documented that CD44 plays an important role in tumor metastasis. We investigated whether there is a correlation between the expression of its isoforms in prostate cancer cells and patient prognosis using 72 cases with biopsy specimens. Immunohistochemistry demonstrated expression of CD44H (68.1%), v6 (36.1...

journal_title：Cancer letters

authors： Takahashi S,Kimoto N,Orita S,Cui L,Sakakibara M,Shirai T

更新日期：1998-07-03 00:00:00

abstract：:In a series of invasive ductal breast carcinoma, we investigated the status of chromosomal and intrachromosomal instability by fluorescence in situ hybridisation and determined the level of mRNA expression for two genes involved in the mitotic spindle checkpoint pathway, BUB1B and MAD2L1. All breast cancers demonstrat...

journal_title：Cancer letters

authors： Scintu M,Vitale R,Prencipe M,Gallo AP,Bonghi L,Valori VM,Maiello E,Rinaldi M,Signori E,Rabitti C,Carella M,Dallapiccola B,Altomare V,Fazio VM,Parrella P

更新日期：2007-09-08 00:00:00

abstract：:Breast cancer cells in their virulent undifferentiated state are characterized by lack of functional estrogen receptors (ER) and/or progesterone receptors (PR) as well as relatively low levels of other normal differentiation markers such as milk proteins and lipid droplets. To date, no method for in situ elevation of ...

journal_title：Cancer letters

authors： Adan Y,Goldman Y,Haimovitz R,Mammon K,Eilon T,Tal S,Tene A,Karmel Y,Shinitzky M

更新日期：2003-05-08 00:00:00

abstract：:Thioproline (TPRO), an effective nitrite trapping agent in vivo, was examined for its detoxifying ability in rats against N-nitrosodimethylamine (NDMA) and N-nitrosocimetidine (NCIM). When NDMA (37-101.5 mg/kg) was administered with TPRO (532 mg/kg), no influence of TPRO on NDMA-induced lethality and histological resu...

journal_title：Cancer letters

authors： Frank N,Tsuda M,Ohgaki H,Frei E,Kato T,Sato S

更新日期：1990-04-30 00:00:00

abstract：:Gastroesophageal reflux disease (GERD) is the main risk factor for Barrett's tumorigenesis. In this study, we investigated the role of NRF2 in response to exposure to acidic bile salts (ABS), in conditions that mimic GERD, using Barrett's esophagus cell models. We detected an increase in NRF2 protein levels, following...

journal_title：Cancer letters

authors： Peng D,Lu H,Zhu S,Zhou Z,Hu T,Chen Z,Zaika A,El-Rifai W

更新日期：2019-08-28 00:00:00

abstract：:Internal tandem duplication (ITD) of the juxtamembrane region of FMS-like tyrosine kinase-3 (FLT3) receptor is a common type of mutation in adult acute myeloid leukemia (AML), and patient response to FLT3 inhibitors appears to be transient due to the emergence of drug resistance. We established two sorafenib-resistant...

journal_title：Cancer letters

authors： Huang A,Ju HQ,Liu K,Zhan G,Liu D,Wen S,Garcia-Manero G,Huang P,Hu Y

更新日期：2016-07-28 00:00:00

abstract：:To search for possible cancer chemopreventive agents from natural sources, we performed primary screening of ten flavanones isolated from plants belonging to Rutaceae and Leguminosae by examining their possible inhibitory effects on Epstein-Barr virus (EBV) early antigen activation induced by 12-O-tetradecanoylphorbol...

journal_title：Cancer letters

authors： Itoigawa M,Ito C,Ju-ichi M,Nobukuni T,Ichiishi E,Tokuda H,Nishino H,Furukawa H

更新日期：2002-02-08 00:00:00

abstract：:Breast carcinomas are frequently characterized by hyperactivated c-erbB receptor tyrosine kinase signaling. Combination of anti-proliferative retinoids with growth-inhibitory c-erbB-specific agents might induce therapeutic benefit. We demonstrate close interactions between the c-erbB and the retinoic acid receptor sys...

journal_title：Cancer letters

authors： Flicker SH,Schneider SM,Offterdinger M,Dittrich E,Fazeny B,Valenta R,Huber H,Dittrich C,Grunt TW

更新日期：1997-05-01 00:00:00

abstract：:In esophageal squamous cell carcinoma (SCC), we used immunohistochemical analysis to further elucidate the correlation of p53 protein expression with clinicopathological factors, as well as with risk factors, such as tobacco smoking, alcohol consumption and a family history of cancer, using odds ratios (ORs). The expr...

journal_title：Cancer letters

authors： Kato H,Yoshikawa M,Miyazaki T,Nakajima M,Fukai Y,Tajima K,Masuda N,Tsukada K,Fukuda T,Nakajima T,Kuwano H

更新日期：2001-06-10 00:00:00

abstract：:The inhibitory effects of some scavengers of oxygen radicals were studied, using a two-stage transformation assay system in vitro 3-methylcholanthrene (3-MC)-initiation and 12-O-tetradecanoylphorbol-13-acetate-(TPA)-promotion in Balb 3T3 cells. Mannitol, a scavenger for hydroxyl radicals, strongly inhibited the TPA-en...

journal_title：Cancer letters

authors： Saito M,Tanaka N,Ohkawa Y,Inui N

更新日期：1987-05-01 00:00:00

abstract：:Intravenous methotrexate (MTX) therapy is widely used for treatment of various neoplastic diseases in children. The optimization of the MTX dose and/or the subsequent leucovorin rescue is based on pharmacokinetic data calculated from plasma concentrations collected after cessation of the MTX administration. The influe...

journal_title：Cancer letters

authors： Eksborg S,Albertioni F,Rask C,Beck O,Palm C,Schroeder H,Peterson C

更新日期：1996-11-29 00:00:00

abstract：:Gastric juice ascorbic acid concentrations were examined in black and white patients. Significantly lower concentrations were found in blacks, in the absence of a significant difference in the plasma concentration of vitamin C between races. Blacks had higher prevalence of Helicobacter pylori infection, higher gastric...

journal_title：Cancer letters

authors： Ruiz B,Correa P,Fontham ET,Rood JC,Malcom GT,Torrado J,Perez A,Ramakrishnan T,Hunter FM

更新日期：1994-08-15 00:00:00

abstract：:Aberrant activation of mammalian target of rapamycin complex 1 (mTORC1), caused by loss or inactivation of TSC1/TSC2 protein complex, leads to negative feedback inhibition of Akt. The exact mechanisms of this process are still not fully understood. Here we present evidence for the involvement of STAT3, a known mTORC1 ...

journal_title：Cancer letters

authors： Zha X,Hu Z,He S,Wang F,Shen H,Zhang H

更新日期：2011-12-27 00:00:00

abstract：:Tumor promotion potential of diacylglycerol (DAG)-rich edible oil was examined using a two-stage mouse skin carcinogenesis model initiated with 7,12-dimethylbenz[a]anthracene (DMBA). Topical treatment with 75 mg DAG oil once a day for 5 days/week for 35 weeks caused papillomas in 4 of 23 (17%) DMBA-treated female ICR ...

journal_title：Cancer letters

authors： Takasuka N,Takahashi M,Hori Y,Kitahashi T,Iigo M,Imai T,Yoshimi N,Sugimura T,Wakabayashi K

更新日期：2009-03-08 00:00:00

abstract：:Recent evidence suggests that the cut-off for age utilized in neuroblastoma risk groups should be increased from the 365-day cut-off currently in use. Separate cooperative group analyses were performed by German and Italian groups and two analyses by the Children's Oncology Group (North America, Australia, New Zealand...

journal_title：Cancer letters

authors： London WB,Boni L,Simon T,Berthold F,Twist C,Schmidt ML,Castleberry RP,Matthay KK,Cohn SL,De Bernardi B

更新日期：2005-10-18 00:00:00

abstract：:Multiple therapeutic strategies have been developed to treat pancreatic cancer. However, the outcomes of these approaches are disappointing. Due to deeper understandings of the pivotal roles of the immune system in pancreatic cancer tumorigenesis and progression, novel therapeutic strategies based on immune cells and ...

journal_title：Cancer letters

authors： Xu JW,Wang L,Cheng YG,Zhang GY,Hu SY,Zhou B,Zhan HX

更新日期：2018-07-01 00:00:00