当前位置： SCI文献检索 > CANCER LETTERS期刊下所有文献 > Fibronectin promotes cell proliferation and invasion through mTOR signaling pathway activation in gallbladder cancer.

Fibronectin promotes cell proliferation and invasion through mTOR signaling pathway activation in gallbladder cancer.

Abstract：

:Fibronectin (FN), a heterodimeric glycoprotein overexpressed in several types of tumors, has been implicated in cancer progression via the activation of integrin-mediated pro-oncogenic pathways. The FN level in human bile fluid is dramatically increased in malignant biliary diseases; however, FN expression and its biological functions in gallbladder cancer (GBC) remain unknown. In this study, we found that FN was overexpressed in GBC tissues and was associated with a worse prognosis in GBC patients. In vitro experimental studies indicated that exogenous FN significantly enhanced cell proliferation, invasion and active MMP-9 secretion in human GBC cell lines (GBC-SD and NOZ). Moreover, the key kinases of the mTOR signaling pathway, including FAK, Akt, mTOR and 4E-BP1, were markedly activated in a time-dependent manner in FN-treated GBC-SD and NOZ cells. The IHC statistical analyses validated that FN expression was positively correlated with the phosphorylation levels of the 4E-BP1 protein in GBC tissues. Furthermore, rapamycin, a specific inhibitor of mTOR, almost completely blocked FN-induced phosphorylation of 4E-BP1 and also partially abrogated the stimulatory effects of FN on GBC cell proliferation and invasion. In vivo, FN treatment significantly promoted the proliferation and metastasis of GBC cells and markedly activated Akt/mTOR/4E-BP1 signaling cascade. These findings demonstrate that FN may play a critical role in the modulation of cell proliferation and invasion via mTOR signaling pathway activation during GBC progression.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Cao Y,Liu X,Lu W,Chen Y,Wu X,Li M,Wang XA,Zhang F,Jiang L,Zhang Y,Hu Y,Xiang S,Shu Y,Bao R,Li H,Wu W,Weng H,Yen Y,Liu Y

doi

10.1016/j.canlet.2015.01.041

subject

Has Abstract

pub_date

2015-05-01 00:00:00

pages

141-50

issue

2

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(15)00087-7

journal_volume

360

pub_type

杂志文章

相关文献

CANCER LETTERS文献大全
  • Influence of lithium on mammary tumor growth in vivo.

    abstract：:The possibility that lithium ions stimulate growth of mammary tumors in vivo has been suggested by their mitogenic action in vitro on normal and neoplastic mammary epithelium [8] and their clinical use as stimulators of neutrophil production in tumor-bearing patients treated with cytotoxic drugs [14,15]. Three experim...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(80)90090-7

    authors： Ziche M,Maiorana A,Oka T,Gullino PM

    更新日期：1980-05-01 00:00:00

  • The carcinogenic effect of butylated hydroxyanisole on the stratified epithelium of the stomach in rat versus pig.

    abstract：:Butylated hydroxyanisole (BHA) was given to pregnant SPF pigs (Danish Landrace) in doses of 0, 50, 200 and 400 mg/kg body wt per day for 110 days. BHA was mixed in the diet (pelleted). Hyperkeratotic and parakeratotic proliferative changes of the stratified epithelium of the stomach were found at various degree in bot...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(83)90090-3

    authors： Olsen P

    更新日期：1983-11-01 00:00:00

  • Effect of cis-unsaturated fatty acids on Meth-A ascitic tumour cells in vitro and in vivo.

    abstract：:Earlier studies performed both by us and by others have demonstrated that some n-3 and n-6 fatty acids can inhibit the growth of tumour cells in vitro. Though studies done with various types of oils rich in n-3 and n-6 fatty acids did show that the tumour incidence and growth can be modified, there were relatively few...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(97)00426-6

    authors： Ramesh G,Das UN

    更新日期：1998-01-30 00:00:00

  • Effects of noradrenaline on interstitial fluid pressure in induced rat mammary tumours.

    abstract：:Interstitial fluid pressure was measured by the wick-in-needle technique in DMBA-induced rat mammary tumours during resting conditions and during noradrenaline infusion. The rate of infusion was chosen to increase the systemic blood pressure by 30-40 mmHg, known to result in a markedly increased vascular resistance of...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(85)90181-8

    authors： Tveit E,Hultborn R,Weiss L

    更新日期：1985-07-01 00:00:00

  • Co-expression of p53 and bcl-2 may correlate to the presence of epstein-barr virus genome and the expression of proliferating cell nuclear antigen in nasopharyngeal carcinoma.

    abstract：:Epstein-Barr virus (EBV) has been well documented in the aetiology of nasopharyngeal carcinoma (NPC), although its role as well as the genetic basis in the genesis of NPC have not been elucidated. The p53 gene mutations are infrequently found in NPC, but the expression of p53 protein, as well as bcl-2 oncoprotein, has...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(00)00582-6

    authors： Niemhom S,Kitazawa S,Murao S,Kunachak S,Maeda S

    更新日期：2000-11-28 00:00:00

  • Distribution and activity of transglutaminase in rat brain carcinogenesis and in gliomas.

    abstract：:Tissue transglutaminase is a calcium-dependent enzyme which may influence cell morphology, cytoskeletal processes and membrane functions. During rat brain carcinogenesis induced by transplacental administration of N-ethyl-N-nitrosourea to BD IX rats, cytosolic tissue transglutaminase activity was increased by about 14...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(99)00049-x

    authors： Tunici P,Sessa A,Rabellotti E,Calloni A,Perin A

    更新日期：1999-06-01 00:00:00

  • Application of the polymerase chain reaction (PCR) to quantify micro-metastasis in an experimental animal.

    abstract：:In vitro cultured r/mHM-SFME-1 cells were injected into the hind foot pads of Balb/c mice. Metastasis was detected in the lungs of tumor-bearing mice by means of both PCR and histological methods. Primers for the PCR were set to amplify a 128 bp exon-1 sequence of the human c-Ha-ras1 gene which had been introduced int...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(94)03722-u

    authors： Matano S,Ryoyama K,Nakamura S,Okada G,Nomura T

    更新日期：1995-05-04 00:00:00

  • Melatonin inhibition of MCF-7 human breast-cancer cells growth: influence of cell proliferation rate.

    abstract：:We have studied whether the cell proliferation rate modifies the inhibitory actions of melatonin on MCF-7 cell growth. The proliferative rate of cells was altered by plating them at different densities (5 x 10(4) to 100 x 10(4) cells/dish) in media with low charcoal-stripped serum concentrations. In this way, populati...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(95)03811-a

    authors： Cos S,Sánchez-Barceló EJ

    更新日期：1995-07-13 00:00:00

  • Induction of apoptosis in human lymphocytes treated with Viscum album L. is mediated by the mistletoe lectins.

    abstract：:Viscum album L. (VAL) is a phytopreparation used in adjuvant cancer therapy with both immunostimulatory and DNA stabilizing properties at low drug concentrations and cytostatic/cytotoxic properties at higher concentrations. The present work examines the cytotoxic effects of VAL extracts produced from mistletoes grown ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(95)04038-2

    authors： Büssing A,Suzart K,Bergmann J,Pfüller U,Schietzel M,Schweizer K

    更新日期：1996-01-19 00:00:00

  • Improving cancer therapies by targeting the physical and chemical hallmarks of the tumor microenvironment.

    abstract：:Tumors are highly heterogeneous at the patient, tissue, cellular, and molecular levels. This multi-scale heterogeneity poses significant challenges for effective therapies, which ideally must not only distinguish between tumorous and healthy tissue, but also fully address the wide variety of tumorous sub-clones. Commo...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2015.12.019

    authors： Ivey JW,Bonakdar M,Kanitkar A,Davalos RV,Verbridge SS

    更新日期：2016-09-28 00:00:00

  • Aromatase-induced endogenous estrogen promotes tumour metastasis through estrogen receptor-α/matrix metalloproteinase 12 axis activation in castration-resistant prostate cancer.

    abstract：:Castration-resistant prostate cancer (CRPC) following androgen deprivation therapy remains a major obstacle advanced prostate cancer management. Aromatase catalyzes estrogen from androgens, yet the role of aromatase-generated endogenous estrogen in CRPC is poorly understood. In this study, we assessed the expression a...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2019.09.001

    authors： Liang Z,Cao J,Tian L,Shen Y,Yang X,Lin Q,Zhang R,Liu H,Du X,Shi J,Zhang J

    更新日期：2019-12-28 00:00:00

  • Emerging next-generation sequencing-based discoveries for targeted osteosarcoma therapy.

    abstract：:Osteosarcoma (OS) is the most common primary bone malignancy and is frequently lethal via metastasis to the lung. While surgical techniques and adjuvant chemotherapies have emerged to combat this deadly cancer, the 5-year survival rate has plateaued over the past four decades. Therapeutic progress has been notably poo...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2020.01.020

    authors： Zhao J,Dean DC,Hornicek FJ,Yu X,Duan Z

    更新日期：2020-04-01 00:00:00

  • Effects of curcumin on the formation of benzo[a]pyrene derived DNA adducts in vitro.

    abstract：:The effects of turmeric (T), curcumins (Cs), aqueous turmeric extract (ATE) and curcumin-free aqueous turmeric extract (CFATE) on the formation of [3H]benzo[a]pyrene ([3H]B(a)P)-derived DNA adducts was studied in vitro employing mouse liver S9. A dose-dependent decrease in binding of [3H]B(a)P metabolites to calf thym...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(95)03903-a

    authors： Deshpande SS,Maru GB

    更新日期：1995-09-04 00:00:00

  • Inhibition of angiogenesis by a novel small peptide consisting of the active fragments of platelet factor-4 and vasostatin.

    abstract：:Inhibition of angiogenesis provides a potential anti-cancer therapy. Here we describe a novel recombinant peptide composed of active fragments of two distinct angiogenesis inhibitors, platelet factor-4 (C-13 fragment) and vasostatin (N-terminal amino acids 135-164) with a nonpolar peptide bridge of Gly-Pro-Gly. This f...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2007.05.002

    authors： Li X,Jiang L,Wang Y,Xiao Y,Huang Y,Yao Q,Yang Y,Wu X

    更新日期：2007-10-18 00:00:00

  • Heat shock (hsp70) and resistance proteins in non-small cell lung carcinomas.

    abstract：:The aim of the study was to prove whether or not an association exists between the heat shock protein 70 (hsp70) and drug resistance. Tumor samples of 90 patients with previously untreated non-small lung carcinomas were investigated immunohistochemically for expression of resistance related proteins. Additionally, res...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(95)03893-2

    authors： Volm M,Koomägi R,Mattern J,Stammler G

    更新日期：1995-08-16 00:00:00

  • PTK2 promotes cancer stem cell traits in hepatocellular carcinoma by activating Wnt/β-catenin signaling.

    abstract：:Emerging evidence indicates that cancer stem cells (CSCs) are involved in tumorigenesis, tumor recurrence, and therapeutic resistance in hepatocellular carcinoma (HCC). However, the mechanisms underlying HCC CSC regulation remain largely unknown. Here we report our analysis of 97 paraffin-embedded HCC tumor specimens....

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2019.02.040

    authors： Fan Z,Duan J,Wang L,Xiao S,Li L,Yan X,Yao W,Wu L,Zhang S,Zhang Y,Li Y,Zhu X,Hu Y,Zhang D,Jiao S,Xu X

    更新日期：2019-05-28 00:00:00

  • Tri-n-butyltin chloride promotes morphological transformation and induces proliferin expression in C3H10T1/2 cells.

    abstract：:Transcripts from the murine gene family proliferin, which are increased by a wide assortment of chemical promoters of C3H10T1/2 cell morphological transformation, were shown to be induced by tri-n-butyltin chloride at concentrations above 50 nM. Two-stage transformation assays, with 3-methylcholanthrene as inducer and...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(93)90112-m

    authors： Parfett CL,Pilon R

    更新日期：1993-07-30 00:00:00

  • Involvement of free radicals in the formation of heterocyclic amines and prevention by antioxidants.

    abstract：:It was found that free radical intermediates, pyrazine cation radial and carbon-centered radicals, generated in the Maillard reaction of sugars/amino acids, were involved in the production of mutagenic and carcinogenic imidazoquinoquizaline heterocyclic amines. Prevention of the generation of these radical intermediat...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(99)00140-8

    authors： Kikugawa K

    更新日期：1999-09-01 00:00:00

  • The third-generation bisphosphonates inhibit proliferation of murine osteosarcoma cells with induction of apoptosis.

    abstract：:Third generation bisphosphonates (BPs), including YM175 and YM529, are known to inhibit bone resorption. The aim of this study was to evaluate the anti-tumor effects of these drugs on murine osteosarcoma cell lines, in terms of proliferation and apoptosis. We found that both YM175 and YM529 strongly inhibited the in v...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2005.06.041

    authors： Horie N,Murata H,Nishigaki Y,Matsui T,Segawa H,Nogawa M,Yuasa T,Kimura S,Maekawa T,Fushiki S,Kubo T

    更新日期：2006-07-08 00:00:00

  • Exosomes: Emerging biomarkers and targets for ovarian cancer.

    abstract：:The limitations of current chemotherapies have motivated research in developing new treatments. Growing evidence shows that interaction between tumors and their microenvironment, but not tumor cells per se, is the key factor in tumor progression and therefore of obvious scientific interest and therapeutic value. Exoso...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2015.07.014

    authors： Tang MK,Wong AS

    更新日期：2015-10-10 00:00:00

  • Nitric oxide as a target of complementary and alternative medicines to prevent and treat inflammation and cancer.

    abstract：:Nitric oxide (NO) and associated reactive nitrogen species (RNS) are involved in many physiological functions. There has been an ongoing debate to whether RNS can inhibit or perpetuate chronic inflammation and associated carcinogenesis. Although the final outcome depends on the genetic make-up of its target, the surro...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2008.03.024

    authors： Hofseth LJ

    更新日期：2008-09-08 00:00:00

  • Modulation of benzo[a]pyrene-induced morphological transformation of Syrian hamster embryo cells by butylated hydroxytoluene and butylated hydroxyanisole.

    abstract：:The Syrian hamster embryo cell transformation assay has been used to investigate the effect of two synthetic antioxidants on morphological transformation induced by the initiator benzo[a]pyrene (BP). A two-stage protocol was employed with an initiation phase of 2 days and a subsequent promotion phase of 5 days. When 1...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(86)90024-8

    authors： Potenberg J,Schiffmann D,Kahl R,Hildebrandt AG,Henschler D

    更新日期：1986-11-01 00:00:00

  • Resveratrol is a potent inducer of apoptosis in human melanoma cells.

    abstract：:Resveratrol is a plant polyphenol found in grapes and red wine. It has been found to have beneficial effects on the cardiovascular system. Resveratrol also inhibits the growth of various tumor cell lines in vitro and inhibits carcinogenesis in vivo. In this study we examined the effect of resveratrol on growth of two ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(02)00676-6

    authors： Niles RM,McFarland M,Weimer MB,Redkar A,Fu YM,Meadows GG

    更新日期：2003-02-20 00:00:00

  • Lipids status in human breast cyst fluids.

    abstract：:Benign mammary gross cystic disease is the most common breast lesion; women with apocrine changes of epithelium lining the cysts are at higher risk for developing breast cancer than the normal population. Total cholesterol, high- and low-density lipoproteins fractions, triglycerides and phospholipids, lipase activity ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：

    authors： Mannello F,Bocchiotti GD,Morano FP,Fratepietro LM,Gazzanelli G

    更新日期：1996-01-02 00:00:00

  • Apoptosis induced by the sonomechanical effects of low intensity pulsed ultrasound in a human leukemia cell line.

    abstract：:To obtain an optimal condition for ultrasound (US)-induced apoptosis that could be useful for cancer therapy, we applied low intensity pulsed US to sonicate U937 cells in vitro. Cells were then incubated at different time intervals before measuring apoptosis. The apoptosis was assessed by DNA fragmentation and phospha...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2004.08.034

    authors： Feril LB Jr,Kondo T,Cui ZG,Tabuchi Y,Zhao QL,Ando H,Misaki T,Yoshikawa H,Umemura S

    更新日期：2005-04-28 00:00:00

  • Non-specific cyclic nucleotide binding in leukemic leukocytes.

    abstract：:Extracts of leukemic lymphocytes and leukemic myelomonocytic cells bind significantly more cAMP/mg protein than do normal cells. The binding of cAMP in leukemic cells is non-specific since the binders are unable to effectively discriminate between cAMP and cGMP in contrast to normal cells. When normal lymphocytes are ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(80)90004-x

    authors： Weber TH,Linkola J

    更新日期：1980-01-01 00:00:00

  • IL-6 induced M1 type macrophage polarization increases radiosensitivity in HPV positive head and neck cancer.

    abstract：:Radiation is a crucial component of head and neck squamous cell carcinoma (HNSC) treatment. Human papillomavirus-positive (HPV+) HNSC is significantly more radiosensitive than HPV- HNSC, but the mechanism underlying this increased sensitivity is unknown. We investigated the possible involvement of macrophage subpopula...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2019.04.032

    authors： Chen X,Fu E,Lou H,Mao X,Yan B,Tong F,Sun J,Wei L

    更新日期：2019-08-01 00:00:00

  • Soluble and membrane-bound catechol-O-methyltransferase in normal and malignant mammary gland.

    abstract：:The levels of 26 kDa-soluble (S) and 30 kDa-membrane-bound (MB) catechol-O-methyltransferase (COMT) polypeptides were determined in paired samples from normal and neoplastic breast tissue of 32 patients with breast cancer. Immunohistochemical staining showed that the COMT reaction in normal mammary tissue was restrict...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(99)00197-4

    authors： Tenhunen J,Heikkilä P,Alanko A,Heinonen E,Akkila J,Ulmanen I

    更新日期：1999-09-20 00:00:00

  • Observation and quantification of aberrant crypts in the murine colon treated with a colon carcinogen: preliminary findings.

    abstract：:In the present study a methodological approach is taken which quantitates aberrant dysplastic crypts in the unsectioned murine colon. C57BL/6J or CF1 female mice (7-8 weeks old) were injected (i.p.) with azoxymethane (5 mg/kg body wt./week) for 4 weeks. Their colons were excised, cut open on the median axis and fixed ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(87)90157-1

    authors： Bird RP

    更新日期：1987-10-30 00:00:00

  • Differential nuclear matrix-intermediate filament expression in human prostate cancer in respect to benign prostatic hyperplasia.

    abstract：:We have characterized the changes in composition of the nuclear matrix-intermediate filament complex (NM-IF) isolated from prostate cancer (PCa), compared with benign prostatic hyperplasia (BPH). We prepared the NM-IF from ten patients undergoing radical retropubic prostectomy; the benign hyperplastic tissue was obtai...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(96)04444-8

    authors： Alberti I,Parodi S,Barboro P,Sanna P,Nicolò G,Allera C,Patrone E,Galli S,Balbi C

    更新日期：1996-12-03 00:00:00