Distribution and activity of transglutaminase in rat brain carcinogenesis and in gliomas.

Abstract:

:Tissue transglutaminase is a calcium-dependent enzyme which may influence cell morphology, cytoskeletal processes and membrane functions. During rat brain carcinogenesis induced by transplacental administration of N-ethyl-N-nitrosourea to BD IX rats, cytosolic tissue transglutaminase activity was increased by about 140% at 30 days of extrauterine life and returned towards the control values at 3-5 months. In the particulate fraction, enzyme activity progressively increased, reaching values similar to those present in the developed gliomas. Tissue transglutaminase activity in gliomas had a behavior inverse to that observed in controls, with a decrease (about 50%) in the cytosol and a marked increase (380%) in the particulate fraction, indicating a redistribution of enzyme activity.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Tunici P,Sessa A,Rabellotti E,Calloni A,Perin A

doi

10.1016/s0304-3835(99)00049-x

keywords:

subject

Has Abstract

pub_date

1999-06-01 00:00:00

pages

47-51

issue

1-2

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(99)00049-X

journal_volume

140

pub_type

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