Application of the polymerase chain reaction (PCR) to quantify micro-metastasis in an experimental animal.

abstract：:Hepatitis C virus Core plays a vital role in the development of hepatocellular carcinoma; however, its action mechanism is still controversial. Here, we showed that Core down-regulated levels of p16, resulting in inactivation of Rb and subsequent activation of E2F1, which lead to growth stimulation of hepatocytes. For...

journal_title：Cancer letters

authors： Park SH,Lim JS,Lim SY,Tiwari I,Jang KL

更新日期：2011-11-01 00:00:00

abstract：:Chemical agents including 5-iodo-2'-deoxyuridine (IUdR), 4-O-methyl 12-O-tetradecanoyl phorbol-13-acetate (TPA), phorbol, and the tumor promoters teleocidin and TPA were tested for their ability to induce Human T-cell leukemia-lymphoma virus Type I (HTLV-I) expression in the low-virus producer MT-1 cell line and in th...

journal_title：Cancer letters

authors： Carter LJ,Blakeslee JR Jr

更新日期：1988-04-01 00:00:00

abstract：:The expression of the WAF1/CIP1 gene product, p21, in enzyme-altered foci (EAF) induced by diethylnitrosamine (DEN) and phenobarbital (PB) was examined. p21 expression in the nucleus of hepatocytes in EAF was decreased compared to surrounding tissue. Fifty-eight percent of all GST-P-positive EAF induced by DEN and 79%...

journal_title：Cancer letters

authors： Martens U,Lennartsson P,Högberg J,Stenius U

更新日期：1996-06-24 00:00:00

abstract：:Sulforaphane (SFN) is an isothiocyanate found in cruciferous vegetables, with particularly high levels detected in broccoli and broccoli sprouts. Over a decade ago, this phytochemical was identified as a likely chemopreventive agent based on its ability to induce Phase 2 detoxification enzymes, as well as to inhibit P...

journal_title：Cancer letters

authors： Myzak MC,Dashwood RH

更新日期：2006-02-28 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. Many kinases have been found to be intimately involved in oncogenesis and the deregulation of kinase function has emerged as a major mechanism by which cancer cells evade normal physiological constraints on growth and surviv...

journal_title：Cancer letters

authors： Xia H,Kong SN,Chen J,Shi M,Sekar K,Seshachalam VP,Rajasekaran M,Goh BKP,Ooi LL,Hui KM

更新日期：2016-12-01 00:00:00

abstract：:N-Acetyltransferase activities with p-aminobenzoic acid and 2-aminofluorene were determined in Anisakis simplex, a nematode found in the intestine of the salt water fish Trichiurus lepturus. The N-acetyltransferase activity was determined using an acetyl CoA recycling assay and high pressure liquid chromatography. The...

journal_title：Cancer letters

authors： Chung JG,Kuo HM,Lin TH,Ho CC,Lee JH,Lai JM,Levy GN,Weber WW

更新日期：1996-08-23 00:00:00

abstract：:Starting with an extract derived from the bark of Mundulea sericea Willd. (Leguminosae) that was active in the process of inhibiting 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ornithine decarboxylase activity (ODC) in cultured mouse epidermal ME 308 cells, the isoflavonoid munetone was isolated and identified ...

journal_title：Cancer letters

authors： Lee SK,Luyengi L,Gerhäuser C,Mar W,Lee K,Mehta RG,Kinghorn AD,Pezzuto JM

更新日期：1999-02-08 00:00:00

abstract：:We investigated the effects of the ethyl acetate extract of grapefruit juice (GFJ), that of orange juice (OJ) and their components on the uptake of [(3)H]vincristine into adriamycin-resistant human myelogenous leukemia cells. Its uptake was increased by the extracts of GFJ and OJ up to 7- and 3-fold, respectively, as ...

journal_title：Cancer letters

authors： Ikegawa T,Ushigome F,Koyabu N,Morimoto S,Shoyama Y,Naito M,Tsuruo T,Ohtani H,Sawada Y

更新日期：2000-11-10 00:00:00

abstract：:In a development trial for an initiation bioassay system, cell proliferation kinetics after partial hepatectomy (PH) or CCl4 administration (1 ml/kg b.w., i.g.) and the effect of administration time after PH or CCl4 treatment on liver cell foci induction by the direct and indirect non-hepatocarcinogens, N-methyl-N'-ni...

journal_title：Cancer letters

authors： Kobayashi K,Mutai M,Goto K,Inada K,Tsukamoto T,Nakanishi H,Tatematsu M

更新日期：1997-09-16 00:00:00

abstract：:Costunolide (CT), a sesquiterpene lactone constituent isolated from Saussurea lappa (Compositae), exerted an antiangiogenic effect. CT selectively inhibited the endothelial cell proliferation induced by vascular endothelial growth factor (VEGF). Further, CT was also found to inhibit the VEGF-induced chemotaxis of huma...

journal_title：Cancer letters

authors： Jeong SJ,Itokawa T,Shibuya M,Kuwano M,Ono M,Higuchi R,Miyamoto T

更新日期：2002-12-10 00:00:00

abstract：:Inheritance of certain polymorphic metabolizing genes is associated with the development of a number of environmental cancers and may also influence the clinicopathological tumor outcome. We have investigated the association between the inheritance of the polymorphic cytochrome P-450 2D6 (CYP2D6) gene and the developm...

journal_title：Cancer letters

authors： Abdel-Rahman SZ,Anwar WA,Abdel-Aal WE,Ghoneim MA,Au WW

更新日期：1997-10-28 00:00:00

abstract：:Human papillomavirus (HPV) infection is one of the most common sexually transmitted infections (STIs) in young women. They can occur in one or multiple areas of the female genitalia. Usually, the vulva is the initial site of implantation for HPV. The purpose of our study is to evaluate the epidemiological aspects, inc...

journal_title：Cancer letters

authors： Frega A,Stentella P,De Ioris A,Piazze JJ,Fambrini M,Marchionni M,Cosmi EV

更新日期：2003-07-10 00:00:00

abstract：:Gastroesophageal reflux disease (GERD) is the main risk factor for Barrett's tumorigenesis. In this study, we investigated the role of NRF2 in response to exposure to acidic bile salts (ABS), in conditions that mimic GERD, using Barrett's esophagus cell models. We detected an increase in NRF2 protein levels, following...

journal_title：Cancer letters

authors： Peng D,Lu H,Zhu S,Zhou Z,Hu T,Chen Z,Zaika A,El-Rifai W

更新日期：2019-08-28 00:00:00

abstract：:The RB-E2F1 pathway is an important mechanism of cell-cycle control, and deregulation of this pathway is one of the key factors contributing to tumorigenesis. Cyclin-dependent kinases (CDKs) and Cyclin D have been known to increase in aggressive thyroid cancer. However, there has been no study to investigate effects o...

journal_title：Cancer letters

authors： Lee HJ,Lee WK,Kang CW,Ku CR,Cho YH,Lee EJ

更新日期：2018-03-28 00:00:00

abstract：:Pancreatic adenocarcinoma (PDAC) is associated with poor clinical outcomes and incomplete responses to conventional therapy. Therefore, there is an unmet clinical need to better understand the predisposing factors for pancreatic cancer in hopes of providing early screening to high-risk patients. While select risk fact...

journal_title：Cancer letters

authors： Principe DR,Rana A

更新日期：2020-08-10 00:00:00

abstract：:BRCA1 and BRCA2 genes were screened for loss-of-function mutations in a series of 85 patients having at least one first- or second-degree relative affected by breast and/or ovarian cancer. All BRCA1 exons and BRCA2 exons 10 and 11 were screened with a combination of methods including SSCP, PTT and direct sequencing. W...

journal_title：Cancer letters

authors： Ladopoulou A,Kroupis C,Konstantopoulou I,Ioannidou-Mouzaka L,Schofield AC,Pantazidis A,Armaou S,Tsiagas I,Lianidou E,Efstathiou E,Tsionou C,Panopoulos C,Mihalatos M,Nasioulas G,Skarlos D,Haites NE,Fountzilas G,Pandis N

更新日期：2002-11-08 00:00:00

abstract：:The cell transforming ability of asbestos dust was investigated using C3H10T 1/2 murine fibroblasts. In a series of experiments both crocidolite and amosite caused no increase in the number of transformed foci over that seen in cultures from untreated cells. The dusts, were, however, capable of augmenting the oncogeni...

journal_title：Cancer letters

authors： Brown RC,Poole A,Fleming GT

更新日期：1983-03-01 00:00:00

abstract：:Gene amplification has been found to be biologically important in cancer. We report a complementary DNA sequence obtained using a subtractive hybridization approach which is frequently and highly amplified in human gliomas. 39/45 (87%) glial tumor specimens (of pathologically low and high grade) revealed increases in ...

journal_title：Cancer letters

authors： Liang BC,Hays L

更新日期：1996-08-02 00:00:00

abstract：:The aim of the present study was to estimate the expression of mRNA, specific for thymidine kinase 1 (TK1), deoxycytidine kinase (dCK), and thymidine phosphorylase (dThdPase), i.e. enzymes involved in pyrimidine and purine metabolism in human papillary thyroid carcinoma (PTC) tissue. Additionally, the expression of dC...

journal_title：Cancer letters

authors： Karbownik M,Brzezianska E,Lewinski A

更新日期：2005-07-28 00:00:00

abstract：:Estrogens are important for the development and growth of estrogen receptor (ER)-positive breast cancer, for which anti-estrogen therapy is one of the most effective treatments. However, its efficacy can be limited by either de novo or acquired resistance. Aromatase is a key enzyme for the biosynthesis of estrogens, a...

journal_title：Cancer letters

authors： Phuong NT,Lim SC,Kim YM,Kang KW

更新日期：2014-08-28 00:00:00

abstract：:It is widely known that dietary lipids can modify the ability of different cancers to grow up and metastasize, especially mammary gland tumors. However, it is still unclear whether n-6 fatty acids behave as tumor promoters in this gland cell population. The effect of different nutritional polyunsaturated fatty acids (...

journal_title：Cancer letters

authors： Muñoz SE,Lopez CB,Valentich MA,Eynard AR

更新日期：1998-04-24 00:00:00

abstract：:Oxaliplatin (trans-l-1,2-diaminocyclohexane oxalato Pt(II); 1R,2R-dach, l-OHP), its trans-d isomer (1S,2S-dach) and cis-dach (1R,2S-dach) isomers were compared in in vitro testing against human ovarian carcinoma cell lines A2780, A2780/CP (cisplatin resistant), A2780/l-OHP (oxaliplatin resistant), colon carcinoma cell...

journal_title：Cancer letters

authors： Pendyala L,Kidani Y,Perez R,Wilkes J,Bernacki RJ,Creaven PJ

更新日期：1995-11-06 00:00:00

abstract：:We investigated the role of the 5-lipoxygenase (5-LOX) pathway of arachidonic acid metabolism in tumour necrosis factor-alpha (TNF-alpha)-induced differentiation of human leukemic HL-60 cells using MK-886, an inhibitor of 5-LOX activating protein. MK-886 augmented cell cycle arrest and differentiation induced by TNF-a...

journal_title：Cancer letters

authors： Stika J,Vondrácek J,Hofmanová J,Simek V,Kozubík A

更新日期：2006-06-18 00:00:00

abstract：:The mutagenic activities of N-nitrosobis(2-hydroxypropyl)amine (BHP) and its related compounds were studied in Salmonella typhimurium TA100 and TA98 strains by Ames's liquid incubation assay in the presence or absence of lung and liver S9 of rats treated with polychlorinated biphenyl (PCB). BHP and its related compoun...

journal_title：Cancer letters

authors： Mori Y,Niwa T,Takahashi H,Toyoshi K,Denda A,Takahashi S,Konishi Y

更新日期：1983-04-01 00:00:00

abstract：:Increased abundance of the mRNA-binding protein human antigen R (HuR) is a characteristic feature of many cancers and frequently associated with a high grade malignancy and therapy resistance. HuR elicits a broad cell survival program mainly by stabilizing or increasing the translation of mRNAs coding for anti-apoptot...

journal_title：Cancer letters

authors： Badawi A,Hehlgans S,Pfeilschifter J,Rödel F,Eberhardt W

更新日期：2017-05-01 00:00:00

abstract：:Studies have been demonstrating Pfaffia paniculata root (Brazilian ginseng) anticarcinogenic activities. We evaluated its chemopreventive effects on preneoplastic hepatic lesions. BALB/c aged-15 days received 10mug/g of diethylnitrosamine carcinogen, i.p. They were fed with the powdered root added to the diet: 0.5, 2 ...

journal_title：Cancer letters

authors： da Silva TC,Paula da Silva A,Akisue G,Luis Avanzo J,Kazumi Nagamine M,Fukumasu H,Matsuzaki P,César Raspantini P,Haraguchi M,Lima Górniak S,Dagli ML

更新日期：2005-08-26 00:00:00

abstract：:The present study was conducted to clarify the mechanism responsible for enhancement of the anti-melanoma activity of levodopa methylester by supplemental ascorbate in vivo. 5-Hydroxydopa, a known cytotoxic agent and the major metabolite formed from levodopa in the presence of ascorbate and mushroom tyrosinase in vitr...

journal_title：Cancer letters

authors： Pierson HF,Meadows GG

更新日期：1985-11-01 00:00:00

abstract：:Poly(ADP-ribose) synthetase activity in human cervical cancer cell nuclei was found to be approximately twice that of normal cervical cell nuclei. Using antipoly(ADP-ribose) antibody, frozen section of normal tissue were stained by indirect-immunofluorescence and it was demonstrated that the fluorescence of nuclei in ...

journal_title：Cancer letters

authors： Fukushima M,Kuzuya K,Ota K,Ikai K

更新日期：1981-12-01 00:00:00

abstract：:Recent evidence suggests that the cut-off for age utilized in neuroblastoma risk groups should be increased from the 365-day cut-off currently in use. Separate cooperative group analyses were performed by German and Italian groups and two analyses by the Children's Oncology Group (North America, Australia, New Zealand...

journal_title：Cancer letters

authors： London WB,Boni L,Simon T,Berthold F,Twist C,Schmidt ML,Castleberry RP,Matthay KK,Cohn SL,De Bernardi B

更新日期：2005-10-18 00:00:00

abstract：:Calcium channel blockers of 3 chemical classes and calmodulin antagonists have recently been shown to enhance the cytotoxicity of conventional cancer chemotherapeutic agents. We tested the ability of nifedipine, a dihydropyridine class calcium channel blocker, to enhance the cytotoxicity of cisplatin, the current chem...

journal_title：Cancer letters

authors： Onoda JM,Jacobs JR,Taylor JD,Sloane BF,Honn KV

更新日期：1986-02-01 00:00:00