Involvement of free radicals in the formation of heterocyclic amines and prevention by antioxidants.

abstract：:The antagonism by 3 synthetic steroids of the induction of tyrosine aminotransferase and tryptophan dioxygenase by dexamethasone were compared in HTC and FAZA hepatoma cells and in isolated liver cells. It was observed: (i) the sensitivity of liver cells to glucocorticoid agonists and antagonists changed in relation t...

journal_title：Cancer letters

authors： Santana MA,Chasserot-Bolaz S,Beck B,Pogson CI

更新日期：1985-07-01 00:00:00

abstract：:The mutagenic activities of N-nitrosobis(2-hydroxypropyl)amine (BHP) and its related compounds were studied in Salmonella typhimurium TA100 and TA98 strains by Ames's liquid incubation assay in the presence or absence of lung and liver S9 of rats treated with polychlorinated biphenyl (PCB). BHP and its related compoun...

journal_title：Cancer letters

authors： Mori Y,Niwa T,Takahashi H,Toyoshi K,Denda A,Takahashi S,Konishi Y

更新日期：1983-04-01 00:00:00

abstract：:scFv fragments of a monoclonal antibody that penetrates living cells and localizes in nuclei were designed as fusion proteins with C-terminal p53 peptides and tested for restoring p53 function in p53 mutant cancer cells. scFv fragments transported a 30-mer C-terminal peptide of p53 into cancer cells and induced cellul...

journal_title：Cancer letters

authors： Weisbart RH,Miller CW,Chan G,Wakelin R,Ferreri K,Koeffler HP

更新日期：2003-06-10 00:00:00

abstract：:Cytokines induce inflammatory and immune responses in tumors after photodynamic therapy (PDT). Since there are no reports of IL-6 in nasopharyngeal cancer (NPC) cells following PDT, we evaluated IL-6 expression in two different NPC tumors after hypericin mediated PDT. Interleukin-6 transcription was significantly upre...

journal_title：Cancer letters

authors： Du H,Bay BH,Mahendran R,Olivo M

更新日期：2006-04-28 00:00:00

abstract：:Although brain tumors are classified as if their lineage were well understood, the relationship between the molecular events that specify neural cell lineage and brain tumors remains enigmatic. Traditionally, cell surface membrane antigens have served as biomarkers that distinguish brain tumor origin and malignancy. I...

journal_title：Cancer letters

authors： Seyfried NT,Huysentruyt LC,Atwood JA 3rd,Xia Q,Seyfried TN,Orlando R

更新日期：2008-05-18 00:00:00

abstract：:In vitro cultured r/mHM-SFME-1 cells were injected into the hind foot pads of Balb/c mice. Metastasis was detected in the lungs of tumor-bearing mice by means of both PCR and histological methods. Primers for the PCR were set to amplify a 128 bp exon-1 sequence of the human c-Ha-ras1 gene which had been introduced int...

journal_title：Cancer letters

authors： Matano S,Ryoyama K,Nakamura S,Okada G,Nomura T

更新日期：1995-05-04 00:00:00

abstract：:We investigated the molecular mechanisms involved in the anti-proliferative activity exerted by conjugated linoleic acid (CLA) on the estrogen unresponsive MDA-MB-231 human breast cancer cell line. The effects on cell proliferation, cell cycle progression and induction of apoptosis were examined. CLA caused the reduct...

journal_title：Cancer letters

authors： Miglietta A,Bozzo F,Bocca C,Gabriel L,Trombetta A,Belotti S,Canuto RA

更新日期：2006-03-28 00:00:00

abstract：:Nitrosamine formation from the reaction of nitroprusside with morpholine was found to be a light-dependent reaction. Maximum nitrosation occurred when the reactants were exposed to UV light (lambda = 275-300 nm). However, considerable nitrosation also occurred with light in the visible spectrum up to 500 nm. No signif...

journal_title：Cancer letters

authors： Cooney RV,Ramseyer J,Ross PD

更新日期：1988-06-15 00:00:00

abstract：:Dihydroagarofuran sesquiterpenes, which were isolated from Tripterygium wilfordii Hook fil. var. regelii Makino and Euonymus sieboldianus Blume, showed inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). Triptogelin A-1, one of the active di...

journal_title：Cancer letters

authors： Ujita K,Takaishi Y,Tokuda H,Nishino H,Iwashima A,Fujita T

更新日期：1993-02-01 00:00:00

abstract：:Activation of the cytoplasmic (Ras-Raf-MEK-ERK) signaling cascade was shown to be both, necessary and sufficient for transformation in vitro as well as in vivo. However, over the last years the involvement of stress-activated protein kinases (SAPKs)/Jun N-terminal kinases (JNKs), and their substrate c-Jun in the proce...

journal_title：Cancer letters

authors： Rennefahrt U,Illert B,Greiner A,Rapp UR,Troppmair J

更新日期：2004-11-08 00:00:00

abstract：:Pancreatic adenocarcinoma cells show characteristics of macrophages as phagocytosis and exocytosis. These phagocytic activities can be inhibited in macrophages by antirheumatic drugs, e.g. gold compounds and antimalarials. We have now tested the activity of auranofin and chloroquine to inhibit growth of a pancreatic t...

journal_title：Cancer letters

authors： Zeilhofer HU,Mollenhauer J,Brune K

更新日期：1989-01-01 00:00:00

abstract：:For biochemical modulation, components of green tea have been shown to be useful modulators in combination with doxorubicin (DOX). We have confirmed that theanine enhances the antitumor activity of DOX due to inhibition of DOX efflux from tumor cells. Because theanine is a glutamate analogue, we found that it is assoc...

journal_title：Cancer letters

authors： Sadzuka Y,Yamashita Y,Sugiyama T,Sonobe T

更新日期：2002-05-28 00:00:00

abstract：:In this study, we aimed to establish a platinum-based chemotherapy response and toxicity prediction model in advanced non-small cell lung cancer (NSCLC) patients. 416 single nucleotide polymorphisms (SNPs) in 185 genes were genotyped, and their association with drug response and toxicity were estimated using logistic ...

journal_title：Cancer letters

authors： Yin JY,Li X,Li XP,Xiao L,Zheng W,Chen J,Mao CX,Fang C,Cui JJ,Guo CX,Zhang W,Gao Y,Zhang CF,Chen ZH,Zhou H,Zhou HH,Liu ZQ

更新日期：2016-07-10 00:00:00

abstract：:The in vitro sensitivities to differentiating agents of a murine neuroblastoma cell line (N18) and a selected variant cell line (N18-LM5) were examined. In addition, the sensitivities to differentiating agents of cells from spontaneous metastases produced by N18 cells were examined. When N18 cells (1 X 10(5) cells/mou...

journal_title：Cancer letters

authors： Takenaga K

更新日期：1983-05-01 00:00:00

abstract：:The objective of this work was to investigate the expression of glutathione S-transferase placental form (GST-P) in 9,10-dimethyl-1,2-benzanthracene (DMBA)-induced hamster buccal pouch carcinogenesis. Lesions were classified histopathologically into four categories, simple hyperplasia, papillary and nodular (PN) hyper...

journal_title：Cancer letters

authors： Iida K,Yamamoto M,Kato M,Yoshida K,Kurita K,Tatematsu M

更新日期：1999-01-29 00:00:00

abstract：:Glioblastoma multiforme (GBM), a malignant brain tumor, is the deadliest form of human cancer with low survival rates because of its highly invasive nature. In recent years, there has been a growing appreciation for the role that glioblastoma stem cells (GSCs) play during tumorigenesis and tumor recurrence of GBM. GSC...

journal_title：Cancer letters

authors： Nakod PS,Kim Y,Rao SS

更新日期：2018-08-10 00:00:00

abstract：:Our purpose is to demonstrate the relationship between microvessel density (MVD), vascular cuffing (VC), vascular endothelial growth factor (VEGF) expression and clinicopathological parameters in ovarian cancer. Surgical specimens from 105 primary ovarian cancers were examined for vascularization and VEGF expression b...

journal_title：Cancer letters

authors： Ogawa S,Kaku T,Kobayashi H,Hirakawa T,Ohishi Y,Kinukawa N,Nakano H

更新日期：2002-02-08 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) patients with activating EGFR mutations are often successfully treated with EGFR tyrosine kinase inhibitor (TKI) such as erlotinib; however, treatment resistance inevitably occurs. Given tumor metabolism of glucose and therapeutic response are intimately linked, we explored the metab...

journal_title：Cancer letters

authors： Chiang CT,Demetriou AN,Ung N,Choudhury N,Ghaffarian K,Ruderman DL,Mumenthaler SM

更新日期：2018-10-10 00:00:00

abstract：:Curcumin, a major component of the Curcuma species, is known to have antioxidant, anti-inflammatory properties and induce apoptosis of cancer cells, however, the precise molecular mechanisms of apoptosis in vitro are unclear. In this study, we showed that curcumin, a plant product containing the phenolic phytochemical...

journal_title：Cancer letters

authors： Lin SS,Huang HP,Yang JS,Wu JY,Hsia TC,Lin CC,Lin CW,Kuo CL,Gibson Wood W,Chung JG

更新日期：2008-12-08 00:00:00

abstract：:Lysophosphatidic acid (LPA) receptors including LPA(1), LPA(2), and LPA(3) mediate lysophosphatidic acid signals. We analyzed the expression of LPA receptors, vascular endothelial growth factor (VEGF), and interleukin-8 in 97 patients from normal ovary to ovarian cancer, using reverse transcription polymerase chain re...

journal_title：Cancer letters

authors： Fujita T,Miyamoto S,Onoyama I,Sonoda K,Mekada E,Nakano H

更新日期：2003-03-31 00:00:00

abstract：:Triple-negative breast cancer (TNBC) treatment offers only limited benefits, and it is very relevant given the significant number of deaths that it causes. DNA repair pathways can enable tumor cells to survive DNA damage that is induced by chemotherapeutic or radiation treatments. Histone deacetylase inhibitors (HDACi...

journal_title：Cancer letters

authors： Wu YH,Hong CW,Wang YC,Huang WJ,Yeh YL,Wang BJ,Wang YJ,Chiu HW

更新日期：2017-08-01 00:00:00

abstract：:Cancer cells are derived from their precursor cells, which normally develop to the matured cells to form individual organs. Neuroblastoma, one of the most common pediatric solid tumors, originates from possible cancer stem cells derived from the neural crest. During the development, neural crest cells segregate into s...

journal_title：Cancer letters

authors： Nakagawara A,Ohira M

更新日期：2004-02-20 00:00:00

abstract：:The effect of a methyl substituent at the non-benzo ring bay-region position of benzo[e]pyrene (B[e]P), cholanthrene (CA) and dibenz[a,j]anthracene (DB[a,j]A) on skin tumor-initiating activity was examined. A methyl substituent at the 1-carbon of B[e]P enhanced tumor-initiating activity of the parent compound (0.18 vs...

journal_title：Cancer letters

authors： Sawyer TW,Chang K,Harvey RG,DiGiovanni J

更新日期：1987-09-01 00:00:00

abstract：:In order to study the interaction between cis-diamminedichloroplatinum(II) (CDDP) and representative human DNA in a highly defined manner, alphoid sequence DNA was isolated from two human parental cancer lines (one of head and neck squamous cell origin, SCC-25, and one of breast carcinoma origin, MCF-7) as well as fro...

journal_title：Cancer letters

authors： Chan V,Elliott KE,Herman TS,Teicher BA

更新日期：1988-12-15 00:00:00

abstract：:We have examined the effect of theanine, a specific amino acid in green tea, on idarubicin (IDA)-induced antitumor activity and toxicity. In combination with theanine, IDA (0.25 mg/kg per day x4 days, a dose that does not show antitumor activity) had significant antitumor activity in P388-bearing mice. The IDA concent...

journal_title：Cancer letters

authors： Sadzuka Y,Sugiyama T,Sonobe T

更新日期：2000-10-01 00:00:00

abstract：:Absent or altered differentiation is one of the major features of cancer cells. Histone deacetylases (HDACs) play a central role in the epigenetic regulation of gene expression. Aberrant activity of HDACs has been documented in several types of cancers, leading to the development of HDAC inhibitors (HDACi) as anti-tum...

journal_title：Cancer letters

authors： Botrugno OA,Santoro F,Minucci S

更新日期：2009-08-08 00:00:00

abstract：:As a promising method for local tumor treatment, nanosecond pulsed electric field (nsPEF) ablation elicits a potent anti-tumor immune response. However, the mechanism of the nsPEF-mediated anti-tumor immune response and its effects on the tumor microenvironment remains unclear. Here, we demonstrated that nsPEF treatme...

journal_title：Cancer letters

authors： Qian J,Chen T,Wu Q,Zhou L,Zhou W,Wu L,Wang S,Lu J,Wang W,Li D,Xie H,Su R,Guo D,Liu Z,He N,Yin S,Zheng S

更新日期：2020-12-28 00:00:00

abstract：:Paclitaxel (Taxol) is currently used as the front-line chemotherapeutic drug for many types of human cancers. However, the emergence of drug resistance has been a major obstacle to the effective treatment of cancers in clinical settings. The transcription factor Forkhead box protein C2 (FOXC2) was recently demonstrate...

journal_title：Cancer letters

authors： Zhou Z,Zhang L,Xie B,Wang X,Yang X,Ding N,Zhang J,Liu Q,Tan G,Feng D,Sun LQ

更新日期：2015-07-28 00:00:00

abstract：:Application of a single high dose of 7,12-dimethylbenz[a]anthracene (DMBA, 1 mg) or N-nitrosomethylurea (NMU, 0.4 mg) to the ears of either athymic nu/nu or phenotypically normal nu/+ mice (BALB/c background) resulted in the appearance of cutaneous sebaceous adenomas as well as squamous cell tumors, both at the site o...

journal_title：Cancer letters

authors： Rice JM,Anderson LM

更新日期：1986-12-01 00:00:00

abstract：:We have characterized the changes in composition of the nuclear matrix-intermediate filament complex (NM-IF) isolated from prostate cancer (PCa), compared with benign prostatic hyperplasia (BPH). We prepared the NM-IF from ten patients undergoing radical retropubic prostectomy; the benign hyperplastic tissue was obtai...

journal_title：Cancer letters

authors： Alberti I,Parodi S,Barboro P,Sanna P,Nicolò G,Allera C,Patrone E,Galli S,Balbi C

更新日期：1996-12-03 00:00:00