Abstract:
:The in vitro sensitivities to differentiating agents of a murine neuroblastoma cell line (N18) and a selected variant cell line (N18-LM5) were examined. In addition, the sensitivities to differentiating agents of cells from spontaneous metastases produced by N18 cells were examined. When N18 cells (1 X 10(5) cells/mouse) were injected into the lateral tail vein of syngeneic A/J mice, only a few metastatic nodules formed in the liver and lung, while similar injection of N18-LM5 cells produced larger numbers of metastatic nodules. Exposure of N18 cells to differentiating agents, such as dibutyryl cyclic 3':5'-AMP (db-cAMP), prostaglandin E1, and dexamethasone, resulted in induction of differentiation in terms of neurite extension. N18-LM5 cells responded to differentiating agents to a greater extent than N18 cells, and most of the cells extended neurites when they were exposed to 1 mM db-cAMP for 3 days. On the other hand, not all cell lines from spontaneous metastases produced by N18 cells responded to db-cAMP. These results suggest that the colonizing potential of neuroblastoma cells is not necessarily correlated with loss of responsiveness to differentiating agents and that various spontaneous metastases show heterogeneity in responsiveness to differentiating agents.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Takenaga Kdoi
10.1016/0304-3835(83)90133-7subject
Has Abstractpub_date
1983-05-01 00:00:00pages
41-6issue
1eissn
0304-3835issn
1872-7980pii
0304-3835(83)90133-7journal_volume
19pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract::The induction of differentiation of SENCAR murine granulocyte-macrophage precursor cells (GM-CFU) by the tumor-promoting phorbol diester 12-O--tetradecanoyl-phorbol-13-acetate (TPA) was inhibited by agents reported to inhibit specific aspects of arachidonic acid metabolism. These agents included phospholipase A2 inhib...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(87)90109-1
更新日期:1987-11-01 00:00:00
abstract::In situ markers for quantitative analysis of cell proliferation and apoptotic cell death have been used to evaluate both the proliferation level and net growth potential of preneoplastic nodules and malignant tumor tissues from rats experimentally induced for hepatocarcinogenesis by the dietary administration of 2-ace...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(96)04291-7
更新日期:1996-08-02 00:00:00
abstract::The identification of the breast cancer susceptibility genes BRCA1 and BRCA2 a few years ago has been greeted with great excitement and has raised hopes that they might illuminate the common mechanisms of this disease. Today we have to recognize that these expectations remain unfulfilled. Mutations in BRCA1 and BRCA2 ...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/s0304-3835(01)00752-2
更新日期:2002-01-10 00:00:00
abstract::Our purpose is to demonstrate the relationship between microvessel density (MVD), vascular cuffing (VC), vascular endothelial growth factor (VEGF) expression and clinicopathological parameters in ovarian cancer. Surgical specimens from 105 primary ovarian cancers were examined for vascularization and VEGF expression b...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(01)00754-6
更新日期:2002-02-08 00:00:00
abstract::The hepatitis B virus (HBV) is a major cause of hepatocellular carcinoma (HCC), partly driven by viral integration and specific oncogenic HBV variants. However, the biological significance of HBV genomes within lymphoid cells (i.e., peripheral blood mononuclear cells, PBMCs) is unclear. Here, we collected available pl...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2020.03.022
更新日期:2020-06-28 00:00:00
abstract::Human hepatoma Hep 3B cells underwent apoptosis in response to 100 microM all-trans retinoic acid (RA) in full serum (10% fetal calf serum) condition in vitro. Cell death began approximately 24 h following treatment, with more than 80% of the cells dead after 60 h. The dead cells, mainly detached cells, exhibited cond...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(96)04407-2
更新日期:1996-10-01 00:00:00
abstract::Butylated hydroxyanisole (BHA) was given to pregnant SPF pigs (Danish Landrace) in doses of 0, 50, 200 and 400 mg/kg body wt per day for 110 days. BHA was mixed in the diet (pelleted). Hyperkeratotic and parakeratotic proliferative changes of the stratified epithelium of the stomach were found at various degree in bot...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(83)90090-3
更新日期:1983-11-01 00:00:00
abstract::The analogs of benzidine were assay for mutagenicity using Salmonella typhimurium TA-98 and TA-100 and a mouse liver enzyme preparation. Only 4-aminobiphenyl produced both frameshift and base pair substitution mutations and 3,3'-dichlorobenzidine was the only compound which was mutagenic without the mammalian enzyme f...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(78)93137-3
更新日期:1978-01-01 00:00:00
abstract::We induced tolerance to hexadecylphosphocholine (HePC) in the human epidermoid tumor cell line, KB. After 70 weeks of adaptation, the IC50 of HePC in the resistant cells KBr was 32-fold higher than in parental KB cells, and they were 30-fold more resistant to another ether lipid analogue, ET-18-OCH3. The KBr cells als...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(99)00146-9
更新日期:1999-08-03 00:00:00
abstract::Up to a 50% rate of thyroid gland tumours was induced in Sprague-Dawley rats after s.c. administration of di-isopropanolnitrosamine (DIPN). The neoplasms occurred both unilaterally and bilaterally, and were identified histologically as adenomas and adenocarcinomas of follicular epithelium origin. In a few instances, a...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(77)80022-0
更新日期:1977-03-01 00:00:00
abstract::Telomeres constitute the ends of the linear eukaryotic chromosomes and are essential for the maintenance of chromosome stability and genome integrity. One of the consequences of an altered telomere structure is the formation of telomeric fusions (TFs), that is aberrant chromosomes in which two elements are fused at th...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2003.08.028
更新日期:2004-01-08 00:00:00
abstract::Currently, animal models are used to test the efficacy of tumor treatment. A significant reduction of tumor mass is lauded as great improvement. As we begin the 21st century, one wonders if this is sufficient and acceptable for cancer treatment. Although the presence of cancer stem cell (CSCs) is not a new phenomenon,...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2014.03.002
更新日期:2015-01-28 00:00:00
abstract::Viscum album L. (VAL) is a phytopreparation used in adjuvant cancer therapy with both immunostimulatory and DNA stabilizing properties at low drug concentrations and cytostatic/cytotoxic properties at higher concentrations. The present work examines the cytotoxic effects of VAL extracts produced from mistletoes grown ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(95)04038-2
更新日期:1996-01-19 00:00:00
abstract::HGT cells are a human gastric cell line derived from a tumour of the stomach. We have investigated the effects of lipoxygenase and cyclooxygenase metabolism inhibitors on HGT cell proliferation, on fatty acid composition of HGT cells and on the incorporation and distribution of arachidonic acid (AA) in HGT lipids. The...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(93)90189-g
更新日期:1993-09-15 00:00:00
abstract::By comparing protein profiles of nasopharyngeal carcinoma HONE1 cells to transformed nasopharyngeal epithelial NP 69 cells, several clusters of differentially expressed proteins were identified. The increased expression of cytokeratin 8 (CK8) and pyruvate kinase M2 was a common feature in four NPC cell lines compared ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2008.02.015
更新日期:2008-07-08 00:00:00
abstract::Mutations of Ki-ras and p53 genes in hepatocellular carcinomas (HCCs) induced by the choline deficient L-amino acid defined (CDAA) diet in rats were investigated by polymerase chain reaction (PCR), single strand conformation polymorphism (SSCP) analysis followed by direct sequencing. Male Fischer 344 rats, 6 weeks old...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(96)04405-9
更新日期:1996-11-12 00:00:00
abstract::Degradation of DNA produces deoxycytidine. Metabolism of deoxycytidine to dCTP inhibits phosphorylation of cytosine arabinoside (araC), fludarabine (FaraA) and 2-chlorodeoxyadenosine (CdA) by deoxycytidine kinase. This study measured plasma deoxycytidine in healthy adults and two leukemia patients and then determined ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(97)00185-7
更新日期:1997-06-24 00:00:00
abstract::Carcinogenic studies were performed on the skin of inbred male Lister rats using 7,12-dimethylbenz[alpha]anthracene (DMBA) in low doses (2.5 mg and 5.0 mg), followed by promotion with croton oil (CO) in one half of the animals. The clinically observed tumour rate did not differ after the two carcinogen doses and was p...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(92)90160-w
更新日期:1992-08-14 00:00:00
abstract::Prostate-specific membrane antigen (PSMA), an established enzyme-biomarker for prostate cancer, has attracted considerable attention as a target for imaging and therapeutic applications. We aimed to determine the effects of PSMA-targeted photodynamic therapy (PDT) on cytoskeletal networks in prostate cancer cells. PSM...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2010.04.003
更新日期:2010-10-01 00:00:00
abstract::The biological characteristic cell locomotion and invasion, melanin content, metalloproteinases and telomerase activity were studied in a parental mouse melanoma cell line B16 and two descendents B16BL6 and B16F10. The invasive potential of melanoma cells was assayed in a transwell cell culture chamber. Melanin conten...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(00)00656-x
更新日期:2001-01-01 00:00:00
abstract::Rectal biopsies and fecal collections were obtained from a consecutive series of 34 outpatients prior to colonoscopy at a gastroenterology clinic. Subsequently, 14 were found to have no colonic pathology, 13 had adenomatous polyps, (3 of those had a previous history of colon cancer) and 7 were diagnosed with colon can...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(88)90023-7
更新日期:1988-01-01 00:00:00
abstract::The current standard approach for assessing carcinogenic potential is to conduct a near lifetime rodent pathology study with the high dose set to the maximum tolerated dose (MTD) of the test chemical. The linearized multistage model is then used as the default approach to estimate the potential human cancer risk at en...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/0304-3835(95)03794-W
更新日期:1995-06-29 00:00:00
abstract::The susceptibility of pepsinogen-altered pyloric glands (PAPG) and neoplastic glandular stomach lesions induced by N-methyl-N-nitro-N-nitrosoguanidine (MNNG) and catechol or sodium cholate in Nagase analbuminemic rats (NAR) was compared to Sprague-Dawley rats (SD). Male NAR and SD rats were given a single dose of 80 m...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(95)03935-p
更新日期:1995-09-25 00:00:00
abstract::Isothiocyanates are found in cruciferous vegetables such as broccoli, Brussels sprouts, cauliflower, and cabbage. Epidemiologic studies suggest that cruciferous vegetable intake may lower overall cancer risk, including colon and prostate cancer. Sulforaphane (SFN) is an isothiocyanate found in cruciferous vegetables a...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2008.04.018
更新日期:2008-10-08 00:00:00
abstract::Bacteria are always a considerable tool for the cancer therapy. The bacteria-derived minicells are re-emerged as a promising drug delivery system for cancer therapy. The minicells are nano-sized, anucleated, non-dividing, and metabolically active cells produced by abnormal bacterial cell division that are able to tran...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2020.07.024
更新日期:2020-10-28 00:00:00
abstract::RNA interference (RNAi) is an evolutionary conserved mechanism for specific gene silencing. There are currently numerous cancer therapy clinical trials based on RNAi technology. Using an adenoviral system as a delivery mediator of RNAi, we investigated the therapeutic effects of targeting three genes simultaneously in...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2011.05.028
更新日期:2011-10-28 00:00:00
abstract::Telomerase, a critical enzyme responsible for continuous cell growth, is repressed in most somatic cells except proliferating progenitor cells and activated lymphocytes, and activated in approximately 85% of human cancer tissues. Telomerase activity is a useful cancer-cell detecting marker in some types of cancers in ...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/s0304-3835(02)00709-7
更新日期:2003-05-15 00:00:00
abstract::Neuroblastoma (NB) is a solid childhood tumour that exhibits heterogeneous biological and clinical phenotypes. Multiple drug resistance marks a major complication especially in high-risk patients with advanced tumour stages and specific genetic aberrations, such as MYCN amplification and lp deletion. As an approach to...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2006.09.010
更新日期:2007-05-18 00:00:00
abstract::Birt-Hogg-Dubé (BHD) syndrome is a rare inherited genodermatosis characterized by benign hamartomatous skin lesions and an increased risk of pneumothorax and renal tumors. Many of the patients harbor insertion/deletion mutations in the hypermutable poly(C)(8) tract in exon 11 of the BHD gene. This mutational hot spot ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2006.06.005
更新日期:2007-04-08 00:00:00
abstract::H. pylori infection causes gastritis, peptic ulcers and gastric cancer. Eradicating H. pylori prevents ulcers, but to what extent this prevents cancer remains unknown, especially if given after intestinal metaplasia has developed. H. pylori infected wild-type (WT) mice do not develop cancer, but mice lacking the tumor...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2015.01.028
更新日期:2015-04-10 00:00:00