Tumor induction by activated JNK occurs through deregulation of cellular growth.

abstract：:Rectal biopsies and fecal collections were obtained from a consecutive series of 34 outpatients prior to colonoscopy at a gastroenterology clinic. Subsequently, 14 were found to have no colonic pathology, 13 had adenomatous polyps, (3 of those had a previous history of colon cancer) and 7 were diagnosed with colon can...

journal_title：Cancer letters

authors： Stadler J,Yeung KS,Furrer R,Marcon N,Himal HS,Bruce WR

更新日期：1988-01-01 00:00:00

abstract：:Liposarcoma is one of the most common soft tissue sarcomas in adults. Recognized histological subtypes include well differentiated/dedifferentiated liposarcoma (WD/DDLS), myxoid liposarcoma (MLS) and pleomorphic liposarcoma. Currently, there are no proper subtype-specific treatments due to the genetic, histological an...

journal_title：Cancer letters

authors： Steinmann S,Gali-Muhtasib H,Huebner K,Al-Halabi R,Abou Merhi R,Aman P,Agaimy A,Haller F,Schneider-Stock R

更新日期：2015-10-28 00:00:00

abstract：:In our joint project in the search for anti-tumor promoters from natural plant sources, we carried out a primary screening of 12 phenylpropanoids isolated from Boronia pinnata Sm. (Rutaceae) by examining their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradeca...

journal_title：Cancer letters

authors： Ito C,Itoigawa M,Furukawa H,Ichiishi E,Mukainaka T,Okuda M,Ogata M,Tokuda H,Nishino H

更新日期：1999-07-19 00:00:00

abstract：:A hitherto unreported lactate dehydrogenase (LD) isoenzyme, which migrates electrophoretically to the relative position between LD2 and LD3 has been identified in the electropheratogram in 7 of 7 (100%) cultured hepatoma cell lines with various degrees of differentiation and is thus given the name LD2-3. LD2-3 seems t...

journal_title：Cancer letters

authors： Liu TZ,Chen PY,Chiu DT,Wei JS,Chang KS,Lin KH

更新日期：1994-12-09 00:00:00

abstract：:Over the last decade the linkage between hyperthermia, heat shock proteins and fever with the body's immune system has been well investigated. The immunomodulatory function of hyperthermia has been found to be quite sensitively regulated by temperature, as different levels of heating can bring different modulatory eff...

journal_title：Cancer letters

authors： Zhang HG,Mehta K,Cohen P,Guha C

更新日期：2008-11-28 00:00:00

abstract：:Twenty-seven patients with malignant teratoma, 19 of which received radiation, are presented and the radiation response analyzed. Radiotherapy seems most effective in the palliation of undifferentiated (embryonal) teratoma of the gonads and sacrococcygeal region in early childhood. It is less effective, yet useful, in...

journal_title：Cancer letters

authors： Pantoja E,Roswit B

更新日期：1975-11-01 00:00:00

abstract：:Activation of telomerase by the induction of a full-length telomerase reverse transcriptase (hTERT) transcript is a critical step during cellular immortalization and malignant transformation. Telomerase activity or hTERT expression has thus served as diagnostic and/or prognostic markers in different types of human mal...

journal_title：Cancer letters

authors： Li W,Li L,Liu Z,Liu C,Liu Z,Strååt K,Björkholm M,Jia J,Xu D

更新日期：2008-02-18 00:00:00

abstract：:Potassium bromate (KBrO(3)) is a rat renal carcinogen and a major drinking water disinfection by-product in water disinfected with ozone. Clear cell renal tumors, the most common form of human renal epithelial neoplasm, are rare in animals but are inducible by KBrO(3) in F344 rats. Detection of cytoplasmic periodic ac...

journal_title：Cancer letters

authors： Shiao YH,Kamata SI,Li LM,Hooth MJ,DeAngelo AB,Anderson LM,Wolf DC

更新日期：2002-12-10 00:00:00

abstract：:The aim of this study was to clarify candidate peptides for peptide-based specific immunotherapy of patients with oral squamous cell carcinoma (SCC). Thirteen peptides were examined for in vitro induction of peptide-specific CD8(+) T lymphocyte (CD8(+)TL) activity in peripheral blood mononuclear cells from 35 patients...

journal_title：Cancer letters

authors： Toyoshima T,Kumamaru W,Hayashida JN,Moriyama M,Kitamura R,Tanaka H,Yamada A,Itoh K,Nakamura S

更新日期：2012-09-01 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) play critical roles in multiple cellular processes in non-small cell lung cancer (NSCLC); however, the involvement of lncRNAs in the transforming growth factor-beta (TGFβ) signaling pathway, the critical tumor cell epithelial-mesenchymal transition (EMT) and metastasis pathway, remains p...

journal_title：Cancer letters

authors： Lu Z,Li Y,Che Y,Huang J,Sun S,Mao S,Lei Y,Li N,Sun N,He J

更新日期：2018-09-28 00:00:00

abstract：:Conditioned medium from a series of human breast cancer cell lines representing the phenotypes of estrogen dependence ZR-75-1, MCF-7), tamoxifen resistance (Z(+)-75-9a1, LY2) and estrogen independence (ZR-PR-Lt) contained four detectable insulin-like growth factor binding proteins (IGFBPs) of MW 24, 34, 44 and 70 kDa....

journal_title：Cancer letters

authors： McCotter D,van den Berg HW,Boylan M,McKibben B

更新日期：1996-02-06 00:00:00

abstract：:AKT is a promising target for anticancer drug development. In this work, a bioinformatics approach was applied to search for AKT inhibitors based on the correlation analysis between phospho-Ser473 AKT expression level and the antiproliferative data of NCI small molecule compounds against NCI 60 cancer cell lines, the ...

journal_title：Cancer letters

authors： Zhang M,Fang X,Liu H,Guo R,Wu X,Li B,Zhu F,Ling Y,Griffith BN,Wang S,Yang D

更新日期：2007-07-18 00:00:00

abstract：:The bmi-1 gene was identified as a common proviral integration site in Moloney murine leukemia virus. In the present studies, we cloned and sequenced the rat bmi-1 gene by reverse transcriptase-polymerase chain reaction (RT-PCR) using degenerate PCR primers of homologous sequences between mouse and human. We found 93%...

journal_title：Cancer letters

authors： Osaka M,Koami K,Sugiyama T

更新日期：1998-11-13 00:00:00

abstract：:Serum beta-glucuronidase activity is shown to differ quantitatively in the following strains of mice, listed in order of increasing activity: C3H, C57BL/6 less than BALB/c, DBA/2, ICR less than SENCAR, A/He. The level of the enzyme in the murine strains is shown to correlate with the urinary excretion of 17-ketosteroi...

journal_title：Cancer letters

authors： Walaszek Z,Hanausek-Walaszek M,Webb TE

更新日期：1986-10-01 00:00:00

abstract：:An increase in the levels of oxidation is a universal feature of genomic DNA of irradiated or aged or even malignant cells. In case of apoptotic death of stressed cells, oxidized DNA can be released in circulation (cfDNA). According to the results of the studies performed in vitro by our group and other researchers, t...

journal_title：Cancer letters

authors： Glebova K,Veiko N,Kostyuk S,Izhevskaya V,Baranova A

更新日期：2015-01-01 00:00:00

abstract：:Since Shh pathway effector, Gli1, is overexpressed in gliomas, we investigated the effect of novel Shh inhibitor SANT-1 on glioma cell viability. Though SANT-1 failed to induce apoptosis, it reduced proliferation of glioma stem-like cells. Apart from canonical Shh cascade, Gli1 is also induced by non-canonical pathway...

journal_title：Cancer letters

authors： Dixit D,Ghildiyal R,Anto NP,Ghosh S,Sharma V,Sen E

更新日期：2013-08-19 00:00:00

abstract：:Epstein-Barr virus (EBV) is known to be linear in viral particles but EBV circularizes into an episomal form after infection. Recently, the presence of integrated EBV DNA has been reported. We investigated EBV integration into the human genome in EBV-associated disease using Southern blotting. One hundred four cases i...

journal_title：Cancer letters

authors： Ohshima K,Suzumiya J,Kanda M,Kato A,Kikuchi M

更新日期：1998-01-09 00:00:00

abstract：:Corynebacterium parvum was investigated in the response of rat Mc7 sarcoma to local waterbath hyperthermia. Heat treatment of 1-1.5 cm3 foot tumors at 43 degrees C for 2 h resulted in complete regression of 71% of the tumors. The Mc7 cure was reduced to 31% when the tumors were heated at 43 degrees C for 1.5 h. C. par...

journal_title：Cancer letters

authors： Shah SA

更新日期：1985-03-01 00:00:00

abstract：:Substantial evidence from epidemiological studies supports the inverse association between the intake of fruits, vegetables and other plant products and cancer incidence. Cancer-preventive constituents of fruits and vegetables may inhibit carcinogen activation, enhance carcinogen detoxification, prevent carcinogens fr...

journal_title：Cancer letters

authors： Tatman D,Mo H

更新日期：2002-01-25 00:00:00

abstract：:Several classes of plant polyphenols namely, flavonoids, chalcones and coumarins exhibited varying degrees of inhibition on the cell proliferation of human colon adenocarcinoma cell line 220.1. At the highest concentration tested (100 microM), many of the chalcones showed > 100% growth inhibition and their order of po...

journal_title：Cancer letters

authors： Yit CC,Das NP

更新日期：1994-07-15 00:00:00

abstract：:We describe an optimized systematic screen of known kinases using osteosarcoma cell lines (KHOS and U-2OS) and a lentiviral-based short hairpin RNA (shRNA) human kinase library. CellTiter 96(R)AQueous One Solution Cell Proliferation Assay was used to measure cell growth and survival. We identified several kinases, inc...

journal_title：Cancer letters

authors： Duan Z,Ji D,Weinstein EJ,Liu X,Susa M,Choy E,Yang C,Mankin H,Hornicek FJ

更新日期：2010-07-28 00:00:00

abstract：:3beta-Methoxyserrat-14-en-21beta-ol (1) and 3alpha-methoxyserrat-14-en-21beta-ol (2) are the most abundant triterpenoids from two Picea plants, Picea jezoensis (Sieb. et Zucc.) Carr. var. jezoensis and P. jezoensis (Sieb. et Zucc.) Carr. hondoensis (Mayr) Rehder, and the total yield of 1 and 2 reach over 1/3 of the ch...

journal_title：Cancer letters

authors： Tanaka R,Shanmugasundaram K,Yamaguchi C,Ishikawa Y,Tokuda H,Nishide K,Node M

更新日期：2004-10-28 00:00:00

abstract：:Interstitial fluid pressure was measured by the wick-in-needle technique in DMBA-induced rat mammary tumours during resting conditions and during noradrenaline infusion. The rate of infusion was chosen to increase the systemic blood pressure by 30-40 mmHg, known to result in a markedly increased vascular resistance of...

journal_title：Cancer letters

authors： Tveit E,Hultborn R,Weiss L

更新日期：1985-07-01 00:00:00

abstract：:Recent clinical studies have indicated that intra-tumoral gene expression levels of 5-fluorouracil (5-FU) metabolism-related enzymes may predict the clinical response of several cancers to 5-FU-based chemotherapy. However, few studies examining oral squamous cell carcinomas (OSCCs) have been reported. In this study, w...

journal_title：Cancer letters

authors： Tateishi Y,Tatemoto Y,Ohno S,Morishita K,Ueta E,Yamamoto T

更新日期：2009-02-18 00:00:00

abstract：:Angiogenesis remains a sensible target for pancreatic ductal adenocarcinoma (PDAC) therapy. VEGF, PDGF, FGF and their receptors are expressed at high levels and correlate with poor prognosis in human PDAC. Nintedanib is a triple angiokinase inhibitor that targets VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β signaling. We invest...

journal_title：Cancer letters

authors： Awasthi N,Hinz S,Brekken RA,Schwarz MA,Schwarz RE

更新日期：2015-03-01 00:00:00

abstract：:Jade family PHD finger 3 (JADE3) plays a role in inducing histone acetylation during transcription, and is involved in the progression of several human cancers; however, its role in colon cancer remains unclear. Herein, we found that JADE3 was markedly upregulated in colon cancer tissues and significantly correlated w...

journal_title：Cancer letters

authors： Jian Y,Wang M,Zhang Y,Ou R,Zhu Z,Ou Y,Chen X,Liang X,Ding Y,Song L,Xu X,Liao W

更新日期：2018-08-01 00:00:00

abstract：:Tumor angiogenesis is a critical step for the growth and metastasis of solid tumors. Vascular endothelial growth factor (VEGF) is the most important angiogenic molecule associated with tumor-induced neovascularization. VEGF exerts its activity through binding to its receptor tyrosine kinase, KDR/Flk-1, expressed on th...

journal_title：Cancer letters

authors： Lee SJ,Lee HM,Ji ST,Lee SR,Mar W,Gho YS

更新日期：2004-05-10 00:00:00

abstract：:Malachite green (MG), an industrial compound and potential environmental health hazard, is highly cytotoxic to mammalian cells in culture. In an attempt to define the biochemical basis, we have compared the cytotoxic effects and morphological alterations shown by MG in Syrian hamster embryo (SHE) cells with the levels...

journal_title：Cancer letters

authors： Panandiker A,Fernandes C,Rao KV

更新日期：1992-12-24 00:00:00

abstract：:The vast majority of cancer deaths are caused by the formation of metastases rather than the primary tumor itself. Despite this clinical importance, the molecular and cellular events that support the dissemination of cancer cells are not yet fully unraveled. We have previously shown that CDX2, a homeotic transcription...

journal_title：Cancer letters

authors： Platet N,Hinkel I,Richert L,Murdamoothoo D,Moufok-Sadoun A,Vanier M,Lavalle P,Gaiddon C,Vautier D,Freund JN,Gross I

更新日期：2017-02-01 00:00:00

abstract：:The mechanism of DDB (dimethyl 4,4'-dimethoxy-5,6,5',6'-dimethylenedioxy biphenyl-2,2'-dicarboxylate) prevention of aflatoxin B1 (AFB1)-induced hepatotoxicity in rats has been investigated. Pretreatment of DDB (200 mg/kg) daily for 4 days significantly suppressed (P < 0.05) the AFB1-induced hepatic damage as evidenced...

journal_title：Cancer letters

authors： Liu TY,Hwua YS,Chao TW,Chi CW

更新日期：1995-03-02 00:00:00