Changes in insulin-like growth factor-I receptor expression and binding protein secretion associated with tamoxifen resistance and estrogen independence in human breast cancer cells in vitro.


:Conditioned medium from a series of human breast cancer cell lines representing the phenotypes of estrogen dependence ZR-75-1, MCF-7), tamoxifen resistance (Z(+)-75-9a1, LY2) and estrogen independence (ZR-PR-Lt) contained four detectable insulin-like growth factor binding proteins (IGFBPs) of MW 24, 34, 44 and 70 kDa. in the tamoxifen resistant lines secretion of the 24 kDA IGFBP was depressed in comparison to the parent lines whilst secretion of the 44 kDa IGFBP was unaffected. Secretion of this species by ZR-PR-LT cells was reduced. Following incubation in medium containing 1% serum both tamoxifen resistant cell lines secreted higher levels of the 44 kDa IGFBP than the respective parent lines. These changes in IGFBP secretion associated with the development of tamoxifen resistance and estrogen independence were accompanied by changes in the expression of receptors for IGF-1.


Cancer Lett


Cancer letters


McCotter D,van den Berg HW,Boylan M,McKibben B




Has Abstract


1996-02-06 00:00:00














  • Identification of novel genes associated with the response to 5-FU treatment in gastric cancer cell lines using a cDNA microarray.

    abstract::The 5-Fluorouracil (5-FU) is an anticancer drug that is widely used in the treatment of cancer. To identify novel genes associated with 5-FU in gastric cancer, the time-dependent expression profiling of genes in response to 5-FU was examined in 5-FU sensitive and/or resistant gastric cancer cell lines using a 'KUGI 14...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Park JS,Young Yoon S,Kim JM,Yeom YI,Kim YS,Kim NS

    更新日期:2004-10-08 00:00:00

  • Reactive oxygen species-mediated kinase activation by dihydrotanshinone in tanshinones-induced apoptosis in HepG2 cells.

    abstract::The role of reactive oxygen species (ROS) and p38 mitogen-activated protein kinases (MAPK) in tanshinones-induced apoptosis was investigated in HepG2 cells in this study. The major tanshinones (cryptotanshinone, dihydrotanshinone, tanshinone I, tanshinone IIA), isolated from Salvia miltiorrhiza, inhibit cell growth an...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Lee WY,Liu KW,Yeung JH

    更新日期:2009-11-18 00:00:00

  • Epigallocatechin-3-gallate effectively attenuates skeletal muscle atrophy caused by cancer cachexia.

    abstract::Cachexia, also known as wasting syndrome notably with skeletal muscle atrophy, costs nearly one-third of all cancer deaths in man. (-)-Epigallocatechin-3-gallate (EGCG), the principal polyphenolic component in green tea, is a potent preventive against cachexia as well as cancers. However, how EGCG counteracts cachexia...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Wang H,Lai YJ,Chan YL,Li TL,Wu CJ

    更新日期:2011-06-01 00:00:00

  • Targeting LRP8 inhibits breast cancer stem cells in triple-negative breast cancer.

    abstract::Triple-negative breast cancer (TNBC) is the most difficult subtype of breast cancer to treat due to a paucity of effective targeted therapies. Many studies have reported that breast cancer stem cells (BCSCs) are enriched in TNBC and are responsible for chemoresistance and metastasis. In this study, we identify LRP8 as...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Lin CC,Lo MC,Moody R,Jiang H,Harouaka R,Stevers N,Tinsley S,Gasparyan M,Wicha M,Sun D

    更新日期:2018-12-01 00:00:00

  • Chemopreventative activity of crude hydroxymatairesinol (HMR) extract in Apc(Min) mice [corrected].

    abstract::We studied the effects of a lignan, hydroxymatairesinol (HMR), and rye bran on intestinal tumor development in adenomatous polyposis colimultiple intestinal neoplasia (Apc)(Min) mice. HMR showed a strong chemopreventive effect in this animal model. The mean number of adenomas in the small intestine was significantly l...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Oikannen SI,Pajari AM,Mutanen M

    更新日期:2000-10-31 00:00:00

  • Binding of adult T-cell leukemia virus to various hematopoietic cells.

    abstract::A newly found human retrovirus, adult T-cell leukemia virus (ATLV) was shown by means of membrane immunofluorescence to bind to various hematopoietic cells including T-, B- and non-T, non-B-cell lines. Partially purified viral gp46 from culture fluids of ATL virus producer lines also bound efficiently to an ATLV-negat...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Yamamoto N,Chosa T,Koyanagi Y,Tochikura T,Schneider J,Hinuma Y

    更新日期:1984-01-01 00:00:00

  • An novel inhibitor of TGF-β type I receptor, IN-1130, blocks breast cancer lung metastasis through inhibition of epithelial-mesenchymal transition.

    abstract::TGF-β signaling plays an important role in breast cancer progression and metastasis. Epithelial-mesenchymal transition (EMT) is an important step in the progression of solid tumors to metastatic disease. We previously reported that IN-1130, a novel transforming growth factor-β type I receptor kinase (ALK5) inhibitor, ...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Park CY,Min KN,Son JY,Park SY,Nam JS,Kim DK,Sheen YY

    更新日期:2014-08-28 00:00:00

  • The metabolic landscape of urological cancers: New therapeutic perspectives.

    abstract::Deregulation of cell metabolism is an established cancer hallmark that contributes to tumor initiation and progression, as well as tumor heterogeneity. In solid tumors, alterations in different metabolic pathways, including glycolysis, pentose phosphate pathway, glutaminolysis and fatty acid metabolism, support the hi...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审


    authors: Miranda-Gonçalves V,Lameirinhas A,Henrique R,Baltazar F,Jerónimo C

    更新日期:2020-05-01 00:00:00

  • Marked elevation of hypusine formation activity on eukaryotic initiation factor 5A in v-HA-RAS transformed mouse NIH3T3 cells.

    abstract::Hypusine formation on the eukaryotic initiation factor 5A (eIF-5A) precursor is ubiquitously present in eukaryotic cells and archebacteria. In this reaction, deoxyhypusine synthase catalyzes the conversion of one unique lysine residue on eIF-5A to deoxyhypusine using spermidine as the substrate. Hydroxylation of the d...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Chen ZP,Chen KY

    更新日期:1997-05-19 00:00:00

  • Comparison of the antiproliferative effects of transforming growth factor-beta, N,N-dimethylformamide and retinoic acid on a human colon carcinoma cell line.

    abstract::In this study we have compared the anti-proliferative effects of transforming growth factor-beta (TGF-beta), N,N-dimethylformamide (DMF) and retinoic acid (RA) on a moderately-differentiated colon carcinoma cell line (JVC). TGF-beta, DMF and RA inhibited the anchorage-independent growth and induced morphological chang...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Hoosein NM,Brattain DE,McKnight MK,Childress KE,Chakrabarty S,Brattain MG

    更新日期:1988-06-15 00:00:00

  • Effect of methylazoxymethanol acetate on adenylate cyclase and 5'-nucleotidase in rat liver plasma membranes.

    abstract::A single tumorigenic dose of methylazoxymethanol acetate increased adenylate cyclase activity in total liver homogenates 70-100% by the seventh day after treatment. The increased activity occurred in the plasma membranes rather than in the nuclei and was accompanied by a significant increase in 5'-nucleotidase activit...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Zedeck MS,Swislocki NI

    更新日期:1975-11-01 00:00:00

  • Further investigations into the effect of non-benzo ring bay-region methyl substituents on tumor-initiating activity of polycyclic hydrocarbons.

    abstract::The effect of a methyl substituent at the non-benzo ring bay-region position of benzo[e]pyrene (B[e]P), cholanthrene (CA) and dibenz[a,j]anthracene (DB[a,j]A) on skin tumor-initiating activity was examined. A methyl substituent at the 1-carbon of B[e]P enhanced tumor-initiating activity of the parent compound (0.18 vs...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Sawyer TW,Chang K,Harvey RG,DiGiovanni J

    更新日期:1987-09-01 00:00:00

  • Staurosporine inhibits the proliferation, alters the cell cycle distribution and induces apoptosis in HT-29 human colon adenocarcinoma cells.

    abstract::Staurosporine (ST), a potent inhibitor of protein kinase C (PKC), was evaluated for its effect on the proliferation of HT-29 colon adenocarcinoma cells; PKC is associated with increased colon cell proliferation. ST inhibited cell proliferation in a time- and concentration-dependent manner by up to 90%. It also blocked...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Qiao L,Koutsos M,Tsai LL,Kozoni V,Guzman J,Shiff SJ,Rigas B

    更新日期:1996-10-01 00:00:00

  • Reversal of drug resistance in breast carcinoma cells by anti-mdr1 ribozyme regulated by the tumor-specific MUC-1 promoter.

    abstract::Multidrug resistance (MDR) is a serious obstacle for cancer chemotherapy. The aim of this study was to reverse MDR of breast carcinoma cells specifically by degrading mdr1 mRNA with anti-mdr1 ribozyme. Our strategy was to limit the expression of ribozyme to only breast-derived cells, but not other type of cells. The r...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Gao P,Zhou GY,Guo LL,Zhang QH,Zhen JH,Fang AJ,Lin XY

    更新日期:2007-10-18 00:00:00

  • Effect of glucocorticoids on TPA-induced inhibition of gap-junctional communication and morphological transformation in Syrian hamster embryo cells.

    abstract::The effect of glucocorticoids on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inhibition of gap-junctional intercellular communication (GJIC) and morphological transformation in Syrian hamster embryo (SHE) cells was examined. Fluocinolone acetonide (FA) and dexamethasone (DEX) almost completely suppressed the ef...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Roseng LE,Rivedal E

    更新日期:1993-08-16 00:00:00

  • Inhibition of transforming growth factor-beta/Smad signaling by phosphatidylinositol 3-kinase pathway.

    abstract::Gastrin-releasing peptide (GRP) activates phosphatidylinositol 3-kinase (PI3-K)/Akt, an important cell survival signaling pathway, to stimulate growth of various cell types. Transforming growth factor (TGF) superfamily ligands activate intracellular Smad signaling to regulate cell growth, differentiation and apoptosis...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Qiao J,Kang J,Ko TC,Evers BM,Chung DH

    更新日期:2006-10-28 00:00:00

  • Metabolic adaptation in hypoxia and cancer.

    abstract::The ability of tumor cells to adapt to changes in oxygen tension is essential for tumor development. Low oxygen concentration influences cellular metabolism and, thus, affects proliferation, migration, and invasion. A focal point of the cell's adaptation to hypoxia is the transcription factor HIF1α (hypoxia-inducible ...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Paredes F,Williams HC,San Martin A

    更新日期:2021-01-11 00:00:00

  • Overexpression of DLC-1 induces cell apoptosis and proliferation inhibition in the renal cell carcinoma.

    abstract::The lack of effective anti-tumor therapy for renal cell carcinoma (RCC) has stimulated the search for novel target whose inhibition could block tumorigenesis. Recently, reduced DLC-1 has been shown to be associated with aggressive and highly metastatic renal cell carcinoma. In this study, the biological role of DLC-1 ...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Zhang T,Zheng J,Jiang N,Wang G,Shi Q,Liu C,Lu Y

    更新日期:2009-09-28 00:00:00

  • Epigenetic silencing of chemokine CCL2 represses macrophage infiltration to potentiate tumor development in small cell lung cancer.

    abstract::Highly invasive and rapidly fatal, small-cell lung cancer (SCLC) has been an insurmountable gulf since discovery. Innate immunity plays a vital role in anti-tumor response, among which macrophages contribute to an indispensable character. Here, we found that macrophage infiltration in SCLC reduced significantly in a s...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Zheng Y,Wang Z,Wei S,Liu Z,Chen G

    更新日期:2021-02-28 00:00:00

  • Abnormal expression, highly efficient detection and novel truncations of midkine in human tumors, cancers and cell lines.

    abstract::We detected aberrant Midkine (MK) expressions in human insulinoma and pancreatic cancer tissues by immunohistochemistry, revealing its potential role in tumorigenesis/carcinogenesis. With a nested-touchdown PCR program we were able to detect the tMK in all human tumor/cancer tissues and cancer/tumor cell lines. Detect...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Tao P,Xu D,Lin S,Ouyang GL,Chang Y,Chen Q,Yuan Y,Zhuo X,Luo Q,Li J,Li B,Ruan L,Li Q,Li Z

    更新日期:2007-08-08 00:00:00

  • The glycosylation state of the precursors of the cathepsin B-like proteinase from human malignant ascitic fluid: possible implication in the secretory pathway of these proenzymes.

    abstract::We have investigated the structure of the carbohydrate moiety of the precursors of the cathepsin B-like proteinase (PCBt). The largest precursor has an apparent molecular size (Mr) of 45-47 Kd and it contains 3 N-linked oligosaccharide chains which were Endo beta N acetylglucosaminidase H (Endo H)-resistant forms. On ...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Pagano M,Dalet-Fumeron V,Engler R

    更新日期:1989-04-01 00:00:00

  • Human hepatocellular carcinoma: expression profiles-based molecular interpretations and clinical applications.

    abstract::Primary liver cancer is the fifth most common cancer worldwide and hepatocellular carcinoma (HCC) accounts for over 85% of all primary liver cancers. The clinical management of advanced and metastatic HCC is challenging on many counts. Besides largely occurs within a background of underlying chronic liver disease and ...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审


    authors: Hui KM

    更新日期:2009-12-01 00:00:00

  • Prevention of spontaneous and chemically induced carcinogenesis using activated carbon fiber adsorbent. III. Inhibitory effect of the activated carbon fiber adsorbent 'Aqualen' on 1,2-dimethylhydrazine-induced intestinal carcinogenesis in rats.

    abstract::Two-month-old outbred female LIO rats were exposed weekly to 15 (experiment I, groups 1, 2 and 3) or to 5 (experiment II, groups 4, 5 and 6) subcutaneous injections of 1,2-dimethylhydrazine (DMH) at a single dose of 21 mg/kg of body weight. From the day of the first injection of the carcinogen, the rats from groups 2,...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Anisimov VN,Zabezhinski MA,Popovich IG,Berstein LM,Kovalenko IG,Lieberman AI,Shmidt JL

    更新日期:1999-04-26 00:00:00

  • Interferon (IFN)-beta induces apoptotic cell death in DHL-4 diffuse large B cell lymphoma cells through tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).

    abstract::The effect of interferon (IFN)-alpha, beta and gamma on the growth of DHL-4 diffuse large B cell lymphoma cells was studied. IFN-beta significantly inhibited the cell growth, and the effect was stronger than that of IFN-alpha. IFN-gamma did not inhibit the cell growth because of lack of IFN-gamma receptors. IFN-beta c...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Oehadian A,Koide N,Mu MM,Hassan F,Islam S,Yoshida T,Yokochi T

    更新日期:2005-07-08 00:00:00

  • Increased susceptibility of the c-Myc overexpressing cell line, SNU-16, to TNF-alpha.

    abstract::Tumor necrosis factor-alpha (TNF-alpha) is a macrophage-derived multifunctional cytokine that acts as a cytostatic or cytotoxic agent in many tumor cells. However, the molecular mechanisms by which tumor cells become sensitive to the cytotoxic action of TNF-alpha are not clear. In this study we demonstrated that the c...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Park IC,Park MJ,Lee SH,Choe TB,Jang JJ,Hong SI

    更新日期:1998-03-13 00:00:00

  • Garlic and associated allyl sulfur components inhibit N-methyl-N-nitrosourea induced rat mammary carcinogenesis.

    abstract::Our previous studies demonstrated that dietary garlic powder supplementation inhibits N-nitrosamine induced DNA alkylation in liver and mammary tissue. The present studies compared the impact of dietary supplementation with garlic powder or two garlic constituents, water-soluble S-allyl cysteine (SAC) and oil-soluble ...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Schaffer EM,Liu JZ,Green J,Dangler CA,Milner JA

    更新日期:1996-04-19 00:00:00

  • Immunotherapy for pancreatic cancer: A long and hopeful journey.

    abstract::Multiple therapeutic strategies have been developed to treat pancreatic cancer. However, the outcomes of these approaches are disappointing. Due to deeper understandings of the pivotal roles of the immune system in pancreatic cancer tumorigenesis and progression, novel therapeutic strategies based on immune cells and ...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审


    authors: Xu JW,Wang L,Cheng YG,Zhang GY,Hu SY,Zhou B,Zhan HX

    更新日期:2018-07-01 00:00:00

  • Reprogramming metabolism by histone methyltransferase NSD2 drives endocrine resistance via coordinated activation of pentose phosphate pathway enzymes.

    abstract::Metabolic reprogramming such as the aerobic glycolysis or Warburg effect is well recognized as a common feature of tumorigenesis. However, molecular mechanisms underlying metabolic alterations for tumor therapeutic resistance are poorly understood. Through gene expression profiling analysis we found that histone H3K36...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Wang J,Duan Z,Nugent Z,Zou JX,Borowsky AD,Zhang Y,Tepper CG,Li JJ,Fiehn O,Xu J,Kung HJ,Murphy LC,Chen HW

    更新日期:2016-08-10 00:00:00

  • Rectal epithelial proliferation characteristics of first degree relatives of sporadic colon cancer patients.

    abstract::Hyperproliferation of rectal epithelium is characteristic of families at high genetic risk for large bowel neoplasia, but has not been well-documented in families of sporadic colorectal cancer patients. This was studied in 119 such first degree relatives and 44 comparison subjects without this family history. All scre...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Rozen P,Fireman Z,Fine N,Chetrit A,Lubin F

    更新日期:1990-05-30 00:00:00

  • Quantitative analysis of changes in cell proliferation and apoptosis during preneoplastic and neoplastic stages of hepatocarcinogenesis in rat.

    abstract::In situ markers for quantitative analysis of cell proliferation and apoptotic cell death have been used to evaluate both the proliferation level and net growth potential of preneoplastic nodules and malignant tumor tissues from rats experimentally induced for hepatocarcinogenesis by the dietary administration of 2-ace...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Kong J,Ringer DP

    更新日期:1996-08-02 00:00:00