Changes in insulin-like growth factor-I receptor expression and binding protein secretion associated with tamoxifen resistance and estrogen independence in human breast cancer cells in vitro.


:Conditioned medium from a series of human breast cancer cell lines representing the phenotypes of estrogen dependence ZR-75-1, MCF-7), tamoxifen resistance (Z(+)-75-9a1, LY2) and estrogen independence (ZR-PR-Lt) contained four detectable insulin-like growth factor binding proteins (IGFBPs) of MW 24, 34, 44 and 70 kDa. in the tamoxifen resistant lines secretion of the 24 kDA IGFBP was depressed in comparison to the parent lines whilst secretion of the 44 kDa IGFBP was unaffected. Secretion of this species by ZR-PR-LT cells was reduced. Following incubation in medium containing 1% serum both tamoxifen resistant cell lines secreted higher levels of the 44 kDa IGFBP than the respective parent lines. These changes in IGFBP secretion associated with the development of tamoxifen resistance and estrogen independence were accompanied by changes in the expression of receptors for IGF-1.


Cancer Lett


Cancer letters


McCotter D,van den Berg HW,Boylan M,McKibben B




Has Abstract


1996-02-06 00:00:00














  • Epigenetic biomarkers in skin cancer.

    abstract::Epigenetic aberrations have been associated with cutaneous melanoma tumorigenesis and progression including dysregulated DNA gene promoter region methylation, histone modification, and microRNA. Several of these major epigenetic aberrations have been developed into biomarkers. Epigenetic biomarkers can be detected in ...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审


    authors: Greenberg ES,Chong KK,Huynh KT,Tanaka R,Hoon DS

    更新日期:2014-01-28 00:00:00

  • Oncogene regulation of endonuclease activation in apoptosis.

    abstract::Recent work has demonstrated that oncogenes and tumor suppressor proteins regulate apoptotic cell death. Current efforts are therefore directed at determining how they exert their effects. It appears that oncogenes can control activation of the apoptosis endonuclease(s) either by regulating the signal(s) that trigger ...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: McConkey DJ,Fernandez A,Trent J 2nd,Ananthaswamy HN

    更新日期:1995-07-20 00:00:00

  • Recent advances in strategies for overcoming hypoxia in photodynamic therapy of cancer.

    abstract::The selectivity of photodynamic therapy (PDT) derived from the tailored accumulation of photosensitizing drug (photosensitizer; PS) in the tumor microenvironment (TME), and from local irradiation, turns it into a "magic bullet" for the treatment of resistant tumors without sparing the healthy tissue and possible adver...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Pucelik B,Sułek A,Barzowska A,Dąbrowski JM

    更新日期:2020-11-01 00:00:00

  • Fibronectin concentration in the plasma of patients with malignant and benign breast disease.

    abstract::Fibronectin concentration was determined in plasma from 97 patients with benign or malignant breast disease and from 62 controls. Median plasma fibronectin concentration (microgram FN/ml plasma) appeared to be significantly higher in patients with non-metastatic or metastatic breast cancer as compared to age-matched c...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Boccardo F,Guarneri D,Zanardi S,Castellani P,Borsi L,Zardi L

    更新日期:1986-12-01 00:00:00

  • Variability of origin for the neocentromeric sequences in analphoid supernumerary marker chromosomes of well-differentiated liposarcomas.

    abstract::Well-differentiated liposarcomas (WDLPS) and dedifferentiated liposarcomas are cytogenetically characterized by the presence of supernumerary ring or giant chromosomes containing amplified material from the 12q14-15 region. These chromosomes contain neocentromeres, which are able to bind the kinetochore proteins and t...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Italiano A,Maire G,Sirvent N,Nuin PA,Keslair F,Foa C,Louis C,Aurias A,Pedeutour F

    更新日期:2009-01-18 00:00:00

  • Determination of cytotoxicity in vivo using 111indium-labeled human tumor cells.

    abstract::Loss of radioactivity from nude mice was determined after inoculation of human tumor cells prelabeled with [111In]indium oxine (111InOx). Elimination of 111In was increased somewhat by treating the mice with diphtheria toxin (DT), which is toxic selectively for human cells compared to mice. Calcium disodium edetate (C...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Lockshin A,Giovanella BC,Kozielski T,Stehlin JS Jr

    更新日期:1984-09-01 00:00:00

  • Adaptations of energy metabolism during cerebellar neurogenesis are co-opted in medulloblastoma.

    abstract::Recent studies show that metabolic patterns typical of cancer cells, including aerobic glycolysis and increased lipogenesis, are not unique to malignancy, but rather originate in physiologic development. In the postnatal brain, where sufficient oxygen for energy metabolism is scrupulously maintained, neural progenitor...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审


    authors: Tech K,Deshmukh M,Gershon TR

    更新日期:2015-01-28 00:00:00

  • Mutations in the VHL gene from potassium bromate-induced rat clear cell renal tumors.

    abstract::Potassium bromate (KBrO(3)) is a rat renal carcinogen and a major drinking water disinfection by-product in water disinfected with ozone. Clear cell renal tumors, the most common form of human renal epithelial neoplasm, are rare in animals but are inducible by KBrO(3) in F344 rats. Detection of cytoplasmic periodic ac...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Shiao YH,Kamata SI,Li LM,Hooth MJ,DeAngelo AB,Anderson LM,Wolf DC

    更新日期:2002-12-10 00:00:00

  • Establishment of a new human pancreatic cancer cell line, NOR-P1, with high angiogenic activity and metastatic potential.

    abstract::We present here a new cell line, NOR-P1, established from a metastatic subcutaneous tumor of a patient with pancreatic cancer. The cells show rapid growth in culture with a doubling time of 16 h and high migration activity. Genetic and molecular analyses revealed high telomerase activity and a mutation in the K-ras on...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Sato N,Mizumoto K,Beppu K,Maehara N,Kusumoto M,Nabae T,Morisaki T,Katano M,Tanaka M

    更新日期:2000-07-31 00:00:00

  • The influence of chemical carcinogens on natural killer cell function in rats. A comparison of 2-acetylaminofluorene with 4-acetylaminofluorene.

    abstract::The influence of the carcinogen 2-acetylaminofluorene (2AAF) administration on splenic natural killer (NK) cell function in two strains of rats has been examined and compared with that of the non-carcinogenic analogue 4-acetylaminofluorene (4AAF). In both strains it was observed that daily exposure to 25 mg kg-1 2AAF ...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Kimber I,Griffin AC,Jones K

    更新日期:1986-01-01 00:00:00

  • Characterization and utilization of two novel anti-erbB-2 monoclonal antibodies in detection of soluble ErbB-2 for breast cancer prognosis.

    abstract::We generated three anti-ErbB-2 monoclonal antibodies (mAbs) by using surface-epitope masking method (SEM method). They were characterized and shown to recognize the extracellular domain (ECD) of ErbB-2 specifically. In order to detect ErbB-2 in the sera of breast cancer patients, we used two of them: A18 and A21 to de...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Li P,Li Y,Li JY,Liu J

    更新日期:2003-04-25 00:00:00

  • Hyperthermia enhances tumor necrosis factor alpha-induced apoptosis of a human gastric cancer cell line.

    abstract::We have investigated the effects of hyperthermia on the apoptosis induced by tumor necrosis factor alpha (TNF-alpha). Confluent monolayers of human gastric cancer cell line MKN45 were either treated or untreated with hyperthermia for 1 h. The cells were subsequently stimulated with TNF-alpha. A 24-h incubation with TN...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Kokura S,Yoshida N,Ueda M,Imamoto E,Ishikawa T,Takagi T,Naito Y,Okanoue T,Yoshikawa T

    更新日期:2003-11-10 00:00:00

  • Synergistic cytotoxic effect of human recombinant tumor necrosis factor alpha combined with dihydroambazone.

    abstract::Dihydroambazone (DHA) is a water-soluble derivative of the experimental anticancer drug ambazone. In vitro, a combination of DHA and human recombinant tumor necrosis factor alpha (TNF) exerted a strong synergism of cytotoxicity against both mouse melanoma B16K cells and the TNF-sensitive mouse fibroblast line L-M (S)....

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Baumgart J,Gase K,Schulze W,Suehnel J,Gutsche W,Behnke D

    更新日期:1990-11-05 00:00:00

  • Significant allelic loss of ANX7region (10q21) in hormone receptor negative breast carcinomas.

    abstract::Loss of heterozygosity (LOH) in the 10q21 region that harbors the tumor suppressor gene ANX7-GTPase gene have been found in 35% of prostate tumors. Therefore, the rationale for this study is that this gene could also be implicated in breast pathogenesis as well. We investigated allelic losses in microsatellites of the...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Leighton X,Srikantan V,Pollard HB,Sukumar S,Srivastava M

    更新日期:2004-07-16 00:00:00

  • Coding polymorphisms in Casp5, Casp8 and DR4 genes may play a role in predisposition to lung cancer.

    abstract::Apoptosis plays a role in the elimination of DNA-damaged cells thus protecting the host from cancer development. Some data indicate that normal variations within the sequence of apoptotic genes may lead to suboptimal apoptotic capacity and therefore increased cancer risk. We tested 19 coding apoptotic gene SNPs in 2-s...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Ulybina YM,Kuligina ES,Mitiushkina NV,Rozanov ME,Ivantsov AO,Ponomariova DN,Togo AV,Levchenko EV,Shutkin VA,Brenister SI,Devilee P,Zhivotovsky B,Hirvonen A,Imyanitov EN

    更新日期:2009-06-18 00:00:00

  • Modification of a transplantable colon tumor and immune responses in mice fed different sources of protein, fat and carbohydrate.

    abstract::The effects of different sources of dietary protein, fat and carbohydrate on tumor development and on tests relating to cell-mediated immunity were investigated in male BALB/c mice after subcutaneous injection of 8 X 10(4) 1,2-dimethylhydrazine (DMH)-induced colon tumor (no. 51) cells. Results indicated that mice fed ...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Nutter RL,Gridley DS,Kettering JD,Andres ML,Aprecio RM,Slater JM

    更新日期:1983-02-01 00:00:00

  • Obesity promotes colonic stem cell expansion during cancer initiation.

    abstract::There is an urgent need to elucidate the mechanistic links between obesity and colon cancer. Convincing evidence for the role of Lgr5(+) stem cells in colon tumorigenesis has been established; however, the influence of obesity on stem cell maintenance is unknown. We assessed the effects of high fat (HF) feeding on col...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: DeClercq V,McMurray DN,Chapkin RS

    更新日期:2015-12-28 00:00:00

  • The expression of the myc proto-oncogene in a dimethylsulfoxide resistant HL-60 cell line.

    abstract::A cell line partially resistant to dimethylsulfoxide (DMSO) was derived from the HL-60 cell line. Cycloleucine, theophylline, sodium butyrate and elevated levels of DMSO were found to induce myeloid differentiation in this cell line while TPA induced monocytic differentiation. The levels of myc RNA and the genomic str...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Grosso LE,Pitot HC

    更新日期:1984-02-01 00:00:00

  • Reactive oxygen species-independent G1 arrest induced by evening primrose extract in Ehrlich ascites tumor cells.

    abstract::We previously demonstrated that evening primrose extract (EPE) induced apoptosis in Ehrlich ascites tumor cells (EATC), and this effect was specific on tumor cells. Furthermore, our results demonstrated that EPE exposure elicited a rapid increase in the activity of superoxide dismutase and intracellular peroxides leve...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Arimura T,Kojima-Yuasa A,Kennedy DO,Matsui-Yuasa I

    更新日期:2004-04-15 00:00:00

  • MicroRNA-135b acts as a tumor promoter by targeting the hypoxia-inducible factor pathway in genetically defined mouse model of head and neck squamous cell carcinoma.

    abstract::Here in, we investigated the mechanism underlying overexpression of miR-135b in the human head and neck squamous cell carcinoma (HNSCC) cell lines and in the HNSCC mouse model. Exogenous expression of miR-135b in these cell lines increased cell proliferation, migration, and colony formation. Gene silencing analysis re...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Zhang L,Sun ZJ,Bian Y,Kulkarni AB

    更新日期:2013-05-01 00:00:00

  • Frequent ras gene mutations in squamous cell cervical cancer.

    abstract::Eighty samples of cervical invasive squamous cell carcinoma were examined for ras gene mutations using polymerase chain reaction (PCR) followed by restriction enzyme digestion. We found 28 (35%) cervical cancers contained ras mutations at H-ras codon 12, 49 (61%) at K-ras codon 12, and 5 (6%) at K-ras codon 13. There ...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Wong YF,Chung TK,Cheung TH,Lam SK,Xu YG,Chang AM

    更新日期:1995-08-16 00:00:00

  • Multi-microarray identifies lower AQP9 expression in adjuvant chemotherapy nonresponders with stage III colorectal cancer.

    abstract::Approximately 25% of stage III colorectal cancer patients do not benefit from standard adjuvant chemotherapies. To identify biomarkers for nonresponders, fresh-frozen tissues of 19 nonresponders and 16 responders were analyzed with gene expression and microRNA arrays. Fifty-nine genes and 17 miRNAs were differentially...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Dou R,Deng Y,Huang L,Fu S,Tan S,Wang L,Lian L,Fang L,Fan X,Jin G,Liu H,Wang J

    更新日期:2013-08-09 00:00:00

  • Carcinogenesis by methylbenzylnitrosamine near the squamocolumnar junction and methylamylnitrosamine metabolism in the mouse forestomach.

    abstract::We repeated and extended a 1973 study by Sander and Schweinsberg on forestomach tumorigenesis in mice by methylbenzylnitrosamine (MBZN). Groups of 80 adult CD-1 mice of both sexes received 96 mg/kg of MBZN subdivided into 24 doses of 4 mg/kg, 12 doses of 8 mg/kg or 6 doses of 16 mg/kg (groups 1-3, respectively). The m...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Schneider P,Hinrichs S,Zulim R,Towery R,Morris C,Mirvish SS

    更新日期:1996-04-19 00:00:00

  • P-glycoprotein expression by human colonic tumor cells influences the growth of tumor cells in vitro.

    abstract::The stability of P-glycoprotein expression by high and low expressing cells obtained by flow sorting from two cell lines established from colonic tumors was assessed. Low expressing cells rapidly recovered expression to a level that was comparable to that determined for uncloned cells. High expressing cells maintained...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Frommel TO

    更新日期:1995-08-01 00:00:00

  • Decreased [20-3H]phorbol-12,13-dibutyrate binding to phospholipase C pretreated epidermal cells.

    abstract::Incubation of mouse epidermal cells (HEL-37) with phospholipase C (Clostridium perfringens) caused about a 50% decrease in the specific binding of [20-3H]phorbol-12,13-dibutyrate. Phospholipase C caused a decrease in the apparent number of binding sites from 2.86 X 10(5) to 1.21 X 10(5) per cell with little effect on ...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Jones MJ,Murray AW

    更新日期:1983-05-01 00:00:00

  • Effect of sex and age on rectal cell renewal in humans.

    abstract::We evaluated the influence of age and sex on rectal cell proliferation of 69 hospital controls and 66 patients with colorectal adenomas, by means of incubation of rectal biopsies with tritiated thymidine and autoradiography. In particular, we evaluated the labeling frequency in the upper 40% of rectal crypts (0 h), ac...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Paganelli GM,Santucci R,Biasco G,Miglioli M,Barbara L

    更新日期:1990-09-01 00:00:00

  • Specificity of photosensitizer accumulation in undifferentiated versus differentiated colon carcinoma cells.

    abstract::The relationship between tumor cell differentiation and photosensitizer accumulation used in PDT is poorly defined. In the present work, specific cell differentiation of colon carcinoma CT26 cells induced by sodium butyrate was manifested by morphological changes, proliferation and protein expression and was correlate...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Siboni G,Amit-Patito I,Weizman E,Waintraub-Porat M,Weitman H,Ehrenberg B,Malik Z

    更新日期:2003-06-30 00:00:00

  • Metastasis of breast tumor cells to brain is suppressed by targeting RLIP alone and in combination with 2'-Hydroxyflavanone.

    abstract::Brain metastasis is an important cause of morbidity and mortality in cancer-patients. Breast tumor cells frequently metastasize to brain and initiate severe therapeutic complications. In the present study, we evaluated the anti-metastatic effects of 2'-hydroxyflavanone (2HF) alone and in combination with RLIP targeted...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Singhal J,Singhal P,Horne D,Salgia R,Awasthi S,Singhal SS

    更新日期:2018-12-01 00:00:00

  • p53 accumulation in the organs of low-dose X-ray-irradiated mice.

    abstract::In order to search for the direct evidence of cellular response to low-dose radiation, we investigated wild-type p53 protein accumulation in several organs of mice after exposure to low doses of X-rays. Significant p53 accumulation within 24 h was observed in the mouse adrenal glands and pancreas after X-ray irradiati...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Wang X,Matsumoto H,Takahashi A,Nakano T,Okaichi K,Ihara M,Ohnishi T

    更新日期:1996-06-24 00:00:00

  • beta-Catenin, Nf-kappaB and FAS protein expression are independent events in head and neck cancer: study of their association with clinical parameters.

    abstract::In spite of much effort, no good markers have yet been found for predicting prognosis or response to therapy in advanced head and neck squamous cell carcinoma (HNSCCs) patients. beta-catenin, a protein involved in the cytoskeleton, cell-cell adhesion and gene transcription, is a factor associated with tumour progressi...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Rodriguez-Pinilla M,Rodriguez-Peralto JL,Hitt R,Sanchez JJ,Sanchez-Verde L,Alameda F,Ballestin C,Sanchez-Cespedes M

    更新日期:2005-12-08 00:00:00