1,2,3,4,6-Penta-O-galloyl-beta-D-glucose blocks endothelial cell growth and tube formation through inhibition of VEGF binding to VEGF receptor.

abstract：:Previously, we had reviewed 43 cases of invasive cancers, adenosquamous cell carcinoma and adenocarcinoma for HPV type infections. With the same cases we extended the investigation to cytomegalovirus (CMV) and herpes simplex virus (HSV) infections. Results show that the prevalence of CMV and HSV infections from these ...

journal_title：Cancer letters

authors： Han CP,Tsao YP,Sun CA,Ng HT,Chen SL

更新日期：1997-12-09 00:00:00

abstract：:The human multidrug resistance ABC transporters provide a protective function in our body against a large number of toxic compounds. These proteins, residing in the plasma membrane, perform an active, ATP-dependent extrusion of such xenobiotics. However, the same proteins are also used by the tumor cells to fight vari...

journal_title：Cancer letters

authors： Cervenak J,Andrikovics H,Ozvegy-Laczka C,Tordai A,Német K,Váradi A,Sarkadi B

更新日期：2006-03-08 00:00:00

abstract：:Cisplatin is an anticancer agent that is effective against several types of cancer, including gastric cancer. However, its therapeutic application is limited by its toxicity in normal tissues and complications caused in patients. In this study, we attempted to clarify how triptolide, an active component extracted from...

journal_title：Cancer letters

authors： Li CJ,Chu CY,Huang LH,Wang MH,Sheu LF,Yeh JI,Hsu HY

更新日期：2012-06-28 00:00:00

abstract：:Normal tissue injury may lead to severe, life threatening, late side effects after therapeutic use of irradiation. Neurological complications caused by radiation of the spinal cord are ascribed to progressive, irreversible damage to the vasculature. Hyperbaric oxygen (HBO) is known to induce angiogenesis in irradiated...

journal_title：Cancer letters

authors： Sminia P,van der Kleij AJ,Carl UM,Feldmeier JJ,Hartmann KA

更新日期：2003-02-28 00:00:00

abstract：:Naturally occurring fecal mutagens, called fecapentaenes, are hypothesized to contribute to large bowel carcinogenesis. To understand health risks it is necessary to relate fecal mutagen concentrations to intestinal pathologies, i.e. colon cancer. However, fast and reliable methods for analysis of stool for fecapentae...

journal_title：Cancer letters

authors： Kleinjans JC,Pluijmen MH,Hageman GJ,Verhagen H

更新日期：1989-01-01 00:00:00

abstract：:Toxicity reduction of cisplatin is necessary for improved treatment of cancer. Here we have demonstrated the synergistic growth-inhibitory effect of cisplatin on cervical cancer cells in-combination with a nontoxic herbal carbazole alkaloid, mahanine. Mahanine enhanced cisplatin-induced apoptosis and reduced its effec...

journal_title：Cancer letters

authors： Das R,Bhattacharya K,Samanta SK,Pal BC,Mandal C

更新日期：2014-08-28 00:00:00

abstract：:Rectal biopsies and fecal collections were obtained from a consecutive series of 34 outpatients prior to colonoscopy at a gastroenterology clinic. Subsequently, 14 were found to have no colonic pathology, 13 had adenomatous polyps, (3 of those had a previous history of colon cancer) and 7 were diagnosed with colon can...

journal_title：Cancer letters

authors： Stadler J,Yeung KS,Furrer R,Marcon N,Himal HS,Bruce WR

更新日期：1988-01-01 00:00:00

abstract：:It is now increasingly evident that the immune system represents a barrier to tumor emergence, growth, and recurrence. Although this idea was originally proposed almost 50 years ago as the "immune surveillance hypothesis", it is commonly recognized that, with few rare exceptions, tumor cells always prevail. Thus, one ...

journal_title：Cancer letters

authors： Rodvold JJ,Mahadevan NR,Zanetti M

更新日期：2016-09-28 00:00:00

abstract：:Sorafenib has been used as a clinical targeted therapy for hepatocellular carcinoma (HCC) for more than a decade. In 2017, regorafenib was approved for HCC treatment and has since been reported to prolong the survival of advanced HCC patients after treatment failure with sorafenib. However, there has been no direct sy...

journal_title：Cancer letters

authors： Liu S,Du Y,Ma H,Liang Q,Zhu X,Tian J

更新日期：2019-07-01 00:00:00

abstract：:Despite being the subject of extensive research and clinical trials, neuroblastoma remains a major therapeutic challenge in pediatric oncology. The p53 protein is a central safeguard that protects cells against genome instability and malignant transformation. Mutated TP53 (the gene encoding p53) is implicated in many ...

journal_title：Cancer letters

authors： Zafar A,Wang W,Liu G,Xian W,McKeon F,Zhou J,Zhang R

更新日期：2021-01-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha) is a macrophage-derived multifunctional cytokine that acts as a cytostatic or cytotoxic agent in many tumor cells. However, the molecular mechanisms by which tumor cells become sensitive to the cytotoxic action of TNF-alpha are not clear. In this study we demonstrated that the c...

journal_title：Cancer letters

authors： Park IC,Park MJ,Lee SH,Choe TB,Jang JJ,Hong SI

更新日期：1998-03-13 00:00:00

abstract：:Berberine, an isoquinoline alkaloid, has a wide range of pharmacological effects, including anti-inflammation, yet the exact mechanism is unknown. Because cyclooxygenase-2 (COX-2) plays a key role in prostaglandins (PGs) synthesis, which is elevated in inflammation, we examined whether the anti-inflammatory mechanism ...

journal_title：Cancer letters

authors： Kuo CL,Chi CW,Liu TY

更新日期：2004-01-20 00:00:00

abstract：:Vaccines containing synthetic peptides derived from tumor-associated antigens (TAA) can elicit potent cytotoxic T lymphocyte (CTL) response if they are formulated in an optimal vaccine delivery system. The aim of this study was to develop a simple and effective lipid-based vaccine delivery system using P5 HER2/neu-der...

journal_title：Cancer letters

authors： Shariat S,Badiee A,Jalali SA,Mansourian M,Yazdani M,Mortazavi SA,Jaafari MR

更新日期：2014-12-01 00:00:00

abstract：:Many members of BCL2 (Bcl-2) apoptosis-related genes were found to be differentially expressed in various malignancies and were proposed as prognostic cancer biomarkers. Recently, a new member of the BCL2 gene family, BCL2L12, was cloned and was found to be expressed in mammary gland. In the present study, 55 specimen...

journal_title：Cancer letters

authors： Thomadaki H,Talieri M,Scorilas A

更新日期：2007-03-08 00:00:00

abstract：:Rituximab is the first anti-cancer antibody approved by the FDA for the treatment of B-cell lymphoma. However, its efficacy remains variable and often modest. Some patients are initially unresponsive to rituximab or later develop resistance to it, and require alternative therapies. Rituximab activity has been thought ...

journal_title：Cancer letters

authors： Lv M,Lin Z,Qiao C,Gen S,Lang X,Li Y,Feng J,Shen B

更新日期：2010-08-01 00:00:00

abstract：:The mutagenic effects of chamuvaritin, dihydrobenzylchalcone isolated from Uvaria chamae, were investigated using Salmonella typhimurium tester strains TA92, TA94--98, TA100--1535, TA1537 and TA1538. The phytochemical was mutagenic in tester strains TA98 and TA100 and required activation by the hepatic S-9 microsomal ...

journal_title：Cancer letters

authors： Uwaifo AO,Okorie DA,Bababunmi EA

更新日期：1979-11-01 00:00:00

abstract：:Chemoresistance remains the major obstacle to achieve optimal prognosis in gastric cancer patients, and the underlying molecular mechanisms of cancer-associated fibroblasts (CAFs) in gastric cancer chemoresistance remain poorly understood. We identified the high pretherapeutical serum IL-8 level in gastric cancer pati...

journal_title：Cancer letters

authors： Zhai J,Shen J,Xie G,Wu J,He M,Gao L,Zhang Y,Yao X,Shen L

更新日期：2019-07-10 00:00:00

abstract：:FOY-305 is a synthetic serine protease inhibitor and ONO-3403 and FO-349 are its derivatives. The effects of these compounds on the proliferation of 13 human neuroblastoma cell lines were investigated in vitro by MTT colorimetric assay. The half maximum inhibition concentrations of ONO-3403 varied between 22 and 90 mi...

journal_title：Cancer letters

authors： Hiwasa T,Kondo K,Nakagawara A,Ohkoshi M

更新日期：1998-04-24 00:00:00

abstract：:G protein-coupled oestrogen receptor 1 (GPER1), predicted to be a novel oestrogen receptor, has been linked to the development and progression of breast cancer. However, the molecular mechanisms underlying its functions remain elusive. Here, we show that the protein levels of GPER1 are negatively associated with those...

journal_title：Cancer letters

authors： Zhang N,Sun P,Xu Y,Li H,Liu H,Wang L,Cao Y,Zhou K,TinghuaiWang

更新日期：2021-02-01 00:00:00

abstract：:Effects of eight heterocyclic amines (HCAs) on pancreatic duct carcinogenesis were investigated in a rapid production model in hamsters. N-Nitrosobis(2-oxopropyl)amine (BOP) was given to effect initiation, followed by augmentation pressure consisting of four daily i.p. injections of 500 mg/kg DL-ethionine, a choline-d...

journal_title：Cancer letters

authors： Yoshimoto M,Tsutsumi M,Iki K,Sasaki Y,Tsujiuchi T,Sugimura T,Wakabayashi K,Konishi Y

更新日期：1999-09-01 00:00:00

abstract：:Gastric adenocarcinoma and esophageal adenocarcinoma are aggressive cancers with a poor prognosis. Therefore, new therapeutic strategies are needed, especially for patients refractory to conventional treatment. Cancer immunotherapy (CIT), is a promising new treatment option and is effective in a proportion of patients...

journal_title：Cancer letters

authors： Koemans WJ,Chalabi M,van Sandick JW,van Dieren JM,Kodach LL

更新日期：2019-02-01 00:00:00

abstract：:Glucosinolates constitute a well-defined group of secondary plant metabolites in cruciferous plants. They occur especially in brassica vegetables, which represent a major part of the human diet. Glucosinolates undergo hydrolysis, catalysed by an endogenous plant enzyme, known as myrosinase, into a range of biological ...

journal_title：Cancer letters

authors： Verkerk R,van der Gaag MS,Dekker M,Jongen WM

更新日期：1997-03-19 00:00:00

abstract：:We have investigated the effects of interferon-alpha (IFN-alpha) and 5-fluorouracil (5-FU) on meningioma cells in two different culture systems, evaluated by the uptake of radiolabelled methionine. With both IFN-alpha and 5-FU an inhibitory effect on the uptake of radiolabelled methionine by the meningioma cells was d...

journal_title：Cancer letters

authors： Zhang ZJ,Wang JL,Muhr C,Smits A

更新日期：1996-02-27 00:00:00

abstract：:The majority of ovarian cancer (OC) patients recur with a platinum-resistant disease. OC cells activate adaptive resistance mechanisms that are only partially described. Here we show that OC cells can adapt to chemotherapy through a positive-feedback loop that favors chemoresistance. In platinum-resistant OC cells we ...

journal_title：Cancer letters

authors： Tocci P,Cianfrocca R,Sestito R,Rosanò L,Di Castro V,Blandino G,Bagnato A

更新日期：2020-11-01 00:00:00

abstract：:The effects of treatment with naturally occurring antioxidants, selenium, beta-carotene, ferulic acid, esculin and eugenol during the promotional phase of tumor development were investigated in male F344 rats pre-treated with 1,2-dimethylhydrazine (DMH) and 1-methyl-1-nitrosourea (MNU). Animals were given 3 subcutaneo...

journal_title：Cancer letters

authors： Imaida K,Hirose M,Yamaguchi S,Takahashi S,Ito N

更新日期：1990-11-19 00:00:00

abstract：:The binding of [14C] azaserine or its metabolites to DNA and protein in the organs of rats and hamsters was determined at various time after treatment with [14C] azaserine. The specific activity of 14C labelling of DNA and protein was determined. Rat liver DNA and protein were most extensively labelled at 90 min post-...

journal_title：Cancer letters

authors： Zurlo J,Coon CI,Longnecker DS,Curphey TJ

更新日期：1982-05-01 00:00:00

abstract：:The age-standardized mortality rates by sex for cancer of all sites and some specific sites were calculated in the 22 areas of Rosario (Argentina). The rates by area were correlated with education, occupation, housing quality and population density, applying Kendall's tau. Cervical cancer rates showed the strongest co...

journal_title：Cancer letters

authors： Poletto L,Morini JC

更新日期：1990-03-01 00:00:00

abstract：:An apoptosis-inducing protein with molecular weight of 60 kDa has been purified from fetal bovine serum. The N-terminal amino acid sequence of this protein (e.g. I-P-L-D-P-V-A-G-Y-K) reveals that it is bovine fetuin, a fetal protein functioning to control embryogenesis. The apoptosis-inducing activity of fetuin is tot...

journal_title：Cancer letters

authors： Yu CL,Tsai MH

更新日期：2001-05-26 00:00:00

abstract：:Human promyelocytic leukemia cells (HL-60) were found to be induced by dimethylsulfoxide and several other compounds to phagocytize, reduce NBT dye, and change into forms that were morphologically similar to granulocytes and macrophages. Arginase also induced these differentiation-associated properties of the cells. T...

journal_title：Cancer letters

authors： Honma Y,Fujita Y,Okabe-Kado J,Kasukabe T,Hozumi M

更新日期：1980-10-01 00:00:00

abstract：:Midkine (MK) is a heparin binding growth factor identified as a product of a retinoic acid-responsive gene; it is frequently expressed at high levels in many human carcinomas. Although the expression of the mRNA encoding truncated MK (tMK) in unique human cancer cells has been reported, the tMK polypeptide itself has ...

journal_title：Cancer letters

authors： Paul S,Mitsumoto T,Yamamoto I,Shinozawa T

更新日期：2001-02-26 00:00:00