Synergistic inhibitory effects of interferon-alpha and 5-fluorouracil in meningioma cells in vitro.

Abstract:

:We have investigated the effects of interferon-alpha (IFN-alpha) and 5-fluorouracil (5-FU) on meningioma cells in two different culture systems, evaluated by the uptake of radiolabelled methionine. With both IFN-alpha and 5-FU an inhibitory effect on the uptake of radiolabelled methionine by the meningioma cells was demonstrated, and we found a synergistic inhibitory effect with a combination of IFN-alpha and 5-FU. To obtain a maximal inhibition of cell metabolism without causing cell toxicity, we were able to decrease the dose of 5-FU by simultaneously adding IFN-alpha. Our results suggest that a combined treatment of IFN-alpha and 5-FU may be a successful alternative for patients with inoperable meningiomas. A novel in vitro positron emission tomography technique was used for the study of metabolic changes in tumour cells caused by drug treatment, which is complementary to conventional cell culture techniques.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Zhang ZJ,Wang JL,Muhr C,Smits A

doi

10.1016/0304-3835(95)04076-5

subject

Has Abstract

pub_date

1996-02-27 00:00:00

pages

99-105

issue

1-2

eissn

0304-3835

issn

1872-7980

pii

0304-3835(95)04076-5

journal_volume

100

pub_type

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