Synergistic inhibitory effects of interferon-alpha and 5-fluorouracil in meningioma cells in vitro.


:We have investigated the effects of interferon-alpha (IFN-alpha) and 5-fluorouracil (5-FU) on meningioma cells in two different culture systems, evaluated by the uptake of radiolabelled methionine. With both IFN-alpha and 5-FU an inhibitory effect on the uptake of radiolabelled methionine by the meningioma cells was demonstrated, and we found a synergistic inhibitory effect with a combination of IFN-alpha and 5-FU. To obtain a maximal inhibition of cell metabolism without causing cell toxicity, we were able to decrease the dose of 5-FU by simultaneously adding IFN-alpha. Our results suggest that a combined treatment of IFN-alpha and 5-FU may be a successful alternative for patients with inoperable meningiomas. A novel in vitro positron emission tomography technique was used for the study of metabolic changes in tumour cells caused by drug treatment, which is complementary to conventional cell culture techniques.


Cancer Lett


Cancer letters


Zhang ZJ,Wang JL,Muhr C,Smits A




Has Abstract


1996-02-27 00:00:00














  • Lactate dehydrogenase 5: an old friend and a new hope in the war on cancer.

    abstract::A hallmark of most cancer cells is an altered metabolism involving a shift to aerobic glycolysis with lactate production coupled with a higher uptake of glucose as the main source of energy. Lactate dehydrogenase 5 (LDH-5) catalyzes the reduction of pyruvate by NADH to form lactate, thus determining the availability o...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审


    authors: Augoff K,Hryniewicz-Jankowska A,Tabola R

    更新日期:2015-03-01 00:00:00

  • Avemar, a nontoxic fermented wheat germ extract, induces apoptosis and inhibits ribonucleotide reductase in human HL-60 promyelocytic leukemia cells.

    abstract::Avemar (MSC) is a nontoxic fermented wheat germ extract demonstrated to significantly improve the survival rate in patients suffering from various malignancies. We investigated its effects in human HL-60 promyelocytic leukemia cells. After 24, 48, and 72 h of incubation, Avemar inhibited the growth of HL-60 cells with...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Saiko P,Ozsvar-Kozma M,Madlener S,Bernhaus A,Lackner A,Grusch M,Horvath Z,Krupitza G,Jaeger W,Ammer K,Fritzer-Szekeres M,Szekeres T

    更新日期:2007-06-08 00:00:00

  • Expression of the inhibitor of apoptosis protein survivin in benign meningiomas.

    abstract::Survivin is a recently characterised inhibitor of apoptosis protein that has been implicated in the pathogenesis of several types of solid organ cancer. This study sought to describe the expression of survivin in a cohort of 90 benign meningiomas, together with the pattern of expression of other genes involved in the ...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Das A,Tan WL,Smith DR

    更新日期:2003-04-25 00:00:00

  • Cancer stem cells in osteosarcoma.

    abstract::Osteosarcoma is the most common primary bone tumour in children and adolescents and advanced osteosarcoma patients with evidence of metastasis share a poor prognosis. Osteosarcoma frequently gains resistance to standard therapies highlighting the need for improved treatment regimens and identification of novel therape...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审


    authors: Brown HK,Tellez-Gabriel M,Heymann D

    更新日期:2017-02-01 00:00:00

  • Repurposing metformin, simvastatin and digoxin as a combination for targeted therapy for pancreatic ductal adenocarcinoma.

    abstract::Patients with pancreatic adenocarcinoma (PDAC) have a 5-year survival rate of 8%, the lowest of any cancer in the United States. Traditional chemotherapeutic regimens, such as gemcitabine- and fluorouracil-based regimens, often only prolong survival by months. Effective precision targeted therapy is therefore urgently...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Liu SH,Yu J,Creeden JF,Sutton JM,Markowiak S,Sanchez R,Nemunaitis J,Kalinoski A,Zhang JT,Damoiseaux R,Erhardt P,Brunicardi FC

    更新日期:2020-10-28 00:00:00

  • Functional Smoothened is required for expression of GLI3 in colorectal carcinoma cells.

    abstract::We investigated a role for Hedgehog signalling in colon cancer by studying transcription of members of the pathway in human colorectal carcinoma cell lines. We determined the methylation status and screened the gene encoding the Hedgehog receptor-associated protein Smoothened (SMO) for putative mutations. In three cel...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Zhu Y,James RM,Peter A,Lomas C,Cheung F,Harrison DJ,Bader SA

    更新日期:2004-04-30 00:00:00

  • α integrin targeting for radiosensitization of three-dimensionally grown human head and neck squamous cell carcinoma cells.

    abstract::Integrin cell adhesion molecules play a crucial role in tumor cell resistance to radio- and chemotherapy and are therefore considered attractive targets for cancer therapy. Here, we assessed the role of β1 integrin-interacting α integrin subunits in more physiological three-dimensional extracellular matrix grown head ...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Steglich A,Vehlow A,Eke I,Cordes N

    更新日期:2015-02-28 00:00:00

  • Glutathione S-transferase-placental form expression and proliferation of hepatocytes in fumonisin B1-treated male and female Sprague-Dawley rats.

    abstract::Fumonisin B1 (FB1), a mycotoxin produced by a common corn contaminant Fusarium moniliforme and a hepatocarcinogen in rats, has been previously suggested to act as a poor initiator, but a better promoter of gamma-glutamyltranspeptidase (GGT)-positive rat liver preneoplastic lesions. Using glutathione S-transferase-plac...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Mehta R,Lok E,Rowsell PR,Miller JD,Suzuki CA,Bondy GS

    更新日期:1998-06-05 00:00:00

  • Cancer chemopreventive activity of flavanones on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis.

    abstract::To search for possible cancer chemopreventive agents from natural sources, we performed primary screening of ten flavanones isolated from plants belonging to Rutaceae and Leguminosae by examining their possible inhibitory effects on Epstein-Barr virus (EBV) early antigen activation induced by 12-O-tetradecanoylphorbol...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Itoigawa M,Ito C,Ju-ichi M,Nobukuni T,Ichiishi E,Tokuda H,Nishino H,Furukawa H

    更新日期:2002-02-08 00:00:00

  • Lung cancer susceptibility in relation to combined polymorphisms of microsomal epoxide hydrolase and glutathione S-transferase P1.

    abstract::Human microsomal epoxide hydrolase (mEH) catalyzes a key step in the biotransformation of benzo[a]pyrene that yields the highly mutagenic (+)-anti-7,8-diol-9,10 epoxide (BPDE). Two polymorphisms have been described in the coding region of the mEH gene (EPHX1) that produce two protein variants: 113Tyr-->113His (exon 3)...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: To-Figueras J,Gené M,Gómez-Catalán J,Piqué E,Borrego N,Corbella J

    更新日期:2001-11-28 00:00:00

  • Glutathione-S-transferase, alcohol dehydrogenase and aldehyde reductase activities during diethylnitrosamine-carcinogenesis in rat liver.

    abstract::Several enzymes metabolize the toxic aldehydes produced during lipid peroxidation, such as 4-hydroxynonenal. During carcinogenesis induced by diethylnitrosamine in rat liver, an increase in aldehyde dehydrogenase, in comparison with normal liver, has already been shown. This paper demonstrates that, although to a less...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Canuto RA,Muzio G,Maggiora M,Biocca ME,Dianzani MU

    更新日期:1993-02-01 00:00:00

  • Overexpression of c-Jun induced by quercetin and resverol inhibits the expression and function of the androgen receptor in human prostate cancer cells.

    abstract::Previously, we reported that quercetin and resveratrol inhibit the function of androgen receptor (AR). Further studies showed that these two polyphenols caused an increase in expression of c-Jun as well as its phosphorylated form in a dose-dependent manner in prostatic cell lines. Gel shift assay showed that induced c...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Yuan H,Pan Y,Young CY

    更新日期:2004-09-30 00:00:00

  • DLK1, delta-like 1 homolog (Drosophila), regulates tumor cell differentiation in vivo.

    abstract::The stem cell-like characteristics of tumor cells are not only essential for tumor development and malignant progression, but also significantly contribute to therapy resistance. However, it remains poorly understood how cancer cell differentiation or stemness is regulated in vivo. We investigated the role of the stem...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Begum A,Kim Y,Lin Q,Yun Z

    更新日期:2012-05-01 00:00:00

  • Src inhibitor dasatinib inhibits growth of breast cancer cells by modulating EGFR signaling.

    abstract::EGF-receptor family members (EGFRs) as well as c-Src are over expressed in approximately 70% of breast cancer, and in most of the tumors c-Src is co-over expressed with at least one of the EGFRs, suggesting that they may interact functionally and play a role in the development and progression of the malignancy. We hyp...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Nautiyal J,Majumder P,Patel BB,Lee FY,Majumdar AP

    更新日期:2009-10-08 00:00:00

  • Studies on the cytostatic and cytotoxic effects and mode of action of 8-nitro-7-hydroxycoumarin.

    abstract::A derivative of coumarin, 8-nitro-7-hydroxycoumarin (8-NO2-7-OHC), was synthesised, purified and characterised. The cytostatic and cytotoxic nature of this compound was determined using both human and animal cell lines grown in vitro for 96 h in the presence of drug (0-500 microM, equivalent to 0-104 microg/ml). 8-NO2...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Egan D,James P,Cooke D,O'Kennedy R

    更新日期:1997-10-14 00:00:00

  • Prevailing over T cell exhaustion: New developments in the immunotherapy of pancreatic cancer.

    abstract::Pancreatic cancer is one of the most aggressive malignancies and has been considered poorly immunogenic for decades. However, this characterization might be over-simplistic. A more sophisticated approach is needed in order to develop new treatment strategies. In this review, we will focus on T cell exhaustion as a phe...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审


    authors: Bauer C,Kühnemuth B,Duewell P,Ormanns S,Gress T,Schnurr M

    更新日期:2016-10-10 00:00:00

  • Correlation between reduction potentials and inhibitory effects on Epstein-Barr virus activation by emodin derivatives.

    abstract::As a continuation of studies using natural and synthetic products as cancer chemopreventive agents, we examined the reduction-oxidation potentials of hydroxylated emodin derivatives prepared from emodin in phosphate buffer at pH 7.2 using cyclic voltammetry. A significant correlation was found between the reduction po...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Koyama J,Inoue M,Morita I,Kobayashi N,Osakai T,Nishino H,Tokuda H

    更新日期:2006-09-28 00:00:00

  • Autoradiographic localization of tritiated suramin in polarized human colon adenocarcinoma cells.

    abstract::In this report we demonstrated that [3H]suramin enters polarized human colon adenocarcinoma cells when added to the apical side of the monolayer. Using light microscopic quantitative autoradiography, we showed that suramin was accumulated in the apical cytoplasm and in the nucleus. In contrast, a weak labeling was not...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Baghdiguian S,Boudier JA,Boudier JL,Fantini J

    更新日期:1993-12-20 00:00:00

  • MicroRNAs and cancer stem cells: therapeutic approaches and future perspectives.

    abstract::Cancer stem cells (CSCs) are a sub-population of cancer cells that possess characteristics associated with normal stem cells but with the peculiarity that they are tumourigenic. This property allows them to persist in the tumour population, causing relapse and metastasis by giving rise to new tumours. Accordingly, if ...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审


    authors: Leal JA,Lleonart ME

    更新日期:2013-09-10 00:00:00

  • Histone deacetylase inhibitors that target tubulin.

    abstract::Epigenetics is defined as heritable changes in gene expression that occur without changes in DNA sequence. Major mechanisms of epigenetics are post-translational histone modifications such as reversible acetylation. Histone deacetylases (HDACs) maintain the acetylation level of histones but also act on non-histone sub...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审


    authors: Schemies J,Sippl W,Jung M

    更新日期:2009-08-08 00:00:00

  • Determination of cytotoxicity in vivo using 111indium-labeled human tumor cells.

    abstract::Loss of radioactivity from nude mice was determined after inoculation of human tumor cells prelabeled with [111In]indium oxine (111InOx). Elimination of 111In was increased somewhat by treating the mice with diphtheria toxin (DT), which is toxic selectively for human cells compared to mice. Calcium disodium edetate (C...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Lockshin A,Giovanella BC,Kozielski T,Stehlin JS Jr

    更新日期:1984-09-01 00:00:00

  • Expression of multidrug resistance-associated protein (MRP) in anaplastic carcinoma of the thyroid.

    abstract::Although the incidence is very low, the prognosis of anaplastic carcinoma of the thyroid is very poor regardless of the results of various therapeutic trials. We found that the mechanism of anti-cancer drug resistance in anaplastic carcinoma of the thyroid was not explicable only in terms of expression of the mdr1 and...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Sugawara I,Arai T,Yamashita T,Yoshida A,Masunaga A,Itoyama S

    更新日期:1994-07-29 00:00:00

  • Induction of integrin β3 by sustained ERK activity promotes the invasiveness of TGFβ-induced mesenchymal tumor cells.

    abstract::The emerging roles of integrin β3 in the epithelial-mesenchymal transition (EMT) and drug resistance underline its significance in cancer metastasis and recurrence. However, the molecular mechanism underlying the distinctive expression of integrin β3 is less understood. In the present report, we demonstrated that repe...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Hong SK,Park JR,Kwon OS,Kim KT,Bae GY,Cha HJ

    更新日期:2016-07-01 00:00:00

  • Specificity of photosensitizer accumulation in undifferentiated versus differentiated colon carcinoma cells.

    abstract::The relationship between tumor cell differentiation and photosensitizer accumulation used in PDT is poorly defined. In the present work, specific cell differentiation of colon carcinoma CT26 cells induced by sodium butyrate was manifested by morphological changes, proliferation and protein expression and was correlate...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Siboni G,Amit-Patito I,Weizman E,Waintraub-Porat M,Weitman H,Ehrenberg B,Malik Z

    更新日期:2003-06-30 00:00:00

  • Differential modulation by dietary n-6 or n-9 unsaturated fatty acids on the development of two murine mammary gland tumors having different metastatic capabilities.

    abstract::It is widely known that dietary lipids can modify the ability of different cancers to grow up and metastasize, especially mammary gland tumors. However, it is still unclear whether n-6 fatty acids behave as tumor promoters in this gland cell population. The effect of different nutritional polyunsaturated fatty acids (...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Muñoz SE,Lopez CB,Valentich MA,Eynard AR

    更新日期:1998-04-24 00:00:00

  • Metformin inhibits castration-induced EMT in prostate cancer by repressing COX2/PGE2/STAT3 axis.

    abstract::Castration is the standard therapeutic treatment for advanced prostate cancer but with limited benefit due to the profound relapse and metastasis. Activation of inflammatory signaling pathway and initiation of epithelial-mesenchymal transition (EMT) are closely related to drug resistance, tumor relapseas well as metas...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Tong D,Liu Q,Liu G,Xu J,Lan W,Jiang Y,Xiao H,Zhang D,Jiang J

    更新日期:2017-03-28 00:00:00

  • Helicobacter pylori upregulates Nanog and Oct4 via Wnt/β-catenin signaling pathway to promote cancer stem cell-like properties in human gastric cancer.

    abstract::Helicobacter pylori (H. pylori) infection is considered a major risk factor for gastric cancer. CagA behaves as a major bacterial oncoprotein playing a key role in H. pylori-induced tumorigenesis. Cancer stem cells (CSCs) are believed to possess the ability to initiate tumorigenesis and promote progression. Although s...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Yong X,Tang B,Xiao YF,Xie R,Qin Y,Luo G,Hu CJ,Dong H,Yang SM

    更新日期:2016-05-01 00:00:00

  • Selective resistance to cytotoxic agents in hepatocytes isolated from partially hepatectomized and neoplastic mouse liver.

    abstract::Hepatocytes were isolated from B6C3F1 male mouse neoplastic livers (containing hepatocellular adenomas and carcinomas) or two-thirds partially hepatectomized livers and tested in primary culture for their cytotoxic response to hepatotoxins. Partially hepatectomized mouse hepatocytes were less sensitive to lindane, met...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Ruch RJ,Klaunig JE,Pereira MA

    更新日期:1985-04-01 00:00:00

  • Targeting solid tumors via T cell receptor complementarity-determining region 3delta in an engineered antibody.

    abstract::Human Vdelta2 gammadelta T lymphocytes killed multiple solid tumors, even displaying comparable therapeutic efficacy with anti-tumor chemical-cis-platinum in an adoptive experiment in both nude and SCID murine model shown in present study. We previously found that T cell receptor (TCR) gammadelta recognize tumors via ...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Wang Z,Zhang T,Hu H,Zhang H,Yang Z,Cui L,He W

    更新日期:2008-12-18 00:00:00

  • Identification and characterization of zinc finger encoding genes from the tumoral exocrine pancreatic cell line AR42J.

    abstract::Zinc finger transcription factors are DNA-binding proteins that are known to determine the identity of cells by regulating cell-specific gene expression. In addition, mutations in some members of this family have been found to be associated with several neoplasias, including Wilms' tumor and leukemias. Because the mec...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Mesa K,Gebelein B,Cook T,Urrutia R

    更新日期:1996-06-05 00:00:00