Fetal fetuin selectively induces apoptosis in cancer cell lines and shows anti-cancer activity in tumor animal models.

abstract：:Tumors are known to cause profound changes in host biology, but the mechanisms responsible for these changes remain unclear. Ornithine decarboxylase (ODC) is a rate-limiting enzyme that catalyzes the biosynthesis of polyamines. The purpose of this study was to examine the effects of MC-26 tumor burden on ODC activity ...

journal_title：Cancer letters

authors： Saydjari R,Beauchamp RD,Townsend CM Jr,Thompson JC

更新日期：1991-06-14 00:00:00

abstract：:ING family genes (Inhibitor of Growth) are tumor suppressor genes that play a vital role in cell homeostasis. It has been shown that their expression is lost or diminished in many cancers and other diseases. The main mechanisms by which they are regulated in oncogenesis have not yet been fully elucidated. The involvem...

journal_title：Cancer letters

authors： Gournay M,Paineau M,Archambeau J,Pedeux R

更新日期：2019-04-10 00:00:00

abstract：:Thiourea (TU) fails to enhance the incidence of foci deficient in adenosine-5'-triphosphatase (ATPase) either by initiation or by promotion in a rat liver foci bioassay. To weanling female Sprague-Dawley rats, 3 x 200 or 3 x 500 mg/kg body wt of TU, respectively, were applied for initiation. One week later Clophen A 5...

journal_title：Cancer letters

authors： Oesterle D,Deml E

更新日期：1988-08-30 00:00:00

abstract：:A hallmark of most cancer cells is an altered metabolism involving a shift to aerobic glycolysis with lactate production coupled with a higher uptake of glucose as the main source of energy. Lactate dehydrogenase 5 (LDH-5) catalyzes the reduction of pyruvate by NADH to form lactate, thus determining the availability o...

journal_title：Cancer letters

authors： Augoff K,Hryniewicz-Jankowska A,Tabola R

更新日期：2015-03-01 00:00:00

abstract：:We studied the effect of staurosporine (SSP), a broad-spectrum protein kinase inhibitor, on the levels of protein kinase C (PKC) activity and proliferation in two murine neuroblastoma cell lines, Neuro2a and its clone NB41A3. The PKC activity was examined in whole cell lysate, cytosolic and particulate fractions. A di...

journal_title：Cancer letters

authors： Mohan DR,Nagarathna R,Krishna M,Jagtap JC,Shastry P

更新日期：1999-05-24 00:00:00

abstract：:We investigated the molecular effects of 3,4,2',4'-tetrahydroxychalcone (butein) treatment in two human hepatoma cancer cell lines-HepG2 and Hep3B. Butein treatment inhibited cancer cell growth by inducing G(2)/M phase arrest and apoptosis. Butein-induced G(2)/M phase arrest was associated with increased ATM, Chk1, an...

journal_title：Cancer letters

authors： Moon DO,Kim MO,Choi YH,Hyun JW,Chang WY,Kim GY

更新日期：2010-02-28 00:00:00

abstract：:The genomic aberration profile of chromosome 20q in distal CIN colon carcinomas was analysed using allelotyping and CGH arrays. Allelotyping revealed carcinomas with allelic imbalance along the full long arm, and carcinomas with fully non-aberrant 20q. Oligonucleotide-based CGH showed that among the carcinomas without...

journal_title：Cancer letters

authors： Nicolet C,Guérin E,Neuville A,Kerckaert JP,Wicker N,Bergmann E,Brigand C,Kedinger M,Gaub MP,Guenot D

更新日期：2009-09-18 00:00:00

abstract：:Dibenzo[a,e]fluoranthene ( DBF ), a non- alternant carcinogenic polycyclic aromatic hydrocarbon (PAH), binds covalently to DNA. The main adducts were characterized as covalent additions of its bay-region and pseudo-bay-region diol-epoxides. The structure of these 2 adducts was analyzed by mass spectrometry using their...

journal_title：Cancer letters

authors： Perin-Roussel O,Croisy A,Ekert B,Zajdela F

更新日期：1984-04-01 00:00:00

abstract：:We have previously demonstrated that O-phospho-L-tyrosine (P-Tyr), a substrate for a wide range of PTPases, inhibits the growth of human renal cell carcinoma and human breast cancer cell lines and suppresses EGF-mediated EGFR tyrosine phosphorylation. We now show that P-Tyr inhibited the growth of the human hepatoma c...

journal_title：Cancer letters

authors： Mishra S,Hamburger AW

更新日期：1996-04-19 00:00:00

abstract：:Our purpose is to demonstrate the relationship between microvessel density (MVD), vascular cuffing (VC), vascular endothelial growth factor (VEGF) expression and clinicopathological parameters in ovarian cancer. Surgical specimens from 105 primary ovarian cancers were examined for vascularization and VEGF expression b...

journal_title：Cancer letters

authors： Ogawa S,Kaku T,Kobayashi H,Hirakawa T,Ohishi Y,Kinukawa N,Nakano H

更新日期：2002-02-08 00:00:00

abstract：:Herpes simplex virus was grown in different lines of human tumor and normal cells. The progeny virus was assayed for resistance to iododeoxycytidine, an indicator of a forward mutation in the virus genome. Virus grown in cells from 4 of 5 tumor lines demonstrated greater fractions mutated to iododeoxycytidine resistan...

journal_title：Cancer letters

authors： Bockstahler LE,Lytle CD,Lubiniecki AS,Cantwell JM,Galleshaw JA

更新日期：1982-11-01 00:00:00

abstract：:The growth of a transplantable myeloid leukaemia into its syngeneic host is accompanied by a progressive increase in the number of blood monocytes. These were shown to be of host origin and were not derived from the inoculated leukaemia cells. The host response which is responsible for the monocytosis differs from tha...

journal_title：Cancer letters

authors： Gauci CL,Wrathmell A,Alexander P

更新日期：1975-09-01 00:00:00

abstract：:To investigate the monoclonality of hepatocellular carcinoma (HCC) and dysplastic nodule (DN) and the origin of multiple lesions, patterns of inactivation of X-linked human androgen receptor gene were studied. Fourteen of 15 patients (93%) were heterozygous in the size of the target, and were informative for clonal an...

journal_title：Cancer letters

authors： Okuda T,Wakasa K,Kubo S,Hamada T,Fujita M,Enomoto T,Haba T,Hirohashi K,Kinoshita H

更新日期：2001-03-10 00:00:00

abstract：:Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription factor composed of alpha and beta subunits, which plays an essential role in cancer cell hypoxia adaptation, glycolysis, and angiogenesis. Normally, HIF-1alpha protein, the dominant subunit of HIF-1, is accumulated in nuclei when cells are exposed to ...

journal_title：Cancer letters

authors： Zhong H,Mabjeesh N,Willard M,Simons J

更新日期：2002-07-26 00:00:00

abstract：:Cancer results from genetic alterations in intracellular signaling pathways, which normally orchestrate the execution of developmental programs and the organismic response to extrinsic factors. Mutations in upstream activators and components of the cytoplasmic (Ras-Raf MEK-ERK) cascade frequently occur in tumors. In v...

journal_title：Cancer letters

authors： Rennefahrt U,Janakiraman M,Ollinger R,Troppmair J

更新日期：2005-01-10 00:00:00

abstract：:A six-month bioassay in A/J mice was conducted to test the hypothesis that chronically inhaled mainstream cigarette smoke would either induce lung cancer or promote lung carcinogenicity induced by the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Groups of 20 female A/J mice were ...

journal_title：Cancer letters

authors： Finch GL,Nikula KJ,Belinsky SA,Barr EB,Stoner GD,Lechner JF

更新日期：1996-02-06 00:00:00

abstract：:The stem cell-like characteristics of tumor cells are not only essential for tumor development and malignant progression, but also significantly contribute to therapy resistance. However, it remains poorly understood how cancer cell differentiation or stemness is regulated in vivo. We investigated the role of the stem...

journal_title：Cancer letters

authors： Begum A,Kim Y,Lin Q,Yun Z

更新日期：2012-05-01 00:00:00

abstract：:Smoking women are probably at a higher risk to develop lung cancer than men. Different explanations exist for these findings, a gender-specific impairment of tobacco carcinogen metabolism being one of them. In this study, we examined the inhibition of NNK reduction to NNAL, the first and most important detoxication st...

journal_title：Cancer letters

authors： Stapelfeld C,Neumann KT,Maser E

更新日期：2017-10-01 00:00:00

abstract：:We describe here the establishment of a new synovial sarcoma cell line, SYO-1, derived from a biphasic synovial sarcoma that developed in the groin of a 19-year-old female. The cell line was maintained for more than 70 passages (more than 24 months) in vitro. The SYO-1 cells in monolayer culture exhibited a spindle sh...

journal_title：Cancer letters

authors： Kawai A,Naito N,Yoshida A,Morimoto Y,Ouchida M,Shimizu K,Beppu Y

更新日期：2004-02-10 00:00:00

abstract：:Pancreatic cancer remains a highly lethal malignancy. We have recently shown that simultaneous expression of Kras and mutant Tp53R175H promotes invasive ductal adenocarcinoma from pancreatic ductal cells. We hypothesized specific mutations in TP53 have divergent mechanisms of transforming ductal cells. In order to und...

journal_title：Cancer letters

authors： Polireddy K,Singh K,Pruski M,Jones NC,Manisundaram NV,Ponnela P,Ouellette M,Van Buren G,Younes M,Bynon JS,Dar WA,Bailey JM

更新日期：2019-07-01 00:00:00

abstract：:Circulating glucose-regulated protein 78 (GRP78) autoantibodies represent potential biomarker of epithelial ovarian cancer. However there is relatively limited identification of these antibodies in response to ovarian cancer. Here, we were interested in characterization of these antibodies and into their role in tumor...

journal_title：Cancer letters

authors： Cohen M,Petignat P

更新日期：2011-10-01 00:00:00

abstract：:The mechanism of DDB (dimethyl 4,4'-dimethoxy-5,6,5',6'-dimethylenedioxy biphenyl-2,2'-dicarboxylate) prevention of aflatoxin B1 (AFB1)-induced hepatotoxicity in rats has been investigated. Pretreatment of DDB (200 mg/kg) daily for 4 days significantly suppressed (P < 0.05) the AFB1-induced hepatic damage as evidenced...

journal_title：Cancer letters

authors： Liu TY,Hwua YS,Chao TW,Chi CW

更新日期：1995-03-02 00:00:00

abstract：:The effect of pretreatment of skin of Sencar mice with topically applied tannic acid, quercetin and green tea polyphenols (GTP) on the skin tumor initiating activity of (+/-)-7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE-2) has been evaluated. The animals were pretreated with ...

journal_title：Cancer letters

authors： Khan WA,Wang ZY,Athar M,Bickers DR,Mukhtar H

更新日期：1988-09-01 00:00:00

abstract：:Bevacizumab (Avastin®, Genentech, CA) was granted accelerated approval by the FDA for metastatic breast cancer in 2008. This occurred after the initial clinical trial, E2100, demonstrated an improvement in progression-free survival (PFS) and overall survival (OS) with the addition of bevacizumab to a standard chemothe...

journal_title：Cancer letters

authors： Afranie-Sakyi JA,Klement GL

更新日期：2015-02-01 00:00:00

abstract：:The capacity of enteric bacteria (E. coli, Salmonella, Pseudomonas, Shigella and Klebsiella) to catalyze the covalent binding of benzo(a)pyrene (BP), cholic acid, deoxycholic acid and cholesterol was investigated. In general, these bacteria were incapable of activating BP to a covalently bound product with calf thymus...

journal_title：Cancer letters

authors： Zachariah PK,Slaga TJ,Berry DL,Bracken WM,Buty SG,Martinsen CM,Juchau MR

更新日期：1977-07-01 00:00:00

abstract：:Integrin cell adhesion molecules play a crucial role in tumor cell resistance to radio- and chemotherapy and are therefore considered attractive targets for cancer therapy. Here, we assessed the role of β1 integrin-interacting α integrin subunits in more physiological three-dimensional extracellular matrix grown head ...

journal_title：Cancer letters

authors： Steglich A,Vehlow A,Eke I,Cordes N

更新日期：2015-02-28 00:00:00

abstract：:A hitherto unreported lactate dehydrogenase (LD) isoenzyme, which migrates electrophoretically to the relative position between LD2 and LD3 has been identified in the electropheratogram in 7 of 7 (100%) cultured hepatoma cell lines with various degrees of differentiation and is thus given the name LD2-3. LD2-3 seems t...

journal_title：Cancer letters

authors： Liu TZ,Chen PY,Chiu DT,Wei JS,Chang KS,Lin KH

更新日期：1994-12-09 00:00:00

abstract：:N-Acetyltransferase activities with p-aminobenzoic acid and 2-aminofluorene were determined in Anisakis simplex, a nematode found in the intestine of the salt water fish Trichiurus lepturus. The N-acetyltransferase activity was determined using an acetyl CoA recycling assay and high pressure liquid chromatography. The...

journal_title：Cancer letters

authors： Chung JG,Kuo HM,Lin TH,Ho CC,Lee JH,Lai JM,Levy GN,Weber WW

更新日期：1996-08-23 00:00:00

abstract：:The addition of recombinant human interleukin-6 (rIL-6) to either soleus or extensor digitorum longus (EDL) muscle preparations did not affect the rate of protein breakdown as measured by the rate of tyrosine released to the medium. In addition, the presence of the cytokine did not influence either the rate of protein...

journal_title：Cancer letters

authors： García-Martínez C,López-Soriano FJ,Argilés JM

更新日期：1994-01-15 00:00:00

abstract：:The effect of ligation of the left ureter on the development of lesions in the urinary bladder were investigated in male F344 rats treated with 0.05% N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) for 2 weeks followed by 0.002% N-ethyl-N-(4-hydroxybutyl)nitrosamine (EHBN) for 10 or 22 weeks. The lesions of the urinary b...

journal_title：Cancer letters

authors： Miyata Y,Fukushima S,Imaida K,Ito N

更新日期：1984-07-01 00:00:00