Association of inhibition of cell growth by O-phospho-L-tyrosine with decreased tyrosine phosphorylation.


:We have previously demonstrated that O-phospho-L-tyrosine (P-Tyr), a substrate for a wide range of PTPases, inhibits the growth of human renal cell carcinoma and human breast cancer cell lines and suppresses EGF-mediated EGFR tyrosine phosphorylation. We now show that P-Tyr inhibited the growth of the human hepatoma cell line HEPG2, and src transformed NIH3T3 cells, but did not inhibit the growth of human ovarian carcinoma SKOV-3 cells. Addition of exogenous P-Tyr inhibited the insulin triggered insulin receptor (IR) tyrosine phosphorylation in the HEPG2 cell line and the tyrosine phosphorylation of a variety of cellular proteins in src-transformed NIH3T3 cells. P-Tyr did not inhibit the tyrosine phosphorylation of gp185 erbB-2 in P-Tyr resistant SKOV-3 cells. Thus, inhibition of cell growth by P-tyr was associated with decreased tyrosine phosphorylation of cellular proteins.


Cancer Lett


Cancer letters


Mishra S,Hamburger AW




Has Abstract


1996-04-19 00:00:00














  • Targeting HER-2/neu-overexpressing breast cancer cells by an antisense iron responsive element-directed gene expression.

    abstract::Overexpression of HER-2/neu proto-oncogene is found in many human cancers including 20-30% of breast cancer and is a predictor of poor prognosis. To target breast cancer cells that overexpress HER-2/neu mRNA, we previously described a novel strategy that combines the principle of antisense (AS) and translational inhib...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Li Z,Xia W,Fang B,Yan DH

    更新日期:2001-12-28 00:00:00

  • Metabolic changes in tumor cells and tumor-associated macrophages: A mutual relationship.

    abstract::In order to adapt to the reduced availability of nutrients and oxygen in the tumor microenvironment and the increased requirements of energy and building blocks necessary for maintaining their high proliferation rate, malignant cells undergo metabolic changes that result in an increased production of lactate, nitric o...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审


    authors: Netea-Maier RT,Smit JWA,Netea MG

    更新日期:2018-01-28 00:00:00

  • Immuno-modulators enhance antigen-specific immunity and anti-tumor effects of mesothelin-specific chimeric DNA vaccine through promoting DC maturation.

    abstract::As a tumor antigen, mesothelin (MSLN) can be identified in various malignancies. MSLN is potential for antigen-specific cancer vaccines. We generated a novel chimeric DNA vaccine using antigen-specific connective tissue growth factor lined with MSLN (CTGF/MSLN). The anti-tumor effects of the CTGF/MSLN DNA vaccine comb...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Chen YL,Chang MC,Chiang YC,Lin HW,Sun NY,Chen CA,Sun WZ,Cheng WF

    更新日期:2018-07-01 00:00:00

  • Down regulation of c-Myc and induction of an angiogenesis inhibitor, thrombospondin-1, by 5-FU in human colon cancer KM12C cells.

    abstract::5-FU is commonly used for treatment of various solid tumors including colon carcinoma. We have previously demonstrated that Egr-1 induced by 5-FU enhanced TSP-1 expression in human colon cancer KM12C cells. In this study, a Genechip analysis of KM12C cells treated with 5-FU revealed down-regulation of 924 genes and up...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Zhao HY,Ooyama A,Yamamoto M,Ikeda R,Haraguchi M,Tabata S,Furukawa T,Che XF,Iwashita K,Oka T,Fukushima M,Nakagawa M,Ono M,Kuwano M,Akiyama S

    更新日期:2008-10-18 00:00:00

  • Regulation of the intestinal mucin MUC2 gene expression in vivo: evidence for the role of promoter methylation.

    abstract::In the present work we investigated the in vivo regulation of the mucin gene MUC2, which is overexpressed in all mucinous colorectal carcinomas. The inhibition of methylation by 5-azadeoxycytidine induces de novo expression of MUC2 in the colon carcinoma cell line COLO 205. The expression is retained in xenograft tiss...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Gratchev A,Siedow A,Bumke-Vogt C,Hummel M,Foss HD,Hanski ML,Kobalz U,Mann B,Lammert H,Mansmann U,Stein H,Riecken EO,Hanski C

    更新日期:2001-07-10 00:00:00

  • Effects of methotrexate on folates in Krebs ascites and L1210 murine leukemia cells.

    abstract::Changes in reduced folates upon exposure of Krebs ascites cells and L1210 murine leukemia cells to methotrexate (MTX) have been measured by stoichiometric entrapment of tissue methylenetetrahydrofolate into a stable ternary complex with thymidylate synthase and tritiated 5-fluoro-2'-deoxy-uridine-5'-monophosphate. Tet...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Kesavan V,Sur P,Doig MT,Scanlon KJ,Priest DG

    更新日期:1986-01-01 00:00:00

  • Mutagenic virus replication in human tumor cells.

    abstract::Herpes simplex virus was grown in different lines of human tumor and normal cells. The progeny virus was assayed for resistance to iododeoxycytidine, an indicator of a forward mutation in the virus genome. Virus grown in cells from 4 of 5 tumor lines demonstrated greater fractions mutated to iododeoxycytidine resistan...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Bockstahler LE,Lytle CD,Lubiniecki AS,Cantwell JM,Galleshaw JA

    更新日期:1982-11-01 00:00:00

  • Promoting effect of intestinal Pseudomonas aeruginosa on gastric tumorigenesis in rats with N-methyl-N'-nitro-N-nitrosoguanidine.

    abstract::The effect of Pseudomonas aeruginosa colonizing in the gut on the development of gastrointestinal tumors was studied in rats treated orally with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). The animals were inoculated with or accidentally colonized by P. aeruginosa after MNNG treatment. In 3 serial experiments, P. aer...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Morishita Y,Shimizu T

    更新日期:1983-01-01 00:00:00

  • Loss of imprinting and overexpression of IGF2 gene in gastric adenocarcinoma.

    abstract::Both insulin-like growth factor II (IGF2) and H19 gene are located on chromosome 11p15.5 in close vicinity to each other, and are imprinted on different parental alleles. Although the exact mechanism remains unclear, loss of imprinting (LOI) leading to the biallelic expression of IGF2 and H19 genes has recently been r...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Wu MS,Wang HP,Lin CC,Sheu JC,Shun CT,Lee WJ,Lin JT

    更新日期:1997-11-25 00:00:00

  • Increased expression of sialyl Lewis(x) antigen as a prognostic factor in patients with stage 0, I, and II gastric cancer.

    abstract::Immunohistochemically detected expression of sialyl Lewis(x) (Le(x)) antigen was analyzed in 101 stage 0-II gastric cancers to clarify its prognostic value after curative gastrectomy. Patients with a high-expression of sialyl Le(x) antigen within their tumors had shorter disease-specific intervals than those with nega...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Nakagoe T,Fukushima K,Sawai T,Tsuji T,Jibiki Ma,Nanashima A,Tanaka K,Yamaguchi H,Yasutake T,Ayabe H,Arisawa K,Ishikawa H

    更新日期:2002-01-25 00:00:00

  • Modulation of cellular phosphoprotein profiles in transformation and redifferentiation of murine AKR embryonic fibroblastic cells.

    abstract::Cellular phosphoprotein profiles from normal mouse embryonic fibroblast AKR-2B cells were compared to those of their permanently, chemically transformed malignant counterparts AKR-MCA cells, and AKR-2B cells reversibly transformed by transforming growth factor (AKR-TGF). Similar 32P-phosphorylation profiles were obser...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Chakrabarty S,Brattain MG

    更新日期:1985-11-01 00:00:00

  • Correlation between reduction potentials and inhibitory effects on Epstein-Barr virus activation by emodin derivatives.

    abstract::As a continuation of studies using natural and synthetic products as cancer chemopreventive agents, we examined the reduction-oxidation potentials of hydroxylated emodin derivatives prepared from emodin in phosphate buffer at pH 7.2 using cyclic voltammetry. A significant correlation was found between the reduction po...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Koyama J,Inoue M,Morita I,Kobayashi N,Osakai T,Nishino H,Tokuda H

    更新日期:2006-09-28 00:00:00

  • Endometrial cancer and somatic G>T KRAS transversion in patients with constitutional MUTYH biallelic mutations.

    abstract::MUTYH-associated polyposis (MAP) is an autosomal recessive condition predisposing to colorectal cancer, caused by constitutional biallelic mutations in the base excision repair (BER) gene MUTYH. Colorectal tumours from MAP patients display an excess of somatic G>T mutations in the APC and KRAS genes due to defective B...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Tricarico R,Bet P,Ciambotti B,Di Gregorio C,Gatteschi B,Gismondi V,Toschi B,Tonelli F,Varesco L,Genuardi M

    更新日期:2009-02-18 00:00:00

  • Ki-67 and CEA expression as prognostic markers in Dukes' C colorectal cancer.

    abstract::This study investigated the relationship between clinicopathological or immunohistochemical factors and postoperative prognosis for Dukes' C colorectal cancer. Short-term survivors died from cancer within 2 years of surgery, whereas long-term survivors were disease-free for over 10 years. The groups differed in Ki-67 ...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Ishida H,Miwa H,Tatsuta M,Masutani S,Imamura H,Shimizu J,Ezumi K,Kato H,Kawasaki T,Furukawa H,Kawakami H

    更新日期:2004-04-15 00:00:00

  • Avemar, a nontoxic fermented wheat germ extract, induces apoptosis and inhibits ribonucleotide reductase in human HL-60 promyelocytic leukemia cells.

    abstract::Avemar (MSC) is a nontoxic fermented wheat germ extract demonstrated to significantly improve the survival rate in patients suffering from various malignancies. We investigated its effects in human HL-60 promyelocytic leukemia cells. After 24, 48, and 72 h of incubation, Avemar inhibited the growth of HL-60 cells with...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Saiko P,Ozsvar-Kozma M,Madlener S,Bernhaus A,Lackner A,Grusch M,Horvath Z,Krupitza G,Jaeger W,Ammer K,Fritzer-Szekeres M,Szekeres T

    更新日期:2007-06-08 00:00:00

  • ZNF32 induces anoikis resistance through maintaining redox homeostasis and activating Src/FAK signaling in hepatocellular carcinoma.

    abstract::Tumor cells need to attain anoikis resistance to survive prior to metastasis making it a vital trait of malignancy. The molecular mechanism by which hepatocellular carcinoma (HCC) cells resist anoikis remains not fully understood. Here, we report that ZNF32 expression is markedly upregulated in HCC cells upon detachme...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Li K,Zhao G,Ao J,Gong D,Zhang J,Chen Y,Li J,Huang L,Xiang R,Hu J,Lin P,Wei Y

    更新日期:2019-02-01 00:00:00

  • Lung cancer susceptibility in relation to combined polymorphisms of microsomal epoxide hydrolase and glutathione S-transferase P1.

    abstract::Human microsomal epoxide hydrolase (mEH) catalyzes a key step in the biotransformation of benzo[a]pyrene that yields the highly mutagenic (+)-anti-7,8-diol-9,10 epoxide (BPDE). Two polymorphisms have been described in the coding region of the mEH gene (EPHX1) that produce two protein variants: 113Tyr-->113His (exon 3)...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: To-Figueras J,Gené M,Gómez-Catalán J,Piqué E,Borrego N,Corbella J

    更新日期:2001-11-28 00:00:00

  • Induction of differentiation of human promyelocytic leukemia cells (HL-60) by arginase.

    abstract::Human promyelocytic leukemia cells (HL-60) were found to be induced by dimethylsulfoxide and several other compounds to phagocytize, reduce NBT dye, and change into forms that were morphologically similar to granulocytes and macrophages. Arginase also induced these differentiation-associated properties of the cells. T...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Honma Y,Fujita Y,Okabe-Kado J,Kasukabe T,Hozumi M

    更新日期:1980-10-01 00:00:00

  • Changes in insulin-like growth factor-I receptor expression and binding protein secretion associated with tamoxifen resistance and estrogen independence in human breast cancer cells in vitro.

    abstract::Conditioned medium from a series of human breast cancer cell lines representing the phenotypes of estrogen dependence ZR-75-1, MCF-7), tamoxifen resistance (Z(+)-75-9a1, LY2) and estrogen independence (ZR-PR-Lt) contained four detectable insulin-like growth factor binding proteins (IGFBPs) of MW 24, 34, 44 and 70 kDa....

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: McCotter D,van den Berg HW,Boylan M,McKibben B

    更新日期:1996-02-06 00:00:00

  • Non-random structural chromosomal changes in ovarian cancer: i(5p) a novel recurrent abnormality.

    abstract::Ovarian cancer represents the leading cause of death among patients with gynecological cancer. The genetic changes underlying the initiation and progression of ovarian cancer have not been well defined. However, non-random structural chromosomal changes have been identified with common chromosomal breakpoints. We have...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Panani AD,Roussos C

    更新日期:2006-04-08 00:00:00

  • Effect of 3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)- quinolinone (vesnarinone) on the growth of gastric cancer cell lines.

    abstract::Vesnarinone (OPC-8212; 3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)-quinolinone ) is a synthetic oral cardiotonic agent that has been used for the treatment of patients with congestive heart failure. Six days of treatment with 30 microg/ml of vesnarinone induced 20-80% growth inhibitions in five out of...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Yokozaki H,Ito R,Ono S,Hayashi K,Tahara E

    更新日期:1999-06-01 00:00:00

  • Circulating RNA as a novel tumor marker: an in vitro study of the origins and characteristics of extracellular RNA.

    abstract::Many clinical studies have shown that circulating RNA rises in cancer patients, but little is known about the origins of abnormally elevated extracellular RNA (exRNA). We designed four different culture conditions: serum-deprived, hypoxia, low temperature and exposure to an anticancer drug to investigate the origins i...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Zhou H,Xu W,Qian H,Yin Q,Zhu W,Yan Y

    更新日期:2008-01-18 00:00:00

  • Cytotoxic effects of 125I-labeled PBZr ligand PK 11195 in prostatic tumor cells: therapeutic implications.

    abstract::The effect of [125I]PK 11195 was examined in human prostatic tumor cells (DU 145) in culture and compared with Na[125I] and non-radioactive PK 11195. [125I]PK 11195 was clearly cytocidal. The data for dose-related cell survival with [125I]PK 11195 showed a linear relationship. Na[125I] or non-labeled PK 11195 at simil...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Alenfall J,Kant R,Batra S

    更新日期:1998-12-25 00:00:00

  • BTB and CNC homology 1 (Bach1) promotes human ovarian cancer cell metastasis by HMGA2-mediated epithelial-mesenchymal transition.

    abstract::Transcriptional factor BTB and CNC homology 1 (Bach1) has been linked to tumor progression and metastasis, but the mechanisms underlying the effects of Bach1 on tumor growth and metastasis are largely uncharacterized. Here, we report that Bach1 expression was significantly higher in human epithelial ovarian cancer (EO...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Han W,Zhang Y,Niu C,Guo J,Li J,Wei X,Jia M,Zhi X,Yao L,Meng D

    更新日期:2019-03-31 00:00:00

  • Farnesol inhibits tumor growth and enhances the anticancer effects of bortezomib in multiple myeloma xenograft mouse model through the modulation of STAT3 signaling pathway.

    abstract::Aberrant activation of signal transducer and activator of transcription 3 (STAT3) is frequently observed in multiple myeloma (MM) cancer and can upregulate the expression of several genes involved in proliferation, survival, metastasis, and angiogenesis. The effect of farnesol (FOH) on STAT3 activation, associated pro...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Lee JH,Kim C,Kim SH,Sethi G,Ahn KS

    更新日期:2015-05-01 00:00:00

  • Cancer heterogeneity and "the struggle for existence": diagnostic and analytical challenges.

    abstract::The notions of inter- and intra-tumour heterogeneity (ITH) have been recognised for many years but recent advances in sequencing technology are allowing the true extent of both forms of heterogeneity to be revealed in detail for the first time. In this review we examine the current evidence for ITH, the possibility of...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审


    authors: Horswell S,Matthews N,Swanton C

    更新日期:2013-11-01 00:00:00

  • Therapeutic effect of neural stem cells expressing TRAIL and bortezomib in mice with glioma xenografts.

    abstract::Treatment of glioblastoma remains a challenge in neuro-oncology. We investigated if treatment with neural stem cells engineered to express membrane-bound TRAIL (NSCs-mTRAIL) alone or in combination with proteasome inhibitors is a feasible therapeutic approach for experimental glioma. Glioma cells showed resistance to ...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Balyasnikova IV,Ferguson SD,Han Y,Liu F,Lesniak MS

    更新日期:2011-11-28 00:00:00

  • Staurosporine inhibits the proliferation, alters the cell cycle distribution and induces apoptosis in HT-29 human colon adenocarcinoma cells.

    abstract::Staurosporine (ST), a potent inhibitor of protein kinase C (PKC), was evaluated for its effect on the proliferation of HT-29 colon adenocarcinoma cells; PKC is associated with increased colon cell proliferation. ST inhibited cell proliferation in a time- and concentration-dependent manner by up to 90%. It also blocked...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Qiao L,Koutsos M,Tsai LL,Kozoni V,Guzman J,Shiff SJ,Rigas B

    更新日期:1996-10-01 00:00:00

  • Combined effects of complex mixtures of potentially anti-carcinogenic compounds on antioxidant enzymes and carcinogen metabolizing enzymes in the rat.

    abstract::The anti-carcinogenic activity of dietary fruit and vegetables observed in several epidemiological and experimental animal studies is likely to be an effect of the combined exposure to a large number of substances acting together. This is plausible, as these compounds are present simultaneously in a diet containing ve...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审


    authors: Vang O,Rasmussen BF,Andersen O

    更新日期:1997-03-19 00:00:00

  • Blockage of a miR-21/EGFR regulatory feedback loop augments anti-EGFR therapy in glioblastomas.

    abstract::Epidermal growth factor receptors (EGFR) expression is frequently amplified in human glioblastoma cells. Nimotuzumab, a monoclonal antibody (mAb) against EGFR, has been used globally in clinics as an anti-cancer agent. It is largely unknown whether the blockade of miR-21, a microRNA that is upregulated in glioma cells...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Zhang KL,Han L,Chen LY,Shi ZD,Yang M,Ren Y,Chen LC,Zhang JX,Pu PY,Kang CS

    更新日期:2014-01-01 00:00:00