Association of inhibition of cell growth by O-phospho-L-tyrosine with decreased tyrosine phosphorylation.


:We have previously demonstrated that O-phospho-L-tyrosine (P-Tyr), a substrate for a wide range of PTPases, inhibits the growth of human renal cell carcinoma and human breast cancer cell lines and suppresses EGF-mediated EGFR tyrosine phosphorylation. We now show that P-Tyr inhibited the growth of the human hepatoma cell line HEPG2, and src transformed NIH3T3 cells, but did not inhibit the growth of human ovarian carcinoma SKOV-3 cells. Addition of exogenous P-Tyr inhibited the insulin triggered insulin receptor (IR) tyrosine phosphorylation in the HEPG2 cell line and the tyrosine phosphorylation of a variety of cellular proteins in src-transformed NIH3T3 cells. P-Tyr did not inhibit the tyrosine phosphorylation of gp185 erbB-2 in P-Tyr resistant SKOV-3 cells. Thus, inhibition of cell growth by P-tyr was associated with decreased tyrosine phosphorylation of cellular proteins.


Cancer Lett


Cancer letters


Mishra S,Hamburger AW




Has Abstract


1996-04-19 00:00:00














  • Time-dependent promotion activity of 17beta-estradiol on uterine carcinogenesis in mice initiated with N-ethyl-N-nitrosourea.

    abstract::The time-dependent promotion activity of 17beta-estradiol (E2) by initiation with N-ethyl-N-nitrosourea (ENU) on induction of mouse uterine endometrial proliferative lesions was examined. Illumination-induced persistent estrous female CD-1 mice were divided into five groups at 9 weeks of age. At 10 weeks of age, mice ...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Takahashi M,Nishimura S,Miyajima K,Sasahara K,Yoshida M,Ando J,Maekawa A

    更新日期:2001-04-26 00:00:00

  • Mammary fibroblasts regulate morphogenesis of normal and tumorigenic breast epithelial cells by mechanical and paracrine signals.

    abstract::Stromal factors play a critical role in the development of the mammary gland. Using a three dimensional-coculture model we demonstrate a significant role for stromal fibroblasts in the regulation of normal mammary epithelial morphogenesis and the control of tumor growth. Both soluble factors secreted by fibroblasts an...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Lühr I,Friedl A,Overath T,Tholey A,Kunze T,Hilpert F,Sebens S,Arnold N,Rösel F,Oberg HH,Maass N,Mundhenke C,Jonat W,Bauer M

    更新日期:2012-12-28 00:00:00

  • Diurnal variation in the response of gamma-ray-induced apoptosis in the mouse intestinal epithelium.

    abstract::The appearance of apoptosis has been used as an index of carcinogen-induced damage incurred by the intestinal epithelium. Here we report that the cytotoxic response elicited by gamma radiation in the duodenal and colonic epithelium of the mouse is markedly affected by the time of day at which the animals are irradiate...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Duncan AM,Ronen A,Blakey DH

    更新日期:1983-12-01 00:00:00

  • The comparison of the prognosis between Epstein-Barr virus (EBV)-positive gastric carcinomas and EBV-negative ones.

    abstract::The relationship between the degree of lymphocytic infiltration into the tumor and the prognosis has not been completely evaluated between Epstein-Barr virus (EBV)-positive and -negative gastric carcinoma (GC). Although the average numbers and the grades of the infiltrating CD8+T cells, natural killer cells, dendritic...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Kijima Y,Ishigami S,Hokita S,Koriyama C,Akiba S,Eizuru Y,Aikou T

    更新日期:2003-10-08 00:00:00

  • Melatonin sensitizes human malignant glioma cells against TRAIL-induced cell death.

    abstract::Despite the common expression of death receptors, many types of cancer including gliomas are resistant to the death receptor ligand (TRAIL). Melatonin antitumoral actions have been extensively described, including oncostatic properties on several tumor types and improvement of chemotherapeutic regimens. Here, we found...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Martín V,García-Santos G,Rodriguez-Blanco J,Casado-Zapico S,Sanchez-Sanchez A,Antolín I,Medina M,Rodriguez C

    更新日期:2010-01-28 00:00:00

  • Effects of eicosanoid metabolism inhibitors on growth of a human gastric tumour cell line (HGT).

    abstract::HGT cells are a human gastric cell line derived from a tumour of the stomach. We have investigated the effects of lipoxygenase and cyclooxygenase metabolism inhibitors on HGT cell proliferation, on fatty acid composition of HGT cells and on the incorporation and distribution of arachidonic acid (AA) in HGT lipids. The...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Denizot Y,Najid A,Rigaud M

    更新日期:1993-09-15 00:00:00

  • p53 protein expression in patients with hepatocellular carcinoma from the high incidence area of Guangxi, Southern China.

    abstract::Mutation of the p53 gene has been reported in hepatocellular carcinoma (HCC) occurring worldwide. The most frequent p53 mutation has been found in HCCs in regions with high hepatitis B virus (HBV) infection and intake of aflatoxin B1 (AFB1). The aim of our study was to examine p53 protein expression in HCCs from a hig...

    journal_title:Cancer letters

    pub_type: 临床试验,杂志文章


    authors: Qin G,Su J,Ning Y,Duan X,Luo D,Lotlikar PD

    更新日期:1997-12-23 00:00:00

  • Low expression of the WAF1/CIP1 gene product, p21, in enzyme-altered foci induced in rat liver by diethylnitrosamine or phenobarbital.

    abstract::The expression of the WAF1/CIP1 gene product, p21, in enzyme-altered foci (EAF) induced by diethylnitrosamine (DEN) and phenobarbital (PB) was examined. p21 expression in the nucleus of hepatocytes in EAF was decreased compared to surrounding tissue. Fifty-eight percent of all GST-P-positive EAF induced by DEN and 79%...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Martens U,Lennartsson P,Högberg J,Stenius U

    更新日期:1996-06-24 00:00:00

  • Excision of DNA damage arising from chemicals of different carcinogenic potencies.

    abstract::Primary cultures of mouse embryo cells are more efficient in excising DNA-carcinogen adducts resulting from exposure to either 7-bromomethylbenz-[alpha]anthracene or the more carcinogen 7-bromomethyl-12-methylbenz[alpha]anthracene than are mouse L 929 cell suspension cultures. However, within each of these systems, th...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Dipple A,Schultz E

    更新日期:1979-07-01 00:00:00

  • Hyaluronan grafted lipid-based nanoparticles as RNAi carriers for cancer cells.

    abstract::RNA interference (RNAi), a natural cellular mechanism for RNA-guided regulation of gene expression could in fact become new therapeutic modality if an appropriate efficient delivery strategy that is also reproducible and safe will be developed. Numerous efforts have been made for the past eight years to address this c...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Landesman-Milo D,Goldsmith M,Leviatan Ben-Arye S,Witenberg B,Brown E,Leibovitch S,Azriel S,Tabak S,Morad V,Peer D

    更新日期:2013-07-01 00:00:00

  • Epstein-Barr virus-activating principle in the ether extracts of soils collected from under plants which contain active diterpene esters.

    abstract::Soil samples were collected from the ground under the plants of Euphorbiaceae and Thymelaeaceae known to possess Epstein-Barr virus-activating diterpene esters. In a test system, the ether extracts of such soil samples at a concentration of 20 micrograms/ml induced Epstein-Barr virus early antigen in approximately 5-2...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Ito Y,Ohigashi H,Koshimizu K,Yi Z

    更新日期:1983-06-01 00:00:00

  • mTORC2 contributes to the metabolic reprogramming in EGFR tyrosine-kinase inhibitor resistant cells in non-small cell lung cancer.

    abstract::Non-small cell lung cancer (NSCLC) patients with activating EGFR mutations are often successfully treated with EGFR tyrosine kinase inhibitor (TKI) such as erlotinib; however, treatment resistance inevitably occurs. Given tumor metabolism of glucose and therapeutic response are intimately linked, we explored the metab...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Chiang CT,Demetriou AN,Ung N,Choudhury N,Ghaffarian K,Ruderman DL,Mumenthaler SM

    更新日期:2018-10-10 00:00:00

  • Increased cell density decreases cysteine proteinase inhibitor activity and increases invasive ability of two prostate tumor cell lines.

    abstract::The ability of a cancer cell to metastasis to a distant site is partly dependent on the secretion of matrix degrading enzymes. The lysosomal cysteine proteinases, cathepsins B and L, have been shown to be secreted by a number of cancer cells and have been implicated in metastasis. Cathepsins B and L are regulated by a...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Colella R,Goodwyn E,Gopal P

    更新日期:2002-11-28 00:00:00

  • Nimesulide inhibits IFN-gamma-induced programmed death-1-ligand 1 surface expression in breast cancer cells by COX-2 and PGE2 independent mechanisms.

    abstract::It is now well established that increased programmed death-1-ligand 1 (PD-L1) surface expression in cancer cells and the resultant T cell suppression contribute to cancer cell immune evasion. Blockade of PD-L1 function has been shown to stimulate anti-cancer immunity. Therefore, compounds that can down-regulate PD-L1 ...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Liang M,Yang H,Fu J

    更新日期:2009-04-08 00:00:00

  • S-trityl-L-cysteine derivative induces caspase-independent cell death in K562 human chronic myeloid leukemia cell line.

    abstract::Effect of CF(3)-STLC, a potent kinesin spindle protein (KSP) inhibitor, on K562 human CML cell line was investigated. Treatment with CF(3)-STLC induced mitotic arrest of the cell cycle with the appearance of characteristic monoastral spindles, subsequent apoptotic cell death and cleavage of PARP-1, caspase-3, and 4E-B...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Shimizu M,Ishii H,Ogo N,Unno Y,Matsuno K,Sawada J,Akiyama Y,Asai A

    更新日期:2010-12-01 00:00:00

  • SDHC-related deficiency of SDH complex activity promotes growth and metastasis of hepatocellular carcinoma via ROS/NFκB signaling.

    abstract::Succinate dehydrogenase is a heterotetrameric complex comprising four nuclear-encoded subunits, catalyzes the oxidation of succinate to fumarate in the tricarboxylic acid cycle. A subset of cancers have been found to be associated with mutations in the four SDH genes. However, the functional roles of the SDH complex i...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Li J,Liang N,Long X,Zhao J,Yang J,Du X,Yang T,Yuan P,Huang X,Zhang J,He X,Xing J

    更新日期:2019-10-01 00:00:00

  • Dihydroartemisinin induces autophagy by suppressing NF-κB activation.

    abstract::Nuclear factor-kappa B (NF-κB) and autophagy are two major regulators involved in both tumor initiation and progression. However, the association between these two signaling pathways still remains obscure. In this work, we demonstrate that dihydroartemisinin (DHA) stimulates the induction of autophagy in several cance...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Hu W,Chen SS,Zhang JL,Lou XE,Zhou HJ

    更新日期:2014-02-28 00:00:00

  • The cellular myb oncogene is amplified, rearranged and activated in human glioblastoma cell lines.

    abstract::The human c-myb gene which encodes a DNA binding protein and which is rarely amplified in neoplastic cells was found to be altered in four human glioblastoma cell lines. It exists in multiple copies in 2 out of 4 cases studied. The degree of amplification as determined by densitometry was about 10-fold, a rearrangemen...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Welter C,Henn W,Theisinger B,Fischer H,Zang KD,Blin N

    更新日期:1990-06-30 00:00:00

  • Carcinogenicity examination of quercetin and rutin in ACI rats.

    abstract::Carcinogenicity of quercetin and rutin were examined in inbred ACI strain rats. Rats were given a diet containing 1% or 5% quercetin or 5% rutin for 540 days, or 10% quercetin and 10% rutin for 850 days. Rats in control groups were fed a normal basal diet. Most tumors found in experimental groups were also found in th...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Hirono I,Ueno I,Hosaka S,Takanashi H,Matsushima T,Sugimura T,Natori S

    更新日期:1981-06-01 00:00:00

  • The predictive power of CD3+ T cell infiltration of oral squamous cell tumors is limited to non-diabetic patients.

    abstract::Diabetes mellitus type II (DM) and immune cell infiltration determine patient outcome in many tumor entities. Here we studied a possible link between the metabolic and immune cell status of OSCC patients. Glucose transporter (GLUT) 1 mRNA expression was elevated in all tumor samples, whereas other glycolytic markers s...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Spanier G,Ugele I,Nieberle F,Symeou L,Schmidhofer S,Brand A,Meier J,Spoerl S,Krupar R,Rümmele P,Siska P,Renner K,Peter K,Gerken M,Beckhove P,Reichert TE,Kreutz M,Singer K

    更新日期:2021-02-28 00:00:00

  • Induction of differentiation of human promyelocytic leukemia cells (HL-60) by arginase.

    abstract::Human promyelocytic leukemia cells (HL-60) were found to be induced by dimethylsulfoxide and several other compounds to phagocytize, reduce NBT dye, and change into forms that were morphologically similar to granulocytes and macrophages. Arginase also induced these differentiation-associated properties of the cells. T...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Honma Y,Fujita Y,Okabe-Kado J,Kasukabe T,Hozumi M

    更新日期:1980-10-01 00:00:00

  • Interleukin-6 stimulates clonogenic growth of primary and metastatic human colon carcinoma cells.

    abstract::Interleukin-6 (IL-6) is a pleiotropic cytokine which exerts biological activities on various cell types including neoplastic cells. We have investigated the biological effect of IL-6 and the expression of IL-6 receptors (IL-6R) on human colorectal carcinoma cell lines. Isreco-1 was derived from the primary site of a c...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Schneider MR,Hoeflich A,Fischer JR,Wolf E,Sordat B,Lahm H

    更新日期:2000-04-03 00:00:00

  • Polymorphisms in the DNA repair genes XPD, XRCC1, XRCC3, and APE/ref-1, and the risk of lung cancer among male smokers in Finland.

    abstract::Associations between lung cancer risk and common polymorphisms in the DNA repair genes xeroderma pigmentosum complementation group D (XPD), X-ray repair cross-complementing group 1 (XRCC1), XRCC3 and apurinic/apyrimidinic endonuclease/redox factor 1 were examined within a randomized clinical trial designed to determin...

    journal_title:Cancer letters

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Misra RR,Ratnasinghe D,Tangrea JA,Virtamo J,Andersen MR,Barrett M,Taylor PR,Albanes D

    更新日期:2003-03-10 00:00:00

  • Mouse trophoblastic cells exhibit a dominant invasiveness phenotype over cancer cells.

    abstract::Invasion process occurs both in mammalian embryo implantation during development and malignant cancer cell metastasis. We investigated the interactions between trophoblasts and metastatic cancer cells and found the phenomenon that mouse trophoblastic cells invaded the monolayer of malignant cancer cells in vitro and a...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Fang LQ,Zhang H,Ding XY,Li DQ,Hou XL,Qiao H,Bai J,Wang ZB

    更新日期:2010-12-28 00:00:00

  • The XPD Asp312Asn and Lys751Gln polymorphisms, corresponding haplotype, and pancreatic cancer risk.

    abstract::We evaluated the association between the XPD exon 10 Asp(312)Asn and exon 23 Lys(751)Gln polymorphisms and the risk of pancreatic cancer in a hospital-based study of 344 patients and 386 controls frequency matched by age, gender, and race. Stratified analyses showed ever smokers carrying the Asn(312)Asn genotype had a...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Jiao L,Hassan MM,Bondy ML,Abbruzzese JL,Evans DB,Li D

    更新日期:2007-01-08 00:00:00

  • Genistein potentiates the effect of arsenic trioxide against human hepatocellular carcinoma: role of Akt and nuclear factor-κB.

    abstract::Hepatocellular carcinoma (HCC) is a highly lethal malignancy mostly because of de novo and acquired resistance to conventional chemotherapy. Constitutive activation of Akt and nuclear factor-κB (NF-κB) represent major cellular abnormalities associated with both the pathogenesis and therapeutic resistance of HCC. The a...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Ma Y,Wang J,Liu L,Zhu H,Chen X,Pan S,Sun X,Jiang H

    更新日期:2011-02-01 00:00:00

  • Absence of hSNF5/INI1 mutation in human lung cancer.

    abstract::Frequent occurrence of chromosome 22q deletions in lung cancer indicates the presence of a tumor suppressor gene on this chromosome arm. The hSNF5/INI1 gene at chromosome 22q11.2 has recently been shown to act as a tumor suppressor in rhabdoid tumors. To investigate whether the hSNF5/INI1 gene located on chromosome 22...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Manda R,Kohno T,Hamada K,Takenoshita S,Kuwano H,Yokota J

    更新日期:2000-05-29 00:00:00

  • The field bean protease inhibitor has the potential to suppress B16F10 melanoma cell lung metastasis in mice.

    abstract::Metastasis is a characteristic and fatal feature of human malignancies. Its regulation is therefore of the utmost significance to clinicians. The present study was undertaken to determine whether a legume-derived protease inhibitor (PI) of trypsin/chymotrypsin, the field bean PI (FBPI), also has plasmin inhibitory act...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Banerji A,Fernandes A,Bane S,Ahire S

    更新日期:1998-07-03 00:00:00

  • Absence of beta-catenin gene mutations in pancreatic duct lesions induced by N-nitrosobis(2-oxopropyl)amine in hamsters.

    abstract::The involvement of beta-catenin gene alterations in pancreatic duct carcinogenesis induced by N-nitrosobis(2-oxopropyl)amine (BOP) in hamsters was examined by polymerase chain reaction-single strand conformation polymorphism analysis and the expression of beta-catenin protein was examined by immunohistochemistry. No m...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Kubozoe T,Tsujiuchi T,Murata N,Sasaki Y,Tsunoda T,Konishi Y,Tsutsumi M

    更新日期:2001-07-10 00:00:00

  • MMGZ01, an anti-DLL4 monoclonal antibody, promotes nonfunctional vessels and inhibits breast tumor growth.

    abstract::Increasing evidence suggests that DLL4 (Delta-like 4)-Notch signaling plays a critical role in cell fate determination and differentiation in tissues. Blocking DLL4-Notch signaling results in inhibition of tumor growth, which is associated with increased nonfunctional vessels and poor perfusion in the tumor. We succes...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Xu Z,Wang Z,Jia X,Wang L,Chen Z,Wang S,Wang M,Zhang J,Wu M

    更新日期:2016-03-01 00:00:00