Association of inhibition of cell growth by O-phospho-L-tyrosine with decreased tyrosine phosphorylation.

Abstract:

:We have previously demonstrated that O-phospho-L-tyrosine (P-Tyr), a substrate for a wide range of PTPases, inhibits the growth of human renal cell carcinoma and human breast cancer cell lines and suppresses EGF-mediated EGFR tyrosine phosphorylation. We now show that P-Tyr inhibited the growth of the human hepatoma cell line HEPG2, and src transformed NIH3T3 cells, but did not inhibit the growth of human ovarian carcinoma SKOV-3 cells. Addition of exogenous P-Tyr inhibited the insulin triggered insulin receptor (IR) tyrosine phosphorylation in the HEPG2 cell line and the tyrosine phosphorylation of a variety of cellular proteins in src-transformed NIH3T3 cells. P-Tyr did not inhibit the tyrosine phosphorylation of gp185 erbB-2 in P-Tyr resistant SKOV-3 cells. Thus, inhibition of cell growth by P-tyr was associated with decreased tyrosine phosphorylation of cellular proteins.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Mishra S,Hamburger AW

doi

10.1016/0304-3835(96)04164-x

subject

Has Abstract

pub_date

1996-04-19 00:00:00

pages

65-71

issue

1-2

eissn

0304-3835

issn

1872-7980

pii

0304-3835(96)04164-X

journal_volume

102

pub_type

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