Mutagenic virus replication in human tumor cells.

abstract：:Although it is well known that ovarian endometriosis occasionally gives rise to ovarian cancers with specific histology such as endometrioid and clear cell carcinomas, its etiology is not fully understood. We have shown that a stressful microenvironment within the endometriotic cyst may lead to cancer development by i...

journal_title：Cancer letters

authors： Mandai M,Matsumura N,Baba T,Yamaguchi K,Hamanishi J,Konishi I

更新日期：2011-11-28 00:00:00

abstract：:The efficacy and mechanism of action of cisplatin and gemcitabine were investigated in a panel of neuroblastoma cell lines and multicellular tumor spheroids. In neuroblastoma spheroids, the combination of cisplatin and gemcitabine induced a complete cytostasis at clinical relevant concentrations. A synergistic effect ...

journal_title：Cancer letters

authors： Besançon OG,Tytgat GA,Meinsma R,Leen R,Hoebink J,Kalayda GV,Jaehde U,Caron HN,van Kuilenburg AB

更新日期：2012-06-01 00:00:00

abstract：:Treatment of human epidermoid carcinoma A431 cells with transplatin (trans-DDP) and beta-hydroxyisovalerylshikon (beta-HIVS) together had a strong inhibitory effect on A431 cells. By contrast, trans-DDP and beta-HIVS by themselves, at the same respective concentrations, had practically no effect. The tyrosine kinase a...

journal_title：Cancer letters

authors： Xu Y,Nakajo S,Nakaya K

更新日期：2002-12-15 00:00:00

abstract：:Multidrug resistance (MDR) interferes with the efficiency of chemotherapy. Therefore, developing novel anti-cancer agents that can overcome MDR is necessary. Here, we screened a series of colchicine binding site inhibitors (CBSIs) and found that 5-(3, 4, 5-trimethoxybenzoyl)-4-methyl-2-(p-tolyl) imidazol (BZML) displa...

journal_title：Cancer letters

authors： Bai Z,Gao M,Zhang H,Guan Q,Xu J,Li Y,Qi H,Li Z,Zuo D,Zhang W,Wu Y

更新日期：2017-08-28 00:00:00

abstract：:Dibenzo[a,e]fluoranthene ( DBF ), a non- alternant carcinogenic polycyclic aromatic hydrocarbon (PAH), binds covalently to DNA. The main adducts were characterized as covalent additions of its bay-region and pseudo-bay-region diol-epoxides. The structure of these 2 adducts was analyzed by mass spectrometry using their...

journal_title：Cancer letters

authors： Perin-Roussel O,Croisy A,Ekert B,Zajdela F

更新日期：1984-04-01 00:00:00

abstract：:Potassium bromate (KBrO(3)) is a rat renal carcinogen and a major drinking water disinfection by-product in water disinfected with ozone. Clear cell renal tumors, the most common form of human renal epithelial neoplasm, are rare in animals but are inducible by KBrO(3) in F344 rats. Detection of cytoplasmic periodic ac...

journal_title：Cancer letters

authors： Shiao YH,Kamata SI,Li LM,Hooth MJ,DeAngelo AB,Anderson LM,Wolf DC

更新日期：2002-12-10 00:00:00

abstract：:(-)-Epigallocatechin gallate (EGCG), a major constituent of green tea, has been shown to exhibit anti-cancer activity. Sulindac is also well known as a cancer-preventive agent against colon cancer, but its usage is restricted because of its adverse effects, as exemplified by gastrointestinal bleeding. In the present s...

journal_title：Cancer letters

authors： Ohishi T,Kishimoto Y,Miura N,Shiota G,Kohri T,Hara Y,Hasegawa J,Isemura M

更新日期：2002-03-08 00:00:00

abstract：:Cucurbitacin B (CuB), has recently emerged as a potent anticancer agent; however, its efficacy in non-small-cell lung cancer (NSCLC) and the mechanism(s) initiating its biological effects remain largely unclear. In this study, CuB potently suppressed the growth of four NSCLC cells (H1299, A549, HCC-827 and H661) in vi...

journal_title：Cancer letters

authors： Kausar H,Munagala R,Bansal SS,Aqil F,Vadhanam MV,Gupta RC

更新日期：2013-05-10 00:00:00

abstract：:Cancer cachexia patients experience significant muscle wasting, which impairs the quality of life and treatment efficacy for patients. Skeletal muscle protein turnover is imparted by increased expression of ubiquitin-proteasome pathway components. Mitogen-activated protein kinases p38 and ERK have been shown to augmen...

journal_title：Cancer letters

authors： Mulder SE,Dasgupta A,King RJ,Abrego J,Attri KS,Murthy D,Shukla SK,Singh PK

更新日期：2020-10-28 00:00:00

abstract：:Pancreatic cancer remains a highly lethal malignancy. We have recently shown that simultaneous expression of Kras and mutant Tp53R175H promotes invasive ductal adenocarcinoma from pancreatic ductal cells. We hypothesized specific mutations in TP53 have divergent mechanisms of transforming ductal cells. In order to und...

journal_title：Cancer letters

authors： Polireddy K,Singh K,Pruski M,Jones NC,Manisundaram NV,Ponnela P,Ouellette M,Van Buren G,Younes M,Bynon JS,Dar WA,Bailey JM

更新日期：2019-07-01 00:00:00

abstract：:The environmental mutagens, 1-nitropyrene, 1,3-dinitropyrene, 1,6-dinitropyrene and 1,8-dinitropyrene were evaluated for their ability to initiate skin tumors in male and female SENCAR mice. 1-Nitropyrene (greater than 99.5% purity) did not induce papilloma formation over a dose range of 0-3.0 mg/mouse after 30 weeks ...

journal_title：Cancer letters

authors： Nesnow S,Triplett LL,Slaga TJ

更新日期：1984-05-01 00:00:00

abstract：:Triple negative breast cancer (TNBC) typically exhibits rapid progression, high mortality and faster relapse rates relative to other breast cancer subtypes. In this report we examine the combination of taxanes (paclitaxel or docetaxel) with a breast cancer stem cell (CSC)-targeting agent sulforaphane for use against T...

journal_title：Cancer letters

authors： Burnett JP,Lim G,Li Y,Shah RB,Lim R,Paholak HJ,McDermott SP,Sun L,Tsume Y,Bai S,Wicha MS,Sun D,Zhang T

更新日期：2017-05-28 00:00:00

abstract：:In the last year, several evidences indicated that pharmacological manipulation of relevant signaling pathways could selectively affect gene expression to influence cell fate. These findings render of extreme importance the elucidation of how external stimuli are transduced to mediate chromatin modifications, resultin...

journal_title：Cancer letters

authors： Chiacchiera F,Simone C

更新日期：2008-06-28 00:00:00

abstract：:Gastric cancer (GC) is a major threat to human health, and its prognosis is poor due to the lack of appropriate biomarkers. LncRNAs are a group of non-protein-coding RNAs that regulate gene expression at the transcriptional or posttranscriptional level. LncRNAs play essential roles in GC initiation and development in ...

journal_title：Cancer letters

authors： Yang Z,Guo X,Li G,Shi Y,Li L

更新日期：2016-02-01 00:00:00

abstract：:Calcium-stimulated, phospholipid dependent protein kinase C activity was found in cytosolic extracts of the epidermis of SENCAR, C57BL/6 and Ha/ICR mice. The enzymes were partially purified by DEAE-cellulose chromatography. There were no significant differences between the 3 strains in basal protein kinase C activity....

journal_title：Cancer letters

authors： Garte SJ,Edinger F,Mufson RA

更新日期：1985-11-01 00:00:00

abstract：:Current in vivo investigations of tumor angiogenesis mainly rely on the results obtained from engrafted models in mice. In the present study, we attempt to assess the potential of human tumor endothelium to form neovasculature in different engrafted tumor models. The tumor endothelial cells were isolated from human es...

journal_title：Cancer letters

authors： Hu H,Zhang Y,Ran Y,Zhou Z,Yu L,Lou J,Yang Z

更新日期：2007-07-08 00:00:00

abstract：:Protease inhibitors (PIs) of synthetic, bacterial or soybean origin have been shown to suppress carcinogen or radiation-induced rat mammary carcinogenesis. We report, for the first time, the effect of year-long feeding of Field bean meal, a rich source of PIs with a 24% protein content, at different protein levels in ...

journal_title：Cancer letters

authors： Fernandes AO,Banerji AP

更新日期：1997-06-03 00:00:00

abstract：:Hyperthermia induces cell death and the usual endpoint to study this is the ability of the cells to form colonies. Hyperthermia is also known to alter membrane characteristics, especially transmembrane potential and this has been correlated with duration and degree of heating. The aim of the present study was to see t...

journal_title：Cancer letters

authors： Remani P,Ostapenko VV,Akagi K,Bhattathiri VN,Nair MK,Tanaka Y

更新日期：1999-10-01 00:00:00

abstract：:Analysis of the loss of heterozygosity (LOH) detected by polymerase chain reaction techniques using 18 polymorphic markers localized to chromosomes 3p, 5, 17, and 18q in 40 Hong Kong Chinese esophageal squamous cell carcinoma (ESC) patients showed that multiple alterations on several chromosomes are involved in ESC de...

journal_title：Cancer letters

authors： Ko JM,Wong CP,Tang CM,Lau KW,Lung ML

更新日期：2001-09-20 00:00:00

abstract：:In experimental cancer chemoprevention studies, the doses of the agent used to produce an inhibitory response are generally very high, sometimes bordering on levels that will result in toxicity to the test animals. The present study was designed to test the hypothesis that low doses of two or more agents may be just a...

journal_title：Cancer letters

authors： Ip C

更新日期：1988-04-01 00:00:00

abstract：:To search for possible cancer chemopreventive agents from natural sources, we performed primary screening of ten flavanones isolated from plants belonging to Rutaceae and Leguminosae by examining their possible inhibitory effects on Epstein-Barr virus (EBV) early antigen activation induced by 12-O-tetradecanoylphorbol...

journal_title：Cancer letters

authors： Itoigawa M,Ito C,Ju-ichi M,Nobukuni T,Ichiishi E,Tokuda H,Nishino H,Furukawa H

更新日期：2002-02-08 00:00:00

abstract：:Colorectal cancer (CRC) is a commonly diagnosed malignancy with unsatisfactory survival outcomes. Recent studies indicate that noncoding RNAs (ncRNAs) can be selectively packaged into exosomes, the extracellular vesicles composed of a lipid bilayer, and delivered from donor to recipient cells, thus regulating the beha...

journal_title：Cancer letters

authors： Wu Q,Liu W,Wang J,Zhu L,Wang Z,Peng Y

更新日期：2020-11-28 00:00:00

abstract：:Currently, animal models are used to test the efficacy of tumor treatment. A significant reduction of tumor mass is lauded as great improvement. As we begin the 21st century, one wonders if this is sufficient and acceptable for cancer treatment. Although the presence of cancer stem cell (CSCs) is not a new phenomenon,...

journal_title：Cancer letters

authors： Nahas G,Bliss SA,Sinha G,Ganta T,Greco SJ,Rameshwar P

更新日期：2015-01-28 00:00:00

abstract：:cDNA libraries were generated from the prostate gland tissue obtained from a normal donor and from a patient with prostate cancer. Subtractive cDNA cloning was used to identify phenotype-specific cDNA sequences from both normal and cancerous prostate tissue. One clone, pN44, isolated from normal prostate tissue, codes...

journal_title：Cancer letters

authors： Liu AY,Bradner RC,Vessella RL

更新日期：1993-10-15 00:00:00

abstract：:The scope of the structure-anticancer activity relationship among various aliphatic and aromatic hydrazones containing the N,N,N',N'-bis(1,2-ethanediyl)-phosphoric diamide moiety was studied. A total of 19 compounds were tested in vivo, using murine lymphocytic leukemia P388. At optimum dose all these compounds were a...

journal_title：Cancer letters

authors： Sosnovsky G,Rao NU

更新日期：1985-12-01 00:00:00

abstract：:This review centers on recent findings with respect to modulating cancer multidrug resistance (MDR) with the well-known antidepressant fluoxetine (prozac). The MDR phenomena and mechanisms are discussed, including the roles of ABC transporters as MDR-pumps and the potential involvement of cancer stem cells. The three ...

journal_title：Cancer letters

authors： Peer D,Margalit R

更新日期：2006-06-18 00:00:00

abstract：:Most brain tumors are highly resistant to chemotherapy because many chemotherapeutic drugs poorly cross the blood-brain barrier, the blood-cerebrospinal-fluid barrier, and the plasma membrane of the tumor cells. This restricted drug delivery is largely due to the presence of integral plasma membrane proteins belonging...

journal_title：Cancer letters

authors： Nies AT

更新日期：2007-08-28 00:00:00

abstract：:Obesity is one of the major modifiable risk factors in breast cancer, with obese adipose tissue showing a pathological role in breast cancer development and malignancy via the release of secretory factors, such as proinflammatory cytokines and adipocytokines. The current article focuses on visfatin and resistin, two s...

journal_title：Cancer letters

authors： Wang YY,Hung AC,Lo S,Yuan SF

更新日期：2021-02-01 00:00:00

abstract：:The process of cooking beef substances which are mutagenic in the Ames Salmonella/microsome bioassay [1,2]. In this study, the formation and disposition of basic mutagens produced by cooking beef at different temperatures were examined. Mutagenic activity increased exponentially with cooking temperature between 137 de...

journal_title：Cancer letters

authors： Rappaport SM,McCartney MC,Wei ET

更新日期：1979-12-01 00:00:00

abstract：:Autophagy plays a critical role in intracellular metabolism and maintaining cellular homeostasis. Certain tumor cells present a higher basal autophagy rate and autophagy inhibition can lead to impaired metabolic dysfunction in autophagy-dependent tumor cells. Autophagy status in immune cells dictates their fate and re...

journal_title：Cancer letters

authors： Ishimwe N,Zhang W,Qian J,Zhang Y,Wen L

更新日期：2020-04-10 00:00:00