Abstract：
:A hallmark of most cancer cells is an altered metabolism involving a shift to aerobic glycolysis with lactate production coupled with a higher uptake of glucose as the main source of energy. Lactate dehydrogenase 5 (LDH-5) catalyzes the reduction of pyruvate by NADH to form lactate, thus determining the availability of NAD(+) to maintain the continuity of glycolysis. It is therefore an important control point in the system of cellular energy release. Its upregulation is common in many malignant tumors. Inhibiting LDH-5 activity has an anti-proliferative effect on cancer cells. It may reverse their resistance to conventional chemo- and radiotherapy. Recent research has renewed interest in LDH-5 as an anticancer drug target. This review summarizes recent studies exploring the role of LDH-5 in cancer growth, its utility as a tumor marker, and developments made in identifying and designing anti-LDH-5 therapeutic agents.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Augoff K,Hryniewicz-Jankowska A,Tabola Rdoi
10.1016/j.canlet.2014.12.035subject
Has Abstractpub_date
2015-03-01 00:00:00pages
1-7issue
1eissn
0304-3835issn
1872-7980pii
S0304-3835(14)00790-3journal_volume
358pub_type
杂志文章,评审相关文献
CANCER LETTERS文献大全abstract：:The constitutional expression of heat shock proteins (HSP) 27, 70 and 90 in human breast, colon and ovarian cancer cells transplanted into severe combined immunodeficient (SCID) mice was evaluated. In addition their induced expression under chemotherapeutic stress was analyzed. The oestrogen receptor positive breast c...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(00)00601-7
更新日期：2000-12-08 00:00:00
abstract：:Caffeine may very well be the most frequently ingested neuroactive drug in the world. Mechanistically, caffeine has been reported to affect cell cycle function, induce programmed cell death or apoptosis and perturb key cell cycle regulatory proteins. Although the effects of caffeine have been heavily investigated, muc...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2006.03.032
更新日期：2007-03-08 00:00:00
abstract：:Liver microsomes from control and treated rats (P4501A, 2B, 2E1-induced) metabolize at variable metabolic rates eight N-nitroso-di-n-alkylamines, including five symmetrical (N-nitroso-dimethyl, -diethyl, -dipropyl, -dibutyl and -diamyl-amines) and four asymmetrical (N-nitrosomethylethyl, methylpropyl, methylbutyl, and...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(95)04078-1
更新日期：1996-02-27 00:00:00
abstract：:A 65K protein, known for promoting nucleocytoplasmic mRNA transport in a cell-free system, was previously found in fetal and tumor cells of the rat. The primary objective of this study was to show specificity of immunohistochemical staining for the 65K protein in the livers of rats subjected to a hepatocarcinogenesis ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(89)90120-1
更新日期：1989-12-01 00:00:00
abstract：:Tissue samples from germ-free and conventional rats fed pectins with different degrees of esterification (DE) were tested for containing indigenous DNA adducts (I-compounds). For 21 days groups of six germ-free and 10 conventional rats each were fed either pectin-free or with diets containing 7.5% of three differently...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(97)04621-1
更新日期：1997-03-19 00:00:00
abstract：:Toxicity reduction of cisplatin is necessary for improved treatment of cancer. Here we have demonstrated the synergistic growth-inhibitory effect of cisplatin on cervical cancer cells in-combination with a nontoxic herbal carbazole alkaloid, mahanine. Mahanine enhanced cisplatin-induced apoptosis and reduced its effec...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2014.05.005
更新日期：2014-08-28 00:00:00
abstract：:The expression of DNA-topoisomerase II was analysed at the protein level in newly diagnosed cases of acute lymphoblastic leukemia (ALL) in children. Blast cells obtained from 81 children with untreated ALL were determined by means of immunocytochemistry. Of the ALL, 49 (60%) were positive for topoisomerase II and 32 (...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(94)90368-9
更新日期：1994-09-15 00:00:00
abstract：:R-spondins play critical roles in development, stem cell survival, and tumorigenicity by modulating Wnt/β-catenin signaling; however, the role of R-spondins in noncanonical Wnt signaling regulation remains largely unknown. We demonstrate here that R-spondin 2 (RSPO2) has an inhibitory effect on colorectal cancer (CRC)...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2017.05.024
更新日期：2017-08-28 00:00:00
abstract：:Vasohibin 2 (VASH2) is an angiogenic factor and cancer-related protein that acts via paracrine mechanisms. Here, we investigated the angiogenic function and mechanism of action of VASH2 in 200 human breast cancer tissues by performing immunohistochemical staining, western blot, indirect sandwich enzyme-linked immunoso...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2016.09.031
更新日期：2016-12-28 00:00:00
abstract：:Internal tandem duplication (ITD) of the juxtamembrane region of FMS-like tyrosine kinase-3 (FLT3) receptor is a common type of mutation in adult acute myeloid leukemia (AML), and patient response to FLT3 inhibitors appears to be transient due to the emergence of drug resistance. We established two sorafenib-resistant...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2016.04.040
更新日期：2016-07-28 00:00:00
abstract：:Metastatic colonization involves paracrine/juxtacrine interactions with the microenvironment inducing an adaptive response through transcriptional regulation. However, the identities of transcription factors (TFs) induced by the metastatic microenvironment in ovarian cancer (OC) and their mechanism of action is poorly...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2017.11.012
更新日期：2018-02-01 00:00:00
abstract：:The effect of diethylstilbestrol propionate (DES; 1 mg/kg body wt. was studied in the female offspring of rats exposed subcutaneously on the 19th day of gestation. Examination of vaginal smears showed persistent estrus in adult rats treated prenatally with DES. Compensatory ovarian hypertrophy (COH) induced by hemicas...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(79)80008-7
更新日期：1979-02-01 00:00:00
abstract：:Sulforaphane (SFN) is an isothiocyanate found in cruciferous vegetables, with particularly high levels detected in broccoli and broccoli sprouts. Over a decade ago, this phytochemical was identified as a likely chemopreventive agent based on its ability to induce Phase 2 detoxification enzymes, as well as to inhibit P...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2005.02.033
更新日期：2006-02-28 00:00:00
abstract：:As a third-generation platinum drug, oxaliplatin has been widely applied in colorectal cancer (CRC); however, acquired resistance to oxaliplatin has become a major obstacle. In the present study, we found that the nuclear transcription factor Y subunit beta (NFYB) and E2F transcription factor 1 (E2F1) expression level...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2017.11.040
更新日期：2018-02-28 00:00:00
abstract：:Multiple therapeutic strategies have been developed to treat pancreatic cancer. However, the outcomes of these approaches are disappointing. Due to deeper understandings of the pivotal roles of the immune system in pancreatic cancer tumorigenesis and progression, novel therapeutic strategies based on immune cells and ...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2018.03.040
更新日期：2018-07-01 00:00:00
abstract：:Aberrant crypt foci (ACF) have recently been identified as early putative preneoplastic lesions which appear in the colons of experimental animals treated with colon carcinogens. In a recent study the two heterocyclic amines, 2-amino-3-methyl-imidazo[4,5-f]quinoline (IQ) and 2-amino-1-methyl-6-phenyl-imidazo[4,5-b]pyr...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(96)04495-3
更新日期：1996-12-20 00:00:00
abstract：:The tumor promoter, phorbol-12-myristate-13-acetate (PMA), elicited a significant increase in lysosomal membrane permeability, as measured by release of free beta-glucurnidase, in guinea pig and hamster isolated hepatic lysosomes in vitro. This response was antagonized by zinc sulfate; zinc compounds having previously...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(80)90065-8
更新日期：1980-07-01 00:00:00
abstract：:Integrins emerge nowadays as crucial actors of tumor aggressiveness and resistance to therapies. Integrin α5β1, the fibronectin receptor, determines malignant properties of colon carcinoma which is one of the most important causes of cancer-related deaths in the world. Here we show that inhibition of α5 integrin subun...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2013.03.018
更新日期：2013-08-19 00:00:00
abstract：:Standard chemotherapy for pancreatic ductal adenocarcinoma (PDAC), nab-paclitaxel (NPT) plus gemcitabine (Gem), has led to an average survival of 8.5 months. Presently, no therapeutics exist that effectively target the KRAS oncogene, activated in 95% of PDACs, but alternative strategies focus on inhibition of downstre...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2019.05.037
更新日期：2019-09-10 00:00:00
abstract：:The acute intraperitoneal toxicities of chlorambucil and chlorambucil-spermidine conjugate have been compared, in mice. Both compounds were neurotoxic and also caused a prolonged fall in bodyweight and a depletion of lymphocyte numbers associated with a fall in the total leukocyte count and loss of spleen and thymus w...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(94)90278-x
更新日期：1994-10-14 00:00:00
abstract：:Immunohistochemically detected expression of sialyl Lewis(x) (Le(x)) antigen was analyzed in 101 stage 0-II gastric cancers to clarify its prognostic value after curative gastrectomy. Patients with a high-expression of sialyl Le(x) antigen within their tumors had shorter disease-specific intervals than those with nega...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(01)00705-4
更新日期：2002-01-25 00:00:00
abstract：:Primary cultures of mouse embryo cells are more efficient in excising DNA-carcinogen adducts resulting from exposure to either 7-bromomethylbenz-[alpha]anthracene or the more carcinogen 7-bromomethyl-12-methylbenz[alpha]anthracene than are mouse L 929 cell suspension cultures. However, within each of these systems, th...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(79)80103-2
更新日期：1979-07-01 00:00:00
abstract：:We aimed to clarify the clinical significance of des-gamma-carboxy prothrombin (DCP) levels in both hepatocellular carcinoma (HCC) and liver tissues with a special reference to the relationship between DCP level in non-cancerous parts of the liver and the multicentric occurrence of HCC. Twenty-eight patients with HCC,...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(00)00539-5
更新日期：2000-10-16 00:00:00
abstract：:We studied the effects of a lignan, hydroxymatairesinol (HMR), and rye bran on intestinal tumor development in adenomatous polyposis colimultiple intestinal neoplasia (Apc)(Min) mice. HMR showed a strong chemopreventive effect in this animal model. The mean number of adenomas in the small intestine was significantly l...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(00)00543-7
更新日期：2000-10-31 00:00:00
abstract：:Obesity is one of the major modifiable risk factors in breast cancer, with obese adipose tissue showing a pathological role in breast cancer development and malignancy via the release of secretory factors, such as proinflammatory cytokines and adipocytokines. The current article focuses on visfatin and resistin, two s...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2020.10.045
更新日期：2021-02-01 00:00:00
abstract：:PM2 DNA, forms I and II, were chemically modified with the ultimate carcinogen N-acetoxy-2-acetylaminofluorene. The products were subjected to 3 analytical procedures: (i) buoyant density centrifugation in the presence of the intercalating dyes ethidium bromide or propidium diiodide; (ii) agarose gel electrophoresis: ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(80)90151-2
更新日期：1980-02-01 00:00:00
abstract：:To further investigate the possibility for retroviral involvement in the etiology of human breast cancer we processed peripheral blood monocytes and malignant breast tissue biopsies from 10 patients with breast cancer (infiltrating ductal carcinoma or infiltrating lobular carcinoma; ages 40-80 years) and 20 normal hea...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(96)04217-6
更新日期：1996-06-05 00:00:00
abstract：:Macrophages that infiltrate tumor tissues, or tumor-associated macrophages (TAMs), affect the malignant behaviors of tumor cells. In this study, we attempted to induce monocytes to differentiate into TAM-like cells producing matrix metalloproteinases (MMPs) by co-culture with tumor cells. When human monocytes were co-...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2011.09.029
更新日期：2012-02-28 00:00:00
abstract：:Human PRL-1, PRL-2, and PRL-3 tyrosine phosphatases induce the malignant transformation of epithelial cells. We tested the hypothesis that the oncogenic effects of PRL occur by increasing cellular proliferation. Cells stably transfected with PRL-1 or PRL-2 exhibited 2.7-3.3-fold increases over control cells in the rat...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(03)00517-2
更新日期：2003-12-30 00:00:00
abstract：:The Chinese Glioma Cooperative Group (CGCG) Guideline Panel for adult diffuse gliomas provided recommendations for diagnostic and therapeutic procedures. The Panel covered all fields of expertise in neuro-oncology, i.e. neurosurgeons, neurologists, neuropathologists, neuroradiologists, radiation and medical oncologist...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2016.01.024
更新日期：2016-06-01 00:00:00
