Lack of initiating and promoting activity of thiourea in rat liver foci bioassay.

abstract：:Inhibition of 5-Lox induces apoptosis in prostate cancer cells by inactivating PKCε which is prevented by 5-oxoETE, and activators of PKCε prevent 5-Lox inhibition-induced apoptosis, suggesting that 5-Lox metabolites exert survival signaling via PKCε. However, mechanisms by which 5-Lox metabolites activate PKCε are no...

journal_title：Cancer letters

authors： Sarveswaran S,Ghosh J

更新日期：2013-08-09 00:00:00

abstract：:The gut microbiota forms a symbiotic relationship with the host and benefits the body in many critical aspects of life. However, immune system defects, alterations in the gut microbiota and environmental changes can destroy this symbiotic relationship and may lead to diseases, including cancer. Due to the anatomic and...

journal_title：Cancer letters

authors： Zhou A,Tang L,Zeng S,Lei Y,Yang S,Tang B

更新日期：2020-04-01 00:00:00

abstract：:Post-transplant lymphoproliferative disorders (PTLDs) represent the most severe complication of both solid organ and hematopoietic stem cell transplantation. The Epstein-Barr Virus (EBV) is the main driver of PTLD, particularly those occurring early after transplantation. EBV-driven malignancies are associated with se...

journal_title：Cancer letters

authors： Petrara MR,Giunco S,Serraino D,Dolcetti R,De Rossi A

更新日期：2015-12-01 00:00:00

abstract：:Improvements in technologies to yield purer circulating tumor cells (CTCs) will enable a broader range of clinical applications. We have previously demonstrated the use of a commercially available cell-adhesion matrix (CAM) assay to capture invasive CTCs (iCTCs). To improve the purity of the isolated iCTCs, here we us...

journal_title：Cancer letters

authors： Premasekharan G,Gilbert E,Okimoto RA,Hamirani A,Lindquist KJ,Ngo VT,Roy R,Hough J,Edwards M,Paz R,Foye A,Sood R,Copren KA,Gubens M,Small EJ,Bivona TG,Collisson EA,Friedlander TW,Paris PL

更新日期：2016-09-28 00:00:00

abstract：:In a search for anti-tumor-promoting agents, we carried out a primary screening of ten 4-phenylcoumarins isolated from Calophyllum inophyllum L. (Guttiferae), by examining their possible inhibitory effects on Epstein--Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate in Raji ...

journal_title：Cancer letters

authors： Itoigawa M,Ito C,Tan HT,Kuchide M,Tokuda H,Nishino H,Furukawa H

更新日期：2001-08-10 00:00:00

abstract：:The concept of metronomic chemotherapy (MC) has evolved from a descriptive preclinical phenomenon encompassing inhibition of angiogenesis to a clinically validated treatment concept involving multiple potential mechanisms of action. Clinicians are progressively more incline to consider MC as a component of mainstream ...

journal_title：Cancer letters

authors： Munzone E,Colleoni M

更新日期：2017-08-01 00:00:00

abstract：:The uptake of several metallophthalocyanine tetrasulfonates by cultured Chinese hamster cells was studied. Uranyl- and chloraluminium were taken up at the highest rate followed by Ni-, Zn-, Cu-, Co- and dichlorosilicon-phthalocyanine tetrasulfonate. The uptake from the growth medium containing 10% serum in which only ...

journal_title：Cancer letters

authors： Ben-Hur E,Siwecki JA,Newman HC,Crane SW,Rosenthal I

更新日期：1987-12-01 00:00:00

abstract：:The ability to induce changes in cell membrane properties is nowadays considered an additional mechanism to explain the pharmacological effects of non-steroidal anti-inflammatory drugs (NSAIDs). We previously demonstrated that the NSAID Licofelone, a dual cyclooxygenase/5-lipoxygenase inhibitor, triggers apoptosis in ...

journal_title：Cancer letters

authors： Tavolari S,Munarini A,Storci G,Laufer S,Chieco P,Guarnieri T

更新日期：2012-08-28 00:00:00

abstract：:Intravenous methotrexate (MTX) therapy is widely used for treatment of various neoplastic diseases in children. The optimization of the MTX dose and/or the subsequent leucovorin rescue is based on pharmacokinetic data calculated from plasma concentrations collected after cessation of the MTX administration. The influe...

journal_title：Cancer letters

authors： Eksborg S,Albertioni F,Rask C,Beck O,Palm C,Schroeder H,Peterson C

更新日期：1996-11-29 00:00:00

abstract：:A 1-week treatment with the hepatocarcinogen beta-blocker DL-1-(2-nitro-3-methyl-phenoxy)-3-tert-butylamino-propan-2-ol (ZAMI 1305) induces the appearance of preneoplastic liver lesions--oval cell hyperplasia, basophilic and gamma-glutamyltranspeptidase positive (GGT+) foci--in female Wistar rats, as evidenced by the ...

journal_title：Cancer letters

authors： Zavanella T,Presta M,Braga G,Dimito E,Mazzocchi C,Ziliani S,Ragnotti G

更新日期：1984-11-01 00:00:00

abstract：:Increased fatty acids (FAs) regulate pancreatic cancer progression, however, the detailed mechanism is not clear, and different forms of FAs may play diversified roles in pancreatic cancer. To elucidate the underlying mechanism, we compared the effects of four major types of FAs on pancreatic cancer growth both in cel...

journal_title：Cancer letters

authors： Yu M,Liu H,Duan Y,Zhang D,Li S,Wang F

更新日期：2015-05-01 00:00:00

abstract：:In this study we demonstrate the involvement of ras oncogenes in bladder cancer at the level of RNA overexpression. We examined 26 bladder specimens, consisting of paired tumor and adjacent normal tissue and found that H-ras transcripts were overexpressed in 39% of the specimens while K-ras and N-ras in 58% of total s...

journal_title：Cancer letters

authors： Vageli D,Kiaris H,Delakas D,Anezinis P,Cranidis A,Spandidos DA

更新日期：1996-10-22 00:00:00

abstract：:Telomerase activity (TA) and telomerase reverse transcriptase (rTERT) were investigated in Sprague-Dawley rats, killed at 6 and 12 h, and 1, 2, 3, 7, and 14 days after 90% pancreatectomy (px), by TRAPeze enzyme-linked immunosorbent assay telomerase detection and reverse transcriptase-polymerase chain reaction. TA incr...

journal_title：Cancer letters

authors： Oh BK,Seong JK,Lee JE,Chae KJ,Roh KJ,Park C,Park YN

更新日期：2002-12-01 00:00:00

abstract：:While the vast majority of cancers are believed to occur sporadically, most forms of cancer, both adult and paediatric, have a hereditary equivalent. In the case of adult malignancies, these include hereditary breast and ovarian cancer and syndromes such as the multiple endocrine neoplasias types 1 and 2 characterised...

journal_title：Cancer letters

authors： Marsh D,Zori R

更新日期：2002-07-26 00:00:00

abstract：:Exosomes are biological nanovesicles that are involved in cell-cell communication via the functionally-active cargo (such as miRNA, mRNA, DNA and proteins). Because of their nanosize, exosomes are explored as nanodevices for the development of new therapeutic applications. However, bulk, safe and cost-effective produc...

journal_title：Cancer letters

authors： Munagala R,Aqil F,Jeyabalan J,Gupta RC

更新日期：2016-02-01 00:00:00

abstract：:The objective of this work was to investigate the expression of glutathione S-transferase placental form (GST-P) in 9,10-dimethyl-1,2-benzanthracene (DMBA)-induced hamster buccal pouch carcinogenesis. Lesions were classified histopathologically into four categories, simple hyperplasia, papillary and nodular (PN) hyper...

journal_title：Cancer letters

authors： Iida K,Yamamoto M,Kato M,Yoshida K,Kurita K,Tatematsu M

更新日期：1999-01-29 00:00:00

abstract：:Human microsomal epoxide hydrolase (mEH) catalyzes a key step in the biotransformation of benzo[a]pyrene that yields the highly mutagenic (+)-anti-7,8-diol-9,10 epoxide (BPDE). Two polymorphisms have been described in the coding region of the mEH gene (EPHX1) that produce two protein variants: 113Tyr-->113His (exon 3)...

journal_title：Cancer letters

authors： To-Figueras J,Gené M,Gómez-Catalán J,Piqué E,Borrego N,Corbella J

更新日期：2001-11-28 00:00:00

abstract：:In this study we combined flow cytometry with fluorescence in situ hybridization to detect numerical aberrations in chromosomes. Fifty-nine human malignant gliomas were examined by flow cytometry for DNA-content and cell cycle analysis and for numerical aberrations of chromosome 1 by in situ hybridization using a chro...

journal_title：Cancer letters

authors： Ehemann V,Hashemi B,Lange A,Otto HF

更新日期：1999-04-26 00:00:00

abstract：:To further investigate the possibility for retroviral involvement in the etiology of human breast cancer we processed peripheral blood monocytes and malignant breast tissue biopsies from 10 patients with breast cancer (infiltrating ductal carcinoma or infiltrating lobular carcinoma; ages 40-80 years) and 20 normal hea...

journal_title：Cancer letters

authors： Hughes G,McKerr G,Allen J,Barnett Y

更新日期：1996-06-05 00:00:00

abstract：:The mucosal glutathione content of the gastrointestinal wall amounted to 50-60% of its concentration in the liver. GSH S-aryltransferase activity (CDNB) was very low in the glandular stomach, colon and rectum amounting to only 5% of liver enzyme activity. There was a marked postpyloric increase in GSH S-aryltransferas...

journal_title：Cancer letters

authors： Siegers CP,Riemann D,Thies E,Younes M

更新日期：1988-05-01 00:00:00

abstract：:Human epidermal growth factor receptor 2 (HER2), a member of the HER family of tyrosine kinases and a binding partner of Heat shock protein 90 (Hsp90), is found amplifies in approximately 25% breast cancers. Treatment of HER2+ breast cancers has been greatly improved in recent years, but the accompanying upregulation ...

journal_title：Cancer letters

authors： Huang W,Wu QD,Zhang M,Kong YL,Cao PR,Zheng W,Xu JH,Ye M

更新日期：2015-01-28 00:00:00

abstract：:The addition of recombinant human interleukin-6 (rIL-6) to either soleus or extensor digitorum longus (EDL) muscle preparations did not affect the rate of protein breakdown as measured by the rate of tyrosine released to the medium. In addition, the presence of the cytokine did not influence either the rate of protein...

journal_title：Cancer letters

authors： García-Martínez C,López-Soriano FJ,Argilés JM

更新日期：1994-01-15 00:00:00

abstract：:The cell transforming ability of asbestos dust was investigated using C3H10T 1/2 murine fibroblasts. In a series of experiments both crocidolite and amosite caused no increase in the number of transformed foci over that seen in cultures from untreated cells. The dusts, were, however, capable of augmenting the oncogeni...

journal_title：Cancer letters

authors： Brown RC,Poole A,Fleming GT

更新日期：1983-03-01 00:00:00

abstract：:A 65K protein, known for promoting nucleocytoplasmic mRNA transport in a cell-free system, was previously found in fetal and tumor cells of the rat. The primary objective of this study was to show specificity of immunohistochemical staining for the 65K protein in the livers of rats subjected to a hepatocarcinogenesis ...

journal_title：Cancer letters

authors： Hanausek-Walaszek M,Del Rio M,Adams AK

更新日期：1989-12-01 00:00:00

abstract：:Oral squamous cell carcinoma (OSCC) is associated with a high potential of tumor recurrence and metastasis, leading to poor prognosis. Cell motility is an important factor in the progression and metastasis of cancers. Recently, Fascin has been linked to tumor progression by induction of cell motility. However, the pre...

journal_title：Cancer letters

authors： Lee TK,Poon RT,Man K,Guan XY,Ma S,Liu XB,Myers JN,Yuen AP

更新日期：2007-09-08 00:00:00

abstract：:A cell line partially resistant to dimethylsulfoxide (DMSO) was derived from the HL-60 cell line. Cycloleucine, theophylline, sodium butyrate and elevated levels of DMSO were found to induce myeloid differentiation in this cell line while TPA induced monocytic differentiation. The levels of myc RNA and the genomic str...

journal_title：Cancer letters

authors： Grosso LE,Pitot HC

更新日期：1984-02-01 00:00:00

abstract：:Pancreatic cancer remains a highly lethal malignancy. We have recently shown that simultaneous expression of Kras and mutant Tp53R175H promotes invasive ductal adenocarcinoma from pancreatic ductal cells. We hypothesized specific mutations in TP53 have divergent mechanisms of transforming ductal cells. In order to und...

journal_title：Cancer letters

authors： Polireddy K,Singh K,Pruski M,Jones NC,Manisundaram NV,Ponnela P,Ouellette M,Van Buren G,Younes M,Bynon JS,Dar WA,Bailey JM

更新日期：2019-07-01 00:00:00

abstract：:The binding of [14C] azaserine or its metabolites to DNA and protein in the organs of rats and hamsters was determined at various time after treatment with [14C] azaserine. The specific activity of 14C labelling of DNA and protein was determined. Rat liver DNA and protein were most extensively labelled at 90 min post-...

journal_title：Cancer letters

authors： Zurlo J,Coon CI,Longnecker DS,Curphey TJ

更新日期：1982-05-01 00:00:00

abstract：:Overexpression of Myristoylated Alanine-Rich C Kinase Substrate (MARCKS) is implicated in drug resistance and progression of multiple myeloma (MM). The basis for MARCKS induction and impact on MM are not known. Here we show that microRNA-34a (miR-34a), regulates MARCKS translation and is under-expressed in drug-resist...

journal_title：Cancer letters

authors： Zhang L,Rastgoo N,Wu J,Zhang M,Pourabdollah M,Zacksenhaus E,Chen Y,Chang H

更新日期：2020-06-28 00:00:00

abstract：:The 825C>T polymorphism in the gene for the G-protein beta3 subunit (GNB3) has been linked to the occurrence of a splice variant of GNB3 and distinct cellular and metabolic features and may be associated with malignant disease. 500 patients with histologically confirmed breast cancer and 500 female age-matched healthy...

journal_title：Cancer letters

authors： Krippl P,Langsenlehner U,Renner W,Yazdani-Biuki B,Wolf G,Wascher TC,Paulweber B,Samonigg H

更新日期：2004-03-31 00:00:00