Abstract:
:A 65K protein, known for promoting nucleocytoplasmic mRNA transport in a cell-free system, was previously found in fetal and tumor cells of the rat. The primary objective of this study was to show specificity of immunohistochemical staining for the 65K protein in the livers of rats subjected to a hepatocarcinogenesis protocol. Altered hepatic foci were induced by feeding male weanling Sprague-Dawley rats 2-acetylaminofluorene (AAF) followed by a phenobarbital (PB) diet. It was shown, using polyclonal antibodies produced in rabbits, that the 65K protein was present in the cells of rat liver putative preneoplastic foci, with little or none being detected in the surrounding cells.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Hanausek-Walaszek M,Del Rio M,Adams AKdoi
10.1016/0304-3835(89)90120-1subject
Has Abstractpub_date
1989-12-01 00:00:00pages
213-21issue
3eissn
0304-3835issn
1872-7980pii
0304-3835(89)90120-1journal_volume
48pub_type
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