Abstract：
:Male Fischer rats were treated at 7 weeks of age with a single oral dose of 1,2-dimethylhydrazine (35 mg/kg). After 1.5 years, the 14 control and 28 treated animals were killed for general autopsy. The incidence of tumor formation in the treated animals was 78.6% as compared to 0% for the control animals. All tumors (1--3/rat) were located in the colon, with the exception of one in the Zymbal's gland of the ear and one in the small intestine. The dosage of 1,2-dimethylhydrazine used in this study is the lowest single oral dose of this carcinogen reported to induce colon tumors.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Schiller CM,Curley WH,McConnell EEdoi
10.1016/0304-3835(80)90131-7subject
Has Abstractpub_date
1980-11-01 00:00:00pages
75-9issue
1eissn
0304-3835issn
1872-7980pii
0304-3835(80)90131-7journal_volume
11pub_type
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