Abstract:
:We studied the influence of the vitamins retinol acetate, alpha-tocopherol acetate and thiamine chloride; the antioxidant sodium selenite and an inhibitor of polyamine biosynthesis, alpha-difluoromethylornithine, on the offspring of transplacental carcinogenesis by ethylnitrosourea in rats. Ethylnitrosourea was given to pregnant rats as a single i.v. injection, at a dose of 75 mg/kg body wt. or 5.5 mg/kg body wt., on the 21st day after conception. Retinol, tocopherol or thiamine was added to the diet, and selenite and alpha-difluoromethylornithine to drinking water of the offspring throughout their postnatal life at moderate doses. In control groups, ethylnitrosourea induced tumors of brain, spinal cord, peripheral nervous system and kidneys in the offspring. alpha-Difluoromethylornithine exerted a slight inhibitory effect; this agent decreased the total tumor multiplicity and the multiplicity of peripheral nervous system tumors and also prolonged survival time. Retinol, tocopherol, thiamine and selenite did not influence the development of the transplacentally-induced tumors.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Alexandrov VA,Bespalov VG,Boone CW,Kelloff GJ,Malone WFdoi
10.1016/0304-3835(91)90225-7keywords:
subject
Has Abstractpub_date
1991-11-01 00:00:00pages
177-84issue
2eissn
0304-3835issn
1872-7980pii
0304-3835(91)90225-7journal_volume
60pub_type
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