Abstract：
:The insulin-like growth factor (IGF) family of ligands, binding proteins and receptors is an important growth factor system involved in both the development of the organism and the maintenance of normal function of many cells of the body. The system also has powerful anti-apoptotic effects. More recently, evidence has accrued to demonstrate that the IGFs play an important role in cancer. Individuals with serum IGF-II levels in the upper quartile of the normal range (and IGF binding protein-3 levels in the lower quartiles) have a relative risk for developing breast, prostate, colon and lung cancer. IGF-II is commonly expressed by tumor cells and may act as an autocrine growth factor; occasionally even reaching target tissues and causing tumor-induced hypoglycemia. The IGF-I receptor is commonly (though not always) overexpressed in many cancers, and many recent studies have identified new signaling pathways emanating from the IGF-I receptor that affect cancer cell proliferation, adhesion, migration and cell death; functions that are critical for cancer cell survival and metastases. In this review, many aspects of the IGF system and its relationship to cancer will be discussed.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
LeRoith D,Roberts CT Jrdoi
10.1016/s0304-3835(03)00159-9keywords:
subject
Has Abstractpub_date
2003-06-10 00:00:00pages
127-37issue
2eissn
0304-3835issn
1872-7980pii
S0304383503001599journal_volume
195pub_type
杂志文章,评审相关文献
CANCER LETTERS文献大全abstract：:Endostatin has been demonstrated to represent a promising novel medicine to treat malignant tumors, and it may be more effective when combined with conventional treatment. Meanwhile, a promising area of research in radiation oncology is the integration of molecular targeting agents to improve the effectiveness of radi...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2008.12.008
更新日期：2009-09-08 00:00:00
abstract：:Protease inhibitors (PIs) of synthetic, bacterial or soybean origin have been shown to suppress carcinogen or radiation-induced rat mammary carcinogenesis. We report, for the first time, the effect of year-long feeding of Field bean meal, a rich source of PIs with a 24% protein content, at different protein levels in ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(97)04721-6
更新日期：1997-06-03 00:00:00
abstract：:It is now increasingly evident that the immune system represents a barrier to tumor emergence, growth, and recurrence. Although this idea was originally proposed almost 50 years ago as the "immune surveillance hypothesis", it is commonly recognized that, with few rare exceptions, tumor cells always prevail. Thus, one ...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2015.09.009
更新日期：2016-09-28 00:00:00
abstract：:Epstein-Barr virus (EBV) is known to be linear in viral particles but EBV circularizes into an episomal form after infection. Recently, the presence of integrated EBV DNA has been reported. We investigated EBV integration into the human genome in EBV-associated disease using Southern blotting. One hundred four cases i...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(97)00368-6
更新日期：1998-01-09 00:00:00
abstract：:N-nitrosobis(2-oxopropyl)amine (BOP)-induced pancreatic adenocarcinomas in Syrian hamsters produce considerable amounts of mucin. The mucin is immunogenic in rabbits and is predominately of A blood group antigenic specificity, as determined by immunodiffusion in agar gel. Indirect immunofluorescence studies with human...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(80)90053-1
更新日期：1980-10-01 00:00:00
abstract：:Cyclooxygenase-2 (COX-2) is a transcriptional target and downstream effector of the ErbB-1 (EGFR) and ErbB-2 signaling pathways. We found that anti-EGFR and anti-ErbB-2 antibodies inhibited ERK phosphorylation and downregulated COX-2 protein expression in HCA-7 human colon carcinoma cells. Both antibodies also augment...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2006.11.020
更新日期：2007-06-28 00:00:00
abstract：:Ovarian cancer represents the leading cause of death among patients with gynecological cancer. The genetic changes underlying the initiation and progression of ovarian cancer have not been well defined. However, non-random structural chromosomal changes have been identified with common chromosomal breakpoints. We have...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2005.04.010
更新日期：2006-04-08 00:00:00
abstract：:Present studies show the in vitro addition of glutathione (GSH) can significantly alter selenite induced growth inhibition of mammary tumor cell line 13 (CMT-13). Preincubation with 100 microM GSH for 24 h partially prevented the growth inhibition caused by 12.6 microM selenite. Pre-incubation with 100 microM GSH for ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(91)90213-2
更新日期：1991-05-01 00:00:00
abstract：:Cancerous breast hyperthermia is seemingly associated with non-neurological vasodilation modulated by nitric oxide (NO). NO, associated with enhanced immune response, is produced autocatalytically involving ferritin as the supplier of Fe2+, which catalyses the formation of NO. NO, in turn, releases Fe2+ from ferritin....
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/0304-3835(94)90354-9
更新日期：1994-08-29 00:00:00
abstract：:As a third-generation platinum drug, oxaliplatin has been widely applied in colorectal cancer (CRC); however, acquired resistance to oxaliplatin has become a major obstacle. In the present study, we found that the nuclear transcription factor Y subunit beta (NFYB) and E2F transcription factor 1 (E2F1) expression level...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2017.11.040
更新日期：2018-02-28 00:00:00
abstract：:To clarify the roles of Bmi-1 in colorectal carcinoma, we examined the expression of Bmi-1 in 41 samples out of 46 colorectal carcinomas by reverse transcription-PCR, whereas all 46 were analyzed by immunostaining. In addition, we analyzed the expression patterns of Bmi-1 in association with p16INK4a and p14ARF (in mo...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2003.07.009
更新日期：2004-01-20 00:00:00
abstract：:To identify novel anti-cancer agents, we created and screened a unique nutraceutical library for activity against acute myeloid leukemia (AML) cells. From this screen, we determined that glucopsychosine was selectively toxic toward AML cell lines and primary AML patient samples with no effect toward normal hematopoiet...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2014.03.003
更新日期：2014-06-28 00:00:00
abstract：:As a tumor antigen, mesothelin (MSLN) can be identified in various malignancies. MSLN is potential for antigen-specific cancer vaccines. We generated a novel chimeric DNA vaccine using antigen-specific connective tissue growth factor lined with MSLN (CTGF/MSLN). The anti-tumor effects of the CTGF/MSLN DNA vaccine comb...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2018.03.032
更新日期：2018-07-01 00:00:00
abstract：:The traditional "one treatment fits all" paradigm disregards the heterogeneity between cancer patients, and within a particular tumor, thus limit the success of common treatments. Moreover, current treatment lacks specificity and therefore most of the anticancer drugs induce severe adverse effects. Personalized medici...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2013.07.029
更新日期：2014-09-28 00:00:00
abstract：:BRAFV600- and MEK1/2-targeting therapies rarely produce durable response in melanoma patients. We investigated five BRAFV600E melanoma cell lines derived from drug-naïve tumor specimens to assess cell death response to encorafenib (Braftovi), a recently FDA-approved BRAFV600 inhibitor. Drug-naïve cell lines (i) did no...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2020.11.036
更新日期：2021-02-28 00:00:00
abstract：:Currently, animal models are used to test the efficacy of tumor treatment. A significant reduction of tumor mass is lauded as great improvement. As we begin the 21st century, one wonders if this is sufficient and acceptable for cancer treatment. Although the presence of cancer stem cell (CSCs) is not a new phenomenon,...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2014.03.002
更新日期：2015-01-28 00:00:00
abstract：:Most brain tumors are highly resistant to chemotherapy because many chemotherapeutic drugs poorly cross the blood-brain barrier, the blood-cerebrospinal-fluid barrier, and the plasma membrane of the tumor cells. This restricted drug delivery is largely due to the presence of integral plasma membrane proteins belonging...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2006.12.023
更新日期：2007-08-28 00:00:00
abstract：:Breast carcinomas are frequently characterized by hyperactivated c-erbB receptor tyrosine kinase signaling. Combination of anti-proliferative retinoids with growth-inhibitory c-erbB-specific agents might induce therapeutic benefit. We demonstrate close interactions between the c-erbB and the retinoic acid receptor sys...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(97)04715-0
更新日期：1997-05-01 00:00:00
abstract：:We studied the influence of the vitamins retinol acetate, alpha-tocopherol acetate and thiamine chloride; the antioxidant sodium selenite and an inhibitor of polyamine biosynthesis, alpha-difluoromethylornithine, on the offspring of transplacental carcinogenesis by ethylnitrosourea in rats. Ethylnitrosourea was given ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(91)90225-7
更新日期：1991-11-01 00:00:00
abstract：:This aim of this study was to measure the typical free radical-induced products of DNA bases in cellular DNA of cervical cancer tissues directly irradiated by applying brachytherapy to the patients. Significant increases in the amounts of modified bases over the control level were observed in the samples isolated afte...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(98)00170-0
更新日期：1998-10-23 00:00:00
abstract：:Liver microsomes from control and treated rats (P4501A, 2B, 2E1-induced) metabolize at variable metabolic rates eight N-nitroso-di-n-alkylamines, including five symmetrical (N-nitroso-dimethyl, -diethyl, -dipropyl, -dibutyl and -diamyl-amines) and four asymmetrical (N-nitrosomethylethyl, methylpropyl, methylbutyl, and...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(95)04078-1
更新日期：1996-02-27 00:00:00
abstract：:Pregnane X receptor (PXR) regulates cell proliferation and carcinogenesis in female reproductive tissue. We showed that PXR was expressed in cervical cells and tissue samples. PXR were lower or greatly diminished in cancer tissues compared to normal control. Functionally, activation of human PXR by rifampicin or ectop...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2014.01.026
更新日期：2014-05-28 00:00:00
abstract：:Invasion process occurs both in mammalian embryo implantation during development and malignant cancer cell metastasis. We investigated the interactions between trophoblasts and metastatic cancer cells and found the phenomenon that mouse trophoblastic cells invaded the monolayer of malignant cancer cells in vitro and a...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2010.08.008
更新日期：2010-12-28 00:00:00
abstract：:Cap-mediated translation is the default mechanism for the synthesis of proteins in eukaryotic cells. Increasingly, malignant cells have been found to have deregulation of this process. Return of normal translational control is associated with loss of tumorigenic potential in pre-clinical models. Currently, a variety o...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2007.08.022
更新日期：2007-12-08 00:00:00
abstract：:Cancer stem cells (CSCs) are a small subpopulation of tumor cells critical for tumor development. Their unique abilities, such as self-renewal, have resulted in tumor resistance to various cancer treatments, including traditional chemotherapy and latest immunotherapy. CSCs-targeting therapy is a promising treatment to...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2020.11.010
更新日期：2021-03-01 00:00:00
abstract：:Previous studies point to protein kinase C (PKC) isozyme eta as a resistance factor in cancer cells. Therefore, we investigated whether down-regulation of PKCeta with second generation antisense oligonucleotides (ODNs) would sensitise A549 human lung carcinoma cells to cytostatics. The effects were compared to the out...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2004.02.001
更新日期：2004-06-25 00:00:00
abstract：:The present study was conducted to investigate protein levels of inducible NO synthase (iNOS) and cayclooxygenase-2 (COX-2) in human colon cancer tissues. Significant increase of iNOS and COX-2 levels in tumors as compared to paired normal tissue was observed in 15 and 28, respectively, of 29 cases investigated. No co...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2005.08.014
更新日期：2006-08-08 00:00:00
abstract：:Preventive intervention of colorectal cancer has become essential as a major portion of the population may develop the disease at some points during their lives. Diet and nutrition play an important role during this multistep colon carcinogenic process. Inhibitory activity of aqueous suspensions of garlic and tomato, ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2003.11.024
更新日期：2004-05-28 00:00:00
abstract：:The human multidrug resistance ABC transporters provide a protective function in our body against a large number of toxic compounds. These proteins, residing in the plasma membrane, perform an active, ATP-dependent extrusion of such xenobiotics. However, the same proteins are also used by the tumor cells to fight vari...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2005.01.061
更新日期：2006-03-08 00:00:00
abstract：:C57BL/10 mice transgenic for HLA-A2 were immunized with either a full-length DNA-construct of the tumor suppressor p53 or with a minigene encoding the p53-derived immunodominant peptide p53(264)LLGRNSFEV272 (L9V). Vaccination with the full-length p53 construct induced potent cytotoxic activity of splenocytes against L...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(98)00353-x
更新日期：1999-04-01 00:00:00
