Abstract：
:Present studies show the in vitro addition of glutathione (GSH) can significantly alter selenite induced growth inhibition of mammary tumor cell line 13 (CMT-13). Preincubation with 100 microM GSH for 24 h partially prevented the growth inhibition caused by 12.6 microM selenite. Pre-incubation with 100 microM GSH for 48 h completely prevented the growth inhibition caused by 12.6 microM selenite. In marked contrast, simultaneous addition of GSH and selenite dramatically increased the severity of selenite-mediated growth inhibition and resulted in cell death. Exposure to selenite (12.6 microM) increased intracellular GSH throughout the 3 day incubation period. Addition of GSH to the medium also led to an approximate 25% increase in intracellular GSH that persisted for 72 h. Cellular retention of selenium following selenite supplementation was decreased up to 70% by GSH preincubation yet increased markedly (greater than or equal to 240%) by the simultaneous addition of GSH and selenite. The rate of selenite uptake was not consistently altered by GSH pretreatment. However, the simultaneous addition of GSH and selenite resulted in a dramatically increased rate of selenium uptake. These data indicate that extracellular GSH can alter the toxicity of supplemental selenite. The protective effect of GSH pre-incubation against selenite toxicity appears to relate to altered selenium retention.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Kuchan MJ,Milner JAdoi
10.1016/0304-3835(91)90213-2subject
Has Abstractpub_date
1991-05-01 00:00:00pages
181-6issue
2eissn
0304-3835issn
1872-7980pii
0304-3835(91)90213-2journal_volume
57pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract：:Conditioned medium from a series of human breast cancer cell lines representing the phenotypes of estrogen dependence ZR-75-1, MCF-7), tamoxifen resistance (Z(+)-75-9a1, LY2) and estrogen independence (ZR-PR-Lt) contained four detectable insulin-like growth factor binding proteins (IGFBPs) of MW 24, 34, 44 and 70 kDa....
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(95)04104-4
更新日期：1996-02-06 00:00:00
abstract：:The effects of 3-aminobenzamide (ABA), a representative inhibitor of poly(ADP-ribose)polymerase, on the induction of gamma-glutamyl-transpeptidase (GGT)-positive foci, an early lesion occurring during hepatocarcinogenesis, in rat liver by various chemicals were studied in Fischer 344 and Wistar rats. ABA exhibited an ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(88)90037-7
更新日期：1988-02-01 00:00:00
abstract：:Cancer cells are derived from their precursor cells, which normally develop to the matured cells to form individual organs. Neuroblastoma, one of the most common pediatric solid tumors, originates from possible cancer stem cells derived from the neural crest. During the development, neural crest cells segregate into s...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/S0304-3835(03)00457-9
更新日期：2004-02-20 00:00:00
abstract：:Elevated cyclooxygenase-2 (COX-2) expression has been observed in various types of cancer. Induction of COX-2 expression has been reported to increase invasiveness and angiogenesis of tumours. While COX-2 overexpression has been repeatedly proven to promote tumor growth, little is known about what initiates its induct...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2005.03.023
更新日期：2006-02-28 00:00:00
abstract：:Dioxane, perchloroethylene, and trichloroethylene were investigated as rat liver altered foci promoters in an initiation/promotion protocol. Animals were initiated with diethylnitrosamine, 30 mg/kg, injected i.p. 24 h after 2/3 partial hepatectomy. The chemical under study was administered by gavage once a day, 5 time...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(87)90099-1
更新日期：1987-07-01 00:00:00
abstract：:CD95, TNFR1, TRAILR1 and TRAILR2 belong to a subgroup of TNF receptors which is characterized by a conserved cell death-inducing protein domain that connects these receptors to the apoptotic machinery of the cell. Activation of death receptors in malignant cells attracts increasing attention as a principle to fight ca...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2010.12.019
更新日期：2013-05-28 00:00:00
abstract：:EGF-receptor family members (EGFRs) as well as c-Src are over expressed in approximately 70% of breast cancer, and in most of the tumors c-Src is co-over expressed with at least one of the EGFRs, suggesting that they may interact functionally and play a role in the development and progression of the malignancy. We hyp...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2009.03.035
更新日期：2009-10-08 00:00:00
abstract：:To better understand causative relations of smoking to lung adenocarcinomas, the frequency of loss of heterozygosity (LOH) of all autosomal chromosomes was compared among the three grades of histological differentiation with 119 pulmonary adenocarcinomas (AC) and 41 squamous cell carcinomas (SCC), using Southern blott...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(02)00383-x
更新日期：2002-12-10 00:00:00
abstract：:The monoclonal antibody against the AC133 epitope of CD133 has been widely used as a cell surface marker of cancer stem cells in several different cancer types. Here, we describe the isolation and characterisation of two RNA aptamers, including the smallest described 15 nucleotide RNA aptamer, which specifically recog...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2012.11.032
更新日期：2013-03-01 00:00:00
abstract：:Tumors are known to cause profound changes in host biology, but the mechanisms responsible for these changes remain unclear. Ornithine decarboxylase (ODC) is a rate-limiting enzyme that catalyzes the biosynthesis of polyamines. The purpose of this study was to examine the effects of MC-26 tumor burden on ODC activity ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(91)90039-k
更新日期：1991-06-14 00:00:00
abstract：:A panel of clinically used tyrosine kinase inhibitors were compared and nilotinib was found to most potently sensitize specific anticancer agents by blocking the functions of ABCB1/P-glycoprotein, ABCG2/BCRP and ABCC10/MRP7 transporters involved in multi-drug resistance. Nilotinib appreciably enhanced the antitumor re...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2012.10.001
更新日期：2013-01-28 00:00:00
abstract：:In this study, we aimed to establish a platinum-based chemotherapy response and toxicity prediction model in advanced non-small cell lung cancer (NSCLC) patients. 416 single nucleotide polymorphisms (SNPs) in 185 genes were genotyped, and their association with drug response and toxicity were estimated using logistic ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2016.04.029
更新日期：2016-07-10 00:00:00
abstract：:In the presence of iron, dihydroartemisinin forms free radicals and causes cell death. Since most cancer cells have high rates of iron intake, dihydroartemisinin would have selective cytotoxic effect on cancer cells. The present experiment was designed to study the effect of dihydroartemisinin and ferrous sulfate on t...
journal_title：Cancer letters
pub_type： 杂志文章
doi：
更新日期：1995-11-27 00:00:00
abstract：:The current standard approach for assessing carcinogenic potential is to conduct a near lifetime rodent pathology study with the high dose set to the maximum tolerated dose (MTD) of the test chemical. The linearized multistage model is then used as the default approach to estimate the potential human cancer risk at en...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/0304-3835(95)03794-W
更新日期：1995-06-29 00:00:00
abstract：:Glypican-5 (GPC5) may be a potential tumor suppressor gene in non-small cell lung cancer (NSCLC). The present study aimed to clarify the GPC5 expression pattern and to explore its potential functions in NSCLC. The expression of GPC5 gene was lower in lung cancer tissues compared with adjacent noncancerous tissues. The...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2013.08.020
更新日期：2013-12-01 00:00:00
abstract：:Hypusine formation on the eukaryotic initiation factor 5A (eIF-5A) precursor is ubiquitously present in eukaryotic cells and archebacteria. In this reaction, deoxyhypusine synthase catalyzes the conversion of one unique lysine residue on eIF-5A to deoxyhypusine using spermidine as the substrate. Hydroxylation of the d...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(97)04741-1
更新日期：1997-05-19 00:00:00
abstract：:Condensed roofing asphalt fumes, generated at 316 degrees C, were collected by cold trap condensation and fractionated by preparative high performance liquid chromatography. Chemical classes in each of the fractions (A-E) were identified by gas chromatography/mass spectroscopy. The fractions, various combinations of f...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(97)00214-0
更新日期：1997-07-15 00:00:00
abstract：:Recent evidence suggests that the cut-off for age utilized in neuroblastoma risk groups should be increased from the 365-day cut-off currently in use. Separate cooperative group analyses were performed by German and Italian groups and two analyses by the Children's Oncology Group (North America, Australia, New Zealand...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2004.12.054
更新日期：2005-10-18 00:00:00
abstract：:Autophagy plays a critical role in intracellular metabolism and maintaining cellular homeostasis. Certain tumor cells present a higher basal autophagy rate and autophagy inhibition can lead to impaired metabolic dysfunction in autophagy-dependent tumor cells. Autophagy status in immune cells dictates their fate and re...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2020.01.034
更新日期：2020-04-10 00:00:00
abstract：:Digalloylresveratrol (DIG) is a new synthetic ester of the naturally occurring polyhydroxyphenolic substances gallic acid and resveratrol which both exert anti-cancer activity in a number of tumor cell lines. The aim of the study was to identify the biochemical effects of DIG in HT-29 human colon cancer cells. DIG ind...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2008.09.020
更新日期：2009-02-18 00:00:00
abstract：:Application of a single high dose of 7,12-dimethylbenz[a]anthracene (DMBA, 1 mg) or N-nitrosomethylurea (NMU, 0.4 mg) to the ears of either athymic nu/nu or phenotypically normal nu/+ mice (BALB/c background) resulted in the appearance of cutaneous sebaceous adenomas as well as squamous cell tumors, both at the site o...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(86)90069-8
更新日期：1986-12-01 00:00:00
abstract：:The expression of the WAF1/CIP1 gene product, p21, in enzyme-altered foci (EAF) induced by diethylnitrosamine (DEN) and phenobarbital (PB) was examined. p21 expression in the nucleus of hepatocytes in EAF was decreased compared to surrounding tissue. Fifty-eight percent of all GST-P-positive EAF induced by DEN and 79%...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(96)04218-8
更新日期：1996-06-24 00:00:00
abstract：:The complex interactions in biological systems have been shown to affect the response to single-targeted therapies which were initially developed under the "reductionist paradigm" of cancer precision medicine. To address these fundamental challenges, great efforts have been dedicated from a network perspective to expl...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2019.05.015
更新日期：2019-08-28 00:00:00
abstract：:Histone deacetylase inhibitors (HDIs) exert direct tumour-toxic activity and sensitise tumour cells for other therapeutic regimens as well as the cytotoxic effects of activated immune cells. However, the HDI suberoylanilide hydroxamic acid (SAHA; vorinostat) interfered with the IL-2 activation of human NK cells and th...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2010.02.024
更新日期：2010-09-28 00:00:00
abstract：:Viscum album L. (VAL) is a phytopreparation used in adjuvant cancer therapy with both immunostimulatory and DNA stabilizing properties at low drug concentrations and cytostatic/cytotoxic properties at higher concentrations. The present work examines the cytotoxic effects of VAL extracts produced from mistletoes grown ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(95)04038-2
更新日期：1996-01-19 00:00:00
abstract：:The effects of caloric restriction on the incidence of mammary tumor development, the levels of the expression of mouse mammary tumor virus (MMTV)- and prolactin-RNA, as well as the levels of serum prolactin, were investigated in virgin RIII/Sa mice, a strain known to display a high incidence of spontaneous mammary tu...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(94)90261-5
更新日期：1994-05-16 00:00:00
abstract：:The three most common genetic abnormalities occurring in malignant lymphomas involve alterations resulting in the deregulated expression of the c-myc and bcl-2 oncogenes and the inactivation of the p53 tumor suppressor gene. Relevant strains of genetically engineered mice, including bcl-2-Ig and E mu-myc transgenic mi...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(95)03836-l
更新日期：1995-07-20 00:00:00
abstract：:Triple negative breast cancer (TNBC) typically exhibits rapid progression, high mortality and faster relapse rates relative to other breast cancer subtypes. In this report we examine the combination of taxanes (paclitaxel or docetaxel) with a breast cancer stem cell (CSC)-targeting agent sulforaphane for use against T...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2017.02.023
更新日期：2017-05-28 00:00:00
abstract：:We planned to determine the relationship between angiogenesis and p53 mutational status in advanced-stage epithelial ovarian cancer. Using 190 tumor samples from patients with stage III and IV ovarian cancer we performed p53 sequencing, immunohistochemistry, and CD31 microvessel density (MVD) determination. MVD was el...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2012.12.016
更新日期：2013-04-30 00:00:00
abstract：:The desensitization mechanism of the EGF receptor (EGFR) is important for the regulation of cancer cells. Although the phosphorylation of EGFR at Tyr1045 and Ser1046/1047 (Ser1046/7) reportedly accounts for such desensitization, the precise mechanism still remains unknown. Therefore, the present study investigated the...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2008.11.034
更新日期：2009-05-08 00:00:00
