Abstract：
:The effects of caloric restriction on the incidence of mammary tumor development, the levels of the expression of mouse mammary tumor virus (MMTV)- and prolactin-RNA, as well as the levels of serum prolactin, were investigated in virgin RIII/Sa mice, a strain known to display a high incidence of spontaneous mammary tumor development. Of the 54 mice fed a low-calorie (LC; 10 kcal/day) diet containing low fat (LF; 5% corn oil) for a period of 72 weeks, only seven mice were found to develop mammary tumors, an incidence of 13%. By contrast, the cumulative tumor incidence in a similar sized group of mice, fed a high-calorie (HC; 16 kcal/day) low fat-containing diet was 73%. Estimation of the relative levels of MMTV-RNA, as determined by Northern and slot blot hybridizations, in the mammary glands of mice fed LCLF and HCLF diets for 8, 10, 16, 28, and 36 weeks revealed that the LCLF diet-fed mice expressed 4-15-fold less RNA than the HCLF diet-fed mice. Interestingly, however, the LCLF diet did not appear to exert any effect on the expression of prolactin RNA even though it reduced the levels of serum prolactin. We suggest that in RII/Sa mice the modulation of MMTV-induced mammary tumors by dietary calorie is linked to the secretion of serum prolactin which, in turn, affects the replication of MMTV required for mammary cell transformation.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Li HW,Zhao W,Sarkar NHdoi
10.1016/0304-3835(94)90261-5subject
Has Abstractpub_date
1994-05-16 00:00:00pages
199-211issue
2eissn
0304-3835issn
1872-7980pii
0304-3835(94)90261-5journal_volume
79pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract：:Human RecQ helicases that share homology with E. coli RecQ helicase play critical roles in diverse biological activities such as DNA replication, transcription, recombination and repair. Mutations in three of the five human RecQ helicases (RecQ1, WRN, BLM, RecQL4 and RecQ5) result in autosomal recessive syndromes char...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2017.10.021
更新日期：2018-01-28 00:00:00
abstract：:Degradation of DNA produces deoxycytidine. Metabolism of deoxycytidine to dCTP inhibits phosphorylation of cytosine arabinoside (araC), fludarabine (FaraA) and 2-chlorodeoxyadenosine (CdA) by deoxycytidine kinase. This study measured plasma deoxycytidine in healthy adults and two leukemia patients and then determined ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(97)00185-7
更新日期：1997-06-24 00:00:00
abstract：:Our previous studies demonstrated that dietary garlic powder supplementation inhibits N-nitrosamine induced DNA alkylation in liver and mammary tissue. The present studies compared the impact of dietary supplementation with garlic powder or two garlic constituents, water-soluble S-allyl cysteine (SAC) and oil-soluble ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(96)04160-2
更新日期：1996-04-19 00:00:00
abstract：:Serum beta-glucuronidase activity is shown to differ quantitatively in the following strains of mice, listed in order of increasing activity: C3H, C57BL/6 less than BALB/c, DBA/2, ICR less than SENCAR, A/He. The level of the enzyme in the murine strains is shown to correlate with the urinary excretion of 17-ketosteroi...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(86)90098-4
更新日期：1986-10-01 00:00:00
abstract：:Doxycycline has been found to induce apoptosis and to inhibit the growth of a variety of tumor cells, in addition to its use as an antibiotic. However, the mechanism of its actions, especially at the molecular level, remains unknown and needs to be resolved. A crucial step possibly lies in the early period of doxycycl...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2009.05.004
更新日期：2009-11-28 00:00:00
abstract：:Heparanase (HPA) is an endoglucuronidase that can promote the shedding of associated cytokines in several types of tumors. However, little is known about what controls the expression of HPA or its role in gastric cancer. In this study, we report for the first time that HGF regulates HPA expression to promote gastric c...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2015.02.043
更新日期：2015-05-28 00:00:00
abstract：:More than 50% of human tumors contain a mutation in p53. Over 90% of tumors are solid tumors. Solid tumors have low oxygenated regions, called hypoxic regions where the tumor cells are more resistant to radio- and chemo-therapy than their well-oxygenated counterparts. In this study, we constructed a cell-permeable p53...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2009.01.030
更新日期：2009-06-28 00:00:00
abstract：:YTH domain containing 2 (YTHDC2) is a member of the DExD/H-box family of ATP-dependent RNA helicases. We previously found that YTHDC2 expression is up-regulated in several human cancer cells. In this study, we demonstrate novel roles for YTHDC2 in metastasis of colon tumor cells via translation-dependent pathway. Knoc...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2016.02.022
更新日期：2016-06-28 00:00:00
abstract：:The traditional "one treatment fits all" paradigm disregards the heterogeneity between cancer patients, and within a particular tumor, thus limit the success of common treatments. Moreover, current treatment lacks specificity and therefore most of the anticancer drugs induce severe adverse effects. Personalized medici...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2013.07.029
更新日期：2014-09-28 00:00:00
abstract：:The rationale for melanoma specific antitumor agents containing phenolic amines is based in part upon the ability of the enzyme tyrosinase to oxidize these prodrugs to toxic intermediates. Two phenolic amine compounds, N-acetyl-4-S-cysteaminylphenol (N-Ac-4-S-CAP) and 4-S-cysteaminylphenol (4-S-CAP), demonstrated grow...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(92)90092-a
更新日期：1992-03-31 00:00:00
abstract：:Trastuzumab (or Herceptin), as the first erbB2-targeted therapy, has been successfully used to treat breast cancer patients with erbB2-overexpressing tumors. However, resistances to trastuzumab frequently occur, and novel strategies/agents are urgently needed to abrogate the resistant phenotype. Our current study expl...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2011.03.019
更新日期：2011-08-01 00:00:00
abstract：:We investigated the influence of TNF-alpha on the metastasis of cancer cells. Treatment of cultured colon 26 cells with TNF-alpha enhanced metastatic properties including production of MMP-9, adhesion, migration and invasion. Cells treated with TNF-alpha in vitro showed marked potential to metastasize to the lung and ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2004.12.027
更新日期：2005-12-08 00:00:00
abstract：:Tumors are known to cause profound changes in host biology, but the mechanisms responsible for these changes remain unclear. Ornithine decarboxylase (ODC) is a rate-limiting enzyme that catalyzes the biosynthesis of polyamines. The purpose of this study was to examine the effects of MC-26 tumor burden on ODC activity ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(91)90039-k
更新日期：1991-06-14 00:00:00
abstract：:Malachite green (MG), an industrial compound and potential environmental health hazard, is highly cytotoxic to mammalian cells in culture. In an attempt to define the biochemical basis, we have compared the cytotoxic effects and morphological alterations shown by MG in Syrian hamster embryo (SHE) cells with the levels...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(92)90131-e
更新日期：1992-12-24 00:00:00
abstract：:The abundance of macrophages is an independent negative prognostic factor in a range of cancer types, linked to the actions of macrophage products on vasculogenesis and cancer cell survival, motility and metastasis. TNF-α is a macrophage product and a product of some cancer cell types that is also associated with adve...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2011.03.020
更新日期：2011-08-01 00:00:00
abstract：:The effects of glucocorticoids and cholesterol on morphological transformation have been studied using hamster embryo cells. The cells were exposed sequentially to benzo[a]pyrene (BP) (3 days) and the tumor promotor 12-O-tetradecanoylphorbol-13-acetate (TPA) (4 days) before scoring for morphologically transformed colo...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(82)90039-8
更新日期：1982-02-01 00:00:00
abstract：:Both PTEN (encoding phosphate and tensin homologue) and p53 are known as cancer suppressor genes, and they are assumed that their gene mutations and loss of heterozygosity (LOH) occur frequently in various types of carcinoma. In the present study, we investigated both the p53 mutation and LOH of PTEN in 113 gastric ca...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2004.12.006
更新日期：2005-09-08 00:00:00
abstract：:Human papillomavirus (HPV) DNA integrations may affect therapeutic responses in cancers through ATM network-related DNA damage response (DDR). We studied whether cisplatin-induced DDR was altered in human HK-2 renal tubular cells immortalized by HPV16 E6/E7 genes. Cytotoxicity assays utilized thiazolyl blue dye and DD...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2014.11.008
更新日期：2015-01-28 00:00:00
abstract：:The growth of primary subcutaneous fibrosarcomas and their pulmonary metastases was studied in normal and athymic Swiss mice. The metastases tended to develop more rapidly than did the primary tumors. However, when growth rates of tumors of small volumes (up to 1 cm3) were compared, the tumor and metastases exhibited ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(82)90129-x
更新日期：1982-03-01 00:00:00
abstract：:Highly invasive and rapidly fatal, small-cell lung cancer (SCLC) has been an insurmountable gulf since discovery. Innate immunity plays a vital role in anti-tumor response, among which macrophages contribute to an indispensable character. Here, we found that macrophage infiltration in SCLC reduced significantly in a s...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2020.11.034
更新日期：2021-02-28 00:00:00
abstract：:Angiogenesis remains a sensible target for pancreatic ductal adenocarcinoma (PDAC) therapy. VEGF, PDGF, FGF and their receptors are expressed at high levels and correlate with poor prognosis in human PDAC. Nintedanib is a triple angiokinase inhibitor that targets VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β signaling. We invest...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2014.12.027
更新日期：2015-03-01 00:00:00
abstract：:Immunogenic, methylcholanthrene-induced sarcomas failed to elicit the production of rapidly cytolytic T lymphocytes in syngeneic mice, although they did elicit the production of more slowly cytotoxic cells. They were, however, susceptible to attack by cytolytic T cells from allo-immune mice and, if infected with ectro...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(78)80046-9
更新日期：1978-08-01 00:00:00
abstract：:In vitro metabolism of dimethylnitrosamine (DMN) by liver microsomal fractions of hamster, rat and chicken revealed that the three species under certain assay conditions, were capable of metabolizing DMN at different rates (hamster greater than rat greater than chicken). The magnitude of the demethylase activity was f...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(85)90169-7
更新日期：1985-02-01 00:00:00
abstract：:We have developed a simple system for rapid detection and measurement of glutathione S-transferase placental form (GSTP1) that detoxify polycyclic aromatic hydrocarbons using the cultured rat normal liver epithelial cell line, (RL34) cells. Survey of fruit extracts for GST inducing ability identified both papaya and a...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(00)00487-0
更新日期：2000-09-01 00:00:00
abstract：:Berberine, an isoquinoline alkaloid, has a wide range of pharmacological effects, including anti-inflammation, yet the exact mechanism is unknown. Because cyclooxygenase-2 (COX-2) plays a key role in prostaglandins (PGs) synthesis, which is elevated in inflammation, we examined whether the anti-inflammatory mechanism ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2003.09.002
更新日期：2004-01-20 00:00:00
abstract：:In order to understand the differences and similarities between tumorigenic and non-tumorigenic HeLaxhuman fibroblast hybrids, gene expression profiles were examined with synthetic oligonucleotide arrays containing nearly 7000 gene probe sets. We used two pairs of genetically related hybrids, each pair representing in...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(01)00437-2
更新日期：2001-04-26 00:00:00
abstract：:The aim of this study was to investigate the interaction of tamoxifen (TAM) with the so-called Type II estrogen binding sites (Type II EBS) in both the cytosolic and the nuclear fraction of the ER-negative A 2780 human ovarian cancer cell line and in an ER-negative ovarian cancer tissue. Although cytosolic and nuclear...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(95)03922-j
更新日期：1995-09-04 00:00:00
abstract：:The pineal has been recently implicated in mammary tumorigenesis. Effect of physiological pinealectomy brought about by subjecting female Holtzman rats to permanent lighting (24 h/day) from birth was studied on the incidence of 9,10-dimethyl-1,2-benzanthracene (DMBA) induced mammary tumors. The incidence of adenocarci...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(82)90012-x
更新日期：1982-09-01 00:00:00
abstract：:Glutathione S-transferases (GST) alpha and pi, glutathione (GSH) and aldehyde dehydrogenase (ADH) were determined in colorectal cancer tissue specimens and in the adjacent normal colon tissue. The median contents in normal and cancer tissue were 8.1 (2.3-30.3) (5-95% quantiles) and 15.1 (5.3-50.3) microg/mg protein fo...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(98)00059-7
更新日期：1998-06-05 00:00:00
abstract：:In our previous rat study, an established intracranial C6 glioma was successfully treated using intratumoral injection of mesenchymal stem cells transduced with the herpes simplex virus-thymidine kinase gene (MSCtk) and systemic administration of ganciclovir (GCV). In the present study, effect of the "bystander effect...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2011.02.037
更新日期：2011-07-01 00:00:00
