Abstract:
:Histone deacetylase inhibitors (HDIs) exert direct tumour-toxic activity and sensitise tumour cells for other therapeutic regimens as well as the cytotoxic effects of activated immune cells. However, the HDI suberoylanilide hydroxamic acid (SAHA; vorinostat) interfered with the IL-2 activation of human NK cells and the priming of human tumour-specific T cells. In contrast, NK or T cells which were activated in the absence of HDIs became resistant to their immunosuppressive action. Therefore, as a therapeutic strategy, first the patient's immune system might be stimulated and then HDIs could sensitise the tumours for the attack of the pre-activated immune effector cells.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Schmudde M,Friebe E,Sonnemann J,Beck JF,Bröker BMdoi
10.1016/j.canlet.2010.02.024subject
Has Abstractpub_date
2010-09-28 00:00:00pages
173-81issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(10)00134-5journal_volume
295pub_type
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