Abstract:
:Dihydroambazone (DHA) is a water-soluble derivative of the experimental anticancer drug ambazone. In vitro, a combination of DHA and human recombinant tumor necrosis factor alpha (TNF) exerted a strong synergism of cytotoxicity against both mouse melanoma B16K cells and the TNF-sensitive mouse fibroblast line L-M (S). Furthermore, in a colony-forming assay with B16K cells a combination of TNF and DHA inhibited colony-formation much more severely than either drug alone. An increased antiproliferative efficiency was also confirmed in vivo against established subcutaneous melanoma B16 tumors of C57BL/6 mice.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Baumgart J,Gase K,Schulze W,Suehnel J,Gutsche W,Behnke Ddoi
10.1016/0304-3835(90)90032-ssubject
Has Abstractpub_date
1990-11-05 00:00:00pages
119-24issue
3eissn
0304-3835issn
1872-7980pii
0304-3835(90)90032-Sjournal_volume
54pub_type
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