Abstract:
:We investigated the influence of TNF-alpha on the metastasis of cancer cells. Treatment of cultured colon 26 cells with TNF-alpha enhanced metastatic properties including production of MMP-9, adhesion, migration and invasion. Cells treated with TNF-alpha in vitro showed marked potential to metastasize to the lung and liver in vivo. U0126, an inhibitor of MEK1/2, inhibited the TNF-alpha-induced activation of extracellular signal-regulated kinase 1/2 (ERK1/2) and the metastatic properties in vitro without affecting cell proliferation. In addition, pretreatment with U0126 in vitro completely abrogated the increased lung metastasis of TNF-alpha-treated cells. These results indicate that TNF-alpha-induced activation of cancer cells through the ERK pathway is sufficient for the enhanced metastatic potential of colon 26 cells.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Choo MK,Sakurai H,Koizumi K,Saiki Idoi
10.1016/j.canlet.2004.12.027keywords:
subject
Has Abstractpub_date
2005-12-08 00:00:00pages
47-56issue
1eissn
0304-3835issn
1872-7980pii
S0304-3835(04)00993-0journal_volume
230pub_type
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