Abstract:
:The human c-myb gene which encodes a DNA binding protein and which is rarely amplified in neoplastic cells was found to be altered in four human glioblastoma cell lines. It exists in multiple copies in 2 out of 4 cases studied. The degree of amplification as determined by densitometry was about 10-fold, a rearrangement within the coding region and an enhanced gene activity of c-myb were noted. The observation of c-myb oncogene amplification and activity in glioblastoma cell lines presents the first report of this effect in human brain tumor cells.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Welter C,Henn W,Theisinger B,Fischer H,Zang KD,Blin Ndoi
10.1016/0304-3835(90)90077-bsubject
Has Abstractpub_date
1990-06-30 00:00:00pages
57-62issue
1eissn
0304-3835issn
1872-7980pii
0304-3835(90)90077-Bjournal_volume
52pub_type
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