Abstract：
:Carbaryl (1-naphthyl methyl carbamate: C12H11NO2) CAS Reg. No. 63-25-2) is a widely used broad spectrum carbamate insecticide known to exert various toxic effects on experimental animals. Along with various other toxicological effects carbaryl is reported to increase the incidence of neoplasm in various tissues in rats after oral or intraperitoneal administration. No study has so far been reported in rodents to assess its carcinogenic/cocarcinogenic potential after topical exposure. In this set of investigations, the complete carcinogenic, tumour initiating and tumour promoting property of carbaryl was tested on the skin of female Swiss albino mice. The animals were exposed to carbaryl through topical painting on the interscapular region at a dose of 100 mg/kg body wt. The results revealed that carbaryl has tumour initiating potential, at the test dose, on mouse skin following two stage, initiation-promotion protocol, but, it failed to induce the tumour(s) when tested for complete carcinogenic and tumour promoting properties.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Shukla Y,Antony M,Mehrotra NKdoi
10.1016/0304-3835(92)90183-vkeywords:
subject
Has Abstractpub_date
1992-02-29 00:00:00pages
133-40issue
2eissn
0304-3835issn
1872-7980pii
0304-3835(92)90183-Vjournal_volume
62pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract：:To identify non-tumor biomarkers for prediction of tumor HPV status and prognosis of patients with squamous cell carcinoma of the oropharynx (SCCOP), we evaluated the association of single nucleotide polymorphisms (SNPs) in pre-miRNAs with HPV16 status and survival for SCCOP patients. We analyzed HPV16 status in tumor...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2012.11.048
更新日期：2013-04-28 00:00:00
abstract：:Matrilysin and gelatinase A, B mRNA expressions were examined in colorectal tumors. Matrilysin mRNA was observed exclusively in tumors, while the others were also found in normal mucosa surrounding tumors. Further analysis revealed that colorectal adenomas with severe dysplasia, not with mild dysplasia, expressed matr...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(96)04336-4
更新日期：1996-10-01 00:00:00
abstract：:A hitherto unreported lactate dehydrogenase (LD) isoenzyme, which migrates electrophoretically to the relative position between LD2 and LD3 has been identified in the electropheratogram in 7 of 7 (100%) cultured hepatoma cell lines with various degrees of differentiation and is thus given the name LD2-3. LD2-3 seems t...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(94)90222-4
更新日期：1994-12-09 00:00:00
abstract：:New, potentially tumor-specific antigens have been described in Bcr/Abl positive leukemias. Besides the main BCR/ABL hybrid fusion transcripts, a small number of transcripts derived from alternative splicing between BCR exons 1, 13, and 14 with ABL exons 4 and 5 have been identified. These variants are expressed in ch...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2008.10.032
更新日期：2009-04-08 00:00:00
abstract：:In the present study, we show that concomitant inhibition of Hedgehog (HH) signaling by the glioma-associated oncogene homolog1 (GLI1)-targeting agent GANT61 and the antiapoptotic BCL-2 protein family member MCL-1 by A-1210477 synergistically induces cell death in HH-driven cancers, i.e. rhabdomyosarcoma (RMS) and med...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2019.08.012
更新日期：2019-11-28 00:00:00
abstract：:The carcinogenic effects of the fungicide manganese ethylenebisdithiocarbamate (maneb) have been investigated in 2 populations of adult crested newt, which have different prevalences of spontaneous melanoma. Animals were exposed percutaneously to a 5 ppm solution of maneb 4 days a week for 37 weeks. No differences in ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(80)90033-6
更新日期：1980-08-01 00:00:00
abstract：:The effects of the ornithine decarboxylase suicide substrate, difluoromethylornithine (DFMO), and of cyclophosphamide, individually and in combination, on the growth of the R3327MAT-Lu prostate derived tumor were determined. DFMO decreased the growth rate and resulted in a 75% reduction in DNA content compared to the ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(82)90093-3
更新日期：1982-05-01 00:00:00
abstract：:Deregulation of cell metabolism is an established cancer hallmark that contributes to tumor initiation and progression, as well as tumor heterogeneity. In solid tumors, alterations in different metabolic pathways, including glycolysis, pentose phosphate pathway, glutaminolysis and fatty acid metabolism, support the hi...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2020.02.034
更新日期：2020-05-01 00:00:00
abstract：:Macrophages that infiltrate tumor tissues, or tumor-associated macrophages (TAMs), affect the malignant behaviors of tumor cells. In this study, we attempted to induce monocytes to differentiate into TAM-like cells producing matrix metalloproteinases (MMPs) by co-culture with tumor cells. When human monocytes were co-...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2011.09.029
更新日期：2012-02-28 00:00:00
abstract：:MDM2 is a phosphoprotein that interacts with P53 and inhibits its activity. Recently, a T/G substitution (SNP309) in the promoter of MDM2 was identified and has been demonstrated to be associated with an increased MDM2 expression and a significantly earlier age of onset of several tumors, including breast cancer. To t...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2005.09.019
更新日期：2006-08-28 00:00:00
abstract：:Suspensions of Walker and HeLa cells, rat fibroblasts and human stimulated lymphocytes were incubated over various periods with the synthetic amino steroid, 2 beta,16 beta-dipiperidino-5 alpha-androstane-3 alpha,17 beta-diol dipivalate (DAP). The acute cell destroying effect was found to be exponentially time and dose...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(77)80032-3
更新日期：1977-03-01 00:00:00
abstract：:5-fluorouracil (5-FU) is widely used in chemotherapy for colorectal cancer (CRC), but a high rate of chemoresistance reduces its effectiveness in clinical treatment. We found remarkably decreased expression of forkhead box 3 (FoxO3) protein, a tumor inhibitor, in 5-FU-resistant SW620 and HCT-8 (SW620/5-FU and HCT-8/5-...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2019.11.042
更新日期：2020-02-01 00:00:00
abstract：:In the present study, the question of whether the ubiquitous environmental pollutant, 1-nitropyrene (1-NP), can induce gamma-glutamyltranspeptidase (GGT)-positive foci, an early lesion occurring during hepatocarcinogenesis, when given orally to F344 rats was examined. Significant induction of GGT-positive foci was obs...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(89)90031-1
更新日期：1989-04-01 00:00:00
abstract：:Enhanced expression of the nucleotide excision repair gene XPA is associated with resistance to cisplatin treatment in human ovarian cancer. Understanding the cause of enhanced XPA expression will provide new molecular targets for therapy directed at overcoming chemoresistance. Enhanced gene expression in cancer cells...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(96)04428-x
更新日期：1996-11-29 00:00:00
abstract：:We previously showed that polyphyllin D (PD) produced a stronger apoptotic effect in R-HepG2 with multi-drug resistance (MDR) than that in its parent HepG2 cells without MDR. In this study, PD was found to elicit mitochondrial fragmentation in live cells by using total internal reflection fluorescence microscopy (TIRF...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2007.11.005
更新日期：2008-03-18 00:00:00
abstract：:Many studies have shown that the activation of beta-catenin signaling can promote oncogenesis, and it is therefore of interest to find agents that modulate this pathway. Recent work has shown using B lymphoma cells that infection by Epstein-Barr virus (EBV) and expression of its latent membrane protein (LMP)-1, cause ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2008.10.041
更新日期：2009-04-18 00:00:00
abstract：:The antitumor effects of 2'-C-cyano-2'-deoxy-1-beta-D- arabinofuranosylcytosine (CN-DAC), a synthetic 1-beta-D-arabinofuranosyl-cytosine (ara-C) derivative, were examined and compared with that of ara-C in murine tumors and in various human tumors using three different chemosensitivity tests. CNDAC extended the life s...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(92)90024-p
更新日期：1992-05-30 00:00:00
abstract：:Cucurbitacin B (CuB), has recently emerged as a potent anticancer agent; however, its efficacy in non-small-cell lung cancer (NSCLC) and the mechanism(s) initiating its biological effects remain largely unclear. In this study, CuB potently suppressed the growth of four NSCLC cells (H1299, A549, HCC-827 and H661) in vi...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2013.01.008
更新日期：2013-05-10 00:00:00
abstract：:Birt-Hogg-Dubé (BHD) syndrome is a rare inherited genodermatosis characterized by benign hamartomatous skin lesions and an increased risk of pneumothorax and renal tumors. Many of the patients harbor insertion/deletion mutations in the hypermutable poly(C)(8) tract in exon 11 of the BHD gene. This mutational hot spot ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2006.06.005
更新日期：2007-04-08 00:00:00
abstract：:Thioproline (TPRO), an effective nitrite trapping agent in vivo, was examined for its detoxifying ability in rats against N-nitrosodimethylamine (NDMA) and N-nitrosocimetidine (NCIM). When NDMA (37-101.5 mg/kg) was administered with TPRO (532 mg/kg), no influence of TPRO on NDMA-induced lethality and histological resu...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(90)90260-5
更新日期：1990-04-30 00:00:00
abstract：:Pregnane X receptor (PXR) regulates cell proliferation and carcinogenesis in female reproductive tissue. We showed that PXR was expressed in cervical cells and tissue samples. PXR were lower or greatly diminished in cancer tissues compared to normal control. Functionally, activation of human PXR by rifampicin or ectop...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2014.01.026
更新日期：2014-05-28 00:00:00
abstract：:We investigated the role of the 5-lipoxygenase (5-LOX) pathway of arachidonic acid metabolism in tumour necrosis factor-alpha (TNF-alpha)-induced differentiation of human leukemic HL-60 cells using MK-886, an inhibitor of 5-LOX activating protein. MK-886 augmented cell cycle arrest and differentiation induced by TNF-a...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2005.06.012
更新日期：2006-06-18 00:00:00
abstract：:The aim of the study was to prove whether or not an association exists between the heat shock protein 70 (hsp70) and drug resistance. Tumor samples of 90 patients with previously untreated non-small lung carcinomas were investigated immunohistochemically for expression of resistance related proteins. Additionally, res...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(95)03893-2
更新日期：1995-08-16 00:00:00
abstract：:Antibodies directed against the L1 cell adhesion protein inhibit growth of SKOV3ip human ovarian cancer cells in vitro and in vivo. Responses of SKOV3ip cells in vitro to anti-L1 mAb chCE7 and Genistein were investigated. Genistein potentiated the anti-proliferative and pro-apoptotic effects of chCE7 in SKOV3ip cells....
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2007.11.012
更新日期：2008-03-18 00:00:00
abstract：:Previously, we have shown that simian virus 40 (SV40) T antigen can directly cause apoptosis in immortalized human epithelial cells under normal growth conditions. In this study, we further characterized the mechanism of T-antigen-mediated apoptosis involving p53 and whether T antigen can suppress erbB2/neu gene expre...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(98)00360-7
更新日期：1999-03-22 00:00:00
abstract：:Brain metastasis is an important cause of morbidity and mortality in cancer-patients. Breast tumor cells frequently metastasize to brain and initiate severe therapeutic complications. In the present study, we evaluated the anti-metastatic effects of 2'-hydroxyflavanone (2HF) alone and in combination with RLIP targeted...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2018.09.015
更新日期：2018-12-01 00:00:00
abstract：:We conducted a pilot study to assess the feasibility using the Electoral Register to carry out a cervical cancer screening programme on a Health District basis. A random sample of 500 names and addresses were drawn from a computerised list of the Electoral Register from three Electoral Wards in Oxford. A pilot study s...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(85)90039-4
更新日期：1985-09-30 00:00:00
abstract：:Although pectenotoxin-2 (PTX-2) is known to modify the actin cytoskeleton, very little is known about its apoptosis mechanism. In this study, we investigated whether PTX-2 induces apoptotic effects through suppression of the NF-kappaB signaling pathway in several leukemia cell types. PTX-2 significantly induced growth...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2008.05.034
更新日期：2008-11-18 00:00:00
abstract：:Polo-like kinase 1 (PLK1) is required for multiple stages of mitosis and has been found to be overexpressed in many human malignancies. Previous studies by our group have revealed PLK1 overexpression as an independent prognostic factor for hepatocellular carcinoma (HCC). However, the underlying mechanisms of the tumor...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2011.01.007
更新日期：2011-04-28 00:00:00
abstract：:We analysed the expression of BIRC5 and BIRC5-2B in primary neuroblastoma (NB) tumors and NB model systems. In tumors, overexpression of BIRC5 correlated closely with its isoform BIRC5-2B. Expression of both transcripts was stage-dependent, associated with poor prognosis and with the expression of the transcription fa...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2009.05.007
更新日期：2009-11-18 00:00:00
