Abstract:
:Enhanced expression of the nucleotide excision repair gene XPA is associated with resistance to cisplatin treatment in human ovarian cancer. Understanding the cause of enhanced XPA expression will provide new molecular targets for therapy directed at overcoming chemoresistance. Enhanced gene expression in cancer cells is often caused by mutations or gene amplification. Molecular analyses of the XPA genes in human ovarian cancers indicate that gene mutation and amplification are not the cause of enhanced XPA mRNA levels in ovarian cancers overexpressing XPA. Altered nucleotide excision repair (NER) gene regulation in chemoresistant tumors is discussed.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
States JC,Reed Edoi
10.1016/s0304-3835(96)04428-xsubject
Has Abstractpub_date
1996-11-29 00:00:00pages
233-7issue
2eissn
0304-3835issn
1872-7980pii
S030438359604428Xjournal_volume
108pub_type
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